ATP5MC3

Summary

ATP5MC3 (ATP synthase membrane subunit c locus 3, HGNC:843) is a protein-coding gene on chromosome 2q31.1, encoding ATP synthase F(0) complex subunit C3, mitochondrial (P48201). Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified.

Source: NCBI Gene 518 — RefSeq curated summary.

At a glance

• Gene–disease (curated): dystonia, early-onset, and/or spastic paraplegia (Strong, GenCC) — +1 more curated relationship
• Clinical variants (ClinVar): 37 total — 2 pathogenic, 1 likely-pathogenic
• Phenotypes (HPO): 9
• MANE Select transcript: NM_001689

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:843
Approved symbol	ATP5MC3
Name	ATP synthase membrane subunit c locus 3
Location	2q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000154518
Ensembl biotype	protein_coding
OMIM	602736
Entrez	518

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 13 protein_coding, 2 retained_intron

ENST00000284727, ENST00000392541, ENST00000409194, ENST00000472782, ENST00000497075, ENST00000877858, ENST00000877859, ENST00000877860, ENST00000877861, ENST00000937346, ENST00000937347, ENST00000937348, ENST00000937349, ENST00000937350, ENST00000941362

RefSeq mRNA: 3 — MANE Select: NM_001689 NM_001002258, NM_001190329, NM_001689

CCDS: CCDS2263

Canonical transcript exons

ENST00000284727 — 5 exons

Exon	Start	End
ENSE00001016410	175176258	175178402
ENSE00001016412	175179057	175179250
ENSE00001588911	175181656	175181710
ENSE00003574305	175181355	175181466
ENSE00003602002	175180098	175180178

Expression profiles

Bgee: expression breadth ubiquitous, 298 present calls, max score 99.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 188.0861 / max 1280.0117, expressed in 1826 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
31936	186.1996	1826
31934	1.2035	473
31935	0.4764	184
31933	0.2066	71

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart right ventricle	UBERON:0002080	99.85	gold quality
left ventricle myocardium	UBERON:0006566	99.79	gold quality
cardiac ventricle	UBERON:0002082	99.72	gold quality
heart left ventricle	UBERON:0002084	99.72	gold quality
body of tongue	UBERON:0011876	99.72	gold quality
renal medulla	UBERON:0000362	99.70	gold quality
pons	UBERON:0000988	99.69	gold quality
apex of heart	UBERON:0002098	99.68	gold quality
myocardium	UBERON:0002349	99.67	gold quality
diaphragm	UBERON:0001103	99.64	gold quality
vena cava	UBERON:0004087	99.64	gold quality
mucosa of transverse colon	UBERON:0004991	99.64	gold quality
cardiac atrium	UBERON:0002081	99.62	gold quality
cardiac muscle of right atrium	UBERON:0003379	99.61	gold quality
right atrium auricular region	UBERON:0006631	99.61	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.60	gold quality
mucosa of sigmoid colon	UBERON:0004993	99.60	gold quality
colonic mucosa	UBERON:0000317	99.56	gold quality
jejunum	UBERON:0002115	99.55	gold quality
heart	UBERON:0000948	99.54	gold quality
penis	UBERON:0000989	99.53	gold quality
pharyngeal mucosa	UBERON:0000355	99.52	gold quality
jejunal mucosa	UBERON:0000399	99.52	gold quality
tongue	UBERON:0001723	99.52	gold quality
duodenum	UBERON:0002114	99.52	gold quality
vastus lateralis	UBERON:0001379	99.46	gold quality
superior surface of tongue	UBERON:0007371	99.43	gold quality
adult mammalian kidney	UBERON:0000082	99.41	gold quality
quadriceps femoris	UBERON:0001377	99.39	gold quality
transverse colon	UBERON:0001157	99.38	gold quality

Single-cell (SCXA)

Detected in 11 experiment(s), a significant marker in 9.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	136.19
E-MTAB-8410	yes	44.41
E-MTAB-9467	yes	30.32
E-CURD-122	yes	20.15
E-MTAB-10042	yes	16.65
E-HCAD-10	yes	12.15
E-CURD-112	yes	11.29
E-HCAD-25	yes	8.19
E-MTAB-7606	no	441.02
E-GEOD-125970	no	42.56
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

90 targeting ATP5MC3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349

Literature-anchored findings (GeneRIF, showing 1)

• ATP5G1, ATP5G2, and ATP5G3 of the ATP synthase are not involved in forming the permeability transition pore. (PMID:28289229)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	atp5mc3a	ENSDARG00000017775
mus_musculus	Atp5mc3	ENSMUSG00000018770
rattus_norvegicus	Atp5mc3	ENSRNOG00000001596

Paralogs (2): ATP5MC2 (ENSG00000135390), ATP5MC1 (ENSG00000159199)

Protein

Protein identifiers

ATP synthase F(0) complex subunit C3, mitochondrial — P48201 (reviewed: P48201)

Alternative names: ATP synthase lipid-binding protein, ATP synthase membrane subunit c locus 3, ATP synthase proteolipid P3, ATP synthase proton-transporting mitochondrial F(0) complex subunit C3, ATPase protein 9, ATPase subunit c

All UniProt accessions (1): P48201

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Subunit / interactions. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with TMEM70 and TMEM242.

Subcellular location. Mitochondrion membrane.

Post-translational modifications. Trimethylated by ATPSCKMT at Lys-110. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.

Disease relevance. Dystonia, early-onset, and/or spastic paraplegia (DYTSPG) [MIM:619681] An autosomal dominant, highly penetrant movement disorder characterized by spastic paraplegia and/or dystonia to varying degrees in affected individuals. Cognition is not affected. There is high intra- and interfamilial variability in phenotype and age of onset. Some patients have onset of progressive focal or generalized dystonia in the first decade, whereas others develop progressive spastic paraplegia as adults. Some affected individuals have manifestations of both disorders. The disease is caused by variants affecting the gene represented in this entry.

Miscellaneous. There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

Similarity. Belongs to the ATPase C chain family.

RefSeq proteins (3): NP_001002258, NP_001177258, NP_001680* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000454	ATP_synth_F0_csu	Family
IPR002379	ATPase_proteolipid_c-like_dom	Domain
IPR020537	ATP_synth_F0_csu_DDCD_BS	Binding_site
IPR035921	F/V-ATP_Csub_sf	Homologous_superfamily
IPR038662	ATP_synth_F0_csu_sf	Homologous_superfamily

Pfam: PF00137

UniProt features (10 total): sequence variant 4, transmembrane region 2, transit peptide 1, chain 1, site 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P48201-F1	71.26	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 125 (reversibly protonated during proton transport)

Post-translational modifications (1): 110

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-163210	Formation of ATP by chemiosmotic coupling
R-HSA-8949613	Cristae formation
R-HSA-1428517	Aerobic respiration and respiratory electron transport
R-HSA-1430728	Metabolism
R-HSA-1592230	Mitochondrial biogenesis
R-HSA-1852241	Organelle biogenesis and maintenance

MSigDB gene sets: 336 (showing top): RNGTGGGC_UNKNOWN, MORF_DNMT1, RRAGTTGT_UNKNOWN, MORF_ESPL1, MODULE_151, GCM_NPM1, MORF_RRM1, MORF_HDAC1, MORF_UBE2N, HSIAO_HOUSEKEEPING_GENES, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, TGACCTY_ERR1_Q2, MORF_HDAC2, GOBP_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS

GO Biological Process (3): proton motive force-driven ATP synthesis (GO:0015986), monoatomic ion transport (GO:0006811), proton transmembrane transport (GO:1902600)

GO Molecular Function (3): lipid binding (GO:0008289), proton transmembrane transporter activity (GO:0015078), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), proton-transporting two-sector ATPase complex, proton-transporting domain (GO:0033177), proton-transporting ATP synthase complex (GO:0045259), membrane (GO:0016020), mitochondrial membrane (GO:0031966)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Aerobic respiration and respiratory electron transport	1
Mitochondrial biogenesis	1
Metabolism	1
Organelle biogenesis and maintenance	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
proton-transporting two-sector ATPase complex	2
ATP biosynthetic process	1
transport	1
monoatomic cation transmembrane transport	1
monoatomic cation transmembrane transporter activity	1
proton transmembrane transport	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
membrane protein complex	1
cation channel complex	1
respiratory chain complex	1
catalytic complex	1
cellular anatomical structure	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1

Protein interactions and networks

STRING

2550 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ATP5MC3	UQCRFS1	P47985	920
ATP5MC3	ATP5F1C	P36542	814
ATP5MC3	ATP5PD	O75947	783
ATP5MC3	CLCN3	P51790	765
ATP5MC3	ATP5PB	P24539	750
ATP5MC3	ATP5F1A	P25705	743
ATP5MC3	ATP5F1E	P56381	726
ATP5MC3	ATP5PF	P18859	720
ATP5MC3	ATP5F1D	P30049	719
ATP5MC3	ATP5F1B	P06576	716
ATP5MC3	ACSF2	Q96CM8	710
ATP5MC3	ATP5PO	P48047	681
ATP5MC3	RPL8	P25120	666
ATP5MC3	EMC2	Q15006	622
ATP5MC3	DMAC2L	Q99766	617

IntAct

20 interactions, top by confidence:

A	B	Type	Score
FPR2	ARL6IP5	psi-mi:“MI:0914”(association)	0.640
	ATP5MC3	psi-mi:“MI:0915”(physical association)	0.560
ATP5MC3	ATP5F1B	psi-mi:“MI:0914”(association)	0.530
TMEM31	PSMD11	psi-mi:“MI:0914”(association)	0.530
FAM241A	NRP1	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
	AGPS	psi-mi:“MI:0915”(physical association)	0.400
	TK2	psi-mi:“MI:0915”(physical association)	0.400
MEP1B	ATP5MC3	psi-mi:“MI:0915”(physical association)	0.370
PROM1	ATP5MC3	psi-mi:“MI:0915”(physical association)	0.370
DGCR2	CCDC85C	psi-mi:“MI:0914”(association)	0.350
CD80	RIMOC1	psi-mi:“MI:0914”(association)	0.350
HTR1E	ESYT2	psi-mi:“MI:0914”(association)	0.350
NIPAL2	ATP5MC3	psi-mi:“MI:0914”(association)	0.350
SLC37A3	PLXNB2	psi-mi:“MI:0914”(association)	0.350
ATP5MC3		psi-mi:“MI:0915”(physical association)	0.000
ABHD16A	ATP5MC3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (26): ATP5G3 (Affinity Capture-RNA), ATP5G3 (Affinity Capture-RNA), ATP5G3 (Two-hybrid), COL20A1 (Affinity Capture-MS), ATP5B (Affinity Capture-MS), GHDC (Affinity Capture-MS), ATP5D (Affinity Capture-MS), GOLGA4 (Affinity Capture-MS), ATP5G3 (Two-hybrid), ATP5G3 (PCA), ATP5G3 (Affinity Capture-MS), TMEM31 (Two-hybrid), ATP5G3 (Affinity Capture-RNA), ATP5B (Affinity Capture-MS), ATPIF1 (Affinity Capture-MS)

ESM2 similar proteins: A1XQS5, A6H666, A8XDX2, B0VYY5, B3DHU2, G5EDB8, O14046, P00842, P05496, P07926, P10175, P11432, P16000, P16221, P17605, P23968, P32876, P48201, P48772, P56383, P56384, Q01931, Q03672, Q06055, Q06056, Q06645, Q06646, Q0V9J0, Q0VCH8, Q2LCR3, Q2TA24, Q37315, Q3ZC75, Q53CG1, Q59550, Q5RAP9, Q5RFL2, Q5SWH9, Q71S46, Q7JX57

Diamond homologs: A1SHI6, A1XQS5, A3PN84, A4WNY7, A5CDC6, A6H4Q2, A8EX89, A8GLV9, A8GUJ2, A8XDX2, A9HDM8, A9RAH4, A9WGS9, B3CQT8, B8G6H1, B9LBM5, C0HK59, C3PM50, C4K0P2, O05331, O08310, P00840, P00842, P05496, P07926, P0C518, P0C519, P13547, P14571, P15014, P16000, P17254, P17605, P21537, P21905, P26855, P32876, P48201, P48880, P48881

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

37 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	1
Uncertain significance	17
Likely benign	3
Benign	3

Top pathogenic / likely-pathogenic (3)

Variant ID	HGVS	Classification
2500983	NM_001689.5(ATP5MC3):c.319C>G (p.Pro107Ala)	Pathogenic
2500984	NM_001689.5(ATP5MC3):c.236G>T (p.Gly79Val)	Pathogenic
976731	NM_001689.5(ATP5MC3):c.318C>G (p.Asn106Lys)	Likely pathogenic

SpliceAI

411 predictions. Top by Δscore:

Variant	Effect	Δscore
2:175179051:GATTA:G	donor_loss	1.0000
2:175179052:ATTAC:A	donor_loss	1.0000
2:175179053:TTA:T	donor_loss	1.0000
2:175179054:TA:T	donor_loss	1.0000
2:175179055:A:AT	donor_loss	1.0000
2:175179056:C:CT	donor_loss	1.0000
2:175179246:GAGCC:G	acceptor_gain	1.0000
2:175179248:GCC:G	acceptor_gain	1.0000
2:175179249:CC:C	acceptor_gain	1.0000
2:175179249:CCC:C	acceptor_gain	1.0000
2:175179250:CC:C	acceptor_gain	1.0000
2:175179251:C:CA	acceptor_loss	1.0000
2:175179251:C:CC	acceptor_gain	1.0000
2:175179252:T:A	acceptor_loss	1.0000
2:175179259:C:CT	acceptor_gain	1.0000
2:175179260:A:T	acceptor_gain	1.0000
2:175180094:TTAC:T	donor_loss	1.0000
2:175180095:TA:T	donor_loss	1.0000
2:175180096:ACCTC:A	donor_loss	1.0000
2:175180097:C:CT	donor_loss	1.0000
2:175180097:CCT:C	donor_gain	1.0000
2:175180114:G:A	donor_gain	1.0000
2:175180174:CGGAT:C	acceptor_gain	1.0000
2:175180179:C:A	acceptor_loss	1.0000
2:175180179:C:CC	acceptor_gain	1.0000
2:175180180:T:A	acceptor_loss	1.0000
2:175181350:CGCA:C	donor_loss	1.0000
2:175181353:A:AC	donor_gain	1.0000
2:175181354:C:CC	donor_gain	1.0000
2:175181354:C:CG	donor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000006288 (2:175178582 T>A,C), RS1000313646 (2:175177883 G>A), RS1000569638 (2:175183463 T>C), RS1000635497 (2:175177365 G>C), RS1000857866 (2:175176676 G>A,T), RS1001056534 (2:175182993 A>C), RS1001194482 (2:175183302 T>C), RS1001649088 (2:175177746 C>T), RS1002326307 (2:175181985 G>T), RS1002653812 (2:175176303 A>C), RS1002707612 (2:175175871 T>C), RS1003741271 (2:175181157 T>C), RS1003920824 (2:175182359 G>T), RS1003991203 (2:175181874 G>C), RS1004487018 (2:175176254 C>T)

Disease associations

OMIM: gene MIM:602736 | disease phenotypes: MIM:619681

GenCC curated gene-disease

Disease	Classification	Inheritance
dystonia, early-onset, and/or spastic paraplegia	Strong	Autosomal dominant

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
mitochondrial disease	Limited	AD

Mondo (1): dystonia, early-onset, and/or spastic paraplegia (MONDO:0859215)

Orphanet (0):

HPO phenotypes

9 total (9 of 9 shown, HPO-id order):

HPO	Term
HP:0000006	Autosomal dominant inheritance
HP:0001258	Spastic paraplegia
HP:0001288	Gait disturbance
HP:0001332	Dystonia
HP:0001347	Hyperreflexia
HP:0003581	Adult onset
HP:0007340	Lower limb muscle weakness
HP:0011463	Childhood onset
HP:0012049	Laryngeal dystonia

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1982235	ATP5MC3		0.00	0

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — F-type ATPase

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, affects cotreatment, increases expression	5
bisphenol A	affects expression, decreases expression, decreases methylation	3
sodium arsenite	decreases expression, increases expression	3
Air Pollutants	decreases expression, increases abundance	3
Cyclosporine	decreases expression	3
Tunicamycin	decreases expression	2
Particulate Matter	decreases expression, increases abundance	2
methylmercuric chloride	decreases expression	1
arsenite	affects binding, increases reaction	1
methylparaben	decreases expression, increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
tris(chloroethyl)phosphate	decreases expression, increases abundance	1
arsenic trichloride	decreases expression, increases abundance	1
CD 437	decreases expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
NSC 689534	affects binding, decreases expression	1
Acetaminophen	affects cotreatment, decreases expression	1
Arsenic	decreases expression, increases abundance	1
Catechin	decreases expression, affects cotreatment	1
Cocaine	decreases expression	1
Copper	affects binding, decreases expression	1
Doxorubicin	increases expression	1
Flame Retardants	decreases expression, increases abundance	1
Formaldehyde	decreases expression	1
Hydralazine	increases expression, affects cotreatment	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Methyl Methanesulfonate	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2SG	Abcam HEK293T ATP5MC3 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.