ATP2B2-IT2

Summary

ATP2B2-IT2 (ATP2B2 intronic transcript 2, HGNC:41310) is a long non-coding RNA gene on chromosome 3p25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41310
Approved symbol	ATP2B2-IT2
Name	ATP2B2 intronic transcript 2
Location	3p25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224771
Ensembl biotype	lncRNA
Entrez	100874325
RNAcentral	URS000075B0DB — lncRNA, 513 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000419591

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419591 — 3 exons

Exon	Start	End
ENSE00001623380	10626766	10626808
ENSE00001656524	10626015	10626485
ENSE00003887149	10628956	10629307

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 87.76.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.76	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.45	gold quality
sural nerve	UBERON:0015488	73.57	gold quality
endometrium	UBERON:0001295	54.77	gold quality
left testis	UBERON:0004533	52.39	gold quality
testis	UBERON:0000473	52.31	gold quality
corpus callosum	UBERON:0002336	51.46	gold quality
right testis	UBERON:0004534	51.28	gold quality
monocyte	CL:0000576	51.11	silver quality
islet of Langerhans	UBERON:0000006	50.70	gold quality
prefrontal cortex	UBERON:0000451	49.61	gold quality
primary visual cortex	UBERON:0002436	49.18	silver quality
tibial nerve	UBERON:0001323	48.64	gold quality
cerebellar cortex	UBERON:0002129	44.92	silver quality
right hemisphere of cerebellum	UBERON:0014890	44.54	silver quality
cerebellar hemisphere	UBERON:0002245	44.32	silver quality
gastrocnemius	UBERON:0001388	44.22	gold quality
brain	UBERON:0000955	43.92	gold quality
anterior cingulate cortex	UBERON:0009835	43.57	silver quality
zone of skin	UBERON:0000014	43.55	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	41.85	silver quality
myometrium	UBERON:0001296	41.23	silver quality
caudate nucleus	UBERON:0001873	40.66	silver quality
amygdala	UBERON:0001876	40.64	silver quality
putamen	UBERON:0001874	39.74	silver quality
right frontal lobe	UBERON:0002810	38.55	silver quality
nucleus accumbens	UBERON:0001882	38.17	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	37.70	silver quality
prostate gland	UBERON:0002367	37.28	silver quality
Ammon’s horn	UBERON:0001954	37.25	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Preliminary research on LncRNA ATP2B2-IT2 in neovascularization of diabetic retinopathy. (PMID:38907191)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.