AQP11

Summary

AQP11 (aquaporin 11, HGNC:19940) is a protein-coding gene on chromosome 11q14.1, encoding Aquaporin-11 (Q8NBQ7). Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain.

Enables glycerol channel activity; hydrogen peroxide channel activity; and water channel activity. Involved in several processes, including glycerol transmembrane transport; hydrogen peroxide transmembrane transport; and intracellular water homeostasis. Located in cell surface; endoplasmic reticulum; and plasma membrane.

Source: NCBI Gene 282679 — RefSeq curated summary.

At a glance

• Gene–disease (curated): polycystic kidney disease (No Known Disease Relationship, GenCC)
• GWAS associations: 2
• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_173039

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19940
Approved symbol	AQP11
Name	aquaporin 11
Location	11q14.1
Locus type	gene with protein product
Status	Approved
Aliases	AQPX1
Ensembl gene	ENSG00000178301
Ensembl biotype	protein_coding
OMIM	609914
Entrez	282679

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000313578, ENST00000528638, ENST00000878997, ENST00000925651

RefSeq mRNA: 2 — MANE Select: NM_173039 NM_001363477, NM_173039

CCDS: CCDS8251

Canonical transcript exons

ENST00000313578 — 3 exons

Exon	Start	End
ENSE00001212931	77589953	77590611
ENSE00002152925	77609298	77610356
ENSE00003673757	77603556	77603672

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 96.26.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.8911 / max 151.2148, expressed in 992 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
115991	1.8630	658
115990	1.0125	620
115992	0.0156	4

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	96.26	gold quality
ileal mucosa	UBERON:0000331	94.76	gold quality
duodenum	UBERON:0002114	90.46	gold quality
adrenal tissue	UBERON:0018303	89.84	gold quality
right adrenal gland	UBERON:0001233	87.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.23	gold quality
sperm	CL:0000019	86.76	gold quality
right adrenal gland cortex	UBERON:0035827	86.57	gold quality
left adrenal gland	UBERON:0001234	85.31	gold quality
left adrenal gland cortex	UBERON:0035825	84.68	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.52	gold quality
adrenal gland	UBERON:0002369	83.73	gold quality
right lobe of liver	UBERON:0001114	82.60	gold quality
adrenal cortex	UBERON:0001235	82.52	gold quality
right testis	UBERON:0004534	78.72	gold quality
liver	UBERON:0002107	78.18	gold quality
left testis	UBERON:0004533	78.04	gold quality
testis	UBERON:0000473	77.44	gold quality
mucosa of transverse colon	UBERON:0004991	76.47	gold quality
left ovary	UBERON:0002119	76.23	gold quality
adult organism	UBERON:0007023	75.96	gold quality
cortical plate	UBERON:0005343	75.69	gold quality
right ovary	UBERON:0002118	75.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.69	gold quality
small intestine	UBERON:0002108	74.54	gold quality
prefrontal cortex	UBERON:0000451	74.50	gold quality
cerebellar hemisphere	UBERON:0002245	74.28	gold quality
cerebellar cortex	UBERON:0002129	74.15	gold quality
ovary	UBERON:0000992	73.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

74 targeting AQP11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-609	99.82	64.26	505
HSA-MIR-548AZ-3P	99.82	70.56	3549

Literature-anchored findings (GeneRIF, showing 13)

• the corresponding NPC motif of AQP11 is essential for full expression of molecular function. (PMID:21118806)
• Built accurate 3D-models for AQP11 and AQP12 and comprehensively compared their sequence and structure to other known aquaporins. (PMID:23359558)
• hAQP11 permeates both water and glycerol, localizing in the vicinity of lipid droplets in human adipocytes. (PMID:24845055)
• Identify rs2276415 as a candidate genetic factor predisposing patients with type 2 diabetes to chronic kidney disease. (PMID:26719361)
• Aquaporins AQP3, -7, -8, and -11 proteins were found in sperm cells and localized in the head (AQP7), in the middle piece (AQP8) and in the tail (AQP3 and -11) in both the plasma membrane and in intracellular structures. (PMID:28042826)
• The AQP11 rs2276415 variant may have a role in chronic kidney disease progression in the Chinese population, independent of traditional risk factors (PMID:30010847)
• These results indicated that hepatitis C virus (HCV) infection induced a miR-27b-mediated reduction in AQP11 expression, leading to a modest reduction in HCV genome levels in the cells. (PMID:31046802)
• Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane. (PMID:31546170)
• Hydrogen peroxide in the ER: A tale of triage. (PMID:31685402)
• Aquaporin-11 Contributes to TGF-beta1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation. (PMID:32512939)
• Aquaporin 11 alleviates retinal Muller intracellular edema through water efflux in diabetic retinopathy. (PMID:36403720)
• Variants in AQP11 may result in autosomal recessive bilateral cystic renal dysgenesis. (PMID:36420936)
• Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors. (PMID:38451099)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	aqp11	ENSDARG00000100555
mus_musculus	Aqp11	ENSMUSG00000042797
rattus_norvegicus	Aqp11	ENSRNOG00000013358
drosophila_melanogaster	AQP	FBGN0033807
caenorhabditis_elegans	aqp-9	WBGENE00000177
caenorhabditis_elegans		WBGENE00000178
caenorhabditis_elegans		WBGENE00000179

Paralogs (2): AQP12A (ENSG00000184945), AQP12B (ENSG00000185176)

Protein

Protein identifiers

Aquaporin-11 — Q8NBQ7 (reviewed: Q8NBQ7)

All UniProt accessions (1): Q8NBQ7

UniProt curated annotations — full annotation on UniProt →

Function. Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development.

Subunit / interactions. Homodimer; disulfide-linked. Homotetramer. Can also form homomultimer.

Subcellular location. Endoplasmic reticulum membrane. Cytoplasmic vesicle membrane. Cell membrane.

Tissue specificity. Detected in the sperm head and tail (at protein level). Expressed in subcutaneous adipocytes. Expressed in testis, kidney and ejaculated spermatozoa.

Post-translational modifications. Not glycosylated.

Domain organisation. The NPC motif is essential for oligomerization and water permeability function.

Similarity. Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.

RefSeq proteins (2): NP_001350406, NP_766627* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000425	MIP	Family
IPR016697	Aquaporin_11/12	Family
IPR023266	Aquaporin_11	Family
IPR023271	Aquaporin-like	Homologous_superfamily
IPR051883	AQP11/12_channel	Family

Pfam: PF00230

Catalyzed reactions (Rhea), 3 shown:

• H2O(in) = H2O(out) (RHEA:29667)
• glycerol(in) = glycerol(out) (RHEA:29675)
• H2O2(out) = H2O2(in) (RHEA:74375)

UniProt features (19 total): topological domain 7, transmembrane region 6, short sequence motif 2, mutagenesis site 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
9VXW	ELECTRON MICROSCOPY	2.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NBQ7-F1	92.82	0.76

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (2):

Position	Phenotype
227	does not affect endoplasmic reticulum localization. does not affect trafficking to the plasma membrane. increases osmoti
227	does not affect endoplasmic reticulum localization. does not affect trafficking to the plasma membrane. reduces protein

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-432047	Passive transport by Aquaporins
R-HSA-382551	Transport of small molecules
R-HSA-445717	Aquaporin-mediated transport

MSigDB gene sets: 167 (showing top): GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION, GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_CARBOHYDRATE_TRANSPORT, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_PROTEOLYSIS, GOBP_ENDOSOME_ORGANIZATION, TGCGCANK_UNKNOWN, GOBP_VESICLE_ORGANIZATION, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, GOBP_PROTEIN_TARGETING, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOCC_CELL_SURFACE, GOBP_KIDNEY_EPITHELIUM_DEVELOPMENT

GO Biological Process (17): protein targeting to membrane (GO:0006612), water transport (GO:0006833), positive regulation of cell population proliferation (GO:0008284), glycoprotein biosynthetic process (GO:0009101), intracellular water homeostasis (GO:0009992), glycerol transmembrane transport (GO:0015793), intracellular oxygen homeostasis (GO:0032364), endosomal lumen acidification (GO:0048388), negative regulation of epithelial cell proliferation (GO:0050680), protein homooligomerization (GO:0051260), proximal tubule development (GO:0072014), hydrogen peroxide transmembrane transport (GO:0080170), negative regulation of response to endoplasmic reticulum stress (GO:1903573), negative regulation of ERAD pathway (GO:1904293), kidney development (GO:0001822), obsolete protein glycosylation (GO:0006486), transmembrane transport (GO:0055085)

GO Molecular Function (4): water channel activity (GO:0015250), glycerol channel activity (GO:0015254), channel activity (GO:0015267), hydrogen peroxide channel activity (GO:0140070)

GO Cellular Component (8): cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), cell surface (GO:0009986), cytoplasmic vesicle membrane (GO:0030659), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Aquaporin-mediated transport	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
channel activity	3
cellular anatomical structure	3
intracellular chemical homeostasis	2
cytoplasm	2
protein targeting	1
establishment of protein localization to membrane	1
fluid transport	1
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
macromolecule biosynthetic process	1
glycoprotein metabolic process	1
carbohydrate derivative biosynthetic process	1
cell volume homeostasis	1
polyol transmembrane transport	1
carbohydrate transmembrane transport	1
endosome organization	1
intracellular pH reduction	1
negative regulation of cell population proliferation	1
epithelial cell proliferation	1
regulation of epithelial cell proliferation	1
protein complex oligomerization	1
nephron tubule development	1
transmembrane transport	1
response to endoplasmic reticulum stress	1
negative regulation of cellular process	1
negative regulation of response to stimulus	1
regulation of response to endoplasmic reticulum stress	1
ERAD pathway	1
negative regulation of proteasomal protein catabolic process	1
negative regulation of response to endoplasmic reticulum stress	1
regulation of ERAD pathway	1
animal organ development	1
renal system development	1
transport	1
cellular process	1
water transmembrane transporter activity	1
glycerol transmembrane transporter activity	1
passive transmembrane transporter activity	1
hydrogen peroxide transmembrane transport	1

Protein interactions and networks

STRING

702 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
AQP11	AQP7	O14520	914
AQP11	AQP8	O94778	910
AQP11	AQP10	Q96PS8	888
AQP11	AQP6	Q13520	888
AQP11	MIP	P30301	886
AQP11	AQP3	Q92482	809
AQP11	AQP5	P55064	804
AQP11	AQP2	P41181	746
AQP11	AQP9	O43315	745
AQP11	AQP1	P29972	627
AQP11	GDPD4	Q6W3E5	438
AQP11	RPS28	P25112	370
AQP11	RAB30	Q15771	370
AQP11	AGT	P01019	355
AQP11	PKD1	P98161	353

IntAct

2 interactions, top by confidence:

A	B	Type	Score
AQP11	STAT5A	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (1): STAT5A (Two-hybrid)

ESM2 similar proteins: A1L134, A6NH21, A6NM10, A6QP75, A7MBM2, E1BE10, E2RD63, F6S3G9, O15554, O43292, O89109, P70295, Q17QQ5, Q32PG7, Q3ZCD2, Q4FZD7, Q5F2F2, Q5GH56, Q5GH64, Q5PQL3, Q60850, Q66K66, Q6IQX7, Q6PIS1, Q6UXT9, Q71RH2, Q7TN60, Q7TNV1, Q7Z403, Q863Y7, Q863Y8, Q8BHH1, Q8CHJ2, Q8CHM1, Q8IU68, Q8IXF9, Q8IZ52, Q8N2A8, Q8N9H8, Q8NBQ7

Diamond homologs: A6NM10, F6S3G9, Q8CHJ2, Q8CHM1, Q8IXF9, Q8NBQ7, Q8BHH1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

465 predictions. Top by Δscore:

Variant	Effect	Δscore
11:77590548:G:GT	donor_gain	0.9900
11:77609292:TTTCA:T	acceptor_loss	0.9900
11:77609293:TTCAG:T	acceptor_loss	0.9900
11:77609294:TCAG:T	acceptor_loss	0.9900
11:77609295:CA:C	acceptor_loss	0.9900
11:77609296:A:C	acceptor_loss	0.9900
11:77609297:GGT:G	acceptor_gain	0.9900
11:77609297:GGTAT:G	acceptor_gain	0.9900
11:77590663:GGCT:G	donor_gain	0.9800
11:77590664:GCTG:G	donor_gain	0.9800
11:77590664:GCT:G	donor_gain	0.9700
11:77609288:T:A	acceptor_loss	0.9700
11:77609296:A:AG	acceptor_gain	0.9700
11:77609297:G:GG	acceptor_gain	0.9700
11:77609339:T:G	acceptor_gain	0.9600
11:77591365:A:G	donor_gain	0.9400
11:77603668:TTTAG:T	donor_loss	0.9400
11:77603669:TTAG:T	donor_loss	0.9400
11:77603670:TAGGT:T	donor_loss	0.9400
11:77603671:AGGT:A	donor_loss	0.9400
11:77603672:GG:G	donor_loss	0.9400
11:77603673:G:GC	donor_loss	0.9400
11:77603674:T:TT	donor_loss	0.9400
11:77590667:G:GG	donor_gain	0.9300
11:77603675:AAGC:A	donor_loss	0.9300
11:77591366:G:GG	donor_gain	0.9100
11:77591370:T:G	donor_gain	0.9000
11:77590563:C:G	donor_gain	0.8600
11:77591484:A:AG	donor_gain	0.8600
11:77609301:T:G	acceptor_gain	0.8600

AlphaMissense

1760 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:77603584:T:A	N216K	0.990
11:77603584:T:G	N216K	0.990
11:77590371:A:C	S127R	0.988
11:77590373:T:A	S127R	0.988
11:77590373:T:G	S127R	0.988
11:77590383:A:C	S131R	0.985
11:77590385:C:A	S131R	0.985
11:77590385:C:G	S131R	0.985
11:77590289:C:A	N99K	0.981
11:77590289:C:G	N99K	0.981
11:77603672:G:C	G246R	0.979
11:77590509:T:C	C173R	0.971
11:77603568:C:T	T211I	0.969
11:77590527:A:C	S179R	0.967
11:77590529:C:A	S179R	0.967
11:77590529:C:G	S179R	0.967
11:77603664:C:G	P243R	0.967
11:77603664:C:A	P243H	0.966
11:77590141:A:T	E50V	0.960
11:77590239:T:G	Y83D	0.960
11:77590502:G:C	E170D	0.960
11:77590502:G:T	E170D	0.960
11:77590183:T:C	L64P	0.959
11:77603579:T:C	F215L	0.959
11:77603581:T:A	F215L	0.959
11:77603581:T:G	F215L	0.959
11:77590140:G:A	E50K	0.956
11:77590166:C:G	C58W	0.955
11:77590501:A:T	E170V	0.953
11:77609298:G:A	G246D	0.953

dbSNP variants (sampled 300 via entrez): RS1000024994 (11:77598861 T>C), RS1000133664 (11:77606340 A>G), RS1000305515 (11:77606064 G>A,C,T), RS1000380703 (11:77607122 G>A,T), RS1000533300 (11:77593911 A>C), RS1000580176 (11:77600578 G>A), RS1000718439 (11:77588041 G>C), RS1000838853 (11:77607422 C>A,T), RS1000869410 (11:77601896 G>A), RS1000966294 (11:77593570 G>A), RS1000982859 (11:77609212 T>C), RS1001177652 (11:77604276 C>T), RS1001203690 (11:77603804 A>G), RS1001438953 (11:77597015 A>G), RS1001507166 (11:77595425 A>G)

Disease associations

OMIM: gene MIM:609914 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
polycystic kidney disease	No Known Disease Relationship	Autosomal recessive

Mondo (1): polycystic kidney disease (MONDO:0020642)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001991_3	Weight loss (gastric bypass surgery)	4.000000e-06
GCST007277_15	Tourette syndrome	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005245	body weight loss

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D007690	Polycystic Kidney Diseases	C12.050.351.968.419.403.875; C12.200.777.419.403.875; C12.950.419.403.875; C16.131.077.717; C16.320.184.625

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: other ic — Aquaporins

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation, increases expression	4
Cyclosporine	decreases expression, increases expression	4
Acetaminophen	decreases expression, increases expression	2
Cisplatin	affects cotreatment, increases expression, decreases expression	2
Valproic Acid	increases expression	2
dicrotophos	decreases expression	1
decabromobiphenyl ether	affects expression	1
arsenite	increases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
pentabromodiphenyl ether	decreases expression	1
2-palmitoylglycerol	increases expression	1
nutlin 3	increases expression, affects cotreatment	1
ICG 001	increases expression	1
abrine	decreases expression	1
quinocetone	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
NSC 689534	affects binding, increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Azathioprine	decreases expression	1
Camptothecin	increases expression	1
Carbamazepine	affects expression	1
Copper	affects binding, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Hydrogen Peroxide	affects expression	1
Phenobarbital	affects expression	1
Plant Extracts	decreases expression, affects cotreatment	1
Quercetin	decreases expression	1
Silicon Dioxide	decreases expression	1
Aflatoxin B1	affects expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D9XQ	Ubigene HeLa AQP11 KO	Cancer cell line	Female

Clinical trials (associated diseases)

25 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02140814	PHASE2	COMPLETED	Uncontrolled, Open Label, Pilot and Feasibility Study of Niacinamide in Polycystic Kidney Disease
NCT02558595	PHASE2	COMPLETED	Pilot Study of Niacinamide in Polycystic Kidney Disease (NIAC-PKD2)
NCT02697617	PHASE2	COMPLETED	Use of Low Dose Pioglitazone to Treat Autosomal Dominant Polycystic Kidney Disease
NCT02166489	PHASE1	COMPLETED	Mesenchymal Stem Cells Transplantation in Patients With Chronic Renal Failure Due to Polycystic Kidney Disease
NCT01009957	PHASE2/PHASE3	TERMINATED	Everolimus on CKD Progression in ADPKD Patients
NCT01680250	PHASE2/PHASE3	UNKNOWN	Sirolimus for Massive Polycystic Liver
NCT00286156	PHASE1/PHASE2	COMPLETED	Pilot Study of Rapamycin as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD)
NCT03423810	EARLY_PHASE1	COMPLETED	Assessing a Dose-Response Relationship of Hydralazine and Its Effects on DNA Methyltransferase 1 in Polycystic Kidney Disease Patients
NCT00792155	Not specified	RECRUITING	Polycystic Kidney Disease Data Repository
NCT01873235	Not specified	RECRUITING	PKD Clinical and Translational Core Study
NCT01931644	Not specified	COMPLETED	At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
NCT02142101	Not specified	COMPLETED	Evaluation of Gut Bacteria in Patients With Polycystic Kidney Disease
NCT02739750	Not specified	COMPLETED	Pioglitazone and Lumbar Bone Marrow Fat in Chronic Kidney Disease
NCT02936791	Not specified	RECRUITING	Early PKD Observational Cohort Study
NCT03726463	Not specified	UNKNOWN	Evaluation of Iliac and Renal Artery for Mechanism of Intracranial Aneurysm in ADPKD
NCT03889392	Not specified	COMPLETED	Evaluation of Nephrectomy Specimen for Intracranial Aneurysm Development in ADPKD
NCT03948113	Not specified	COMPLETED	Outcome of Autosomal Dominant Polycystic Kidney Disease Patients on Peritoneal Dialysis: a National Retrospective Study Based on Two French Registries (the French Language Peritoneal Dialysis Registry and the French Renal Epidemiology and Information Network).
NCT04039061	Not specified	RECRUITING	ADPKD Patient Registry
NCT05215964	Not specified	UNKNOWN	The Association Between Skeletal Muscle Mass and Severity of Polycystic Liver Disease and Polycystic Kidney Disease
NCT06036992	Not specified	ACTIVE_NOT_RECRUITING	Study and Management of Cystic Complications in Autosomal Dominant Polycystic Kidney Disease
NCT06325644	Not specified	RECRUITING	Well-Formulated Ketogenic Diet Polycystic Kidney Disease
NCT06728228	Not specified	RECRUITING	Amnioinfusion for Fetal Renal Failure
NCT06841224	Not specified	ENROLLING_BY_INVITATION	The Factors Affecting IPP in Peritoneal Dialysis Patients with Polycystic Kidney Disease
NCT06867471	Not specified	RECRUITING	Effects of Exogenous Ketosis on Proteinuria and Renal Function
NCT07310641	Not specified	COMPLETED	Descriptive Analysis of Preimplantation Genetic Test (PGT)in Couples With Polycystic Kidney Disease (PKD). In the ADPKD Subgroup Evaluation of Outcomes and Complications Comparing Couples in Which the Father is Affected With Couples in Which the Mother is Affected