ARAP1-AS1

Summary

ARAP1-AS1 (ARAP1 antisense RNA 1, HGNC:39993) is a long non-coding RNA gene on chromosome 11q13.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39993
Approved symbol	ARAP1-AS1
Name	ARAP1 antisense RNA 1
Location	11q13.4
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000256007
Ensembl biotype	lncRNA
Entrez	100874075
RNAcentral	URS0000379690 — lncRNA, 388 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000542022

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000542022 — 2 exons

Exon	Start	End
ENSE00002236110	72685075	72685421
ENSE00002244691	72693768	72693808

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 91.10.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	91.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.12	gold quality
lower esophagus mucosa	UBERON:0035834	88.31	gold quality
blood	UBERON:0000178	87.50	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.19	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.57	gold quality
primary visual cortex	UBERON:0002436	84.41	gold quality
cortex of kidney	UBERON:0001225	84.03	gold quality
bone marrow cell	CL:0002092	83.73	gold quality
mucosa of transverse colon	UBERON:0004991	82.74	gold quality
spleen	UBERON:0002106	82.26	gold quality
liver	UBERON:0002107	82.06	gold quality
colonic epithelium	UBERON:0000397	81.73	gold quality
right adrenal gland cortex	UBERON:0035827	80.96	gold quality
right lobe of liver	UBERON:0001114	80.68	gold quality
hindlimb stylopod muscle	UBERON:0004252	80.48	gold quality
sural nerve	UBERON:0015488	80.45	gold quality
skeletal muscle tissue	UBERON:0001134	80.40	gold quality
tonsil	UBERON:0002372	80.28	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.21	gold quality
kidney	UBERON:0002113	79.82	gold quality
hypothalamus	UBERON:0001898	79.48	gold quality
superior frontal gyrus	UBERON:0002661	79.07	gold quality
ventricular zone	UBERON:0003053	78.93	gold quality
adrenal gland	UBERON:0002369	78.75	gold quality
lymph node	UBERON:0000029	78.58	gold quality
left adrenal gland cortex	UBERON:0035825	78.58	gold quality
left adrenal gland	UBERON:0001234	78.34	gold quality
placenta	UBERON:0001987	78.12	gold quality
adenohypophysis	UBERON:0002196	78.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• High ARAP1-AS1 expression is associated with bladder cancer. (PMID:30404578)
• lncRNA-ARAP1-AS1 and ARAP1-AS2 enhanced ARAP1 mRNA expression and may be involved in the pathogenesis of diabetes and DN. (PMID:31079598)
• High ARAP1-AS1 expression is associated with Cell Migration and Invasion in Colorectal Cancer. (PMID:31173500)
• Long non-coding RNA ARAP1-AS1 accelerates cell proliferation and migration in breast cancer through miR-2110/HDAC2/PLIN1 axis. (PMID:32110804)
• Long Non-Coding RNA ARAP1-AS1 Facilitates the Progression of Cervical Cancer by Regulating miR-149-3p and POU2F2. (PMID:33965958)
• Long non-coding RNA ARAP1-AS1 contributes to cell proliferation and migration in clear cell renal cell carcinoma via the miR-361-3p/placental growth factor axis. (PMID:34516333)
• LncRNA ARAP1-AS1 Promotes Bladder Cancer Development by Regulating the miR-3918/KIF20A Axis. (PMID:35556220)
• LncRNA ARAP1-AS1 targets miR-516b-5p/PDE5A axis to facilitate the progression of thyroid cancer. (PMID:36730555)
• lncRNA ARAP1-AS1 enhances proliferation and impairs apoptosis of lymphoma cells by sponging miR-6867-5p. (PMID:37599524)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.