ARHGEF2-AS2

Summary

ARHGEF2-AS2 (ARHGEF2 antisense RNA 2, HGNC:55175) is a long non-coding RNA gene on chromosome 1q22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55175
Approved symbol	ARHGEF2-AS2
Name	ARHGEF2 antisense RNA 2
Location	1q22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000273002
Ensembl biotype	lncRNA
Entrez	107985209
RNAcentral	URS00026A2639 — lncRNA, 2178 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000610146, ENST00000756615, ENST00000756616, ENST00000756617, ENST00000756618

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610146 — 2 exons

Exon	Start	End
ENSE00003703802	155978799	155978835
ENSE00003704483	155980867	155982986

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 73.93.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5311 / max 81.5612, expressed in 205 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5650	0.5311	205

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	73.93	silver quality
right uterine tube	UBERON:0001302	70.00	gold quality
spleen	UBERON:0002106	67.66	gold quality
blood	UBERON:0000178	67.11	gold quality
colonic epithelium	UBERON:0000397	66.39	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	65.37	gold quality
lymph node	UBERON:0000029	65.35	gold quality
bone marrow cell	CL:0002092	64.52	silver quality
vermiform appendix	UBERON:0001154	64.35	gold quality
tonsil	UBERON:0002372	63.37	gold quality
stromal cell of endometrium	CL:0002255	63.24	gold quality
granulocyte	CL:0000094	62.26	gold quality
substantia nigra	UBERON:0002038	61.11	gold quality
cerebellar hemisphere	UBERON:0002245	60.96	gold quality
cerebellar cortex	UBERON:0002129	60.91	gold quality
cerebellum	UBERON:0002037	60.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.78	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.65	gold quality
cortical plate	UBERON:0005343	60.39	silver quality
ascending aorta	UBERON:0001496	60.27	gold quality
small intestine	UBERON:0002108	60.27	gold quality
thoracic aorta	UBERON:0001515	60.12	gold quality
metanephros cortex	UBERON:0010533	59.80	gold quality
descending thoracic aorta	UBERON:0002345	59.76	gold quality
myometrium	UBERON:0001296	59.51	gold quality
right coronary artery	UBERON:0001625	59.46	gold quality
apex of heart	UBERON:0002098	59.24	gold quality
popliteal artery	UBERON:0002250	59.03	gold quality
tibial artery	UBERON:0007610	59.00	gold quality
ventricular zone	UBERON:0003053	58.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.75

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.