ARF4-AS1

Summary

ARF4-AS1 (ARF4 antisense RNA 1, HGNC:51593) is a long non-coding RNA gene on chromosome 3p14.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51593
Approved symbol	ARF4-AS1
Name	ARF4 antisense RNA 1
Location	3p14.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272146
Entrez	106144532
RNAcentral	URS00008E39FC — lncRNA, 548 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 86.51.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8522 / max 67.7696, expressed in 257 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36994	0.7798	240
36995	0.0725	36

Top tissues by expression

137 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.51	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.05	gold quality
cerebellar vermis	UBERON:0004720	77.74	gold quality
bone marrow cell	CL:0002092	76.74	gold quality
hindlimb stylopod muscle	UBERON:0004252	76.66	gold quality
sural nerve	UBERON:0015488	75.27	gold quality
calcaneal tendon	UBERON:0003701	74.55	gold quality
quadriceps femoris	UBERON:0001377	74.53	gold quality
islet of Langerhans	UBERON:0000006	73.52	gold quality
stromal cell of endometrium	CL:0002255	72.62	gold quality
skeletal muscle tissue	UBERON:0001134	72.09	gold quality
right uterine tube	UBERON:0001302	71.77	gold quality
cortical plate	UBERON:0005343	71.67	gold quality
bone marrow	UBERON:0002371	71.25	gold quality
muscle of leg	UBERON:0001383	71.17	gold quality
corpus callosum	UBERON:0002336	70.87	gold quality
pituitary gland	UBERON:0000007	70.86	gold quality
gastrocnemius	UBERON:0001388	70.81	gold quality
adenohypophysis	UBERON:0002196	70.64	gold quality
testis	UBERON:0000473	70.47	gold quality
muscle tissue	UBERON:0002385	70.42	gold quality
ventricular zone	UBERON:0003053	70.11	gold quality
left testis	UBERON:0004533	70.01	gold quality
right testis	UBERON:0004534	69.93	gold quality
leukocyte	CL:0000738	69.59	gold quality
monocyte	CL:0000576	69.33	gold quality
thymus	UBERON:0002370	69.31	silver quality
granulocyte	CL:0000094	68.92	gold quality
rectum	UBERON:0001052	68.83	gold quality
pancreas	UBERON:0001264	68.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.68

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000178729 (3:57596438 C>T), RS1001470837 (3:57601036 A>C), RS1002037413 (3:57595843 C>T), RS1002185449 (3:57597868 C>T), RS1002483627 (3:57599570 G>A,C), RS1002532823 (3:57599921 T>C), RS1002686662 (3:57597739 G>A), RS1002849975 (3:57595867 C>T), RS1003387939 (3:57600667 C>T), RS1003483696 (3:57598114 C>A,T), RS1003537808 (3:57598400 C>T), RS1003939741 (3:57598799 C>A), RS1004370081 (3:57599200 A>G), RS1005014110 (3:57599403 C>T), RS1005125425 (3:57599176 ACT>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
Cadmium Chloride	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.