ARHGAP5-AS1

Summary

ARHGAP5-AS1 (ARHGAP5 antisense RNA 1 (head to head), HGNC:20279) is a long non-coding RNA gene on chromosome 14q12.

Enables ubiquitin ligase inhibitor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process.

Source: NCBI Gene 84837 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20279
Approved symbol	ARHGAP5-AS1
Name	ARHGAP5 antisense RNA 1 (head to head)
Location	14q12
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC15504
Ensembl gene	ENSG00000258655
Ensembl biotype	lncRNA
Entrez	84837
RNAcentral	URS000075C624 — lncRNA, 1281 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000553596

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553596 — 1 exons

Exon	Start	End
ENSE00004119093	32073914	32076861

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 84.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.7207 / max 74.6188, expressed in 1473 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142752	2.2469	1112
142750	1.0449	594
142753	0.8169	483
142751	0.6119	339

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	84.22	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.76	gold quality
tibialis anterior	UBERON:0001385	81.98	silver quality
lower esophagus mucosa	UBERON:0035834	80.33	gold quality
right atrium auricular region	UBERON:0006631	79.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.83	gold quality
cardiac atrium	UBERON:0002081	78.69	gold quality
amygdala	UBERON:0001876	78.57	gold quality
heart left ventricle	UBERON:0002084	78.37	gold quality
cardiac ventricle	UBERON:0002082	77.94	gold quality
apex of heart	UBERON:0002098	77.72	gold quality
esophagus squamous epithelium	UBERON:0006920	77.20	gold quality
heart	UBERON:0000948	76.99	gold quality
cardiac muscle of right atrium	UBERON:0003379	76.92	gold quality
anterior cingulate cortex	UBERON:0009835	76.43	gold quality
esophagus mucosa	UBERON:0002469	76.22	gold quality
putamen	UBERON:0001874	75.95	gold quality
saliva-secreting gland	UBERON:0001044	75.89	gold quality
bone marrow cell	CL:0002092	75.82	silver quality
popliteal artery	UBERON:0002250	75.74	gold quality
tibial artery	UBERON:0007610	75.72	gold quality
adenohypophysis	UBERON:0002196	75.67	gold quality
caudate nucleus	UBERON:0001873	74.89	gold quality
minor salivary gland	UBERON:0001830	74.74	gold quality
islet of Langerhans	UBERON:0000006	74.66	gold quality
nucleus accumbens	UBERON:0001882	74.61	gold quality
pituitary gland	UBERON:0000007	74.58	gold quality
right frontal lobe	UBERON:0002810	74.43	gold quality
mucosa of stomach	UBERON:0001199	74.42	gold quality
esophagus	UBERON:0001043	74.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein. (PMID:34370213)
• N(6) -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma. (PMID:36354136)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.