ARFIP2

Summary

ARFIP2 (ARF interacting protein 2, HGNC:17160) is a protein-coding gene on chromosome 11p15.4, encoding Arfaptin-2 (P53365). Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network.

Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization; mitophagy; and protein localization to phagophore assembly site. Located in several cellular components, including nucleolus; ruffle; and trans-Golgi network membrane.

Source: NCBI Gene 23647 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 46 total
• Druggable target: yes
• MANE Select transcript: NM_001376558

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17160
Approved symbol	ARFIP2
Name	ARF interacting protein 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	POR1
Ensembl gene	ENSG00000132254
Ensembl biotype	protein_coding
OMIM	601638
Entrez	23647

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 22 protein_coding, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000254584, ENST00000396777, ENST00000423813, ENST00000445086, ENST00000525235, ENST00000525329, ENST00000529847, ENST00000530410, ENST00000531037, ENST00000614314, ENST00000860044, ENST00000860045, ENST00000860046, ENST00000860047, ENST00000860048, ENST00000860049, ENST00000860050, ENST00000860051, ENST00000860052, ENST00000860053, ENST00000931131, ENST00000931132, ENST00000931133, ENST00000931134, ENST00000931135, ENST00000931136, ENST00000931137

RefSeq mRNA: 17 — MANE Select: NM_001376558 NM_001242854, NM_001242855, NM_001242856, NM_001370406, NM_001370408, NM_001370409, NM_001370411, NM_001370412, NM_001370413, NM_001376558, NM_001376559, NM_001376560, NM_001376561, NM_001376562, NM_001376563, NM_001376564, NM_012402

CCDS: CCDS55739, CCDS55740, CCDS73250, CCDS7765

Canonical transcript exons

ENST00000396777 — 8 exons

Exon	Start	End
ENSE00000903318	6478738	6478959
ENSE00000903319	6479140	6479258
ENSE00001864228	6476519	6477268
ENSE00001890156	6481231	6481331
ENSE00003556446	6477718	6477892
ENSE00003567193	6479972	6480068
ENSE00003606832	6480323	6480463
ENSE00003674815	6478041	6478198

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 97.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 35.0887 / max 188.6634, expressed in 1819 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118431	34.1528	1819
118432	0.9359	622

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	97.50	gold quality
type B pancreatic cell	CL:0000169	97.35	gold quality
body of pancreas	UBERON:0001150	97.29	gold quality
adenohypophysis	UBERON:0002196	96.69	gold quality
pituitary gland	UBERON:0000007	96.49	gold quality
body of stomach	UBERON:0001161	96.47	gold quality
right uterine tube	UBERON:0001302	96.40	gold quality
trachea	UBERON:0003126	96.37	gold quality
rectum	UBERON:0001052	96.33	gold quality
olfactory bulb	UBERON:0002264	96.26	silver quality
minor salivary gland	UBERON:0001830	96.25	gold quality
right lobe of thyroid gland	UBERON:0001119	96.16	gold quality
nasal cavity epithelium	UBERON:0005384	96.06	gold quality
left lobe of thyroid gland	UBERON:0001120	95.97	gold quality
islet of Langerhans	UBERON:0000006	95.85	gold quality
saliva-secreting gland	UBERON:0001044	95.84	gold quality
metanephros cortex	UBERON:0010533	95.62	gold quality
mucosa of transverse colon	UBERON:0004991	95.59	gold quality
mouth mucosa	UBERON:0003729	95.51	gold quality
pancreas	UBERON:0001264	95.41	gold quality
transverse colon	UBERON:0001157	95.40	gold quality
stomach	UBERON:0000945	95.36	gold quality
thyroid gland	UBERON:0002046	95.21	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.12	gold quality
stromal cell of endometrium	CL:0002255	95.00	gold quality
skin of leg	UBERON:0001511	94.93	gold quality
skin of abdomen	UBERON:0001416	94.86	gold quality
endocervix	UBERON:0000458	94.68	gold quality
left adrenal gland cortex	UBERON:0035825	94.60	gold quality
mucosa of stomach	UBERON:0001199	94.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.87

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

91 targeting ARFIP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-2116-3P	99.74	64.32	889
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-1208	99.70	68.28	1533
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-1260A	99.61	66.67	1098
HSA-MIR-1260B	99.61	66.67	1098
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-4489	99.50	65.56	785

Literature-anchored findings (GeneRIF, showing 8)

• arfaptin 2 is involved in regulating huntingtin protein aggregation (PMID:11854752)
• arfaptin 2 phosphorylation at Ser260 by Akt inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment (PMID:15809304)
• The Arl1.Arfaptin-2 BAR structure suggests that one of the two Arl1 molecules competes with Rac1, which binds to the concave face of the Arfaptin-2 BAR homodimer and may hinder its membrane association. (PMID:22679020)
• both Arf1 activation and high membrane curvature are required for efficient recruitment of Arfaptin2 to membranes (PMID:23638170)
• The binding of arfaptin1, but not arfaptin2, to PI(4)P is regulated by protein kinase D (PKD) mediated phosphorylation at Ser100 within the AH. (PMID:23695357)
• The data indicate that arfaptin 2 is the first molecule to regulate NF-kappaB signaling by interacting with the functional IkappaB kinase complex but not by direct inhibiting IKKbeta phosphorylation. (PMID:26296658)
• Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR. (PMID:33837886)
• Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2. (PMID:38302034)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	arfip2b	ENSDARG00000056664
danio_rerio	arfip2a	ENSDARG00000059244
mus_musculus	Arfip2	ENSMUSG00000030881
rattus_norvegicus	Arfip2	ENSRNOG00000018440
drosophila_melanogaster	Arfip	FBGN0037884
caenorhabditis_elegans		WBGENE00010040

Paralogs (2): PICK1 (ENSG00000100151), ARFIP1 (ENSG00000164144)

Protein

Protein identifiers

Arfaptin-2 — P53365 (reviewed: P53365)

Alternative names: ADP-ribosylation factor-interacting protein 2, Partner of RAC1

All UniProt accessions (4): P53365, A0A087X1E4, E9PPY7, E9PRV8

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG.

Subunit / interactions. Forms homodimers or heterodimers with ARFIP1. Interacts with RAC1. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Interacts with ARL1. Interacts (via N-terminus) with IKBKB and IKBKG; these interactions inhibit activation of NF-kappa-B.

Subcellular location. Golgi apparatus. trans-Golgi network membrane.

Isoforms (3)

UniProt ID	Names	Canonical?
P53365-1	1	yes
P53365-2	2
P53365-3	3

RefSeq proteins (17): NP_001229783, NP_001229784, NP_001229785, NP_001357335, NP_001357337, NP_001357338, NP_001357340, NP_001357341, NP_001357342, NP_001363487, NP_001363488, NP_001363489, NP_001363490, NP_001363491, NP_001363492, NP_001363493, NP_036534 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR010504	AH_dom	Domain
IPR027267	AH/BAR_dom_sf	Homologous_superfamily
IPR030798	Arfaptin_fam	Family

Pfam: PF06456

UniProt features (16 total): helix 5, turn 2, modified residue 2, splice variant 2, chain 1, domain 1, region of interest 1, mutagenesis site 1, sequence conflict 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
1I4D	X-RAY DIFFRACTION	2.5
1I4T	X-RAY DIFFRACTION	2.6
1I4L	X-RAY DIFFRACTION	2.7
1I49	X-RAY DIFFRACTION	2.8
4DCN	X-RAY DIFFRACTION	3.01

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P53365-F1	81.84	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 72, 76

Mutagenesis-validated functional residues (1):

Position	Phenotype
99	abolished ability to regulate atg9a trafficking.

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic

MSigDB gene sets: 199 (showing top): GGGACCA_MIR133A_MIR133B, MODULE_52, GOBP_VACUOLE_ORGANIZATION, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_REGULATION_OF_ACTIN_NUCLEATION, AREB6_03, MAZ_Q6, BROWNE_HCMV_INFECTION_16HR_UP, GOCC_RUFFLE, REACTOME_MEMBRANE_TRAFFICKING, GOMF_GTPASE_BINDING, GGGTGGRR_PAX4_03, GOBP_MACROAUTOPHAGY, GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS, CTAGGAA_MIR384

GO Biological Process (10): mitophagy (GO:0000423), intracellular protein transport (GO:0006886), small GTPase-mediated signal transduction (GO:0007264), lamellipodium assembly (GO:0030032), actin cytoskeleton organization (GO:0030036), ruffle organization (GO:0031529), regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315), protein localization to phagophore assembly site (GO:0034497), autophagy (GO:0006914), intracellular protein localization (GO:0008104)

GO Molecular Function (10): GTP binding (GO:0005525), phospholipid binding (GO:0005543), protein domain specific binding (GO:0019904), GTP-dependent protein binding (GO:0030742), small GTPase binding (GO:0031267), identical protein binding (GO:0042802), cadherin binding (GO:0045296), phosphatidylinositol-4-phosphate binding (GO:0070273), membrane curvature sensor activity (GO:0140090), protein binding (GO:0005515)

GO Cellular Component (9): ruffle (GO:0001726), nucleolus (GO:0005730), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), cytosol (GO:0005829), plasma membrane (GO:0005886), cell cortex (GO:0005938), trans-Golgi network membrane (GO:0032588), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Intra-Golgi and retrograde Golgi-to-ER traffic	1
Vesicle-mediated transport	1
Membrane Trafficking	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein binding	3
cellular anatomical structure	3
cytoplasm	3
intracellular protein localization	2
lipid binding	2
cell periphery	2
autophagy of mitochondrion	1
macroautophagy	1
protein transport	1
intracellular transport	1
intracellular signaling cassette	1
lamellipodium organization	1
plasma membrane bounded cell projection assembly	1
cytoskeleton organization	1
actin filament-based process	1
plasma membrane bounded cell projection organization	1
Arp2/3 complex-mediated actin nucleation	1
regulation of actin nucleation	1
autophagosome assembly	1
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
macromolecule localization	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
GTPase binding	1
cell adhesion molecule binding	1
anion binding	1
phosphatidylinositol phosphate binding	1
molecular sensor activity	1
binding	1
cell leading edge	1
plasma membrane bounded cell projection	1
nuclear lumen	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1
membrane	1
trans-Golgi network	1

Protein interactions and networks

STRING

1012 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ARFIP2	ARF6	P26438	849
ARFIP2	ARF1	P10947	807
ARFIP2	CDKN2A	P42771	759
ARFIP2	BIN1	O00499	678
ARFIP2	ARF5	P26437	661
ARFIP2	ARF3	P16587	598
ARFIP2	KPNA2	P52292	595
ARFIP2	SYNJ2	O15056	511
ARFIP2	VDAC1	P21796	505
ARFIP2	AMPH	P49418	501
ARFIP2	KIF23	Q02241	498
ARFIP2	AKT1	P31749	497
ARFIP2	BAIAP2	Q9UQB8	482
ARFIP2	CYFIP2	Q96F07	475
ARFIP2	WASF2	Q9Y6W5	458

IntAct

256 interactions, top by confidence:

A	B	Type	Score
RAC1	ARFIP2	psi-mi:“MI:0407”(direct interaction)	0.910
RAC1	ARFIP2	psi-mi:“MI:2364”(proximity)	0.910
RAC1	ARFIP2	psi-mi:“MI:0915”(physical association)	0.910
ARFIP2	ARFIP2	psi-mi:“MI:0915”(physical association)	0.830
ARFIP2	ARFIP1	psi-mi:“MI:0915”(physical association)	0.750
KRT15	ARFIP2	psi-mi:“MI:0915”(physical association)	0.720
MAL2	ARFIP2	psi-mi:“MI:0915”(physical association)	0.720
ARFIP2	KRT15	psi-mi:“MI:0915”(physical association)	0.720
ARFIP2	SH3GLB1	psi-mi:“MI:0915”(physical association)	0.720
ARFIP2	MAL2	psi-mi:“MI:0915”(physical association)	0.720
ITGB3BP	ARFIP2	psi-mi:“MI:0915”(physical association)	0.670
AGTRAP	ARFIP2	psi-mi:“MI:0915”(physical association)	0.670
ARFIP2	ITGB3BP	psi-mi:“MI:0915”(physical association)	0.670
ARFIP2	AGTRAP	psi-mi:“MI:0915”(physical association)	0.670

BioGRID (157): ARFIP2 (Two-hybrid), ARFIP2 (Two-hybrid), ARFIP2 (Two-hybrid), ARFIP2 (Two-hybrid), AGTRAP (Two-hybrid), TRIM54 (Two-hybrid), CEP63 (Two-hybrid), USHBP1 (Two-hybrid), ING5 (Two-hybrid), MAL2 (Two-hybrid), HAUS1 (Two-hybrid), ARFIP2 (Affinity Capture-RNA), ARFIP1 (Affinity Capture-MS), ARFIP2 (Affinity Capture-MS), DTNBP1 (Two-hybrid)

ESM2 similar proteins: A1A4L0, A6H6A9, B4F779, G5E8V9, O35382, O60890, O95219, P0CAX5, P53365, P53367, Q08DP6, Q28E02, Q3ZCL5, Q4V7P7, Q566W7, Q5EAD0, Q5R4C2, Q5RCW6, Q5T0N5, Q5VWJ9, Q5ZJ17, Q60437, Q62824, Q6AY65, Q6GMN2, Q6PCS4, Q6Y5D8, Q6ZQ82, Q7YQL5, Q7YQL6, Q80TY0, Q8BHY8, Q8BKX1, Q8CE50, Q8K221, Q8K3G9, Q8K3H0, Q8N6S4, Q8NEU8, Q8R511

Diamond homologs: G5E8V9, P34445, P53365, P53367, Q3ZCL5, Q6AY65, Q8K221, Q9JHU5

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
AKT	unknown	ARFIP2	phosphorylation
AKT1	unknown	ARFIP2	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 63 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
regulation of actin cytoskeleton organization	5	14.1×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1680 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6477712:TGGCA:T	donor_loss	1.0000
11:6477713:GGCAC:G	donor_loss	1.0000
11:6477714:GCACC:G	donor_loss	1.0000
11:6477715:CACCT:C	donor_loss	1.0000
11:6477716:A:AT	donor_loss	1.0000
11:6477717:C:CG	donor_loss	1.0000
11:6477728:T:TA	donor_gain	1.0000
11:6477888:CCAGC:C	acceptor_gain	1.0000
11:6477889:CAGC:C	acceptor_gain	1.0000
11:6477889:CAGCC:C	acceptor_gain	1.0000
11:6477890:AGCCT:A	acceptor_loss	1.0000
11:6477891:GC:G	acceptor_gain	1.0000
11:6477891:GCCT:G	acceptor_loss	1.0000
11:6477892:CC:C	acceptor_gain	1.0000
11:6477893:C:CC	acceptor_gain	1.0000
11:6478035:CCACA:C	donor_loss	1.0000
11:6478036:CACAC:C	donor_loss	1.0000
11:6478038:CACCT:C	donor_loss	1.0000
11:6478039:ACCTG:A	donor_loss	1.0000
11:6478040:C:CG	donor_loss	1.0000
11:6478054:A:AC	donor_gain	1.0000
11:6478055:C:CC	donor_gain	1.0000
11:6478055:CTGTT:C	donor_gain	1.0000
11:6478056:TGTTT:T	donor_gain	1.0000
11:6478080:T:TA	donor_gain	1.0000
11:6478090:TGGTG:T	donor_gain	1.0000
11:6478194:TCCTC:T	acceptor_gain	1.0000
11:6478195:CCTCC:C	acceptor_gain	1.0000
11:6478196:CTC:C	acceptor_gain	1.0000
11:6478198:CCTG:C	acceptor_loss	1.0000

AlphaMissense

2202 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:6477246:A:G	L298P	1.000
11:6477731:A:G	L286P	1.000
11:6477742:C:A	K282N	1.000
11:6477742:C:G	K282N	1.000
11:6477744:T:C	K282E	1.000
11:6477872:C:G	R239P	1.000
11:6477878:G:T	A237D	1.000
11:6478041:C:A	R232M	1.000
11:6478041:C:G	R232T	1.000
11:6478077:T:C	D220G	1.000
11:6478077:T:G	D220A	1.000
11:6478078:C:G	D220H	1.000
11:6479140:C:A	K105N	1.000
11:6479140:C:G	K105N	1.000
11:6479145:A:C	Y104D	1.000
11:6479145:A:T	Y104N	1.000
11:6479158:C:A	W99C	1.000
11:6479158:C:G	W99C	1.000
11:6479160:A:G	W99R	1.000
11:6479160:A:T	W99R	1.000
11:6479168:A:T	V96D	1.000
11:6477217:A:C	Y308D	0.999
11:6477228:G:T	A304D	0.999
11:6477229:C:G	A304P	0.999
11:6477721:G:C	N289K	0.999
11:6477721:G:T	N289K	0.999
11:6477722:T:A	N289I	0.999
11:6477723:T:C	N289D	0.999
11:6477734:A:G	F285S	0.999
11:6477740:A:G	L283P	0.999

dbSNP variants (sampled 300 via entrez): RS1000365664 (11:6481926 C>G), RS1001483841 (11:6482248 C>G,T), RS1001714070 (11:6476408 G>A), RS1002050326 (11:6482457 A>G), RS1002596206 (11:6477647 G>A,C), RS1003293859 (11:6477380 T>C), RS1003347778 (11:6477696 G>A), RS1003530884 (11:6482985 T>A), RS1003717335 (11:6479545 G>A), RS1003881127 (11:6481637 G>A,T), RS1004898451 (11:6476697 G>A), RS1004952506 (11:6476473 C>T), RS1005048709 (11:6480479 C>A,G,T), RS1005287628 (11:6482773 A>G,T), RS1005403483 (11:6476946 C>T)

Disease associations

OMIM: gene MIM:601638 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066871 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	increases expression	2
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
pirinixic acid	increases activity, increases expression, affects binding	1
kojic acid	decreases expression	1
beta-lapachone	increases expression	1
potassium chromate(VI)	increases expression	1
nickel sulfate	increases expression	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1
Arbutin	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	decreases phosphorylation	1
Diethylstilbestrol	decreases expression	1
Doxorubicin	increases expression	1
Ozone	affects cotreatment, increases expression, increases abundance	1
Rotenone	increases expression	1
Selenium	increases expression	1
Smoke	decreases expression	1
Dihydrotestosterone	increases expression	1
Cyclosporine	increases expression	1
Volatile Organic Compounds	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652870	Binding	Binding affinity to human ARFIP2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1JW	Abcam HeLa ARFIP2 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.