ARAP1-AS2

Summary

ARAP1-AS2 (ARAP1 antisense RNA 2, HGNC:39994) is a long non-coding RNA gene on chromosome 11q13.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39994
Approved symbol	ARAP1-AS2
Name	ARAP1 antisense RNA 2
Location	11q13.4
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245148
Ensembl biotype	lncRNA
Entrez	100506020
RNAcentral	URS000030B95E — lncRNA, 1824 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000500163

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500163 — 2 exons

Exon	Start	End
ENSE00001987369	72703864	72705607
ENSE00001989218	72700474	72700553

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 80.73.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	80.73	gold quality
bone marrow	UBERON:0002371	76.14	gold quality
blood	UBERON:0000178	74.92	gold quality
colonic epithelium	UBERON:0000397	72.81	silver quality
granulocyte	CL:0000094	69.36	gold quality
sural nerve	UBERON:0015488	68.63	silver quality
monocyte	CL:0000576	65.77	gold quality
leukocyte	CL:0000738	65.47	gold quality
skeletal muscle tissue	UBERON:0001134	63.41	gold quality
apex of heart	UBERON:0002098	63.41	gold quality
tonsil	UBERON:0002372	61.33	gold quality
right adrenal gland cortex	UBERON:0035827	60.80	gold quality
adrenal tissue	UBERON:0018303	60.60	gold quality
upper lobe of left lung	UBERON:0008952	60.55	gold quality
right adrenal gland	UBERON:0001233	60.53	gold quality
right lung	UBERON:0002167	59.85	gold quality
lung	UBERON:0002048	59.50	gold quality
cortical plate	UBERON:0005343	59.43	silver quality
ventricular zone	UBERON:0003053	59.28	gold quality
adrenal gland	UBERON:0002369	58.91	gold quality
spleen	UBERON:0002106	58.66	gold quality
ovary	UBERON:0000992	58.64	gold quality
left ovary	UBERON:0002119	58.52	gold quality
lymph node	UBERON:0000029	58.34	gold quality
right atrium auricular region	UBERON:0006631	58.30	gold quality
right ovary	UBERON:0002118	58.27	gold quality
left adrenal gland cortex	UBERON:0035825	58.21	gold quality
liver	UBERON:0002107	58.04	gold quality
heart left ventricle	UBERON:0002084	58.01	gold quality
left adrenal gland	UBERON:0001234	57.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• lncRNA-ARAP1-AS1 and ARAP1-AS2 enhanced ARAP1 mRNA expression and may be involved in the pathogenesis of diabetes and DN. (PMID:31079598)
• The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells. (PMID:31975379)
• LncRNA ARAP1-AS2 promotes high glucose-induced human proximal tubular cell injury via persistent transactivation of the EGFR by interacting with ARAP1. (PMID:32969198)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.