ASB16-AS1

Summary

ASB16-AS1 (ASB16 antisense RNA 1, HGNC:25442) is a long non-coding RNA gene on chromosome 17q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25442
Approved symbol	ASB16-AS1
Name	ASB16 antisense RNA 1
Location	17q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	DKFZp762C2414
Ensembl gene	ENSG00000267080
Ensembl biotype	lncRNA
Entrez	339201
RNAcentral	URS000075CE59 — lncRNA, 2275 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 37 — 37 lncRNA

ENST00000585457, ENST00000588785, ENST00000591166, ENST00000592897, ENST00000618557, ENST00000656516, ENST00000667107, ENST00000667684, ENST00000669052, ENST00000689255, ENST00000755665, ENST00000755666, ENST00000755667, ENST00000755668, ENST00000755669, ENST00000755670, ENST00000755671, ENST00000755672, ENST00000755673, ENST00000755674, ENST00000755675, ENST00000755676, ENST00000755677, ENST00000755678, ENST00000755679, ENST00000755680, ENST00000755681, ENST00000755682, ENST00000755683, ENST00000755684, ENST00000755685, ENST00000755686, ENST00000755687, ENST00000755688, ENST00000755689, ENST00000755690, ENST00000755691

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585457 — 4 exons

Exon	Start	End
ENSE00002740993	44175973	44177816
ENSE00002758907	44186565	44186707
ENSE00003238644	44182930	44183093
ENSE00003247553	44181623	44181720

Expression profiles

Bgee: expression breadth ubiquitous, 176 present calls, max score 90.90.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.2155 / max 91.6704, expressed in 1762 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166314	5.3983	1688
166313	1.6459	970
166312	1.1713	804

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	90.90	gold quality
gastrocnemius	UBERON:0001388	90.29	gold quality
muscle of leg	UBERON:0001383	89.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.69	gold quality
adenohypophysis	UBERON:0002196	84.49	gold quality
right uterine tube	UBERON:0001302	83.69	gold quality
apex of heart	UBERON:0002098	83.66	gold quality
granulocyte	CL:0000094	83.56	gold quality
pituitary gland	UBERON:0000007	83.39	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.08	gold quality
endocervix	UBERON:0000458	83.07	gold quality
mucosa of transverse colon	UBERON:0004991	83.05	gold quality
right ovary	UBERON:0002118	82.78	gold quality
left ovary	UBERON:0002119	82.63	gold quality
spleen	UBERON:0002106	82.61	gold quality
lower esophagus mucosa	UBERON:0035834	82.48	gold quality
cerebellar hemisphere	UBERON:0002245	82.40	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.40	gold quality
cerebellar cortex	UBERON:0002129	82.26	gold quality
body of uterus	UBERON:0009853	82.26	gold quality
ectocervix	UBERON:0012249	81.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.68	gold quality
lower esophagus	UBERON:0013473	81.67	gold quality
right lobe of thyroid gland	UBERON:0001119	81.62	gold quality
left uterine tube	UBERON:0001303	81.25	gold quality
ganglionic eminence	UBERON:0004023	81.12	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	80.76	gold quality
left lobe of thyroid gland	UBERON:0001120	80.74	gold quality
small intestine Peyer’s patch	UBERON:0003454	80.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	80.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Our findings support that ASB16-AS1 and SYN2 may represent two novel functional genes underlying bone mineral density variation (PMID:29763751)
• the present study revealed that lncRNA ASB16-AS1 improves the proliferation, migration, and invasion of glioma cells. (PMID:30949502)
• Long noncoding RNA ASB16-AS1 inhibits adrenocortical carcinoma cell growth by promoting ubiquitination of RNA-binding protein HuR. (PMID:33219221)
• [LncRNA ASB16-AS1 regulates the proliferation, migration and invasion of esophageal cancer cells by targeting miR-1258]. (PMID:34289570)
• LncRNA ASB16-AS1 drives proliferation, migration, and invasion of colorectal cancer cells through regulating miR-185-5p/TEAD1 axis. (PMID:34870557)
• LncRNA ASB16-AS1 accelerates cellular process and chemoresistance of ovarian cancer cells by regulating GOLM1 expression via targeting miR-3918. (PMID:37429067)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.