ATG10

Summary

ATG10 (autophagy related 10, HGNC:20315) is a protein-coding gene on chromosome 5q14.1-q14.2, encoding Ubiquitin-like-conjugating enzyme ATG10 (Q9H0Y0). E2-like enzyme involved in autophagy.

Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).

Source: NCBI Gene 83734 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_031482

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20315
Approved symbol	ATG10
Name	autophagy related 10
Location	5q14.1-q14.2
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP586I0418, FLJ13954
Ensembl gene	ENSG00000152348
Ensembl biotype	protein_coding
OMIM	610800
Entrez	83734

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 27 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000282185, ENST00000355178, ENST00000458350, ENST00000504770, ENST00000508814, ENST00000510085, ENST00000513443, ENST00000513634, ENST00000514253, ENST00000866604, ENST00000866605, ENST00000866606, ENST00000866607, ENST00000866608, ENST00000866609, ENST00000866610, ENST00000866611, ENST00000866612, ENST00000866613, ENST00000866614, ENST00000919272, ENST00000919273, ENST00000919274, ENST00000919275, ENST00000919276, ENST00000919277, ENST00000919278, ENST00000969578, ENST00000969579, ENST00000969580

RefSeq mRNA: 2 — MANE Select: NM_031482 NM_001131028, NM_031482

CCDS: CCDS4057

Canonical transcript exons

ENST00000282185 — 8 exons

Exon	Start	End
ENSE00001004797	82058495	82058602
ENSE00001004800	82164399	82164537
ENSE00001004801	82253314	82253429
ENSE00001178524	81987559	81987678
ENSE00001825593	82254068	82256133
ENSE00003558422	82252562	82252659
ENSE00003561231	82178490	82178587
ENSE00003848202	81972023	81972306

Expression profiles

Bgee: expression breadth ubiquitous, 227 present calls, max score 85.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.8636 / max 110.0044, expressed in 1777 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57353	7.1832	1738
203606	1.6805	1088

Top tissues by expression

264 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.26	gold quality
islet of Langerhans	UBERON:0000006	82.50	gold quality
monocyte	CL:0000576	81.48	gold quality
mononuclear cell	CL:0000842	81.19	gold quality
adrenal tissue	UBERON:0018303	81.13	gold quality
leukocyte	CL:0000738	80.93	gold quality
ganglionic eminence	UBERON:0004023	80.17	gold quality
tibial artery	UBERON:0007610	80.04	gold quality
popliteal artery	UBERON:0002250	80.02	gold quality
gastrocnemius	UBERON:0001388	79.89	gold quality
skin of abdomen	UBERON:0001416	79.89	gold quality
muscle of leg	UBERON:0001383	79.63	gold quality
aorta	UBERON:0000947	79.54	gold quality
right coronary artery	UBERON:0001625	79.51	gold quality
stromal cell of endometrium	CL:0002255	79.49	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	79.35	gold quality
rectum	UBERON:0001052	79.33	gold quality
skin of leg	UBERON:0001511	79.21	gold quality
ascending aorta	UBERON:0001496	79.16	gold quality
thoracic aorta	UBERON:0001515	79.12	gold quality
ventricular zone	UBERON:0003053	78.91	gold quality
mucosa of transverse colon	UBERON:0004991	78.89	gold quality
left coronary artery	UBERON:0001626	78.72	gold quality
calcaneal tendon	UBERON:0003701	78.59	gold quality
descending thoracic aorta	UBERON:0002345	78.47	gold quality
pancreas	UBERON:0001264	78.43	gold quality
body of pancreas	UBERON:0001150	78.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	77.96	gold quality
zone of skin	UBERON:0000014	77.86	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 10.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	44284.03
E-MTAB-9543	yes	41587.97
E-MTAB-7407	yes	41200.99
E-HCAD-56	yes	764.66
E-MTAB-10283	yes	644.94
E-MTAB-8410	yes	588.39
E-MTAB-8495	yes	540.30
E-GEOD-149689	yes	506.84
E-MTAB-10290	yes	219.62
E-ANND-3	yes	7.83

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1

miRNA regulators (miRDB)

86 targeting ATG10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4775	99.98	75.00	6394
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-590-3P	99.96	74.34	6478
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-4659A-3P	99.80	72.62	4248

Literature-anchored findings (GeneRIF, showing 16)

• Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis indicating that ATG10 may be a potential prognostic maker in colorectal cancer. (PMID:23285162)
• results suggest that genetic variants in ATG10 may implicate with breast cancer susceptibility in Chinese population. Further large and functional studies are needed to confirm our findings (PMID:23850577)
• 3 novel miRNAs, MIR4458, MIR4667-5p, and MIR4668-5p, regulate autophagy-mediated elimination of B. pseudomallei by targeting ATG10 (PMID:26151773)
• Findings suggest that eQTL/meQTL variations of ATG10 could influence lung cancer survival through regulating ATG10 expression. (PMID:27225307)
• Expression of ATG10 negatively regulated by PTBP1 and is associated with metastasis of colorectal cancer cells. (PMID:27836735)
• ATG10 rs1864182 gene polymorphism was associated with the decreased risk of coal workers’ pneumoconiosis in a Chinese population. (PMID:28844669)
• ATG10, a canonical long isoform in autophagy process, can facilitate hepatitis C virus-subgenomic replicon amplification by promoting autophagosome formation and by combining with and detaining autophagosomes in cellular periphery, causing impaired autophagy flux. (PMID:28900156)
• findings provide important information for understanding the differential roles on HCV replication and autophagy flux between ATG10 and ATG10S, and how the structure-function relationship of ATG10 transformed by a single -SH group loss on Cys(44) and Cys(135) in ATG10 protein, which may be a new target against HCV replication. (PMID:30319633)
• Results found ATG10 rs10514231 was significantly associated with the occurrence of grade 3-4 oral mucositis and myelosuppression in nasopharyngeal carcinoma (NPC) patients treated with radiotherapy. (PMID:31692259)
• A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells. (PMID:31996071)
• A study on the potential role of autophagy-related protein 10 as a biomarker for ulcerative colitis. (PMID:33904657)
• Analysis of rs1864182 and rs1864183 variants in ATG10 gene and antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese Guangxi population. (PMID:34961976)
• The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma. (PMID:35902797)
• Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10. (PMID:36194366)
• Association of ATG10 rs1864183, ATG16L1 rs2241880 and miR-126 with esophageal cancer. (PMID:38281293)
• METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1. (PMID:39407279)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	atg10	ENSDARG00000104846
mus_musculus	Atg10	ENSMUSG00000021619
rattus_norvegicus	Atg10	ENSRNOG00000016342

Protein

Protein identifiers

Ubiquitin-like-conjugating enzyme ATG10 — Q9H0Y0 (reviewed: Q9H0Y0)

Alternative names: Autophagy-related protein 10

All UniProt accessions (4): Q9H0Y0, D6RBD1, D6RC89, D6RDX3

UniProt curated annotations — full annotation on UniProt →

Function. E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis.

Subunit / interactions. Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7. Interacts with IRGM.

Subcellular location. Cytoplasm.

Similarity. Belongs to the ATG10 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H0Y0-1	1	yes
Q9H0Y0-2	2

RefSeq proteins (2): NP_001124500, NP_113670* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007135	Atg3/Atg10	Family

Pfam: PF03987

UniProt features (7 total): sequence variant 3, splice variant 2, chain 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H0Y0-F1	81.14	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 166 (glycyl thioester intermediate)

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-1632852	Macroautophagy
R-HSA-9612973	Autophagy

MSigDB gene sets: 109 (showing top): GOBP_VACUOLE_ORGANIZATION, GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MACROAUTOPHAGY, GOBP_ER_NUCLEUS_SIGNALING_PATHWAY, GOBP_ORGANELLE_ASSEMBLY, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, CUI_TCF21_TARGETS_2_DN, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, GOBP_AUTOPHAGOSOME_ORGANIZATION, GOMF_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY, GEORGES_TARGETS_OF_MIR192_AND_MIR215

GO Biological Process (6): autophagosome assembly (GO:0000045), mitophagy (GO:0000423), autophagy (GO:0006914), ER overload response (GO:0006983), protein transport (GO:0015031), protein modification by small protein conjugation (GO:0032446)

GO Molecular Function (5): Atg12 transferase activity (GO:0019777), Atg12 conjugating enzyme activity (GO:0061651), protein binding (GO:0005515), transferase activity (GO:0016740), ubiquitin-like protein transferase activity (GO:0019787)

GO Cellular Component (2): cytosol (GO:0005829), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Autophagy	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
Atg12 activating enzyme activity	1
protein-phosphatidylethanolamide deconjugating activity	1
Atg12 conjugating enzyme activity	1
Atg12 ligase activity	1
organelle assembly	1
Atg1/ULK1 kinase complex assembly	1
autophagosome organization	1
autophagy of mitochondrion	1
macroautophagy	1
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
ER-nucleus signaling pathway	1
response to endoplasmic reticulum stress	1
cellular response to biotic stimulus	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
protein modification by small protein conjugation or removal	1
ubiquitin-like protein transferase activity	1
Atg12 transferase activity	1
ubiquitin-like protein conjugating enzyme activity	1
binding	1
catalytic activity	1
aminoacyltransferase activity	1
catalytic activity, acting on a protein	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

850 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ATG10	ATG12	O94817	999
ATG10	ATG7	O95352	999
ATG10	ATG5	Q9H1Y0	997
ATG10	IRGM	A1A4Y4	987
ATG10	ATG13	O75143	978
ATG10	ATG16L1	Q676U5	950
ATG10	RB1CC1	Q8TDY2	949
ATG10	ATG3	Q9NT62	947
ATG10	MAP1LC3A	Q9H492	879
ATG10	ATG4B	Q9Y4P1	875
ATG10	ULK1	O75385	865
ATG10	ATG4A	Q8WYN0	864
ATG10	ATG4C	Q96DT6	855
ATG10	GABARAPL2	P60520	852
ATG10	F5GZY7	F5GZY7	851

IntAct

56 interactions, top by confidence:

A	B	Type	Score
ATG10	ATG12	psi-mi:“MI:0914”(association)	0.670
ATG10	ATG5	psi-mi:“MI:0915”(physical association)	0.560
CASP6	ATG10	psi-mi:“MI:0915”(physical association)	0.560
GNB2	ATG10	psi-mi:“MI:0915”(physical association)	0.560
HIP1	ATG10	psi-mi:“MI:0915”(physical association)	0.560
LAMP2	ATG10	psi-mi:“MI:0915”(physical association)	0.560
PRKN	ATG10	psi-mi:“MI:0915”(physical association)	0.560
RAN	ATG10	psi-mi:“MI:0915”(physical association)	0.560
KIF1B	ATG10	psi-mi:“MI:0915”(physical association)	0.560
RNF11	ATG10	psi-mi:“MI:0915”(physical association)	0.560
PRPF40A	ATG10	psi-mi:“MI:0915”(physical association)	0.560
COQ8A	ATG10	psi-mi:“MI:0915”(physical association)	0.560
SNCA	ATG10	psi-mi:“MI:0915”(physical association)	0.560
ATXN1	ATG10	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (223): ATG12 (Affinity Capture-MS), ATG7 (Affinity Capture-MS), ATG12 (Affinity Capture-MS), ATG7 (Affinity Capture-MS), ATG10 (Affinity Capture-MS), IFNL2 (Affinity Capture-Western), IRGM (Affinity Capture-Western), IRGM (Two-hybrid), ATG10 (Two-hybrid), TAX1BP1 (Phenotypic Enhancement), RB1CC1 (Phenotypic Enhancement), ATG101 (Phenotypic Enhancement), CAPZB (Phenotypic Enhancement), ACTB (Phenotypic Enhancement), GDI2 (Phenotypic Enhancement)

ESM2 similar proteins: A4IFQ0, A4QNE0, A7YY45, B0K012, O94888, O95453, P42694, P54198, P54277, P57060, P69341, Q05B58, Q08BT5, Q13572, Q13769, Q1RMZ1, Q3U2J5, Q3ZBE1, Q4R8V9, Q569B7, Q5F480, Q5R9U9, Q5RC51, Q5RCR8, Q5RDU9, Q5REY7, Q5ZIA0, Q5ZLS2, Q5ZMQ0, Q61666, Q68FX7, Q6DFV5, Q6GR37, Q6NRL4, Q6NW29, Q7SXV1, Q8BKT7, Q8K2D3, Q8W0Z9, Q96F86

Diamond homologs: A1CAN8, A1DF15, A3LX85, A5DN42, A5DVH6, A6S8P6, A6ZS81, A7F172, A7KAI2, A7KAL4, A7TK16, C8VDI2, F7VSU2, G2XNY3, I1RX50, M7UQV4, O43035, P0CM34, P0CM35, P40344, Q0U388, Q0VCL3, Q0WWQ1, Q2H427, Q2U7R4, Q4WUE5, Q51LD2, Q550A8, Q5ABQ7, Q5I0S6, Q6AZ50, Q6BSC4, Q6C4Q9, Q6CL19, Q6FQJ2, Q6GQE7, Q6PFS7, Q755K1, Q7SDY2, Q9CPX6

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
ATG10	up-regulates	ATG12	binding
ATG10	up-regulates	ATG12/5/16L1	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 22 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Macroautophagy	7	42.5×	2e-08
Autophagy	5	39.0×	8e-06

GO biological processes:

GO term	Partners	Fold	FDR
autophagosome maturation	8	127.7×	1e-13
mitophagy	8	115.6×	2e-13
autophagosome assembly	8	81.7×	3e-12
macroautophagy	5	54.7×	2e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	33
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3243 predictions. Top by Δscore:

Variant	Effect	Δscore
5:81972089:G:GT	donor_gain	1.0000
5:81987553:TTGCA:T	acceptor_loss	1.0000
5:81987554:TGCAG:T	acceptor_loss	1.0000
5:81987555:GCAGT:G	acceptor_loss	1.0000
5:81987556:CAGTT:C	acceptor_loss	1.0000
5:81987557:A:AG	acceptor_gain	1.0000
5:81987557:AGT:A	acceptor_loss	1.0000
5:81987558:G:GA	acceptor_gain	1.0000
5:81987558:GTT:G	acceptor_gain	1.0000
5:81987558:GTTA:G	acceptor_gain	1.0000
5:81987558:GTTAT:G	acceptor_gain	1.0000
5:81987674:CAAAG:C	donor_loss	1.0000
5:81987675:AAAG:A	donor_loss	1.0000
5:81987676:AAGGT:A	donor_loss	1.0000
5:81987677:AGGT:A	donor_loss	1.0000
5:81987679:G:T	donor_loss	1.0000
5:81987680:T:A	donor_loss	1.0000
5:82058479:T:A	acceptor_gain	1.0000
5:82058480:G:A	acceptor_gain	1.0000
5:82058482:T:TA	acceptor_gain	1.0000
5:82121411:G:T	donor_gain	1.0000
5:82164469:A:AG	donor_gain	1.0000
5:82252656:A:AG	donor_gain	1.0000
5:82252660:G:GG	donor_gain	1.0000
5:82252707:GT:G	donor_gain	1.0000
5:82276394:TCA:T	donor_loss	1.0000
5:82276395:CA:C	donor_loss	1.0000
5:82276396:A:AC	donor_gain	1.0000
5:82276396:ACCT:A	donor_gain	1.0000
5:82276397:C:CC	donor_gain	1.0000

AlphaMissense

1451 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:82253336:T:A	W192R	0.995
5:82253336:T:C	W192R	0.995
5:81987658:T:A	W30R	0.992
5:81987658:T:C	W30R	0.992
5:82164481:T:A	V100D	0.992
5:81987660:G:C	W30C	0.989
5:81987660:G:T	W30C	0.989
5:82252598:C:G	H164D	0.989
5:82164508:C:A	P109H	0.987
5:82252567:T:A	H153Q	0.987
5:82252567:T:G	H153Q	0.987
5:82253342:A:C	S194R	0.986
5:82253344:C:A	S194R	0.986
5:82253344:C:G	S194R	0.986
5:82252566:A:G	H153R	0.983
5:82253340:T:C	L193P	0.983
5:82164495:A:C	S105R	0.981
5:82164497:C:A	S105R	0.981
5:82164497:C:G	S105R	0.981
5:82178577:T:A	I148N	0.981
5:82252586:T:C	F160L	0.979
5:82252588:T:A	F160L	0.979
5:82252588:T:G	F160L	0.979
5:81987659:G:C	W30S	0.978
5:82253338:G:C	W192C	0.978
5:82253338:G:T	W192C	0.978
5:81987604:T:C	F12L	0.977
5:81987606:C:A	F12L	0.977
5:81987606:C:G	F12L	0.977
5:81987626:T:C	F19S	0.977

dbSNP variants (sampled 300 via entrez): RS1000005023 (5:82244967 G>A), RS1000023263 (5:82166074 A>G), RS1000056171 (5:82138674 T>C), RS1000059863 (5:82076098 G>A,T), RS1000060573 (5:82029692 G>T), RS1000064345 (5:81984175 G>A), RS1000071640 (5:82242944 A>G), RS1000078198 (5:82200695 T>C), RS1000078695 (5:82036845 A>G), RS1000101312 (5:82108025 G>A), RS1000107969 (5:82138547 T>C,G), RS1000113875 (5:82006487 A>G), RS1000126815 (5:82174112 T>C), RS1000130193 (5:82083834 A>C,G), RS1000137966 (5:82127542 C>A,T)

Disease associations

OMIM: gene MIM:610800 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST002941_13	Airway imaging phenotypes	1.000000e-06
GCST004950_32	Breast cancer	5.000000e-11
GCST004988_197	Breast cancer	2.000000e-12
GCST007236_69	Breast cancer	4.000000e-09
GCST007324_4	Adventurousness	7.000000e-10
GCST007325_154	General risk tolerance (MTAG)	8.000000e-12
GCST009921_1	Carotid intima media thickness (mean)	3.000000e-08
GCST011741_51	LDL cholesterol levels in HIV infection	9.000000e-06
GCST011743_39	HDL cholesterol levels in HIV infection	5.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007627	airway imaging measurement
EFO:0008579	risk-taking behaviour
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004612	high density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

2 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1864183	ATG10		0.00	0
rs10514231	ATG10		0.00	0

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, affects expression, affects cotreatment	5
sodium arsenite	affects expression, decreases expression, affects cotreatment, increases abundance	4
Benzo(a)pyrene	decreases expression	4
Arsenic	affects methylation, affects cotreatment, affects expression, decreases expression, increases abundance	3
potassium chromate(VI)	affects cotreatment, decreases expression	2
Aflatoxin B1	affects expression, decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
7-hydroxydehydronuciferine	increases expression	1
methylmercuric chloride	decreases expression, increases expression	1
bisphenol A	affects cotreatment, increases methylation	1
sinomenine	decreases expression, decreases reaction	1
arsenite	increases expression	1
butyraldehyde	decreases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
pentanal	decreases expression	1
polyhexamethyleneguanidine	decreases expression	1
chromium hexavalent ion	decreases expression	1
trovafloxacin	affects cotreatment, increases expression	1
buprofezin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
dorsomorphin	decreases expression, affects cotreatment	1
4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide	decreases expression	1
bisphenol S	affects cotreatment, decreases methylation	1
Irinotecan	decreases expression	1
Fulvestrant	increases methylation, decreases methylation, affects cotreatment	1
Dieldrin	increases response to substance	1
Estradiol	decreases expression	1
Formaldehyde	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1KB	Abcam HeLa ATG10 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.