ATP2B1-AS1

Summary

ATP2B1-AS1 (ATP2B1 antisense RNA 1, HGNC:27883) is a long non-coding RNA gene on chromosome 12q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27883
Approved symbol	ATP2B1-AS1
Name	ATP2B1 antisense RNA 1
Location	12q21.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000271614
Ensembl biotype	lncRNA
Entrez	338758
RNAcentral	URS000075E810 — lncRNA, 2998 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 50 — 50 lncRNA

ENST00000547370, ENST00000549551, ENST00000651272, ENST00000652964, ENST00000716128, ENST00000716129, ENST00000716130, ENST00000716131, ENST00000716132, ENST00000716133, ENST00000716134, ENST00000716135, ENST00000716136, ENST00000716137, ENST00000716138, ENST00000739864, ENST00000739865, ENST00000739866, ENST00000739867, ENST00000820483, ENST00000820484, ENST00000820485, ENST00000820486, ENST00000820487, ENST00000820488, ENST00000820489, ENST00000820490, ENST00000820491, ENST00000820492, ENST00000820493, ENST00000820494, ENST00000820495, ENST00000820496, ENST00000820497, ENST00000820498, ENST00000820499, ENST00000820500, ENST00000820501, ENST00000820502, ENST00000820503, ENST00000820504, ENST00000820505, ENST00000820506, ENST00000820507, ENST00000820508, ENST00000820509, ENST00000820510, ENST00000820511, ENST00000820512, ENST00000820513

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000547370 — 4 exons

Exon	Start	End
ENSE00002333662	89921067	89921169
ENSE00002348331	89882665	89882891
ENSE00002377452	89935822	89935987
ENSE00002391786	89937093	89937143

Expression profiles

Bgee: expression breadth ubiquitous, 222 present calls, max score 98.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.4302 / max 865.2991, expressed in 1498 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
127260	11.4975	1247
127257	1.6357	470
127256	1.3158	454
127262	0.3187	77
127261	0.3082	127
127259	0.2317	94
127258	0.1225	41

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	98.17	gold quality
endothelial cell	CL:0000115	94.45	gold quality
Brodmann (1909) area 23	UBERON:0013554	92.11	gold quality
middle temporal gyrus	UBERON:0002771	91.99	gold quality
buccal mucosa cell	CL:0002336	89.32	silver quality
entorhinal cortex	UBERON:0002728	88.81	gold quality
cartilage tissue	UBERON:0002418	87.83	gold quality
superior frontal gyrus	UBERON:0002661	86.19	gold quality
postcentral gyrus	UBERON:0002581	85.48	gold quality
parietal lobe	UBERON:0001872	85.47	gold quality
primary visual cortex	UBERON:0002436	84.24	gold quality
occipital lobe	UBERON:0002021	83.42	gold quality
Brodmann (1909) area 46	UBERON:0006483	82.71	gold quality
lateral nuclear group of thalamus	UBERON:0002736	82.47	gold quality
cerebellar vermis	UBERON:0004720	82.35	gold quality
monocyte	CL:0000576	81.86	gold quality
granulocyte	CL:0000094	81.53	gold quality
leukocyte	CL:0000738	81.27	gold quality
bone marrow	UBERON:0002371	81.06	gold quality
nucleus accumbens	UBERON:0001882	80.44	gold quality
temporal lobe	UBERON:0001871	79.73	gold quality
prefrontal cortex	UBERON:0000451	78.87	gold quality
ileal mucosa	UBERON:0000331	78.77	gold quality
mucosa of paranasal sinus	UBERON:0005030	78.68	silver quality
frontal cortex	UBERON:0001870	78.64	gold quality
cerebral cortex	UBERON:0000956	78.21	gold quality
neocortex	UBERON:0001950	78.20	gold quality
skin of hip	UBERON:0001554	78.10	gold quality
lateral globus pallidus	UBERON:0002476	78.09	silver quality
lower lobe of lung	UBERON:0008949	77.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Silencing of ATP2B1-AS1 contributes to protection against myocardial infarction in mouse via blocking NFKBIA-mediated NF-kappaB signalling pathway. (PMID:32155320)
• Elevated linc00936 or silenced microRNA-425-3p inhibits immune escape of gastric cancer cells via elevation of ZC3H12A. (PMID:33756228)
• Long non-coding ribonucleic acid ATP2B1-AS1 modulates endothelial permeability through regulating the miR-4729-IQGAP2 axis in diabetic retinopathy. (PMID:34935307)
• LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3. (PMID:35297352)
• LINC00936 exacerbated myocardial infarction progression via miR-4795-3p/Wnt3a signaling pathway based on biological and imaging methods. (PMID:35410528)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.