ARMC8

Summary

ARMC8 (armadillo repeat containing 8, HGNC:24999) is a protein-coding gene on chromosome 3q22.3, encoding Armadillo repeat-containing protein 8 (Q8IUR7). Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.

Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex.

Source: NCBI Gene 25852 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 88 total
• MANE Select transcript: NM_001363941

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24999
Approved symbol	ARMC8
Name	armadillo repeat containing 8
Location	3q22.3
Locus type	gene with protein product
Status	Approved
Aliases	HSPC056, DKFZP434A043, GID5, VID28
Ensembl gene	ENSG00000114098
Ensembl biotype	protein_coding
OMIM	618521
Entrez	25852

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 24 protein_coding, 5 retained_intron, 1 nonsense_mediated_decay

ENST00000358441, ENST00000460495, ENST00000461600, ENST00000461822, ENST00000463485, ENST00000464181, ENST00000466749, ENST00000466762, ENST00000468560, ENST00000469044, ENST00000469860, ENST00000470549, ENST00000470821, ENST00000470842, ENST00000471453, ENST00000471709, ENST00000481646, ENST00000485396, ENST00000486832, ENST00000489213, ENST00000491704, ENST00000494015, ENST00000538260, ENST00000878615, ENST00000878616, ENST00000878617, ENST00000926886, ENST00000941952, ENST00000941953, ENST00000941954

RefSeq mRNA: 8 — MANE Select: NM_001363941 NM_001267041, NM_001267042, NM_001282342, NM_001363941, NM_001363942, NM_014154, NM_015396, NM_213654

CCDS: CCDS3098, CCDS54646, CCDS58853, CCDS58854, CCDS75020, CCDS87139, CCDS87140

Canonical transcript exons

ENST00000469044 — 22 exons

Exon	Start	End
ENSE00000525807	138228918	138229010
ENSE00000778741	138235034	138235114
ENSE00000794877	138209817	138209893
ENSE00001240600	138237309	138237384
ENSE00001851486	138187301	138187599
ENSE00001920492	138295859	138298373
ENSE00003475513	138264131	138264212
ENSE00003484507	138290546	138290639
ENSE00003487060	138284431	138284526
ENSE00003498636	138274449	138274544
ENSE00003559903	138223389	138223531
ENSE00003576062	138289048	138289120
ENSE00003581869	138270040	138270132
ENSE00003605618	138267155	138267241
ENSE00003607236	138263739	138263821
ENSE00003607896	138223636	138223733
ENSE00003632508	138245088	138245183
ENSE00003649949	138239468	138239528
ENSE00003684146	138221926	138221997
ENSE00003688557	138272967	138273116
ENSE00003692678	138241783	138241983
ENSE00003787617	138237482	138237572

Expression profiles

Bgee: expression breadth ubiquitous, 282 present calls, max score 97.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.1258 / max 372.8987, expressed in 1815 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
38779	21.7583	1788
38778	6.9361	1719
38777	4.4314	1561

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	97.84	gold quality
secondary oocyte	CL:0000655	97.46	gold quality
cerebellar hemisphere	UBERON:0002245	95.16	gold quality
cerebellar cortex	UBERON:0002129	95.08	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.80	gold quality
cerebellum	UBERON:0002037	94.11	gold quality
mucosa of stomach	UBERON:0001199	93.47	gold quality
calcaneal tendon	UBERON:0003701	93.41	gold quality
gastrocnemius	UBERON:0001388	92.90	gold quality
bone marrow cell	CL:0002092	92.72	gold quality
muscle of leg	UBERON:0001383	92.72	gold quality
popliteal artery	UBERON:0002250	92.47	gold quality
tibial artery	UBERON:0007610	92.47	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	92.44	gold quality
adrenal tissue	UBERON:0018303	92.40	gold quality
cortical plate	UBERON:0005343	92.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.22	gold quality
lower esophagus	UBERON:0013473	92.20	gold quality
biceps brachii	UBERON:0001507	92.19	gold quality
ganglionic eminence	UBERON:0004023	92.04	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.00	gold quality
left coronary artery	UBERON:0001626	91.83	gold quality
aorta	UBERON:0000947	91.78	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	91.78	gold quality
tibialis anterior	UBERON:0001385	91.72	gold quality
muscle organ	UBERON:0001630	91.51	gold quality
monocyte	CL:0000576	91.48	gold quality
mononuclear cell	CL:0000842	91.40	gold quality
colonic epithelium	UBERON:0000397	91.33	gold quality
leukocyte	CL:0000738	91.32	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.20
E-MTAB-6142	no	195.34

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1

miRNA regulators (miRDB)

193 targeting ARMC8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-128-3P	99.95	71.17	2484

Literature-anchored findings (GeneRIF, showing 10)

• RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells (PMID:17467196)
• Data suggest that armadillo repeat containing protein 8 (ARMC8) might serve as a therapeutic target in non-small cell lung cancer (NSCLC). (PMID:24894675)
• Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma. (PMID:25119601)
• invasiveness and migration capacity of HT29 cells transfected with ARMc8 were significantly greater than those of control cells (p < 0.001), while ARMc8 siRNA treatment significantly reduced cell invasion and migration in LoVo cells (PMID:26081621)
• ARMc8 may enhance the invasion and metastasis of ovarian cancer cells (PMID:26232863)
• results indicate that Armc8 may be a potential cancer marker in hepatocellular carcinoma (PMID:26944057)
• Knockdown of ARMC8 significantly inhibited osteosarcoma cell proliferation in vitro and markedly inhibited xenograft tumor growth in vivo. ARMC8 silencing also suppressed the epithelial-mesenchymal transition (EMT) phenotype, as well as inhibited the migration and invasion of osteosarcoma cells. (PMID:27712595)
• Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions. (PMID:30482882)
• Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/beta-catenin pathway and EMT in cutaneous squamous cell carcinomas. (PMID:34016486)
• MiR-455-3p inhibits gastric cancer progression by repressing Wnt/beta-catenin signaling through binding to ARMC8. (PMID:37400847)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	armc8	ENSDARG00000062258
mus_musculus	Armc8	ENSMUSG00000032468
rattus_norvegicus	Armc8	ENSRNOG00000014521

Protein

Protein identifiers

Armadillo repeat-containing protein 8 — Q8IUR7 (reviewed: Q8IUR7)

All UniProt accessions (12): Q8IUR7, B7Z637, C9J2I1, C9J625, C9J8P8, C9JAA7, C9JBY2, G5E9V6, G5E9V7, H7C4J4, H7C5B7, H7C5H2

UniProt curated annotations — full annotation on UniProt →

Function. Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.

Subunit / interactions. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles.

Subcellular location. Nucleus. Cytoplasm.

Isoforms (6)

UniProt ID	Names	Canonical?
Q8IUR7-1	1	yes
Q8IUR7-2	2
Q8IUR7-3	3
Q8IUR7-6	6
Q8IUR7-7	7
Q8IUR7-8	8

RefSeq proteins (8): NP_001253970, NP_001253971, NP_001269271, NP_001350870, NP_001350871, NP_054873, NP_056211, NP_998819 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000225	Armadillo	Repeat
IPR011989	ARM-like	Homologous_superfamily
IPR016024	ARM-type_fold	Homologous_superfamily
IPR038739	ARMC8/Vid28	Family

Pfam: PF00514

UniProt features (87 total): helix 42, repeat 14, strand 10, sequence conflict 8, splice variant 6, modified residue 3, turn 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7NSC	ELECTRON MICROSCOPY	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IUR7-F1	94.16	0.92

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 2, 337, 512

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-9861718	Regulation of pyruvate metabolism
R-HSA-1428517	Aerobic respiration and respiratory electron transport
R-HSA-1430728	Metabolism
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-70268	Pyruvate metabolism

MSigDB gene sets: 248 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, REACTOME_INNATE_IMMUNE_SYSTEM, TGCGCANK_UNKNOWN, GOCC_SECRETORY_GRANULE, GCANCTGNY_MYOD_Q6, ATACCTC_MIR202, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, ACTGCAG_MIR173P, GGGTGGRR_PAX4_03, GTACAGG_MIR486, CAGCTG_AP4_Q5, YY1_Q6, LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN, OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP, FOSTER_TOLERANT_MACROPHAGE_UP

GO Biological Process (1): proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (9): ubiquitin ligase complex (GO:0000151), extracellular region (GO:0005576), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), GID complex (GO:0034657), specific granule lumen (GO:0035580), tertiary granule lumen (GO:1904724)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Innate Immune System	1
Pyruvate metabolism	1
Metabolism	1
Immune System	1
Aerobic respiration and respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
binding	1
intracellular protein-containing complex	1
transferase complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
ubiquitin ligase complex	1
secretory granule lumen	1
specific granule	1
intracellular organelle lumen	1
tertiary granule	1

Protein interactions and networks

STRING

1128 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ARMC8	GID8	Q9NWU2	985
ARMC8	RMND5A	Q9H871	948
ARMC8	GID4	Q8IVV7	941
ARMC8	WDR26	Q9H7D7	932
ARMC8	RMND5B	Q96G75	894
ARMC8	MAEA	Q7L5Y9	870
ARMC8	RANBP10	Q6VN20	804
ARMC8	RANBP9	Q96S59	734
ARMC8	MKLN1	Q9UL63	726
ARMC8	YPEL5	P62699	674
ARMC8	DDX50	Q9BQ39	646
ARMC8	DDX21	Q9NR30	608
ARMC8	ZMYND19	Q96E35	607
ARMC8	UBE2H	P37286	594
ARMC8	WDR37	Q9Y2I8	588

IntAct

177 interactions, top by confidence:

A	B	Type	Score
PRKCZ	PRKCI	psi-mi:“MI:0914”(association)	0.890
BAIAP2	YWHAZ	psi-mi:“MI:0914”(association)	0.800
ARMC8	HTRA2	psi-mi:“MI:0914”(association)	0.750
EGFR	CTNND1	psi-mi:“MI:0914”(association)	0.750
ZMYND19	TNFAIP1	psi-mi:“MI:0914”(association)	0.670
RANBP10	MAEA	psi-mi:“MI:0914”(association)	0.640
RANBP9	YPEL5	psi-mi:“MI:0914”(association)	0.640
CRIPTO	AIP	psi-mi:“MI:0914”(association)	0.640
CCDC120	AIP	psi-mi:“MI:0914”(association)	0.640
NDUFS6	NDUFS8	psi-mi:“MI:0914”(association)	0.640
MPP2	LIN7A	psi-mi:“MI:0914”(association)	0.640
PRG2	YPEL5	psi-mi:“MI:0914”(association)	0.640
GID8	HTRA2	psi-mi:“MI:0914”(association)	0.610
ARMC8	TCF12	psi-mi:“MI:0915”(physical association)	0.560
TCF12	ARMC8	psi-mi:“MI:0915”(physical association)	0.560
TNNT1	ARMC8	psi-mi:“MI:0915”(physical association)	0.550
INSL6	POTEF	psi-mi:“MI:0914”(association)	0.530
JPH4	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
GPS2	DCTN6	psi-mi:“MI:0914”(association)	0.530
TIGD5	P4HA2	psi-mi:“MI:0914”(association)	0.530
PRICKLE3	SIAH2	psi-mi:“MI:0914”(association)	0.530
CBFA2T3	CBFA2T2	psi-mi:“MI:0914”(association)	0.530
BMP1	TLL1	psi-mi:“MI:0914”(association)	0.530

BioGRID (360): ARMC8 (Two-hybrid), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS)

ESM2 similar proteins: A0A3L7I2I8, A0JMZ3, A5HK05, A7MB89, A7YWD2, O60733, O75031, O94829, O94955, P0C7A6, P42694, P49754, P97570, P97819, Q05AL1, Q1LVW0, Q29RM5, Q2KI54, Q2T9K6, Q3UFS0, Q3UJZ3, Q4V890, Q5KU39, Q5R6S3, Q5R974, Q5T9G4, Q5TYQ1, Q5VZK9, Q68FK4, Q6DFV5, Q6EDY6, Q6NYU2, Q6QI06, Q6R327, Q7T3P8, Q8C0T1, Q8CEF1, Q8IUR7, Q8NFZ0, Q91W86

Diamond homologs: Q05AL1, Q2KI54, Q5R6S3, Q68FK4, Q8IUR7, Q9DBR3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 195 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Regulation of pyruvate metabolism	9	37.5×	4e-10
Deactivation of the beta-catenin transactivating complex	6	10.2×	3e-03
Mitochondrial translation	8	8.0×	2e-03
Mitochondrial translation initiation	8	7.4×	2e-03
Mitochondrial translation elongation	8	7.4×	2e-03
Mitochondrial ribosome-associated quality control	8	7.2×	2e-03
Mitochondrial translation termination	8	6.4×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

88 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	56
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4210 predictions. Top by Δscore:

Variant	Effect	Δscore
3:138209894:G:GG	donor_gain	1.0000
3:138221919:A:AG	acceptor_gain	1.0000
3:138221920:A:G	acceptor_gain	1.0000
3:138221923:CA:C	acceptor_loss	1.0000
3:138221924:A:AG	acceptor_gain	1.0000
3:138221925:G:GA	acceptor_loss	1.0000
3:138221925:G:GG	acceptor_gain	1.0000
3:138221925:GA:G	acceptor_gain	1.0000
3:138221925:GAGAC:G	acceptor_gain	1.0000
3:138221996:AGGT:A	donor_loss	1.0000
3:138221998:GT:G	donor_loss	1.0000
3:138221999:T:G	donor_loss	1.0000
3:138223387:A:AG	acceptor_gain	1.0000
3:138223388:G:GG	acceptor_gain	1.0000
3:138223388:GATT:G	acceptor_gain	1.0000
3:138223530:AGG:A	donor_loss	1.0000
3:138223531:GGTA:G	donor_loss	1.0000
3:138223532:G:A	donor_loss	1.0000
3:138223533:T:A	donor_loss	1.0000
3:138223633:TA:T	acceptor_loss	1.0000
3:138223634:A:T	acceptor_loss	1.0000
3:138223635:G:A	acceptor_loss	1.0000
3:138223635:GGACT:G	acceptor_gain	1.0000
3:138223731:ACAGT:A	donor_loss	1.0000
3:138223732:CA:C	donor_gain	1.0000
3:138223732:CAGT:C	donor_loss	1.0000
3:138223733:AG:A	donor_loss	1.0000
3:138223734:G:C	donor_loss	1.0000
3:138223734:G:GG	donor_gain	1.0000
3:138223735:TGAG:T	donor_loss	1.0000

AlphaMissense

4408 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:138221934:A:T	K44I	1.000
3:138221935:A:C	K44N	1.000
3:138221935:A:T	K44N	1.000
3:138221943:T:A	V47E	1.000
3:138221948:G:A	G49R	1.000
3:138221948:G:C	G49R	1.000
3:138221949:G:A	G49E	1.000
3:138221949:G:T	G49V	1.000
3:138221963:A:C	K54Q	1.000
3:138221963:A:G	K54E	1.000
3:138221964:A:T	K54I	1.000
3:138221965:A:C	K54N	1.000
3:138221965:A:T	K54N	1.000
3:138221973:T:C	L57P	1.000
3:138221991:T:A	V63D	1.000
3:138223457:G:A	G88E	1.000
3:138223463:T:C	L90P	1.000
3:138223466:C:A	A91D	1.000
3:138223471:G:C	G93R	1.000
3:138223496:T:C	L101P	1.000
3:138264151:G:C	R413T	1.000
3:138264151:G:T	R413I	1.000
3:138267213:T:C	L453P	1.000
3:138267224:T:C	F457L	1.000
3:138267226:T:A	F457L	1.000
3:138267226:T:G	F457L	1.000
3:138209845:T:A	V25D	0.999
3:138209854:T:C	L28P	0.999
3:138209886:G:C	G39R	0.999
3:138209890:T:A	V40D	0.999

dbSNP variants (sampled 300 via entrez): RS1000010339 (3:138253471 T>C), RS1000011875 (3:138205611 G>A), RS1000022483 (3:138262137 G>A,C), RS1000234727 (3:138234158 T>C), RS1000249386 (3:138227445 T>A), RS1000327694 (3:138269253 A>C), RS1000345460 (3:138227765 T>G), RS1000379987 (3:138269681 C>G,T), RS1000455921 (3:138221246 G>C), RS1000457625 (3:138278792 A>G), RS1000487314 (3:138279125 A>G), RS1000489810 (3:138218818 A>C), RS1000545928 (3:138254788 A>G,T), RS1000552618 (3:138208839 C>T), RS1000576771 (3:138225966 G>A)

Disease associations

OMIM: gene MIM:618521 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST90002397_665	Mean spheric corpuscular volume	2.000000e-09
GCST90020024_1270	A body shape index	8.000000e-10
GCST90020025_474	Waist-to-hip ratio adjusted for BMI	1.000000e-09
GCST90020027_1848	Waist-hip index	8.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007789	BMI-adjusted waist circumference
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, increases expression	7
trichostatin A	affects cotreatment, decreases expression, increases expression	3
Benzo(a)pyrene	increases expression, decreases expression	2
Phenylmercuric Acetate	decreases expression, affects cotreatment	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
urushiol	increases expression	1
methylmercuric chloride	decreases expression	1
2-butenal	decreases expression	1
beta-lapachone	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	increases methylation	1
jinfukang	decreases expression	1
Irinotecan	decreases expression	1
Sunitinib	increases expression	1
Arsenic Trioxide	increases expression	1
Demecolcine	decreases expression	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Hydrogen Peroxide	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Lead	affects splicing	1
Methyl Methanesulfonate	decreases expression	1
Phthalic Acids	decreases methylation	1
Testosterone	decreases expression	1
Theophylline	affects cotreatment, increases expression	1
Tretinoin	increases expression	1
Vincristine	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.