ARGLU1-DT

Summary

ARGLU1-DT (ARGLU1 divergent transcript, HGNC:43691) is a long non-coding RNA gene on chromosome 13q33.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43691
Approved symbol	ARGLU1-DT
Name	ARGLU1 divergent transcript
Location	13q33.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272274
Ensembl biotype	lncRNA
Entrez	283483
RNAcentral	URS000075CDFA — lncRNA, 1967 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 26 lncRNA, 1 retained_intron

ENST00000421601, ENST00000607593, ENST00000653952, ENST00000656762, ENST00000658356, ENST00000661468, ENST00000663663, ENST00000664222, ENST00000665026, ENST00000667614, ENST00000690745, ENST00000700965, ENST00000715699, ENST00000715700, ENST00000743676, ENST00000743677, ENST00000761728, ENST00000761729, ENST00000761730, ENST00000761731, ENST00000761732, ENST00000761733, ENST00000761734, ENST00000761735, ENST00000761736, ENST00000761737, ENST00000761738

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421601 — 4 exons

Exon	Start	End
ENSE00004027627	106668646	106668928
ENSE00004116299	106671516	106672177
ENSE00004116301	106650422	106650574
ENSE00004116315	106653881	106654154

Expression profiles

Bgee: expression breadth ubiquitous, 150 present calls, max score 85.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5205 / max 28.6649, expressed in 1156 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135963	1.7458	999
135964	0.7426	359
135965	0.0321	10

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	85.53	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.25	gold quality
esophagus mucosa	UBERON:0002469	72.22	gold quality
cortical plate	UBERON:0005343	70.68	gold quality
right lung	UBERON:0002167	70.03	gold quality
amniotic fluid	UBERON:0000173	69.95	gold quality
adult mammalian kidney	UBERON:0000082	64.89	gold quality
metanephros cortex	UBERON:0010533	63.13	gold quality
upper lobe of left lung	UBERON:0008952	63.11	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	62.99	gold quality
esophagus	UBERON:0001043	62.90	gold quality
upper lobe of lung	UBERON:0008948	62.84	gold quality
ganglionic eminence	UBERON:0004023	61.55	gold quality
right lobe of liver	UBERON:0001114	61.20	gold quality
sural nerve	UBERON:0015488	60.85	silver quality
hindlimb stylopod muscle	UBERON:0004252	60.34	gold quality
lung	UBERON:0002048	59.67	gold quality
anterior cingulate cortex	UBERON:0009835	59.36	gold quality
prefrontal cortex	UBERON:0000451	59.06	gold quality
vagina	UBERON:0000996	58.99	gold quality
cortex of kidney	UBERON:0001225	58.85	gold quality
kidney	UBERON:0002113	58.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	57.67	gold quality
visceral pleura	UBERON:0002401	56.69	gold quality
islet of Langerhans	UBERON:0000006	56.57	gold quality
metanephros	UBERON:0000081	56.32	gold quality
lymph node	UBERON:0000029	56.03	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.79	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.78	gold quality
vermiform appendix	UBERON:0001154	55.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Reduced LINC00551 expression promotes proliferation and invasion of esophageal squamous cancer by increase in HSP27 phosphorylation. (PMID:32677057)
• Overexpression of LINC00551 promotes autophagy-dependent ferroptosis of lung adenocarcinoma via upregulating DDIT4 by sponging miR-4328. (PMID:36570007)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.