ATP1A1-AS1

Summary

ATP1A1-AS1 (ATP1A1 antisense RNA 1, HGNC:28262) is a long non-coding RNA gene on chromosome 1p13.1.

Predicted to enable U4 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U6 snRNP.

Source: NCBI Gene 84852 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28262
Approved symbol	ATP1A1-AS1
Name	ATP1A1 antisense RNA 1
Location	1p13.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC16179
Ensembl gene	ENSG00000203865
Ensembl biotype	lncRNA
OMIM	618305
Entrez	84852
RNAcentral	URS0000759F49 — lncRNA, 1552 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000369491, ENST00000369492, ENST00000493908, ENST00000608511, ENST00000674553, ENST00000674823, ENST00000674834, ENST00000674941, ENST00000675264, ENST00000675524, ENST00000675545, ENST00000675607, ENST00000675659, ENST00000675742, ENST00000675762, ENST00000676321, ENST00000688925

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000369491 — 4 exons

Exon	Start	End
ENSE00001450152	116405751	116406148
ENSE00001450153	116411261	116411315
ENSE00003901610	116418459	116418598
ENSE00003903171	116411620	116411710

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 95.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2126 / max 45.8352, expressed in 1543 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14004	4.2126	1543

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	95.82	silver quality
left lobe of thyroid gland	UBERON:0001120	94.34	gold quality
right lobe of thyroid gland	UBERON:0001119	93.77	gold quality
thyroid gland	UBERON:0002046	92.65	gold quality
metanephros cortex	UBERON:0010533	91.66	gold quality
mucosa of transverse colon	UBERON:0004991	91.53	gold quality
colonic epithelium	UBERON:0000397	90.96	gold quality
minor salivary gland	UBERON:0001830	90.30	gold quality
small intestine Peyer’s patch	UBERON:0003454	89.35	gold quality
body of pancreas	UBERON:0001150	88.58	gold quality
skin of abdomen	UBERON:0001416	88.08	gold quality
skin of leg	UBERON:0001511	87.94	gold quality
tendon	UBERON:0000043	87.25	gold quality
transverse colon	UBERON:0001157	87.21	gold quality
sural nerve	UBERON:0015488	87.06	gold quality
lower esophagus mucosa	UBERON:0035834	86.95	gold quality
mucosa of stomach	UBERON:0001199	86.77	gold quality
mouth mucosa	UBERON:0003729	86.59	gold quality
saliva-secreting gland	UBERON:0001044	86.42	gold quality
small intestine	UBERON:0002108	86.41	gold quality
right lung	UBERON:0002167	86.39	gold quality
adenohypophysis	UBERON:0002196	86.26	gold quality
upper lobe of left lung	UBERON:0008952	85.90	gold quality
cortex of kidney	UBERON:0001225	85.07	gold quality
zone of skin	UBERON:0000014	84.61	gold quality
adult mammalian kidney	UBERON:0000082	84.55	gold quality
pituitary gland	UBERON:0000007	84.37	gold quality
pancreas	UBERON:0001264	84.05	gold quality
adrenal tissue	UBERON:0018303	83.85	gold quality
bone marrow cell	CL:0002092	83.71	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	6244.48
E-ANND-3	yes	7.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA ATP1A1-AS1 inhibits cell proliferation and promotes cell apoptosis in thyroid carcinoma by regulating the miR-620/IRF2BP2 axis. (PMID:36002076)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.