ARHGAP12

Summary

ARHGAP12 (Rho GTPase activating protein 12, HGNC:16348) is a protein-coding gene on chromosome 10p11.22, encoding Rho GTPase-activating protein 12 (Q8IWW6). GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Source: NCBI Gene 94134 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 131 total — 2 pathogenic
• MANE Select transcript: NM_018287

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16348
Approved symbol	ARHGAP12
Name	Rho GTPase activating protein 12
Location	10p11.22
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20737, FLJ10971, FLJ21785
Ensembl gene	ENSG00000165322
Ensembl biotype	protein_coding
OMIM	610577
Entrez	94134

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 31 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000311380, ENST00000344936, ENST00000375245, ENST00000375250, ENST00000396144, ENST00000454919, ENST00000492028, ENST00000493008, ENST00000497085, ENST00000497103, ENST00000872611, ENST00000872612, ENST00000872613, ENST00000872614, ENST00000872615, ENST00000919762, ENST00000919763, ENST00000955735, ENST00000955736, ENST00000955737, ENST00000955738, ENST00000955739, ENST00000955740, ENST00000955741, ENST00000955742, ENST00000955743, ENST00000955744, ENST00000955745, ENST00000955746, ENST00000955747, ENST00000955748, ENST00000955749, ENST00000955750, ENST00000955751, ENST00000955752

RefSeq mRNA: 6 — MANE Select: NM_018287 NM_001270695, NM_001270696, NM_001270697, NM_001270698, NM_001270699, NM_018287

CCDS: CCDS59214, CCDS59215, CCDS59216, CCDS7170, CCDS73082

Canonical transcript exons

ENST00000344936 — 20 exons

Exon	Start	End
ENSE00001092088	31843461	31843586
ENSE00001092094	31852517	31852597
ENSE00001092095	31861395	31861658
ENSE00001163893	31839637	31839711
ENSE00001300227	31910525	31910563
ENSE00001304383	31854066	31854206
ENSE00001373213	31908172	31908926
ENSE00001915056	31805398	31807832
ENSE00001931342	31928683	31928831
ENSE00002516115	31839305	31839319
ENSE00003499385	31810649	31810747
ENSE00003525621	31831739	31831800
ENSE00003556241	31817788	31817886
ENSE00003608447	31820387	31820488
ENSE00003609003	31809230	31809307
ENSE00003613326	31808994	31809128
ENSE00003630534	31808649	31808751
ENSE00003637343	31814259	31814361
ENSE00003666611	31826304	31826385
ENSE00003679471	31812707	31812823

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 98.27.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.0921 / max 145.5389, expressed in 1748 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108976	13.8495	1735
108975	1.3161	782
108973	0.7603	331
108977	0.1662	71

Top tissues by expression

297 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	98.27	gold quality
calcaneal tendon	UBERON:0003701	98.10	gold quality
tendon	UBERON:0000043	96.27	gold quality
tendon of biceps brachii	UBERON:0008188	95.93	silver quality
adrenal tissue	UBERON:0018303	94.79	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	93.77	gold quality
spinal cord	UBERON:0002240	93.13	gold quality
body of pancreas	UBERON:0001150	93.12	gold quality
ventricular zone	UBERON:0003053	92.58	gold quality
pancreas	UBERON:0001264	91.80	gold quality
islet of Langerhans	UBERON:0000006	91.57	gold quality
rectum	UBERON:0001052	91.35	gold quality
minor salivary gland	UBERON:0001830	91.34	gold quality
tibial nerve	UBERON:0001323	91.04	gold quality
mucosa of stomach	UBERON:0001199	90.90	gold quality
colonic epithelium	UBERON:0000397	90.89	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.73	gold quality
spleen	UBERON:0002106	90.29	gold quality
endocervix	UBERON:0000458	90.15	gold quality
body of stomach	UBERON:0001161	89.97	gold quality
gall bladder	UBERON:0002110	89.89	gold quality
saliva-secreting gland	UBERON:0001044	89.82	gold quality
stomach	UBERON:0000945	89.71	gold quality
corpus epididymis	UBERON:0004359	89.61	gold quality
mouth mucosa	UBERON:0003729	89.43	gold quality
corpus callosum	UBERON:0002336	89.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.30	gold quality
skin of abdomen	UBERON:0001416	89.12	gold quality
choroid plexus epithelium	UBERON:0003911	89.08	gold quality
ganglionic eminence	UBERON:0004023	89.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

253 targeting ARHGAP12, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3646	100.00	73.56	5283
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882

Literature-anchored findings (GeneRIF, showing 3)

• molecular cloning and characterization of ARHGAP12 (PMID:11854031)
• ARHGAP12 inactivates RAC1, thereby impairing cell motility, invasion and adhesion to the extracellular matrix. The gene is transcriptionally suppressed by Hepatocyte Growth Factor in vitro. (PMID:18504429)
• Met-driven invasive growth involves transcriptional regulation of Arhgap12. (PMID:18504429)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	arhgap12a	ENSDARG00000008548
danio_rerio	arhgap12b	ENSDARG00000026482
mus_musculus	Arhgap12	ENSMUSG00000041225
rattus_norvegicus	Arhgap12	ENSRNOG00000017791
drosophila_melanogaster	RhoGAP16F	FBGN0030893
caenorhabditis_elegans		WBGENE00008006

Paralogs (3): ARHGAP15 (ENSG00000075884), ARHGAP9 (ENSG00000123329), ARHGAP27 (ENSG00000159314)

Protein

Protein identifiers

Rho GTPase-activating protein 12 — Q8IWW6 (reviewed: Q8IWW6)

Alternative names: Rho-type GTPase-activating protein 12

All UniProt accessions (3): Q8IWW6, H0Y5D8, Q1RLN5

UniProt curated annotations — full annotation on UniProt →

Function. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8IWW6-1	1, ARHGAP12b	yes
Q8IWW6-2	2, ARHGAP12a
Q8IWW6-3	3
Q8IWW6-4	4

RefSeq proteins (6): NP_001257624, NP_001257625, NP_001257626, NP_001257627, NP_001257628, NP_060757* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000198	RhoGAP_dom	Domain
IPR001202	WW_dom	Domain
IPR001452	SH3_domain	Domain
IPR001849	PH_domain	Domain
IPR008936	Rho_GTPase_activation_prot	Homologous_superfamily
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR035491	ARHGAP12_SH3	Domain
IPR036020	WW_dom_sf	Homologous_superfamily
IPR036028	SH3-like_dom_sf	Homologous_superfamily
IPR050729	Rho-GAP	Family

Pfam: PF00018, PF00169, PF00397, PF00620, PF16618

UniProt features (33 total): modified residue 10, compositionally biased region 6, domain 5, region of interest 4, splice variant 3, sequence conflict 2, chain 1, site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IWW6-F1	67.68	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 692 (arginine finger; crucial for gtp hydrolysis by stabilizing the transition state)

Post-translational modifications (10): 165, 176, 201, 213, 215, 230, 231, 240, 243, 592

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-9013149	RAC1 GTPase cycle
R-HSA-9013405	RHOD GTPase cycle
R-HSA-9013424	RHOV GTPase cycle
R-HSA-9035034	RHOF GTPase cycle

MSigDB gene sets: 272 (showing top): GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, GOBP_EPITHELIUM_DEVELOPMENT, MORF_MSH3, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, TGCACTT_MIR519C_MIR519B_MIR519A, CMYB_01, MORF_ATRX, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, AGTCTTA_MIR499, GGGCATT_MIR365, CATTTCA_MIR203, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2

GO Biological Process (7): morphogenesis of an epithelial sheet (GO:0002011), phagocytosis, engulfment (GO:0006911), actin filament organization (GO:0007015), small GTPase-mediated signal transduction (GO:0007264), negative regulation of small GTPase mediated signal transduction (GO:0051058), regulation of postsynapse assembly (GO:0150052), signal transduction (GO:0007165)

GO Molecular Function (2): GTPase activator activity (GO:0005096), protein binding (GO:0005515)

GO Cellular Component (5): phagocytic cup (GO:0001891), cytoplasm (GO:0005737), plasma membrane (GO:0005886), postsynapse (GO:0098794), glutamatergic synapse (GO:0098978)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RHO GTPase cycle	4

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
synapse	2
morphogenesis of an epithelium	1
phagocytosis	1
plasma membrane invagination	1
actin cytoskeleton organization	1
supramolecular fiber organization	1
intracellular signaling cassette	1
small GTPase-mediated signal transduction	1
regulation of small GTPase mediated signal transduction	1
negative regulation of intracellular signal transduction	1
regulation of synapse assembly	1
postsynapse assembly	1
regulation of postsynapse organization	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
GTPase activity	1
enzyme activator activity	1
GTPase regulator activity	1
binding	1
plasma membrane	1
intracellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

1472 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ARHGAP12	PLEK2	Q9NYT0	700
ARHGAP12	PLEK	P08567	690
ARHGAP12	LIN7C	Q9NUP9	463
ARHGAP12	HAUS8	Q9BT25	440
ARHGAP12	TBC1D30	Q9Y2I9	425
ARHGAP12	PHF3	Q92576	423
ARHGAP12	NEO1	Q92859	419
ARHGAP12	LHFPL2	Q6ZUX7	415
ARHGAP12	RNF182	Q8N6D2	415
ARHGAP12	NWD2	Q9ULI1	403
ARHGAP12	H3BQ15	H3BQ15	390
ARHGAP12	RASGEF1B	Q0VAM2	389
ARHGAP12	AMDHD2	Q9Y303	388
ARHGAP12	DNAJC27	Q9NZQ0	386
ARHGAP12	ARHGAP1	Q07960	380

IntAct

15 interactions, top by confidence:

A	B	Type	Score
ARHGAP12	SRPK2	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
ARHGAP12	SRPK1	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
ARHGAP12	MAGEB10	psi-mi:“MI:0915”(physical association)	0.400
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
RAB5A	PSMD14	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
ACTB	ENAH	psi-mi:“MI:0914”(association)	0.350
ACTG1	ENAH	psi-mi:“MI:0914”(association)	0.350
ARHGAP12	WASL	psi-mi:“MI:0914”(association)	0.350
ARHGAP12	HSPA8	psi-mi:“MI:0914”(association)	0.350
MAPK11	OBSL1	psi-mi:“MI:0914”(association)	0.350
RBM15	ILVBL	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (89): ARHGAP12 (Two-hybrid), ARHGAP12 (Affinity Capture-MS), MUC5B (Affinity Capture-MS), BPIFB1 (Affinity Capture-MS), DMBT1 (Affinity Capture-MS), IGHA1 (Affinity Capture-MS), ARHGAP12 (Affinity Capture-MS), ARHGAP12 (Proximity Label-MS), ARHGAP12 (Proximity Label-MS), ARHGAP12 (Two-hybrid), ARHGAP12 (Two-hybrid), ARHGAP12 (Two-hybrid), ARHGAP12 (Affinity Capture-MS), ARHGAP12 (Proximity Label-MS), ARHGAP12 (FRET)

ESM2 similar proteins: A2CEA7, A4IF90, B0S6J3, D3ZGS3, D4A208, F1LYQ8, F1M386, F1MSG6, F1P065, F1PBJ0, G5EDB9, H2KZZ6, O14827, O43295, O43307, O75044, P27671, P28818, P46941, P70392, Q13972, Q15057, Q3UTH8, Q45FX5, Q53QZ3, Q58DL7, Q5DU57, Q5FVC7, Q5ZMM3, Q6AYC5, Q6IVG4, Q6ZQK5, Q7Z6B7, Q811M1, Q812A2, Q8C0D4, Q8CHG7, Q8IWW6, Q8T0G4, Q8TEU7

Diamond homologs: A0A0G2JTR4, A1A4S6, A2AB59, A2RUV4, A4IF90, A4II46, A6QNS3, A6X8Z5, A7KAX9, A7YY57, A8WRJ2, D3ZFJ3, E7EZG2, E7F3F0, F1LXF1, O14559, O94466, P11274, P15882, P30337, P34288, P38339, P46941, P52757, P55194, P81128, P97393, Q03070, Q08DP6, Q10164, Q12979, Q13017, Q15311, Q17QN0, Q20498, Q2M1Z3, Q3TBD2, Q3UIA2, Q52LW3, Q53QZ3

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
ARHGAP12	“down-regulates activity”	RAC1	“gtpase-activating protein”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 18 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Clathrin-mediated endocytosis	5	30.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

131 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	98
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
1328108	GRCh37/hg19 10p11.23-11.22(chr10:30624523-33688350)x1	Pathogenic
4279341	GRCh37/hg19 10p12.1-11.22(chr10:28970254-33231328)x1	Pathogenic

SpliceAI

3644 predictions. Top by Δscore:

Variant	Effect	Δscore
10:31807828:TAACT:T	acceptor_gain	1.0000
10:31807831:CT:C	acceptor_gain	1.0000
10:31808645:CTA:C	donor_loss	1.0000
10:31808646:TA:T	donor_loss	1.0000
10:31808647:A:C	donor_loss	1.0000
10:31808648:CCTT:C	donor_gain	1.0000
10:31808747:TTGCT:T	acceptor_gain	1.0000
10:31808748:TGCT:T	acceptor_gain	1.0000
10:31808750:CT:C	acceptor_gain	1.0000
10:31808751:TCTGA:T	acceptor_loss	1.0000
10:31808752:C:CA	acceptor_loss	1.0000
10:31808752:C:CC	acceptor_gain	1.0000
10:31808992:A:AC	donor_gain	1.0000
10:31808993:C:CG	donor_gain	1.0000
10:31808993:CTA:C	donor_gain	1.0000
10:31808993:CTAA:C	donor_gain	1.0000
10:31809124:CTCAT:C	acceptor_gain	1.0000
10:31809126:CAT:C	acceptor_gain	1.0000
10:31809127:ATCTG:A	acceptor_loss	1.0000
10:31809128:TC:T	acceptor_loss	1.0000
10:31809129:C:CC	acceptor_gain	1.0000
10:31809129:CTGA:C	acceptor_loss	1.0000
10:31809130:T:A	acceptor_loss	1.0000
10:31809305:AACC:A	acceptor_loss	1.0000
10:31809307:CCT:C	acceptor_loss	1.0000
10:31809308:CT:C	acceptor_loss	1.0000
10:31809309:T:A	acceptor_loss	1.0000
10:31810643:TCTTA:T	donor_loss	1.0000
10:31810644:CTTA:C	donor_loss	1.0000
10:31810645:TTACC:T	donor_loss	1.0000

AlphaMissense

5620 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:31807764:A:G	L812P	1.000
10:31807773:C:T	G809D	1.000
10:31807774:C:G	G809R	1.000
10:31807779:A:T	V807D	1.000
10:31808655:A:G	L787P	1.000
10:31809053:C:G	R735P	1.000
10:31809064:T:A	K731N	1.000
10:31809064:T:G	K731N	1.000
10:31809065:T:A	K731I	1.000
10:31809068:A:G	L730P	1.000
10:31809074:C:T	G728E	1.000
10:31809075:C:G	G728R	1.000
10:31809075:C:T	G728R	1.000
10:31809099:A:G	W720R	1.000
10:31809099:A:T	W720R	1.000
10:31809250:A:G	L703P	1.000
10:31809274:C:T	G695D	1.000
10:31809282:T:A	R692S	1.000
10:31809282:T:G	R692S	1.000
10:31809283:C:G	R692T	1.000
10:31809292:C:T	G689E	1.000
10:31809293:C:A	G689W	1.000
10:31809293:C:G	G689R	1.000
10:31809293:C:T	G689R	1.000
10:31812730:A:T	V643D	1.000
10:31812745:G:T	P638H	1.000
10:31812746:G:A	P638S	1.000
10:31817823:A:G	W566R	1.000
10:31817823:A:T	W566R	1.000
10:31817858:A:G	L554P	1.000

dbSNP variants (sampled 300 via entrez): RS1000027426 (10:31928964 G>A,C), RS1000043857 (10:31891350 G>C), RS1000067292 (10:31889340 T>C), RS1000071350 (10:31847690 G>A), RS1000082144 (10:31847407 A>G), RS1000087003 (10:31895696 C>G), RS1000119057 (10:31917953 C>T), RS1000128246 (10:31898204 G>A), RS1000128439 (10:31855770 C>G), RS1000133158 (10:31813035 C>A), RS1000138678 (10:31887906 C>G), RS1000145916 (10:31826712 A>G), RS1000167473 (10:31822872 C>T), RS1000176127 (10:31864670 T>C), RS1000244782 (10:31915740 G>C)

Disease associations

OMIM: gene MIM:610577 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002424_4	C-reactive protein levels	3.000000e-06
GCST004278_30	Pulse pressure	1.000000e-09
GCST007096_63	Pulse pressure	3.000000e-09
GCST007099_45	Systolic blood pressure	7.000000e-06
GCST007638_41	Glycine levels	9.000000e-09
GCST009158_6	Uterine fibroids	2.000000e-10
GCST009725_90	Intraocular pressure	2.000000e-06

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004458	C-reactive protein measurement
EFO:0005763	pulse pressure measurement
EFO:0006335	systolic blood pressure
EFO:0009767	glycine measurement
EFO:0004695	intraocular pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs2799018	Efficacy	3	methylphenidate	Attention Deficit Disorder with Hyperactivity

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs2799018	ARHGAP12	3	0.00	1	methylphenidate

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects methylation, decreases expression, affects cotreatment, increases abundance, increases expression	5
bisphenol A	decreases expression, increases expression	2
Arsenic	decreases expression, increases abundance, affects methylation, affects cotreatment	2
Valproic Acid	affects expression, decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	affects expression, decreases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
FR900359	affects phosphorylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
cobaltous chloride	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
bisphenol S	decreases methylation	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	affects phosphorylation	1
Catechin	affects cotreatment, decreases expression	1
Formaldehyde	decreases expression	1
Ivermectin	decreases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.