ARHGEF4-AS1

Summary

ARHGEF4-AS1 (ARHGEF4 antisense RNA 1, HGNC:55716) is a long non-coding RNA gene on chromosome 2q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55716
Approved symbol	ARHGEF4-AS1
Name	ARHGEF4 antisense RNA 1
Location	2q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233221
Ensembl biotype	lncRNA
Entrez	121853076
RNAcentral	URS00026A205B — lncRNA, 2829 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000429282, ENST00000446213, ENST00000660150

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429282 — 2 exons

Exon	Start	End
ENSE00001706540	130830978	130833116
ENSE00001758028	130836310	130836994

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 95.35.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
quadriceps femoris	UBERON:0001377	95.35	gold quality
cerebellar vermis	UBERON:0004720	92.75	gold quality
kidney	UBERON:0002113	91.81	silver quality
bone marrow	UBERON:0002371	91.63	silver quality
spleen	UBERON:0002106	91.54	silver quality
skeletal muscle tissue	UBERON:0001134	90.44	silver quality
lung	UBERON:0002048	87.02	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.67	gold quality
thymus	UBERON:0002370	77.77	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.96	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.25	silver quality
body of pancreas	UBERON:0001150	62.29	gold quality
temporal lobe	UBERON:0001871	59.93	gold quality
amygdala	UBERON:0001876	59.90	gold quality
pancreas	UBERON:0001264	59.44	gold quality
substantia nigra	UBERON:0002038	59.06	gold quality
caudate nucleus	UBERON:0001873	58.86	gold quality
spinal cord	UBERON:0002240	58.71	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	58.67	gold quality
putamen	UBERON:0001874	58.28	gold quality
ectocervix	UBERON:0012249	57.21	gold quality
Ammon’s horn	UBERON:0001954	56.49	gold quality
ovary	UBERON:0000992	56.19	gold quality
prefrontal cortex	UBERON:0000451	56.18	gold quality
nucleus accumbens	UBERON:0001882	55.97	gold quality
hypothalamus	UBERON:0001898	55.94	gold quality
left ovary	UBERON:0002119	55.81	gold quality
brain	UBERON:0000955	55.41	gold quality
pituitary gland	UBERON:0000007	55.18	gold quality
adenohypophysis	UBERON:0002196	54.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.