AQP4-AS1

Summary

AQP4-AS1 (AQP4 antisense RNA 1, HGNC:26399) is a long non-coding RNA gene on chromosome 18q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26399
Approved symbol	AQP4-AS1
Name	AQP4 antisense RNA 1
Location	18q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ30507
Ensembl gene	ENSG00000260372
Ensembl biotype	lncRNA
Entrez	147429
RNAcentral	URS00000BF0FE — lncRNA, 2392 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 37 — 37 lncRNA

ENST00000568797, ENST00000578701, ENST00000579964, ENST00000582605, ENST00000583852, ENST00000627963, ENST00000628174, ENST00000628325, ENST00000631265, ENST00000656494, ENST00000656601, ENST00000657709, ENST00000658581, ENST00000659210, ENST00000661645, ENST00000664268, ENST00000664897, ENST00000666726, ENST00000668155, ENST00000669364, ENST00000670815, ENST00000716276, ENST00000716277, ENST00000716280, ENST00000716281, ENST00000724581, ENST00000724582, ENST00000724583, ENST00000724584, ENST00000724585, ENST00000830504, ENST00000830505, ENST00000830506, ENST00000830507, ENST00000830508, ENST00000830509, ENST00000830510

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000568797 — 8 exons

Exon	Start	End
ENSE00002579794	26892871	26892992
ENSE00002580997	26933616	26933749
ENSE00002601989	26934280	26936673
ENSE00002606095	26932993	26933122
ENSE00002623817	26865308	26865360
ENSE00002624057	26924760	26924845
ENSE00002626127	26930670	26930823
ENSE00002627604	26925817	26925862

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 91.92.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5329 / max 40.1242, expressed in 104 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
169779	0.1751	72
169778	0.1358	63
169774	0.0932	52
169775	0.0699	40
169777	0.0589	38

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	91.92	gold quality
bronchus	UBERON:0002185	89.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.40	gold quality
mucosa of paranasal sinus	UBERON:0005030	82.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.29	gold quality
buccal mucosa cell	CL:0002336	77.81	gold quality
right lobe of thyroid gland	UBERON:0001119	77.18	gold quality
caudate nucleus	UBERON:0001873	76.77	gold quality
amygdala	UBERON:0001876	75.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.32	gold quality
left lobe of thyroid gland	UBERON:0001120	74.25	gold quality
right frontal lobe	UBERON:0002810	74.13	gold quality
anterior cingulate cortex	UBERON:0009835	73.90	gold quality
putamen	UBERON:0001874	73.71	gold quality
nucleus accumbens	UBERON:0001882	73.46	gold quality
corpus callosum	UBERON:0002336	73.08	gold quality
thyroid gland	UBERON:0002046	72.80	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.96	gold quality
spinal cord	UBERON:0002240	71.67	gold quality
prefrontal cortex	UBERON:0000451	71.46	gold quality
hindlimb stylopod muscle	UBERON:0004252	71.26	gold quality
hypothalamus	UBERON:0001898	71.06	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.42	gold quality
right uterine tube	UBERON:0001302	69.26	gold quality
monocyte	CL:0000576	68.59	gold quality
neocortex	UBERON:0001950	68.59	gold quality
leukocyte	CL:0000738	68.07	gold quality
blood	UBERON:0000178	68.06	gold quality
forebrain	UBERON:0001890	67.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Targeting long noncoding RNA-AQP4-AS1 for the treatment of retinal neurovascular dysfunction in diabetes mellitus. (PMID:35172268)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.