ARB2A

Summary

ARB2A (ARB2 cotranscriptional regulator A, HGNC:25365) is a protein-coding gene on chromosome 5q15, encoding Cotranscriptional regulator ARB2A (Q8WUF8). Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7.

Predicted to contribute to siRNA binding activity. Predicted to be involved in neural crest cell development; regulation of alternative mRNA splicing, via spliceosome; and regulatory ncRNA-mediated heterochromatin formation. Located in endoplasmic reticulum.

Source: NCBI Gene 83989 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 109 total — 5 pathogenic, 2 likely-pathogenic
• MANE Select transcript: NM_032042

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25365
Approved symbol	ARB2A
Name	ARB2 cotranscriptional regulator A
Location	5q15
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP564D172, Toupee
Ensembl gene	ENSG00000113391
Ensembl biotype	protein_coding
OMIM	621249
Entrez	83989

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 14 protein_coding, 3 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000395965, ENST00000502503, ENST00000504768, ENST00000505869, ENST00000506398, ENST00000509163, ENST00000509739, ENST00000510445, ENST00000511139, ENST00000881903, ENST00000881904, ENST00000881905, ENST00000881906, ENST00000881907, ENST00000881908, ENST00000881909, ENST00000881910, ENST00000933325, ENST00000950072

RefSeq mRNA: 3 — MANE Select: NM_032042 NM_001163417, NM_001163418, NM_032042

CCDS: CCDS4069, CCDS54879, CCDS54880

Canonical transcript exons

ENST00000395965 — 11 exons

Exon	Start	End
ENSE00001666024	93881470	93881688
ENSE00001799102	93776159	93776243
ENSE00001914830	94111511	94111663
ENSE00001926306	93617725	93621129
ENSE00003540712	94050731	94050831
ENSE00003557198	93958777	93958968
ENSE00003568241	93964458	93964523
ENSE00003606945	93824148	93824267
ENSE00003629078	94053126	94053227
ENSE00003655593	94074646	94074769
ENSE00003690770	93784383	93784499

Expression profiles

Bgee: expression breadth ubiquitous, 281 present calls, max score 96.29.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.6228 / max 320.8463, expressed in 1785 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
62611	21.6515	1776
62610	2.9526	1319
62608	1.8152	1013
62595	1.3676	624
62609	0.3601	151
62594	0.2647	122
62607	0.2112	72

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	96.29	gold quality
tendon	UBERON:0000043	93.74	gold quality
tendon of biceps brachii	UBERON:0008188	91.85	silver quality
caput epididymis	UBERON:0004358	91.79	gold quality
cranial nerve II	UBERON:0000941	91.41	gold quality
colonic epithelium	UBERON:0000397	91.00	gold quality
corpus epididymis	UBERON:0004359	90.40	gold quality
paraflocculus	UBERON:0005351	90.39	gold quality
cortical plate	UBERON:0005343	89.77	gold quality
cauda epididymis	UBERON:0004360	89.66	gold quality
bronchial epithelial cell	CL:0002328	89.50	gold quality
adrenal tissue	UBERON:0018303	89.29	gold quality
stromal cell of endometrium	CL:0002255	89.26	gold quality
ganglionic eminence	UBERON:0004023	89.06	gold quality
seminal vesicle	UBERON:0000998	89.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.94	gold quality
middle frontal gyrus	UBERON:0002702	87.98	gold quality
ventricular zone	UBERON:0003053	87.93	gold quality
endothelial cell	CL:0000115	87.81	gold quality
sural nerve	UBERON:0015488	87.63	gold quality
entorhinal cortex	UBERON:0002728	87.16	gold quality
medial globus pallidus	UBERON:0002477	87.04	gold quality
upper leg skin	UBERON:0004262	86.14	gold quality
frontal pole	UBERON:0002795	85.99	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.86	gold quality
islet of Langerhans	UBERON:0000006	85.79	gold quality
Brodmann (1909) area 10	UBERON:0013541	85.34	gold quality
parietal pleura	UBERON:0002400	85.13	gold quality
corpus callosum	UBERON:0002336	85.12	gold quality
mammary duct	UBERON:0001765	85.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.06

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

126 targeting ARB2A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-374A-5P	99.90	71.34	2923

Literature-anchored findings (GeneRIF, showing 11)

• The changes of C5orf21 gene expression are correlated with diabetic macroangiopathy. (PMID:20137623)
• FAM172 protein expression in human aortic smooth muscle cells was up-regulated by high glucose levels in a concentration-dependent and time-course manner. (PMID:20818486)
• FAM172A protein promotes cell proliferation, inhibits cell apoptosis and facilitates S-phase entry in HEK293 cells. (PMID:21092515)
• FAM172A protein is expressed at high levels in human papillary thyroid carcinoma, which may promote cell proliferation via activation of the p38 MAPK signaling pathway. (PMID:26573560)
• FAM172A might play a role in the carcinogenesis of CRC by inhibiting the growth and invasion of CRC cells. The mechanisms by which FAM172A exerts its function seem to involve activation of ERS signaling. (PMID:26637224)
• our study showed that miR27a expression is a diagnostic and prognostic marker and correlates with overall survival of patients with CRC. Therefore, it may be a therapeutic approach for preventing metastasis of CRC to inhibit expression of miR27a or increase expression of FAM172A. (PMID:28440497)
• Mesenchymal circulating tumor cells and FAM172A detection may predict highrisk stage II colorectal cancer. Our research proved that circulating tumor cells were feasible surrogate samples to detect gene expression and could serve as a predictive biomarker for tumor evaluation (PMID:28618931)
• FAM172A recombinant protein could induce proliferation of HepG2 cells, in which the MAPK/ERK and PI3K/Akt signaling pathways might be involved. The role of FAM172A in HepG2 cell proliferation also indicated its possible involvement in hepatocellular carcinoma. (PMID:31915594)
• FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling. (PMID:31988090)
• FAM172A promotes follicular thyroid carcinogenesis and may be a marker of FTC. (PMID:33095186)
• The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import. (PMID:37221016)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	arb2a	ENSDARG00000052697
mus_musculus	Arb2a	ENSMUSG00000064138
rattus_norvegicus	Arb2a	ENSRNOG00000013844
drosophila_melanogaster	CG10038	FBGN0038013
caenorhabditis_elegans		WBGENE00013561

Protein

Protein identifiers

Cotranscriptional regulator ARB2A — Q8WUF8 (reviewed: Q8WUF8)

Alternative names: ARB2 cotranscriptional regulator A, Cotranscriptional regulator FAM172A, Protein FAM172A

All UniProt accessions (3): Q8WUF8, B4DMI0, E9PBM2

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity.

Subunit / interactions. Interacts with AGO2. Found in a complex, composed of AGO2, CHD7 and ARB2A.

Subcellular location. Nucleus. Cytoplasm. Endoplasmic reticulum.

Similarity. Belongs to the ARB2A family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8WUF8-1	1	yes
Q8WUF8-2	2
Q8WUF8-3	3
Q8WUF8-4	4

RefSeq proteins (3): NP_001156889, NP_001156890, NP_114431* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029058	AB_hydrolase_fold	Homologous_superfamily
IPR048263	Arb2	Family
IPR053858	Arb2_dom	Domain

Pfam: PF22749

UniProt features (13 total): sequence variant 3, splice variant 3, signal peptide 1, chain 1, sequence conflict 1, region of interest 1, short sequence motif 1, compositionally biased region 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WUF8-F1	84.01	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 293 (nucleophile)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 178 (showing top): AAGCAAT_MIR137, GOBP_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME, KAAB_HEART_ATRIUM_VS_VENTRICLE_UP, PAX8_B, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, GOBP_MESENCHYMAL_CELL_DIFFERENTIATION, GOBP_RNA_SPLICING, GOBP_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME, GOBP_MESENCHYME_DEVELOPMENT, GOBP_STEM_CELL_DIFFERENTIATION, YYCATTCAWW_UNKNOWN, GOBP_CHROMATIN_REMODELING, GOBP_HETEROCHROMATIN_ORGANIZATION, GOBP_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, GOBP_NEURAL_CREST_CELL_DIFFERENTIATION

GO Biological Process (5): regulation of alternative mRNA splicing, via spliceosome (GO:0000381), mRNA processing (GO:0006397), RNA splicing (GO:0008380), neural crest cell development (GO:0014032), regulatory ncRNA-mediated heterochromatin formation (GO:0031048)

GO Molecular Function (2): protein binding (GO:0005515), siRNA binding (GO:0035197)

GO Cellular Component (3): nucleus (GO:0005634), endoplasmic reticulum (GO:0005783), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
intracellular membrane-bounded organelle	2
alternative mRNA splicing, via spliceosome	1
regulation of mRNA splicing, via spliceosome	1
mRNA metabolic process	1
neural crest cell differentiation	1
stem cell development	1
regulatory ncRNA-mediated gene silencing	1
heterochromatin formation	1
binding	1
regulatory RNA binding	1
cytoplasm	1
endomembrane system	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

510 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ARB2A	PLAC8L1	A1L4L8	710
ARB2A	POU5F2	Q8N7G0	612
ARB2A	GRIK3	Q13003	601
ARB2A	NR2F1	P10589	577
ARB2A	SLF1	Q9BQI6	572
ARB2A	MCTP1	Q6DN14	551
ARB2A	PCYOX1	Q9UHG3	517
ARB2A	KIAA0825	Q8IV33	505
ARB2A	CPPED1	Q9BRF8	486
ARB2A	NR2F2	P24468	433
ARB2A	C5orf47	Q569G3	431
ARB2A	PRR33	A8MZF0	400
ARB2A	RNPC3	Q96LT9	394
ARB2A	BRAF	P15056	387
ARB2A	PRDM10	Q9NQV6	377

IntAct

40 interactions, top by confidence:

A	B	Type	Score
DYNLL1	BLTP3B	psi-mi:“MI:0914”(association)	0.730
DYNLL2	BLTP3B	psi-mi:“MI:0914”(association)	0.640
SKP1	MYCBP2	psi-mi:“MI:0914”(association)	0.640
ATXN7L3	USP27X	psi-mi:“MI:0914”(association)	0.640
FGL1	LCMT2	psi-mi:“MI:0914”(association)	0.640
MESD	ARB2A	psi-mi:“MI:0915”(physical association)	0.560
KIR3DL2	METTL15	psi-mi:“MI:0914”(association)	0.530
TANK	TRAF5	psi-mi:“MI:0914”(association)	0.530
ZNF331	USP9Y	psi-mi:“MI:0914”(association)	0.530
ATP5F1D	NDUFB5	psi-mi:“MI:0914”(association)	0.530
DEFB1	NMT2	psi-mi:“MI:0914”(association)	0.530
DNAJC3	DEDD	psi-mi:“MI:0914”(association)	0.530
Dynll1		psi-mi:“MI:0915”(physical association)	0.400
METTL14	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
STYX	BANF1	psi-mi:“MI:0914”(association)	0.350
STYX	PAK4	psi-mi:“MI:0914”(association)	0.350
TAOK2	AIP	psi-mi:“MI:0914”(association)	0.350
FGL1	DNM1L	psi-mi:“MI:0914”(association)	0.350
SKP1	BHLHE40	psi-mi:“MI:0914”(association)	0.350
TTC9C	PLD2	psi-mi:“MI:0914”(association)	0.350
ZXDB	SETD1A	psi-mi:“MI:0914”(association)	0.350
RBX1	OBSL1	psi-mi:“MI:0914”(association)	0.350
CHAF1B	KDM4A	psi-mi:“MI:0914”(association)	0.350
DHX34	ARG2	psi-mi:“MI:0914”(association)	0.350
DNAJB9	POTEF	psi-mi:“MI:0914”(association)	0.350
SKP1	RNASET2	psi-mi:“MI:0914”(association)	0.350
TTC9C	LIPA	psi-mi:“MI:0914”(association)	0.350

BioGRID (38): FAM172A (Affinity Capture-MS), FAM172A (Co-fractionation), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS), FAM172A (Proximity Label-MS), MESDC2 (Two-hybrid), FAM172A (Affinity Capture-MS), FAM172A (Affinity Capture-MS)

ESM2 similar proteins: A6NC97, A6QQL3, D3ZGS3, F1S5L4, O74429, O94830, P06623, P09543, P13233, P16330, P97564, Q01968, Q0P464, Q10271, Q2TBM9, Q30DN6, Q3TNH5, Q5GJ77, Q5PQK1, Q5REG8, Q5RFD0, Q5SNQ7, Q5XUN4, Q5ZK44, Q61586, Q62240, Q6DIP8, Q6IQX0, Q6J5K9, Q6P5U7, Q7T297, Q7YTB0, Q80Y84, Q8C650, Q8CIG3, Q8NB78, Q8T773, Q8VHT6, Q8W1S1, Q8WUF8

Diamond homologs: A6NC97, Q3TNH5, Q5ZK44, Q6DIP8, Q7T297, Q8WUF8, Q557B6, Q95RN0, Q9XW78

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

109 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	5
Likely pathogenic	2
Uncertain significance	84
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (7)

Variant ID	HGVS	Classification
3062838	GRCh37/hg19 5q14.3-15(chr5:91884840-93976422)x1	Pathogenic
563091	GRCh37/hg19 5q14.3-21.3(chr5:91504101-104858348)x1	Pathogenic
59667	GRCh38/hg38 5q14.3-15(chr5:91386552-98365880)x1	Pathogenic
59670	GRCh38/hg38 5q15(chr5:93598243-94237822)x1	Pathogenic
686679	GRCh37/hg19 5q15(chr5:92386982-94865113)x1	Pathogenic
152045	GRCh38/hg38 5q14.3-15(chr5:92031269-93947338)x1	Likely pathogenic
3062820	GRCh37/hg19 5q15(chr5:92845157-93475376)x1	Likely pathogenic

SpliceAI

5418 predictions. Top by Δscore:

Variant	Effect	Δscore
5:93621127:TGCC:T	acceptor_loss	1.0000
5:93621128:GC:G	acceptor_gain	1.0000
5:93621128:GCC:G	acceptor_loss	1.0000
5:93621129:CC:C	acceptor_gain	1.0000
5:93621129:CCTGC:C	acceptor_loss	1.0000
5:93621130:C:A	acceptor_loss	1.0000
5:93621130:C:CC	acceptor_gain	1.0000
5:93621131:T:G	acceptor_loss	1.0000
5:93784377:TCTCA:T	donor_loss	1.0000
5:93784378:CTCAC:C	donor_loss	1.0000
5:93784379:TCACC:T	donor_loss	1.0000
5:93784380:CACCT:C	donor_loss	1.0000
5:93784381:ACCTC:A	donor_loss	1.0000
5:93784382:C:T	donor_loss	1.0000
5:93784500:C:CC	acceptor_gain	1.0000
5:93785403:T:TC	acceptor_gain	1.0000
5:93824143:CTTA:C	donor_loss	1.0000
5:93824144:TTA:T	donor_loss	1.0000
5:93824145:TACCA:T	donor_loss	1.0000
5:93824146:A:AC	donor_gain	1.0000
5:93824146:AC:A	donor_gain	1.0000
5:93824146:ACC:A	donor_loss	1.0000
5:93824147:C:CG	donor_gain	1.0000
5:93824147:CC:C	donor_gain	1.0000
5:93824147:CCA:C	donor_gain	1.0000
5:93824147:CCAG:C	donor_gain	1.0000
5:93824147:CCAGT:C	donor_gain	1.0000
5:93824263:TTTTC:T	acceptor_gain	1.0000
5:93824264:TTTC:T	acceptor_gain	1.0000
5:93824266:TC:T	acceptor_gain	1.0000

AlphaMissense

2757 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:93776177:A:G	C364R	1.000
5:93776229:C:A	W346C	1.000
5:93776229:C:G	W346C	1.000
5:93776230:C:G	W346S	1.000
5:93776231:A:G	W346R	1.000
5:93776231:A:T	W346R	1.000
5:93784394:A:G	W338R	1.000
5:93784394:A:T	W338R	1.000
5:93784441:G:A	S322F	1.000
5:93784442:A:G	S322P	1.000
5:93784444:T:A	D321V	1.000
5:93784445:C:G	D321H	1.000
5:93784453:G:T	A318E	1.000
5:93824149:A:G	L302P	1.000
5:93824167:C:T	G296E	1.000
5:93824168:C:G	G296R	1.000
5:93824168:C:T	G296R	1.000
5:93824170:C:A	G295V	1.000
5:93824170:C:T	G295E	1.000
5:93824171:C:G	G295R	1.000
5:93824171:C:T	G295R	1.000
5:93824175:G:C	S293R	1.000
5:93824175:G:T	S293R	1.000
5:93824176:C:A	S293I	1.000
5:93824177:T:G	S293R	1.000
5:93958811:C:T	G178D	1.000
5:93958812:C:G	G178R	1.000
5:93958849:C:A	W165C	1.000
5:93958849:C:G	W165C	1.000
5:93958850:C:G	W165S	1.000

dbSNP variants (sampled 300 via entrez): RS1000010610 (5:93972771 G>A), RS1000011429 (5:93828155 G>A,T), RS1000012584 (5:93822595 T>C), RS1000019332 (5:93852330 G>A), RS1000025956 (5:93749363 T>A), RS1000032702 (5:93628463 G>A), RS1000033667 (5:94019496 T>C), RS1000034057 (5:93841439 C>T), RS1000035061 (5:93678714 C>T), RS1000048037 (5:93908785 A>G), RS1000058388 (5:94024861 T>G), RS1000059474 (5:93926605 T>C,G), RS1000065944 (5:94110291 T>G), RS1000067036 (5:93635944 A>C), RS1000077305 (5:94110046 A>G)

Disease associations

OMIM: gene MIM:621249 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST006881_7	Hippocampal tail volume (corrected for total hippocampal volume)	3.000000e-09
GCST010132_4	Processed meat consumption	9.000000e-10
GCST010136_8	Fruit consumption	1.000000e-08
GCST010143_22	Meat-related diet	6.000000e-11
GCST010701_76	Cortical surface area (MOSTest)	4.000000e-09
GCST010702_129	Subcortical volume (MOSTest)	2.000000e-15
GCST010703_4	Brain morphology (MOSTest)	5.000000e-34
GCST012490_468	Femur bone mineral density x serum urate levels interaction	6.000000e-10
GCST90093325_8	Language functional connectivity	2.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement
EFO:0004531	urate measurement
EFO:0007797	language measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, increases methylation	6
Valproic Acid	affects expression, decreases expression	3
trichostatin A	affects cotreatment, decreases expression	2
Aflatoxin B1	decreases methylation, decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
geldanamycin	increases expression	1
methyleugenol	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	decreases expression	1
potassium chromate(VI)	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
ICG 001	increases expression	1
abrine	decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
jinfukang	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	decreases expression	1
Vorinostat	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants, Occupational	affects expression	1
Atrazine	decreases expression	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Mercuric Chloride	decreases expression	1
Mustard Gas	decreases expression	1
Silicon Dioxide	decreases expression	1
Thimerosal	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.