ASB1

Summary

ASB1 (ankyrin repeat and SOCS box containing 1, HGNC:16011) is a protein-coding gene on chromosome 2q37.3, encoding Ankyrin repeat and SOCS box protein 1 (Q9Y576). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation.

Source: NCBI Gene 51665 — RefSeq curated summary.

At a glance

• GWAS associations: 16
• Clinical variants (ClinVar): 63 total — 5 pathogenic
• MANE Select transcript: NM_001040445

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16011
Approved symbol	ASB1
Name	ankyrin repeat and SOCS box containing 1
Location	2q37.3
Locus type	gene with protein product
Status	Approved
Aliases	ASB-1
Ensembl gene	ENSG00000065802
Ensembl biotype	protein_coding
OMIM	605758
Entrez	51665

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 5 protein_coding_CDS_not_defined, 3 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000264607, ENST00000409297, ENST00000438264, ENST00000463352, ENST00000468122, ENST00000469885, ENST00000473306, ENST00000481566, ENST00000491653, ENST00000867386

RefSeq mRNA: 2 — MANE Select: NM_001040445 NM_001040445, NM_001330196

CCDS: CCDS33416, CCDS82582

Canonical transcript exons

ENST00000264607 — 5 exons

Exon	Start	End
ENSE00001074110	238433554	238433695
ENSE00001246892	238446384	238452250
ENSE00001883621	238426927	238427119
ENSE00003468990	238435711	238436013
ENSE00003688411	238444342	238444727

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 93.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.2342 / max 82.6070, expressed in 1808 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
26349	8.3307	1676
26348	2.2824	1367
26345	1.8460	779
26344	1.7071	946
26347	0.8264	546
26346	0.1833	85
26350	0.0531	22
26351	0.0053	2

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	93.72	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.62	gold quality
nucleus accumbens	UBERON:0001882	92.54	gold quality
right atrium auricular region	UBERON:0006631	92.24	gold quality
putamen	UBERON:0001874	92.18	gold quality
amygdala	UBERON:0001876	91.66	gold quality
cardiac atrium	UBERON:0002081	91.51	gold quality
heart left ventricle	UBERON:0002084	91.23	gold quality
spinal cord	UBERON:0002240	91.15	gold quality
cardiac ventricle	UBERON:0002082	90.88	gold quality
hypothalamus	UBERON:0001898	90.79	gold quality
substantia nigra	UBERON:0002038	90.73	gold quality
caudate nucleus	UBERON:0001873	90.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.17	gold quality
midbrain	UBERON:0001891	89.99	gold quality
cingulate cortex	UBERON:0003027	89.94	gold quality
medial globus pallidus	UBERON:0002477	89.83	gold quality
anterior cingulate cortex	UBERON:0009835	89.83	gold quality
right frontal lobe	UBERON:0002810	89.73	gold quality
heart	UBERON:0000948	89.57	gold quality
adenohypophysis	UBERON:0002196	89.29	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.27	gold quality
globus pallidus	UBERON:0001875	89.10	gold quality
gastrocnemius	UBERON:0001388	88.98	gold quality
Ammon’s horn	UBERON:0001954	88.94	gold quality
granulocyte	CL:0000094	88.92	gold quality
hindlimb stylopod muscle	UBERON:0004252	88.84	gold quality
left testis	UBERON:0004533	88.79	gold quality
muscle of leg	UBERON:0001383	88.77	gold quality
prefrontal cortex	UBERON:0000451	88.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

148 targeting ASB1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-526B-3P	99.88	74.06	2587

Literature-anchored findings (GeneRIF, showing 1)

• Epigenetic regulation of the stress-responsive Asb1 gene in anxiety-related phenotypes. (PMID:28540928)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	asb1	ENSDARG00000026635
mus_musculus	Asb1	ENSMUSG00000026311
rattus_norvegicus	Asb1	ENSRNOG00000020322
caenorhabditis_elegans		WBGENE00014077

Paralogs (1): ANKRD16 (ENSG00000134461)

Protein

Protein identifiers

Ankyrin repeat and SOCS box protein 1 — Q9Y576 (reviewed: Q9Y576)

All UniProt accessions (3): Q9Y576, B9A047, F8WBM8

UniProt curated annotations — full annotation on UniProt →

Function. Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2. Functions as a tumor suppressor by enhancing CHCHD3 ‘Lys-48’-linked ubiquitination, leading to inhibition of the CHCHD3/ROS signaling pathway. Suppresses TAB2-linked ‘Lys-48’ polyubiquitination and consequently facilitates the initiation of NF-kappa-B and MAPK signaling cascades. May play a role in testis development.

Subunit / interactions. Interacts with CUL5 and RNF7. Interacts with TAB2 and TAB3.

Subcellular location. Cytoplasm.

Domain organisation. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the ankyrin SOCS box (ASB) family.

RefSeq proteins (2): NP_001035535, NP_001317125 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001496	SOCS_box	Domain
IPR002110	Ankyrin_rpt	Repeat
IPR036036	SOCS_box-like_dom_sf	Homologous_superfamily
IPR036770	Ankyrin_rpt-contain_sf	Homologous_superfamily
IPR037331	ASB1_SOCS	Domain

Pfam: PF07525, PF12796, PF13606

UniProt features (8 total): repeat 6, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y576-F1	80.61	0.53

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-8951664	Neddylation
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-1280218	Adaptive Immune System
R-HSA-168256	Immune System
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification
R-HSA-983169	Class I MHC mediated antigen processing & presentation

MSigDB gene sets: 133 (showing top): REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GOBP_MALE_GENITALIA_DEVELOPMENT, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, GOBP_REPRODUCTIVE_SYSTEM_DEVELOPMENT, HUI_MAPK14_TARGETS_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, GOBP_CYTOKINE_PRODUCTION, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_SEX_DIFFERENTIATION

GO Biological Process (5): negative regulation of cytokine production (GO:0001818), protein ubiquitination (GO:0016567), male genitalia development (GO:0030539), intracellular signal transduction (GO:0035556), proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

GO Molecular Function (3): ubiquitin-like ligase-substrate adaptor activity (GO:1990756), protein binding (GO:0005515), ubiquitin protein ligase activity (GO:0061630)

GO Cellular Component (3): ubiquitin ligase complex (GO:0000151), cytosol (GO:0005829), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Post-translational protein modification	1
Class I MHC mediated antigen processing & presentation	1
Immune System	1
Metabolism of proteins	1
Adaptive Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular anatomical structure	2
cellular anatomical structure	2
cytokine production	1
regulation of cytokine production	1
negative regulation of gene expression	1
negative regulation of multicellular organismal process	1
protein modification by small protein conjugation	1
male sex differentiation	1
genitalia development	1
reproductive system development	1
signal transduction	1
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
enzyme-substrate adaptor activity	1
binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
intracellular protein-containing complex	1
transferase complex	1
cytoplasm	1

Protein interactions and networks

STRING

1418 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ASB1	IFT54	Q8TDR0	758
ASB1	CISH	Q9NSE2	756
ASB1	CUL5	Q93034	678
ASB1	RNF7	Q9UBF6	629
ASB1	ELOB	Q15370	561
ASB1	ASB6	Q9NWX5	537
ASB1	ASB17	Q8WXJ9	492
ASB1	KCTD7	Q96MP8	475
ASB1	TBL2	Q9Y4P3	439
ASB1	JAK3	P52333	426
ASB1	WSB1	Q9Y6I7	400
ASB1	EXOC6	Q8TAG9	396
ASB1	CDH6	P55285	380
ASB1	STOX1	Q6ZVD7	379
ASB1	ELOC	Q15369	373

IntAct

37 interactions, top by confidence:

A	B	Type	Score
CUL5	SOCS2	psi-mi:“MI:0914”(association)	0.880
CUL5	ASB1	psi-mi:“MI:0915”(physical association)	0.740
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
RNF7	ASB1	psi-mi:“MI:0915”(physical association)	0.670
CUL5	SOCS6	psi-mi:“MI:0914”(association)	0.640
CUL5	SOCS7	psi-mi:“MI:0914”(association)	0.640
ASB1	YWHAG	psi-mi:“MI:0915”(physical association)	0.560
ASB1	SETDB1	psi-mi:“MI:0915”(physical association)	0.560
KAT5	ASB1	psi-mi:“MI:0915”(physical association)	0.560
LMO3	ASB1	psi-mi:“MI:0915”(physical association)	0.560
CASQ2	PES1	psi-mi:“MI:0914”(association)	0.530
GPS1	PXDNL	psi-mi:“MI:0914”(association)	0.530
KCTD17	CBX4	psi-mi:“MI:0914”(association)	0.530
PNMA2	CCDC85C	psi-mi:“MI:0914”(association)	0.530
RNF7	SOCS7	psi-mi:“MI:0914”(association)	0.530
Eloc	ASB1	psi-mi:“MI:0915”(physical association)	0.370
CUL5	DDX3X	psi-mi:“MI:0914”(association)	0.350
TSHB	SMCHD1	psi-mi:“MI:0914”(association)	0.350
CASQ2	TSNARE1	psi-mi:“MI:0914”(association)	0.350

BioGRID (55): ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-RNA), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Affinity Capture-MS), ASB1 (Proximity Label-MS), ASB1 (Affinity Capture-MS)

ESM2 similar proteins: A6NK59, A7MB89, B4E2M5, P0C6P7, P0C927, Q08DV6, Q29RM5, Q3SX45, Q3SZE4, Q3UMR0, Q495B1, Q4V890, Q5R5S1, Q5REW9, Q5RFS1, Q5U2S6, Q5ZM55, Q6GPE5, Q7T3P8, Q810B6, Q8C0T1, Q8C6Y6, Q8CEF1, Q8CEL2, Q8HXA6, Q8K0L0, Q8N9B4, Q8VHS6, Q8WXH4, Q8WXK1, Q91ZT8, Q96DX5, Q96JP0, Q96NW4, Q96Q27, Q9BSK4, Q9CQ31, Q9GKW8, Q9H0C1, Q9P2R3

Diamond homologs: Q02989, Q17QS6, Q3SZE4, Q5RFS1, Q70X92, Q810B6, Q862Z2, Q8VBX0, Q8WWX0, Q8WXH4, Q8WXK3, Q91ZT8, Q91ZU0, Q96DX5, Q9BSK4, Q9CQ31, Q9D1A4, Q9J4Z6, Q9WV74, Q9XZC0, Q9Y576, A2RT91, A6NK59, P0C927, Q08DV6, Q3SX45, Q3V096, Q58CT0, Q5U2S6, Q7Z5J8, Q8C6Y6, Q8HXA6, Q8K0L0, Q8N9B4, Q8VHS6, Q8WXK1, Q96Q27, Q9WV72, Q9Y575, Q9J519

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 29 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neddylation	7	15.8×	3e-05

GO biological processes:

GO term	Partners	Fold	FDR
proteasome-mediated ubiquitin-dependent protein catabolic process	6	11.2×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	5
Likely pathogenic	0
Uncertain significance	46
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (5)

Variant ID	HGVS	Classification
148337	GRCh38/hg38 2q37.1-37.3(chr2:234058757-239443690)x1	Pathogenic
3148871	GRCh37/hg19 2q37.3(chr2:237577774-239670026)x3	Pathogenic
59178	GRCh38/hg38 2q37.3(chr2:237813997-240410487)x3	Pathogenic
816585	GRCh37/hg19 2q37.1-37.3(chr2:234791927-242783384)x1	Pathogenic
981208	GRCh37/hg19 2q37.1-37.3(chr2:233110452-243028452)x1	Pathogenic

SpliceAI

1183 predictions. Top by Δscore:

Variant	Effect	Δscore
2:238426993:G:GT	donor_gain	1.0000
2:238433548:G:GA	acceptor_gain	1.0000
2:238433694:AGGTG:A	donor_loss	1.0000
2:238433695:GGTGA:G	donor_loss	1.0000
2:238433697:T:G	donor_loss	1.0000
2:238435710:G:GA	acceptor_gain	1.0000
2:238435710:GCC:G	acceptor_gain	1.0000
2:238436018:G:GG	donor_gain	1.0000
2:238444336:CTGCA:C	acceptor_loss	1.0000
2:238444337:TGCAG:T	acceptor_loss	1.0000
2:238444338:GCAGG:G	acceptor_loss	1.0000
2:238444339:CAGG:C	acceptor_loss	1.0000
2:238444340:A:AG	acceptor_gain	1.0000
2:238444340:AG:A	acceptor_gain	1.0000
2:238444340:AGG:A	acceptor_loss	1.0000
2:238444341:G:GA	acceptor_gain	1.0000
2:238444341:GG:G	acceptor_gain	1.0000
2:238444341:GGT:G	acceptor_gain	1.0000
2:238444341:GGTA:G	acceptor_gain	1.0000
2:238444341:GGTAC:G	acceptor_gain	1.0000
2:238444728:G:GG	donor_gain	1.0000
2:238426928:G:GG	donor_gain	0.9900
2:238426951:G:GT	donor_gain	0.9900
2:238427007:T:TA	donor_gain	0.9900
2:238430432:GGCT:G	donor_gain	0.9900
2:238430433:GCTG:G	donor_gain	0.9900
2:238433547:A:AG	acceptor_gain	0.9900
2:238433683:A:T	donor_gain	0.9900
2:238433692:GGAG:G	donor_gain	0.9900
2:238433693:G:GT	donor_gain	0.9900

AlphaMissense

2162 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:238435842:A:T	D108V	0.999
2:238444442:A:C	S199R	0.999
2:238444444:C:A	S199R	0.999
2:238444444:C:G	S199R	0.999
2:238433638:C:A	A45D	0.998
2:238433646:G:T	G48W	0.998
2:238435761:C:A	P81Q	0.998
2:238435764:T:G	L82W	0.998
2:238435767:G:C	R83P	0.998
2:238435776:C:A	A86D	0.998
2:238435809:T:C	L97P	0.998
2:238435841:G:C	D108H	0.998
2:238435841:G:T	D108Y	0.998
2:238435842:A:C	D108A	0.998
2:238435848:A:T	K110I	0.998
2:238435908:T:C	L130P	0.998
2:238433647:G:T	G48V	0.997
2:238435761:C:G	P81R	0.997
2:238435764:T:C	L82S	0.997
2:238435773:C:A	A85E	0.997
2:238435775:G:C	A86P	0.997
2:238435809:T:A	L97H	0.997
2:238435843:C:A	D108E	0.997
2:238435843:C:G	D108E	0.997
2:238435860:C:A	A114D	0.997
2:238435908:T:A	L130H	0.997
2:238435911:T:C	L131P	0.997
2:238435959:C:A	P147H	0.997
2:238435785:G:T	G89V	0.996
2:238435871:G:C	A118P	0.996

dbSNP variants (sampled 300 via entrez): RS1000047305 (2:238448599 T>G), RS1000212024 (2:238426608 G>A,C,T), RS1000352995 (2:238447649 T>G), RS1000517245 (2:238425449 C>A), RS1000695669 (2:238430573 T>A), RS1000726589 (2:238430333 G>A), RS1000927193 (2:238436678 A>G), RS1000953235 (2:238425151 C>T), RS1001030594 (2:238444177 G>A), RS1001052652 (2:238441767 A>G), RS1001083682 (2:238441560 C>A,G,T), RS1001293533 (2:238435031 T>C,G), RS1001325486 (2:238444403 C>A,G,T), RS1001395643 (2:238440705 C>A,T), RS1001426776 (2:238440517 A>C,G)

Disease associations

OMIM: gene MIM:605758 | disease phenotypes: MIM:600430

GenCC curated gene-disease

Mondo (1): 2q37 microdeletion syndrome (MONDO:0010886)

Orphanet (1): 2q37 microdeletion syndrome (Orphanet:1001)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

16 associations (top):

Study	Trait	p-value
GCST001251_1	Pulmonary function	7.000000e-08
GCST003453_7	Chronotype	1.000000e-08
GCST003784_4	Multiple system atrophy	4.000000e-06
GCST003983_3	Male-pattern baldness	2.000000e-37
GCST004185_18	Lung function (FEV1/FVC)	3.000000e-10
GCST004250_35	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	4.000000e-06
GCST004792_4	Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals	7.000000e-06
GCST005790_88	Rosacea symptom severity	1.000000e-06
GCST007565_124	Morning person	8.000000e-36
GCST007565_147	Morning person	4.000000e-43
GCST007565_209	Morning person	3.000000e-18
GCST007576_2	Chronotype	4.000000e-43
GCST007576_375	Chronotype	9.000000e-14
GCST007692_11	Chronic obstructive pulmonary disease	3.000000e-08
GCST009391_1159	Metabolite levels	9.000000e-07
GCST010002_412	Refractive error	6.000000e-16

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0003892	pulmonary function measurement
EFO:0004314	forced expiratory volume
EFO:0004713	FEV/FVC ratio
EFO:0007965	response to combination chemotherapy
EFO:0009180	rosacea severity measurement
EFO:0008328	chronotype measurement
EFO:0010460	anthranilic acid measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C538317	Chromosome 2q37 deletion syndrome (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, affects expression, affects cotreatment	5
trichostatin A	affects cotreatment, decreases expression	3
Benzo(a)pyrene	decreases expression, increases methylation, increases mutagenesis	3
Air Pollutants	increases expression, affects cotreatment, decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
apocarotenal	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	decreases expression, increases abundance, affects cotreatment	1
bisphenol A	decreases expression	1
sodium arsenite	increases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acrolein	increases abundance, affects cotreatment, decreases expression	1
Cycloheximide	affects cotreatment, increases expression	1
Dexamethasone	decreases expression	1
Hydrogen Peroxide	affects expression	1
Ozone	decreases expression, increases abundance, affects cotreatment	1
Plant Extracts	affects cotreatment, increases expression	1
Selenium	affects cotreatment, increases expression	1
Silicon Dioxide	increases expression	1

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT01238250	Not specified	RECRUITING	Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight