ARMC10

Summary

ARMC10 (armadillo repeat containing 10, HGNC:21706) is a protein-coding gene on chromosome 7q22.1, encoding Armadillo repeat-containing protein 10 (Q8N2F6). May play a role in cell survival and cell growth.

This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.

Source: NCBI Gene 83787 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 69 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_031905

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21706
Approved symbol	ARMC10
Name	armadillo repeat containing 10
Location	7q22.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC3195, SVH
Ensembl gene	ENSG00000170632
Ensembl biotype	protein_coding
OMIM	611864
Entrez	83787

Gene structure

Transcript identifiers

Ensembl transcripts: 43 — 40 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000306450, ENST00000323716, ENST00000323735, ENST00000425331, ENST00000428183, ENST00000431642, ENST00000434153, ENST00000441711, ENST00000454559, ENST00000479145, ENST00000541300, ENST00000873928, ENST00000873929, ENST00000873930, ENST00000873931, ENST00000873932, ENST00000873933, ENST00000873934, ENST00000873935, ENST00000873936, ENST00000873937, ENST00000873938, ENST00000873939, ENST00000873940, ENST00000873941, ENST00000873942, ENST00000873943, ENST00000873944, ENST00000873945, ENST00000873946, ENST00000873947, ENST00000873948, ENST00000873949, ENST00000873950, ENST00000873951, ENST00000873952, ENST00000918992, ENST00000918993, ENST00000966197, ENST00000966198, ENST00000966199, ENST00000966200, ENST00000966201

RefSeq mRNA: 6 — MANE Select: NM_031905 NM_001161009, NM_001161010, NM_001161011, NM_001161012, NM_001161013, NM_031905

CCDS: CCDS55145, CCDS55146, CCDS55147, CCDS55148, CCDS55149, CCDS5728

Canonical transcript exons

ENST00000323716 — 7 exons

Exon	Start	End
ENSE00001132763	103083682	103083830
ENSE00001245499	103075777	103075881
ENSE00003580352	103092477	103092653
ENSE00003583962	103097277	103097348
ENSE00003647303	103086630	103086764
ENSE00003727557	103098299	103099759
ENSE00003847213	103075140	103075411

Expression profiles

Bgee: expression breadth ubiquitous, 141 present calls, max score 93.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 39.2630 / max 246.1887, expressed in 1826 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
80273	36.2732	1826
80272	2.9899	1523

Top tissues by expression

141 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	93.44	gold quality
superior frontal gyrus	UBERON:0002661	92.78	gold quality
endometrium	UBERON:0001295	92.59	gold quality
cortical plate	UBERON:0005343	92.27	gold quality
frontal cortex	UBERON:0001870	92.01	gold quality
frontal lobe	UBERON:0016525	92.01	gold quality
body of pancreas	UBERON:0001150	92.00	gold quality
substantia nigra	UBERON:0002038	91.96	gold quality
islet of Langerhans	UBERON:0000006	91.82	gold quality
hypothalamus	UBERON:0001898	91.77	gold quality
anterior cingulate cortex	UBERON:0009835	91.77	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.76	gold quality
amygdala	UBERON:0001876	91.74	gold quality
temporal lobe	UBERON:0001871	91.69	gold quality
cerebral cortex	UBERON:0000956	91.67	gold quality
descending thoracic aorta	UBERON:0002345	91.65	gold quality
pancreas	UBERON:0001264	91.62	gold quality
right coronary artery	UBERON:0001625	91.57	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.50	gold quality
left ovary	UBERON:0002119	91.39	gold quality
telencephalon	UBERON:0001893	91.38	gold quality
ovary	UBERON:0000992	91.36	gold quality
ganglionic eminence	UBERON:0004023	91.23	gold quality
embryo	UBERON:0000922	91.22	gold quality
Ammon’s horn	UBERON:0001954	91.15	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.08	gold quality
thoracic aorta	UBERON:0001515	91.05	gold quality
aorta	UBERON:0000947	91.04	gold quality
ascending aorta	UBERON:0001496	91.04	gold quality
popliteal artery	UBERON:0002250	91.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.55

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

66 targeting ARMC10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-7-5P	99.67	70.53	1809
HSA-MIR-452-5P	99.65	69.63	1762
HSA-MIR-4676-3P	99.65	69.31	1733
HSA-MIR-892C-3P	99.65	69.38	1745
HSA-MIR-4524A-5P	99.57	71.73	1193
HSA-MIR-4524B-5P	99.57	71.68	1195
HSA-MIR-4437	99.52	65.29	1266
HSA-MIR-569	99.42	66.32	1009
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-504-3P	99.30	67.18	1745

Literature-anchored findings (GeneRIF, showing 4)

• a novel gene SVH, up-regulated in hepatocellular carcinoma, was identified; four variants SVH-A, -B, -C, and -D, resulting from alternative splicing in the coding region of the SVH transcript, were observed and localized in the endoplasmic reticulum (PMID:12839973)
• Data show that the serine S45 site of armadillo repeat containing 10 (ARMC10) can be phosphorylated by AMP-activated protein kinase (AMPK) both in vitro and in vivo. . (PMID:30631047)
• The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons. (PMID:37556559)
• ARMC10 regulates mitochondrial dynamics and affects mitochondrial function via the Wnt/beta-catenin signalling pathway involved in ischaemic stroke. (PMID:38924214)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Armc10	ENSMUSG00000038525
rattus_norvegicus	Armc10	ENSRNOG00000012785

Paralogs (10): ARMCX3 (ENSG00000102401), ARMCX5 (ENSG00000125962), ARMCX1 (ENSG00000126947), ARMC12 (ENSG00000157343), GPRASP2 (ENSG00000158301), ARMCX2 (ENSG00000184867), ARMCX4 (ENSG00000196440), GPRASP3 (ENSG00000198908), GPRASP1 (ENSG00000198932), ARMCX6 (ENSG00000198960)

Protein

Protein identifiers

Armadillo repeat-containing protein 10 — Q8N2F6 (reviewed: Q8N2F6)

Alternative names: Splicing variant involved in hepatocarcinogenesis protein

All UniProt accessions (5): Q8N2F6, C9J5N7, H7BXM8, H7BXQ8, H7C2M7

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.

Subunit / interactions. Interacts with the DNA-binding domain of p53/TP53.

Subcellular location. Endoplasmic reticulum membrane Mitochondrion outer membrane.

Tissue specificity. Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.

Miscellaneous. Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.

Isoforms (6)

UniProt ID	Names	Canonical?
Q8N2F6-1	1, SVH-A	yes
Q8N2F6-2	2, SVH-B
Q8N2F6-3	3, SVH-C
Q8N2F6-4	4, SVH-D
Q8N2F6-5	5
Q8N2F6-6	6

RefSeq proteins (6): NP_001154481, NP_001154482, NP_001154483, NP_001154484, NP_001154485, NP_114111* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006911	ARM-rpt_dom	Domain
IPR011989	ARM-like	Homologous_superfamily
IPR016024	ARM-type_fold	Homologous_superfamily
IPR051303	Armcx_regulator	Family

Pfam: PF04826

UniProt features (21 total): modified residue 10, splice variant 4, chain 1, transmembrane region 1, sequence variant 1, sequence conflict 1, repeat 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N2F6-F1	80.88	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 45, 50, 45, 50, 45, 50, 45, 50, 45, 85

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 142 (showing top): GOBP_AXO_DENDRITIC_TRANSPORT, GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR, GOBP_GROWTH, GOBP_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_APOPTOTIC_SIGNALING_PATHWAY, GOCC_MITOCHONDRIAL_ENVELOPE, GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR, GOBP_POSITIVE_REGULATION_OF_GROWTH, GOBP_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY, GOBP_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR, GOCC_NEURON_PROJECTION

GO Biological Process (3): positive regulation of growth rate (GO:0040010), negative regulation of apoptotic process (GO:0043066), negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)

GO Molecular Function (3): p53 binding (GO:0002039), DNA binding domain binding (GO:0050692), protein binding (GO:0005515)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
intracellular membrane-bounded organelle	2
regulation of growth rate	1
positive regulation of growth	1
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
intrinsic apoptotic signaling pathway by p53 class mediator	1
negative regulation of signal transduction by p53 class mediator	1
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	1
negative regulation of intrinsic apoptotic signaling pathway	1
protein binding	1
protein domain specific binding	1
binding	1
mitochondrial membrane	1
organelle outer membrane	1
endomembrane system	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1179 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ARMC10	TRAK2	O60296	635
ARMC10	RHOT1	Q8IXI2	596
ARMC10	MAP3K9	P80192	508
ARMC10	MTFR1L	Q9H019	444
ARMC10	FBXL13	Q8NEE6	429
ARMC10	LRIT2	A6NDA9	423
ARMC10	OGDHL	Q9ULD0	414
ARMC10	TCEA2	Q15560	410
ARMC10	SMARCD1	Q96GM5	395
ARMC10	SPDYE2	Q495Y8	394
ARMC10	ARMC1	Q9NVT9	382
ARMC10	HTT	P42858	372
ARMC10	HDAC7	Q8WUI4	365
ARMC10	ILK	P57043	360
ARMC10	MROH8	Q9H579	360

IntAct

21 interactions, top by confidence:

A	B	Type	Score
EXOC1	EXOC5	psi-mi:“MI:0914”(association)	0.730
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
MME		psi-mi:“MI:0914”(association)	0.350
COQ9	NDUFS8	psi-mi:“MI:0914”(association)	0.350
CUL4A	DDX39A	psi-mi:“MI:0914”(association)	0.350
LHFPL5	GNAQ	psi-mi:“MI:0914”(association)	0.350
ARMC10	ACTA2	psi-mi:“MI:0914”(association)	0.350
LHFPL5	TMEM259	psi-mi:“MI:0914”(association)	0.350
ARMC10	IGHG2	psi-mi:“MI:0914”(association)	0.350
MTCH2	IPO5	psi-mi:“MI:0914”(association)	0.350
CHRM4	EXOC5	psi-mi:“MI:0914”(association)	0.350
CHRNB2	SNX2	psi-mi:“MI:0914”(association)	0.350
ERF	DVL2	psi-mi:“MI:0914”(association)	0.350
FBXL16	STK25	psi-mi:“MI:0914”(association)	0.350
GSDME	DDX39A	psi-mi:“MI:0914”(association)	0.350
HPN	DDX39A	psi-mi:“MI:0914”(association)	0.350
VSIG1	RIMOC1	psi-mi:“MI:0914”(association)	0.350
SLC39A11	ESYT2	psi-mi:“MI:0914”(association)	0.350
PARL	HAX1	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (43): ARMC10 (Affinity Capture-MS), ARMC10 (Affinity Capture-RNA), ARMC10 (Affinity Capture-MS), ARMC10 (Two-hybrid), TCEA2 (Two-hybrid), FAM25A (Two-hybrid), FAM25G (Two-hybrid), CAPNS2 (Two-hybrid), FAM25C (Two-hybrid), ARMC10 (Proximity Label-MS), ARMC10 (Proximity Label-MS), ARMC10 (Proximity Label-MS), ARMC10 (Proximity Label-MS), ARMC10 (Proximity Label-MS), ARMC10 (Proximity Label-MS)

ESM2 similar proteins: A0JM23, A6H7D1, A7MBF6, A8C752, A8C754, B1AY13, F4IG73, F4JD14, O17482, O75165, O88480, O95876, P0C6R2, P0CI65, P50851, Q1RMS6, Q32NR9, Q3UHQ6, Q3V129, Q5R4M2, Q5TIA1, Q5ZL91, Q642P2, Q69YN4, Q69ZR2, Q6AZT7, Q6PIY5, Q6ZS30, Q7Z494, Q86VV8, Q8C456, Q8JGR7, Q8N2F6, Q8NEN0, Q8NFP9, Q8R4Y8, Q8TEL6, Q8W4P9, Q91VB4, Q969F9

Diamond homologs: B1WBW4, Q3UZB0, Q5H9R4, Q5JY77, Q5R4B2, Q5R7U0, Q5R9J3, Q5RDG2, Q5U310, Q5U4C1, Q5XID7, Q6A058, Q6P1M9, Q6PI77, Q7L311, Q8BHS6, Q8BUY8, Q8N2F6, Q920R4, Q96D09, Q9BE11, Q9CX83, Q9D0L7, Q9P291, Q9UH62, Q6PB60, Q71HP2, Q66HF0, Q7L4S7, Q8K3A6

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
AMPK	“up-regulates activity”	ARMC10	phosphorylation
ARMC10	“down-regulates activity”	TP53	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

69 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	53
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
60283	GRCh38/hg38 7q22.1-22.3(chr7:102808199-105701108)x1	Pathogenic

SpliceAI

1687 predictions. Top by Δscore:

Variant	Effect	Δscore
7:103083677:T:G	acceptor_gain	1.0000
7:103083678:GCAGA:G	acceptor_loss	1.0000
7:103083679:CAGAA:C	acceptor_loss	1.0000
7:103083680:A:AG	acceptor_gain	1.0000
7:103083681:G:GA	acceptor_gain	1.0000
7:103083681:GA:G	acceptor_gain	1.0000
7:103083681:GAA:G	acceptor_gain	1.0000
7:103083681:GAAGA:G	acceptor_gain	1.0000
7:103083827:CCAA:C	donor_gain	1.0000
7:103083828:CAAGT:C	donor_loss	1.0000
7:103083831:G:C	donor_loss	1.0000
7:103083831:G:GG	donor_gain	1.0000
7:103083833:AA:A	donor_loss	1.0000
7:103086624:TCGTA:T	acceptor_loss	1.0000
7:103086625:CGTAG:C	acceptor_loss	1.0000
7:103086626:GTAGG:G	acceptor_loss	1.0000
7:103086627:TAGG:T	acceptor_loss	1.0000
7:103086628:A:AG	acceptor_gain	1.0000
7:103086628:AGGC:A	acceptor_loss	1.0000
7:103086629:G:GG	acceptor_gain	1.0000
7:103086629:G:GT	acceptor_loss	1.0000
7:103086629:GGCT:G	acceptor_gain	1.0000
7:103086763:AGGT:A	donor_loss	1.0000
7:103086764:GGT:G	donor_loss	1.0000
7:103086765:G:GC	donor_loss	1.0000
7:103086765:G:GG	donor_gain	1.0000
7:103086766:T:G	donor_loss	1.0000
7:103097342:TGCCC:T	donor_gain	1.0000
7:103097349:G:GG	donor_gain	1.0000
7:103075409:CAGGT:C	donor_loss	0.9900

AlphaMissense

2209 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:103083816:T:C	F127L	0.991
7:103083818:T:A	F127L	0.991
7:103083818:T:G	F127L	0.991
7:103086732:A:C	S166R	0.985
7:103086734:T:A	S166R	0.985
7:103086734:T:G	S166R	0.985
7:103086749:T:A	N171K	0.977
7:103086749:T:G	N171K	0.977
7:103086640:G:C	R135P	0.975
7:103086730:T:C	L165P	0.974
7:103083730:T:C	L98P	0.966
7:103075328:G:A	G19D	0.965
7:103075322:G:A	G17D	0.964
7:103083811:C:A	A125E	0.964
7:103083739:T:C	L101P	0.963
7:103086664:T:A	V143D	0.961
7:103086717:G:C	A161P	0.961
7:103086708:G:C	A158P	0.960
7:103075310:G:A	G13D	0.959
7:103083786:G:C	A117P	0.957
7:103075309:G:C	G13R	0.955
7:103092547:T:C	L200P	0.955
7:103075321:G:C	G17R	0.952
7:103086721:T:C	L162P	0.952
7:103075327:G:C	G19R	0.945
7:103083810:G:C	A125P	0.941
7:103086637:T:G	I134S	0.935
7:103075333:T:C	C21R	0.934
7:103086637:T:A	I134N	0.934
7:103086701:A:C	K155N	0.934

dbSNP variants (sampled 300 via entrez): RS1000349097 (7:103075119 G>A), RS1000421039 (7:103075219 C>A,G,T), RS1000483619 (7:103096998 T>C), RS1000496598 (7:103073466 G>A), RS1000605143 (7:103096634 G>A,C), RS1000754246 (7:103074481 C>T), RS1000957763 (7:103078494 G>A,C), RS1001083476 (7:103085482 G>A), RS1001359407 (7:103091679 A>G,T), RS1001416536 (7:103076388 G>T), RS1001617607 (7:103074620 G>A,C,T), RS1001688128 (7:103095600 C>G,T), RS1001737482 (7:103089301 G>A), RS1001859673 (7:103086428 C>A), RS1001887035 (7:103098605 T>G)

Disease associations

OMIM: gene MIM:611864 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5465331 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
FR900359	increases phosphorylation	1
sodium arsenate	decreases expression	1
decabromobiphenyl ether	affects expression	1
beta-lapachone	increases expression	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	increases reaction, affects binding	1
perfluorohexanesulfonic acid	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
NSC 689534	affects binding, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	increases expression	1
Catechin	affects cotreatment, decreases expression	1
Copper	affects binding, decreases expression	1
Formaldehyde	decreases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Plant Extracts	increases expression, affects cotreatment	1
Rotenone	decreases expression	1
Thiram	decreases expression	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1
Genistein	increases expression, increases reaction	1
Particulate Matter	decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5338444	Binding	Binding affinity to Armc10 (unknown origin) at 200 uM preincubated for 2 hrs followed by pronase addition and measured after 30 mins by coomassie blue staining based SDS-PAGE gel analysis	Structurally Diverse Alkaloids with Anti-Renal-Fibrosis Activity from the Centipede Scolopendra subspinipes mutilans. — J Nat Prod

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SD50	HAP1 ARMC10 (-) 1	Cancer cell line	Male
CVCL_SD51	HAP1 ARMC10 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.