ATOSB

Summary

ATOSB (atos homolog B, HGNC:25666) is a protein-coding gene on chromosome 9p13.3, encoding Atos homolog protein B (Q7L5A3). Transcription regulator that may syncronize transcriptional and translational programs.

Located in nucleus.

Source: NCBI Gene 80256 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 83 total
• MANE Select transcript: NM_025182

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25666
Approved symbol	ATOSB
Name	atos homolog B
Location	9p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11560, bA182N22.6
Ensembl gene	ENSG00000005238
Ensembl biotype	protein_coding
OMIM	620169
Entrez	80256

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 27 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000322813, ENST00000378557, ENST00000378561, ENST00000378566, ENST00000488109, ENST00000603301, ENST00000605104, ENST00000605244, ENST00000605392, ENST00000903792, ENST00000903793, ENST00000903794, ENST00000903795, ENST00000903796, ENST00000903797, ENST00000903798, ENST00000903799, ENST00000903800, ENST00000903801, ENST00000903802, ENST00000919194, ENST00000919195, ENST00000919196, ENST00000919197, ENST00000971394, ENST00000971395, ENST00000971396, ENST00000971397, ENST00000971398

RefSeq mRNA: 2 — MANE Select: NM_025182 NM_001317991, NM_025182

CCDS: CCDS6578

Canonical transcript exons

ENST00000322813 — 9 exons

Exon	Start	End
ENSE00001091889	35106538	35106643
ENSE00001091897	35108594	35108737
ENSE00001422512	35107381	35108349
ENSE00003228447	35105682	35105857
ENSE00003296377	35106252	35106410
ENSE00003424246	35105941	35106009
ENSE00003507714	35115805	35115862
ENSE00003685988	35106833	35106891
ENSE00003903780	35104117	35105374

Expression profiles

Bgee: expression breadth ubiquitous, 280 present calls, max score 93.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.2365 / max 392.7626, expressed in 1789 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100575	11.6110	1736
100569	3.2065	1152
100574	1.1280	449
100576	1.0291	661
100570	0.6370	315
100571	0.4238	170
100572	0.1074	44
100573	0.0937	41

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	93.52	gold quality
monocyte	CL:0000576	92.84	gold quality
mononuclear cell	CL:0000842	92.77	gold quality
leukocyte	CL:0000738	92.62	gold quality
blood	UBERON:0000178	91.78	gold quality
lower esophagus mucosa	UBERON:0035834	91.23	gold quality
diaphragm	UBERON:0001103	91.01	gold quality
inferior vagus X ganglion	UBERON:0005363	90.21	gold quality
subthalamic nucleus	UBERON:0001906	90.12	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	89.94	gold quality
spinal cord	UBERON:0002240	89.79	gold quality
right coronary artery	UBERON:0001625	89.67	gold quality
type B pancreatic cell	CL:0000169	89.45	gold quality
ascending aorta	UBERON:0001496	89.21	gold quality
thoracic aorta	UBERON:0001515	89.15	gold quality
dorsal plus ventral thalamus	UBERON:0001897	89.05	gold quality
left ventricle myocardium	UBERON:0006566	89.01	silver quality
right lung	UBERON:0002167	89.00	gold quality
ileal mucosa	UBERON:0000331	88.85	gold quality
descending thoracic aorta	UBERON:0002345	88.76	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.46	gold quality
apex of heart	UBERON:0002098	88.36	gold quality
esophagus mucosa	UBERON:0002469	88.29	gold quality
stromal cell of endometrium	CL:0002255	88.21	gold quality
aorta	UBERON:0000947	88.10	gold quality
spleen	UBERON:0002106	87.78	gold quality
pharyngeal mucosa	UBERON:0000355	87.70	gold quality
CA1 field of hippocampus	UBERON:0003881	87.59	gold quality
coronary artery	UBERON:0001621	87.54	gold quality
vena cava	UBERON:0004087	87.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.05

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

miRNA regulators (miRDB)

73 targeting ATOSB, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4534	99.99	66.58	1907
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-7845-5P	99.88	64.88	771
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-498-5P	99.76	69.64	1807
HSA-MIR-11181-3P	99.75	66.38	2205

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	atosb	ENSDARG00000068650
mus_musculus	Atosb	ENSMUSG00000036002
rattus_norvegicus	Atosb	ENSRNOG00000009323

Paralogs (1): ATOSA (ENSG00000047346)

Protein

Protein identifiers

Atos homolog protein B — Q7L5A3 (reviewed: Q7L5A3)

All UniProt accessions (1): Q7L5A3

UniProt curated annotations — full annotation on UniProt →

Function. Transcription regulator that may syncronize transcriptional and translational programs.

Subcellular location. Nucleus.

Domain organisation. The protein contains a transactivation domain (TAD) which may be required for transcriptional activation of a subset of target genes.

Similarity. Belongs to the ATOS family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q7L5A3-1	1	yes
Q7L5A3-2	2
Q7L5A3-3	3

RefSeq proteins (2): NP_001304920, NP_079458* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR025261	Atos-like_cons_dom	Domain
IPR033473	Atos-like_C	Domain
IPR051506	ATOS_Transcription_Regulators	Family

Pfam: PF13889, PF13915

UniProt features (12 total): region of interest 4, splice variant 2, compositionally biased region 2, modified residue 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7L5A3-F1	56.25	0.23

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 254, 255

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 175 (showing top): RNGTGGGC_UNKNOWN, SP3_Q3, MODULE_45, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, MODULE_16, GGGTGGRR_PAX4_03, USF_C, MODULE_66, MODULE_118, BROWNE_HCMV_INFECTION_48HR_DN, MODULE_379, GROSS_HYPOXIA_VIA_ELK3_UP, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, chr9p13, HIF1_Q3

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

316 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ATOSB	CEBPZOS	A8MTT3	586
ATOSB	ATP11C	Q8NB49	527
ATOSB	DGKA	P23743	508
ATOSB	RAPH1	Q70E73	507
ATOSB	TENT5A	Q96IP4	507
ATOSB	SCAPER	Q9BY12	507
ATOSB	RHNO1	Q9BSD3	506
ATOSB	ZNHIT1	O43257	500
ATOSB	PSME1	Q06323	475
ATOSB	USP6NL	Q92738	469
ATOSB	SPATA6	Q9NWH7	443
ATOSB	SPIN4	Q56A73	438
ATOSB	NAGA	P17050	430
ATOSB	HYCC2	Q8IXS8	429
ATOSB	B4GALT7	Q9UBV7	418
ATOSB	CDR2	Q01850	418

IntAct

220 interactions, top by confidence:

A	B	Type	Score
ATOSB	IKZF1	psi-mi:“MI:0915”(physical association)	0.800
IKZF1	ATOSB	psi-mi:“MI:0915”(physical association)	0.800
TRIM27	ATOSB	psi-mi:“MI:0915”(physical association)	0.780
ATOSB	TRIM27	psi-mi:“MI:0915”(physical association)	0.780
ATOSB	CEP70	psi-mi:“MI:0915”(physical association)	0.740
CEP70	ATOSB	psi-mi:“MI:0915”(physical association)	0.740
ATOSB	FHL5	psi-mi:“MI:0915”(physical association)	0.740
TRAF4	ATOSB	psi-mi:“MI:0915”(physical association)	0.740
ATOSB	TRAF4	psi-mi:“MI:0915”(physical association)	0.740
FHL5	ATOSB	psi-mi:“MI:0915”(physical association)	0.740
ATOSB	KIF20A	psi-mi:“MI:0915”(physical association)	0.670
KIF20A	ATOSB	psi-mi:“MI:0915”(physical association)	0.670
MDFI	ATOSB	psi-mi:“MI:0915”(physical association)	0.670
ATOSB	MDFI	psi-mi:“MI:0915”(physical association)	0.670
DIP2A	ATOSB	psi-mi:“MI:0915”(physical association)	0.560
DNAJA3	ATOSB	psi-mi:“MI:0915”(physical association)	0.560
ATOSB	DNAJA3	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (74): FAM214B (Two-hybrid), FAM214B (Two-hybrid), FAM214B (Two-hybrid), FAM214B (Two-hybrid), FAM214B (Two-hybrid), CEP70 (Two-hybrid), FAM214B (Two-hybrid), FAM214B (Two-hybrid), FAM214B (Two-hybrid), FHL5 (Two-hybrid), TRAF4 (Two-hybrid), FAM214B (Two-hybrid), MDFI (Two-hybrid), AKAP8L (Two-hybrid), ZRANB1 (Two-hybrid)

ESM2 similar proteins: A1YF56, D3ZJK7, E1BEA8, F1MUS9, O09139, O15534, O35973, O43435, O43638, O75333, O77728, O94983, O95935, O95947, P12813, P22736, P51666, P56261, P57082, P70325, P70326, P70327, Q0V8F0, Q15744, Q4JF29, Q4R676, Q5BIM2, Q5I2P1, Q5PQM8, Q61660, Q63247, Q63HR2, Q64731, Q66JL1, Q6PZD9, Q7L5A3, Q80Y50, Q810F8, Q861Q9, Q8AV66

Diamond homologs: Q1LV22, Q32MH5, Q4R676, Q5BIM2, Q5FW46, Q5PQM8, Q5RBA3, Q5ZI58, Q69ZK7, Q7JXG9, Q7L5A3, Q8BR27

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

83 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	77
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1204 predictions. Top by Δscore:

Variant	Effect	Δscore
9:35105799:G:T	acceptor_gain	1.0000
9:35105806:C:CT	acceptor_gain	1.0000
9:35105853:AAGGT:A	acceptor_gain	1.0000
9:35105854:AGGT:A	acceptor_gain	1.0000
9:35105855:GGT:G	acceptor_gain	1.0000
9:35105856:GTC:G	acceptor_loss	1.0000
9:35105857:TCTAG:T	acceptor_loss	1.0000
9:35105858:C:CA	acceptor_loss	1.0000
9:35105858:C:CC	acceptor_gain	1.0000
9:35105859:T:A	acceptor_loss	1.0000
9:35105940:CCA:C	donor_gain	1.0000
9:35106006:TGCCC:T	acceptor_loss	1.0000
9:35106009:CCTG:C	acceptor_loss	1.0000
9:35106010:C:A	acceptor_loss	1.0000
9:35106011:T:G	acceptor_loss	1.0000
9:35106209:AT:A	donor_gain	1.0000
9:35106643:CCTGG:C	acceptor_gain	1.0000
9:35106829:TTA:T	donor_loss	1.0000
9:35106831:A:AC	donor_gain	1.0000
9:35106831:ACAG:A	donor_gain	1.0000
9:35106832:C:CT	donor_gain	1.0000
9:35106832:CA:C	donor_gain	1.0000
9:35106832:CAG:C	donor_gain	1.0000
9:35106832:CAGC:C	donor_gain	1.0000
9:35106832:CAGCT:C	donor_gain	1.0000
9:35106890:TC:T	acceptor_gain	1.0000
9:35106891:CC:C	acceptor_gain	1.0000
9:35106892:C:CC	acceptor_gain	1.0000
9:35106895:C:CT	acceptor_gain	1.0000
9:35106904:A:C	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000055107 (9:35112845 G>A), RS1000087148 (9:35116744 T>G), RS1000872643 (9:35114217 G>A), RS1000967150 (9:35114835 G>A), RS1001112008 (9:35114387 C>G,T), RS1001211918 (9:35118323 T>C,G), RS1001388208 (9:35112501 C>G), RS1001445158 (9:35103767 T>C), RS1001925373 (9:35114146 G>C), RS1001994083 (9:35107388 G>A,C), RS1002086073 (9:35118184 G>A), RS1002475225 (9:35104756 T>A), RS1002584736 (9:35111370 G>A,T), RS1002617889 (9:35104534 G>A,T), RS1002980911 (9:35112123 G>T)

Disease associations

OMIM: gene MIM:620169 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006295_15	Response to quetiapine in schizophrenia	9.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects cotreatment, decreases expression, increases expression	5
trichostatin A	affects cotreatment, decreases expression	2
sodium arsenite	increases expression, decreases expression	2
entinostat	decreases expression, affects cotreatment	2
Air Pollutants	affects cotreatment, decreases expression, increases abundance, affects expression	2
Estradiol	decreases expression, affects cotreatment, increases expression	2
Ozone	affects cotreatment, decreases expression, increases abundance, affects expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases abundance, affects cotreatment, decreases expression	1
mono-(2-ethylhexyl)phthalate	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
potassium chromate(VI)	decreases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
15-acetyldeoxynivalenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Calcitriol	increases expression, affects cotreatment	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.