ARFIP1

Summary

ARFIP1 (ARF interacting protein 1, HGNC:21496) is a protein-coding gene on chromosome 4q31.3, encoding Arfaptin-1 (P53367). Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network.

Enables phosphatidylinositol-4-phosphate binding activity. Involved in negative regulation of retrograde transport, endosome to Golgi. Acts upstream of or within intracellular protein transport and regulation of protein secretion. Located in Golgi membrane; cytosol; and trans-Golgi network membrane.

Source: NCBI Gene 27236 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 63 total — 1 pathogenic, 3 likely-pathogenic
• MANE Select transcript: NM_001025595

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21496
Approved symbol	ARFIP1
Name	ARF interacting protein 1
Location	4q31.3
Locus type	gene with protein product
Status	Approved
Aliases	HSU52521
Ensembl gene	ENSG00000164144
Ensembl biotype	protein_coding
OMIM	605928
Entrez	27236

Gene structure

Transcript identifiers

Ensembl transcripts: 55 — 49 protein_coding, 6 protein_coding_CDS_not_defined

ENST00000353617, ENST00000356064, ENST00000405727, ENST00000429148, ENST00000451320, ENST00000509413, ENST00000510497, ENST00000510831, ENST00000511289, ENST00000513361, ENST00000514499, ENST00000891682, ENST00000891683, ENST00000891684, ENST00000891685, ENST00000891686, ENST00000891687, ENST00000891688, ENST00000891689, ENST00000891690, ENST00000891691, ENST00000891692, ENST00000891693, ENST00000891694, ENST00000891695, ENST00000891696, ENST00000891697, ENST00000891698, ENST00000891699, ENST00000891700, ENST00000891701, ENST00000891702, ENST00000891703, ENST00000914065, ENST00000914066, ENST00000914067, ENST00000914068, ENST00000914069, ENST00000914070, ENST00000914071, ENST00000914072, ENST00000914073, ENST00000914074, ENST00000914075, ENST00000914076, ENST00000914077, ENST00000914078, ENST00000914079, ENST00000914080, ENST00000955260, ENST00000955261, ENST00000955262, ENST00000955263, ENST00000955264, ENST00000955265

RefSeq mRNA: 6 — MANE Select: NM_001025595 NM_001025593, NM_001025595, NM_001287431, NM_001287432, NM_001287433, NM_014447

CCDS: CCDS34080, CCDS3780

Canonical transcript exons

ENST00000353617 — 9 exons

Exon	Start	End
ENSE00001434477	152779954	152780226
ENSE00003474697	152870753	152870848
ENSE00003525254	152888133	152888307
ENSE00003544398	152863606	152863714
ENSE00003566580	152872452	152872564
ENSE00003893125	152882723	152882880
ENSE00003893849	152910064	152912357
ENSE00003895713	152880963	152881184
ENSE00003895784	152829625	152829726

Expression profiles

Bgee: expression breadth ubiquitous, 284 present calls, max score 97.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.5961 / max 896.0929, expressed in 1810 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50031	20.5656	1806
50035	1.6864	114
50030	0.8351	380
50032	0.3814	180
50036	0.1277	26

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	97.05	gold quality
esophagus squamous epithelium	UBERON:0006920	96.83	gold quality
epithelium of nasopharynx	UBERON:0001951	95.36	gold quality
visceral pleura	UBERON:0002401	94.75	gold quality
tibia	UBERON:0000979	94.62	gold quality
parietal pleura	UBERON:0002400	94.22	gold quality
pleura	UBERON:0000977	94.02	gold quality
mucosa of sigmoid colon	UBERON:0004993	93.85	gold quality
calcaneal tendon	UBERON:0003701	93.80	gold quality
colonic mucosa	UBERON:0000317	93.71	gold quality
epithelium of esophagus	UBERON:0001976	93.47	gold quality
germinal epithelium of ovary	UBERON:0001304	93.45	gold quality
amniotic fluid	UBERON:0000173	93.36	gold quality
oocyte	CL:0000023	93.19	gold quality
squamous epithelium	UBERON:0006914	92.98	gold quality
endometrium	UBERON:0001295	92.87	gold quality
rectum	UBERON:0001052	92.80	gold quality
sperm	CL:0000019	92.70	gold quality
gingival epithelium	UBERON:0001949	92.30	gold quality
choroid plexus epithelium	UBERON:0003911	92.07	gold quality
mucosa of transverse colon	UBERON:0004991	92.02	gold quality
mucosa of paranasal sinus	UBERON:0005030	92.02	gold quality
islet of Langerhans	UBERON:0000006	91.94	gold quality
seminal vesicle	UBERON:0000998	91.77	gold quality
corpus epididymis	UBERON:0004359	91.48	gold quality
gingiva	UBERON:0001828	90.98	gold quality
lower esophagus mucosa	UBERON:0035834	90.85	gold quality
bronchial epithelial cell	CL:0002328	90.74	gold quality
skin of hip	UBERON:0001554	90.51	gold quality
pigmented layer of retina	UBERON:0001782	90.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.23

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

107 targeting ARFIP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-1305	99.91	71.43	3443

Literature-anchored findings (GeneRIF, showing 2)

• inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in fibrosarcoma cells (PMID:12606037)
• The binding of arfaptin1, but not arfaptin2, to PI(4)P is regulated by protein kinase D (PKD) mediated phosphorylation at Ser100 within the AH. (PMID:23695357)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	arfip1	ENSDARG00000070055
mus_musculus	Arfip1	ENSMUSG00000074513
rattus_norvegicus	Arfip1	ENSRNOG00000010533
drosophila_melanogaster	Arfip	FBGN0037884
caenorhabditis_elegans		WBGENE00010040

Paralogs (2): PICK1 (ENSG00000100151), ARFIP2 (ENSG00000132254)

Protein

Protein identifiers

Arfaptin-1 — P53367 (reviewed: P53367)

Alternative names: ADP-ribosylation factor-interacting protein 1

All UniProt accessions (2): B4E273, P53367

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.

Subunit / interactions. Forms homodimers or heterodimers with ARFIP2. Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3. Interacts with ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6. Interacts with ARL1. Interacts with ATG9A.

Subcellular location. Golgi apparatus. trans-Golgi network membrane.

Tissue specificity. Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.

Post-translational modifications. Phosphorylated by PRKD1; phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery.

Isoforms (3)

UniProt ID	Names	Canonical?
P53367-1	B, 1b	yes
P53367-2	A, 1a
P53367-3	3

RefSeq proteins (6): NP_001020764, NP_001020766, NP_001274360, NP_001274361, NP_001274362, NP_055262 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR010504	AH_dom	Domain
IPR027267	AH/BAR_dom_sf	Homologous_superfamily
IPR030798	Arfaptin_fam	Family

Pfam: PF06456

UniProt features (17 total): modified residue 9, splice variant 2, initiator methionine 1, chain 1, mutagenesis site 1, domain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P53367-F1	76.85	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 69, 79, 132, 361, 2, 5, 28, 36, 39

Mutagenesis-validated functional residues (1):

Position	Phenotype
132	complete loss of phosphorylation by prkd1.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 223 (showing top): MULLIGHAN_NPM1_SIGNATURE_3_UP, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_REGULATION_OF_ACTIN_NUCLEATION, GOBP_VESICLE_MEDIATED_TRANSPORT, GGGTGGRR_PAX4_03, SP1_Q2_01, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS, GTGCCTT_MIR506, HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_DN, GOBP_REGULATION_OF_PROTEIN_SECRETION, GOBP_NEGATIVE_REGULATION_OF_TRANSPORT, GOCC_TRANS_GOLGI_NETWORK, TGCTGAY_UNKNOWN, GOBP_REGULATION_OF_CELLULAR_LOCALIZATION

GO Biological Process (5): intracellular protein transport (GO:0006886), regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315), regulation of protein secretion (GO:0050708), negative regulation of retrograde transport, endosome to Golgi (GO:1905280), intracellular protein localization (GO:0008104)

GO Molecular Function (4): phospholipid binding (GO:0005543), protein domain specific binding (GO:0019904), phosphatidylinositol-4-phosphate binding (GO:0070273), protein binding (GO:0005515)

GO Cellular Component (5): Golgi membrane (GO:0000139), cytosol (GO:0005829), trans-Golgi network membrane (GO:0032588), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
cellular anatomical structure	2
intracellular protein localization	1
protein transport	1
intracellular transport	1
Arp2/3 complex-mediated actin nucleation	1
regulation of actin nucleation	1
protein secretion	1
regulation of protein transport	1
regulation of secretion by cell	1
negative regulation of intracellular transport	1
retrograde transport, endosome to Golgi	1
regulation of retrograde transport, endosome to Golgi	1
macromolecule localization	1
lipid binding	1
protein binding	1
anion binding	1
phosphatidylinositol phosphate binding	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
trans-Golgi network	1
organelle membrane	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1038 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ARFIP1	ARF6	P26438	900
ARFIP1	AKT1	P31749	834
ARFIP1	ARF5	P26437	800
ARFIP1	ARF1	P10947	791
ARFIP1	ARF3	P16587	745
ARFIP1	RAC1	P15154	660
ARFIP1	AMPH	P49418	605
ARFIP1	TIGD4	Q8IY51	591
ARFIP1	ICA1	P78506	551
ARFIP1	BIN1	O00499	547
ARFIP1	CDKN2A	P42771	537
ARFIP1	TMEM154	Q6P9G4	532
ARFIP1	NCF2	P19878	525
ARFIP1	COPB1	P53618	520
ARFIP1	TMEM131L	A2VDJ0	492

IntAct

102 interactions, top by confidence:

A	B	Type	Score
HSPA8	GAK	psi-mi:“MI:0914”(association)	0.760
ARFIP2	ARFIP1	psi-mi:“MI:0915”(physical association)	0.750
ARFIP2	ARFIP1	psi-mi:“MI:0914”(association)	0.750
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
ARFIP1	ARL1	psi-mi:“MI:0915”(physical association)	0.640
ARFIP1	ARL1	psi-mi:“MI:0914”(association)	0.640
ARFIP1	AFF1	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	MAGEA6	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	CMTM5	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	KRT27	psi-mi:“MI:0915”(physical association)	0.560
SMPD2	ARFIP1	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	KRT33B	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	SMIM5	psi-mi:“MI:0915”(physical association)	0.560
SCAMP1	ARFIP1	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	RPRM	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	BSND	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	SFT2D1	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	TNFRSF10D	psi-mi:“MI:0915”(physical association)	0.560
SYNGR3	ARFIP1	psi-mi:“MI:0915”(physical association)	0.560
ARFIP1	DESI2	psi-mi:“MI:0915”(physical association)	0.560
AFF1	ARFIP1	psi-mi:“MI:0915”(physical association)	0.560
PICK1	ILVBL	psi-mi:“MI:0914”(association)	0.530
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
PICK1	ATP6AP2	psi-mi:“MI:0914”(association)	0.530

BioGRID (175): ARFIP1 (Affinity Capture-MS), ARFIP1 (Affinity Capture-MS), AACS (Co-fractionation), AKR1A1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation), ARFIP1 (Co-fractionation)

ESM2 similar proteins: A1A4L0, A6H6A9, B4F779, G5E8V9, O35382, O60890, O95219, P0CAX5, P53365, P53367, Q08DP6, Q28E02, Q3ZCL5, Q4V7P7, Q566W7, Q5EAD0, Q5R4C2, Q5RCW6, Q5T0N5, Q5VWJ9, Q5ZJ17, Q60437, Q62824, Q6AY65, Q6GMN2, Q6PCS4, Q6Y5D8, Q6ZQ82, Q7YQL5, Q7YQL6, Q80TY0, Q8BHY8, Q8BKX1, Q8CE50, Q8K221, Q8K3G9, Q8K3H0, Q8N6S4, Q8NEU8, Q8R511

Diamond homologs: G5E8V9, P34445, P53365, P53367, Q3ZCL5, Q6AY65, Q8K221, Q9JHU5

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
PRKD1	up-regulates	ARFIP1	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 67 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Intra-Golgi and retrograde Golgi-to-ER traffic	6	15.3×	7e-04
Clathrin-mediated endocytosis	6	12.5×	1e-03
Membrane Trafficking	8	7.2×	1e-03
Vesicle-mediated transport	8	6.8×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	3
Uncertain significance	45
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (4)

Variant ID	HGVS	Classification
442937	GRCh37/hg19 4q31.3-32.2(chr4:153203431-162912359)x1	Pathogenic
146396	GRCh38/hg38 4q31.3-32.1(chr4:151299810-160314050)x1	Likely pathogenic
155550	GRCh38/hg38 4q31.3-32.1(chr4:152500649-155788803)x3	Likely pathogenic
814616	GRCh37/hg19 4q31.3-32.1(chr4:153061243-157994448)x1	Likely pathogenic

SpliceAI

3288 predictions. Top by Δscore:

Variant	Effect	Δscore
4:152829617:T:TA	acceptor_gain	1.0000
4:152829621:TTA:T	acceptor_loss	1.0000
4:152829621:TTAGG:T	acceptor_gain	1.0000
4:152829622:TA:T	acceptor_loss	1.0000
4:152829622:TAGG:T	acceptor_gain	1.0000
4:152829623:A:AG	acceptor_gain	1.0000
4:152829623:A:AT	acceptor_loss	1.0000
4:152829623:AG:A	acceptor_gain	1.0000
4:152829623:AGGA:A	acceptor_gain	1.0000
4:152829624:G:GC	acceptor_gain	1.0000
4:152829624:GG:G	acceptor_gain	1.0000
4:152829624:GGA:G	acceptor_gain	1.0000
4:152829624:GGAG:G	acceptor_gain	1.0000
4:152829624:GGAGT:G	acceptor_gain	1.0000
4:152829723:TAGG:T	donor_gain	1.0000
4:152829725:GG:G	donor_gain	1.0000
4:152829726:GG:G	donor_gain	1.0000
4:152829727:G:GG	donor_gain	1.0000
4:152863593:A:AG	acceptor_gain	1.0000
4:152863594:A:G	acceptor_gain	1.0000
4:152863596:T:G	acceptor_gain	1.0000
4:152870825:G:GT	donor_gain	1.0000
4:152872449:CAG:C	acceptor_loss	1.0000
4:152872450:A:AG	acceptor_gain	1.0000
4:152872450:AGGT:A	acceptor_gain	1.0000
4:152872451:G:GA	acceptor_gain	1.0000
4:152872451:GGT:G	acceptor_gain	1.0000
4:152872451:GGTG:G	acceptor_gain	1.0000
4:152872560:ATAAG:A	donor_loss	1.0000
4:152872561:TAAG:T	donor_loss	1.0000

AlphaMissense

2456 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:152872544:T:A	W131R	1.000
4:152872544:T:C	W131R	1.000
4:152872546:G:C	W131C	1.000
4:152872546:G:T	W131C	1.000
4:152872559:T:G	Y136D	1.000
4:152872564:G:C	K137N	1.000
4:152872564:G:T	K137N	1.000
4:152880973:A:C	Q141P	1.000
4:152880981:T:C	S144P	1.000
4:152881138:T:C	L196P	1.000
4:152882880:G:C	R264T	1.000
4:152882880:G:T	R264M	1.000
4:152888133:G:C	R264S	1.000
4:152888133:G:T	R264S	1.000
4:152888146:G:C	A269P	1.000
4:152888147:C:A	A269E	1.000
4:152888152:C:A	R271S	1.000
4:152888153:G:C	R271P	1.000
4:152888264:G:C	R308P	1.000
4:152888294:T:C	L318P	1.000
4:152910086:T:C	L330P	1.000
4:152872536:T:A	V128D	0.999
4:152872547:A:C	S132R	0.999
4:152872549:T:A	S132R	0.999
4:152872549:T:G	S132R	0.999
4:152872562:A:G	K137E	0.999
4:152880970:G:C	R140P	0.999
4:152880974:G:C	Q141H	0.999
4:152880974:G:T	Q141H	0.999
4:152880979:T:A	I143N	0.999

dbSNP variants (sampled 300 via entrez): RS1000014776 (4:152891789 A>G), RS1000018955 (4:152824293 A>G), RS1000037858 (4:152803689 A>G), RS1000044015 (4:152904760 G>A,C,T), RS1000063526 (4:152805626 G>A), RS1000120434 (4:152781902 T>C), RS1000145152 (4:152894394 T>C), RS1000168153 (4:152779905 T>C), RS1000202950 (4:152800923 G>A), RS1000223088 (4:152870412 T>A), RS1000234607 (4:152889923 T>G), RS1000267239 (4:152889176 C>G), RS1000272024 (4:152870697 G>A), RS1000281782 (4:152837274 T>C), RS1000291368 (4:152784617 T>C)

Disease associations

OMIM: gene MIM:605928 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST90002385_261	High light scatter reticulocyte count	2.000000e-12
GCST90002386_8	High light scatter reticulocyte percentage of red cells	2.000000e-12
GCST90002395_657	Mean platelet volume	5.000000e-15
GCST90002404_89	Red cell distribution width	1.000000e-38
GCST90002406_100	Reticulocyte fraction of red cells	2.000000e-12

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, decreases expression	3
bisphenol A	decreases expression, affects cotreatment, increases methylation	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
bisphenol F	increases expression	1
dicrotophos	decreases expression	1
geldanamycin	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases abundance, affects cotreatment, decreases expression	1
decabromobiphenyl ether	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	decreases expression, increases abundance	1
tetrabromobisphenol A	decreases expression	1
manganese chloride	increases abundance, increases expression	1
1-nitropyrene	increases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
2,3,5-(triglutathion-S-yl)hydroquinone	decreases ADP-ribosylation	1
nutlin 3	affects cotreatment, increases secretion	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
jinfukang	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
bisphenol AF	increases expression	1
Arsenic Trioxide	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2S0	Abcam HEK293T ARFIP1 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.