ASMTL-AS1

Summary

ASMTL-AS1 (ASMTL antisense RNA 1, HGNC:25811) is a long non-coding RNA gene on chromosome Xp22.33 and Yp11.32.

This gene serves as the antisense to the acetylserotonin O-methyltransferase-like gene. Multiple non-coding transcript variants have been found for this gene.

Source: NCBI Gene 80161 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25811
Approved symbol	ASMTL-AS1
Name	ASMTL antisense RNA 1
Location	Xp22.33 and Yp11.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ13330
Ensembl gene	ENSG00000236017
Ensembl biotype	lncRNA
Entrez	80161
RNAcentral	URS0002A46F93 — lncRNA, 1249 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000419737, ENST00000420411, ENST00000425740, ENST00000443929, ENST00000602357, ENST00000740402, ENST00000740403, ENST00000740404, ENST00000740405, ENST00000740406

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419737 — 3 exons

Exon	Start	End
ENSE00001635036	1412743	1412888
ENSE00003334245	1413749	1414028
ENSE00003355244	1403459	1403585

Expression profiles

Bgee: expression breadth ubiquitous, 193 present calls, max score 95.96.

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	95.96	gold quality
pancreatic ductal cell	CL:0002079	95.44	gold quality
right lobe of thyroid gland	UBERON:0001119	95.27	gold quality
right adrenal gland cortex	UBERON:0035827	94.58	gold quality
pituitary gland	UBERON:0000007	94.57	gold quality
left lobe of thyroid gland	UBERON:0001120	94.47	gold quality
right lobe of liver	UBERON:0001114	93.96	gold quality
right adrenal gland	UBERON:0001233	93.64	gold quality
sural nerve	UBERON:0015488	93.54	gold quality
left adrenal gland cortex	UBERON:0035825	93.44	gold quality
thyroid gland	UBERON:0002046	93.18	gold quality
left adrenal gland	UBERON:0001234	93.12	gold quality
apex of heart	UBERON:0002098	92.78	gold quality
adrenal cortex	UBERON:0001235	92.53	gold quality
metanephros cortex	UBERON:0010533	92.18	gold quality
right uterine tube	UBERON:0001302	92.16	gold quality
spleen	UBERON:0002106	91.23	gold quality
mucosa of transverse colon	UBERON:0004991	90.78	gold quality
vena cava	UBERON:0004087	90.35	silver quality
adrenal gland	UBERON:0002369	89.89	gold quality
right frontal lobe	UBERON:0002810	89.22	gold quality
right hemisphere of cerebellum	UBERON:0014890	88.62	gold quality
granulocyte	CL:0000094	88.31	gold quality
cortex of kidney	UBERON:0001225	88.23	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.22	gold quality
transverse colon	UBERON:0001157	88.16	gold quality
upper lobe of left lung	UBERON:0008952	88.06	gold quality
minor salivary gland	UBERON:0001830	88.03	gold quality
omental fat pad	UBERON:0010414	87.56	gold quality
mucosa of stomach	UBERON:0001199	87.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Exosome-transferred long non-coding RNA ASMTL-AS1 contributes to malignant phenotypes in residual hepatocellular carcinoma after insufficient radiofrequency ablation. (PMID:32722884)
• A novel tumor suppressor ASMTL-AS1 regulates the miR-1228-3p/SOX17/beta-catenin axis in triple-negative breast cancer. (PMID:34006305)
• Long non-coding RNA ASMTL-AS1 deteriorates the oncogenicity of osteosarcoma by decoying microRNA-342-3p and consequently raising ADAM9 expression. (PMID:34597997)
• ASMTL-AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis. (PMID:34658100)
• Downregulation of lncRNA ASMTL-AS1 in Epithelial Ovarian Cancer Correlates with Worse Prognosis and Cancer Progression. (PMID:35835145)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.