AQP5-AS1

Summary

AQP5-AS1 (AQP5 and AQP2 antisense RNA 2, HGNC:55474) is a long non-coding RNA gene on chromosome 12q13.12. Reduces filamentous actin fibers by interacting with aquaporin AQP2 which leads to inhibition of the expression of SEPTIN4 and integrin ITGB4.

Involved in actin filament organization and regulation of epidermal growth factor receptor signaling pathway.

Source: NCBI Gene 101927318 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55474
Approved symbol	AQP5-AS1
Name	AQP5 and AQP2 antisense RNA 2
Location	12q13.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC025154.2, MIAC
Ensembl gene	ENSG00000257588
Ensembl biotype	lncRNA
Entrez	101927318
RNAcentral	URS000075AC03 — lncRNA, 593 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000550214, ENST00000550530, ENST00000552379, ENST00000750790, ENST00000750791, ENST00000750792, ENST00000750793, ENST00000750794

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000550214 — 2 exons

Exon	Start	End
ENSE00004095458	49962667	49962952
ENSE00004095459	49958872	49959644

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 91.38.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0942 / max 13.8160, expressed in 35 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
130891	0.0942	35

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	91.38	gold quality
bone marrow cell	CL:0002092	86.83	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.80	gold quality
tonsil	UBERON:0002372	79.63	gold quality
metanephros cortex	UBERON:0010533	77.87	gold quality
saliva-secreting gland	UBERON:0001044	76.59	gold quality
minor salivary gland	UBERON:0001830	75.68	gold quality
cortex of kidney	UBERON:0001225	74.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.08	gold quality
adult mammalian kidney	UBERON:0000082	71.54	gold quality
kidney	UBERON:0002113	71.19	gold quality
skin of leg	UBERON:0001511	68.79	gold quality
zone of skin	UBERON:0000014	67.65	gold quality
ventricular zone	UBERON:0003053	66.58	gold quality
skin of abdomen	UBERON:0001416	66.11	gold quality
duodenum	UBERON:0002114	63.52	gold quality
ganglionic eminence	UBERON:0004023	63.12	gold quality
thoracic mammary gland	UBERON:0005200	62.16	gold quality
body of stomach	UBERON:0001161	60.65	gold quality
stomach	UBERON:0000945	60.30	gold quality
gall bladder	UBERON:0002110	58.78	gold quality
esophagus mucosa	UBERON:0002469	56.98	gold quality
esophagus	UBERON:0001043	56.29	gold quality
endocervix	UBERON:0000458	56.05	gold quality
lower esophagus mucosa	UBERON:0035834	55.43	gold quality
pancreas	UBERON:0001264	55.40	gold quality
liver	UBERON:0002107	55.37	gold quality
body of pancreas	UBERON:0001150	55.36	gold quality
adrenal tissue	UBERON:0018303	55.20	gold quality
monocyte	CL:0000576	54.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.61

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.