ATP8B4

Summary

ATP8B4 (ATPase phospholipid transporting 8B4 (putative), HGNC:13536) is a protein-coding gene on chromosome 15q21.2, encoding Probable phospholipid-transporting ATPase IM (Q8TF62). Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids.

This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 79895 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 193 total — 2 pathogenic
• MANE Select transcript: NM_024837

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13536
Approved symbol	ATP8B4
Name	ATPase phospholipid transporting 8B4 (putative)
Location	15q21.2
Locus type	gene with protein product
Status	Approved
Aliases	ATPIM, KIAA1939
Ensembl gene	ENSG00000104043
Ensembl biotype	protein_coding
OMIM	609123
Entrez	79895

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 14 protein_coding, 5 retained_intron, 4 nonsense_mediated_decay, 4 protein_coding_CDS_not_defined

ENST00000284509, ENST00000557955, ENST00000558024, ENST00000558203, ENST00000558458, ENST00000558498, ENST00000558829, ENST00000558906, ENST00000558959, ENST00000559726, ENST00000559829, ENST00000559998, ENST00000560161, ENST00000560354, ENST00000560437, ENST00000560479, ENST00000561104, ENST00000561385, ENST00000674213, ENST00000895127, ENST00000895128, ENST00000895129, ENST00000895130, ENST00000895131, ENST00000895132, ENST00000966552, ENST00000966553

RefSeq mRNA: 1 — MANE Select: NM_024837 NM_024837

CCDS: CCDS32238

Canonical transcript exons

ENST00000284509 — 28 exons

Exon	Start	End
ENSE00001015182	50047351	50047464
ENSE00001015187	50044594	50044692
ENSE00001335315	50074127	50074185
ENSE00001409398	50106939	50107008
ENSE00001410822	50119123	50119233
ENSE00003458760	50038768	50038829
ENSE00003462316	50002153	50002223
ENSE00003479631	49901092	49901239
ENSE00003484702	49879376	49879459
ENSE00003495337	49918839	49918950
ENSE00003498008	49916934	49917039
ENSE00003502436	49972582	49972790
ENSE00003514055	49979617	49979813
ENSE00003529878	49981206	49981294
ENSE00003538639	49898068	49898251
ENSE00003553728	49961977	49962020
ENSE00003588538	49866346	49866484
ENSE00003601952	49987391	49987549
ENSE00003626253	49897292	49897515
ENSE00003660187	49934017	49934182
ENSE00003669068	49876278	49876523
ENSE00003671300	49931119	49931307
ENSE00003672617	49923379	49923494
ENSE00003674000	49920246	49920410
ENSE00003676761	49996677	49996759
ENSE00003677893	50010845	50010917
ENSE00003686704	49862245	49862375
ENSE00003727775	49858238	49860475

Expression profiles

Bgee: expression breadth ubiquitous, 195 present calls, max score 93.47.

FANTOM5 (CAGE): breadth broad, TPM avg 7.5501 / max 1063.3763, expressed in 514 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149837	2.4484	150
149838	1.4202	127
149840	0.9212	99
149834	0.6783	246
149835	0.6192	238
149843	0.4768	106
149841	0.3149	134
149836	0.2258	88
149833	0.1837	102
149828	0.0856	25

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	93.47	gold quality
bone marrow	UBERON:0002371	91.07	gold quality
calcaneal tendon	UBERON:0003701	89.23	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.27	gold quality
left uterine tube	UBERON:0001303	86.67	gold quality
trabecular bone tissue	UBERON:0002483	85.86	gold quality
monocyte	CL:0000576	84.83	gold quality
mononuclear cell	CL:0000842	84.52	gold quality
gall bladder	UBERON:0002110	84.29	gold quality
leukocyte	CL:0000738	84.14	gold quality
subcutaneous adipose tissue	UBERON:0002190	84.07	gold quality
adipose tissue	UBERON:0001013	80.72	gold quality
connective tissue	UBERON:0002384	80.25	gold quality
granulocyte	CL:0000094	79.81	gold quality
body of uterus	UBERON:0009853	79.76	gold quality
right coronary artery	UBERON:0001625	78.37	gold quality
stromal cell of endometrium	CL:0002255	78.23	gold quality
colonic epithelium	UBERON:0000397	77.70	gold quality
omental fat pad	UBERON:0010414	76.70	gold quality
adipose tissue of abdominal region	UBERON:0007808	76.68	gold quality
peritoneum	UBERON:0002358	76.60	gold quality
smooth muscle tissue	UBERON:0001135	76.30	gold quality
tibial nerve	UBERON:0001323	76.26	gold quality
endocervix	UBERON:0000458	75.89	gold quality
sural nerve	UBERON:0015488	75.78	gold quality
spleen	UBERON:0002106	75.24	gold quality
left coronary artery	UBERON:0001626	74.03	gold quality
rectum	UBERON:0001052	73.89	gold quality
blood	UBERON:0000178	73.59	gold quality
right ovary	UBERON:0002118	73.05	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	32.81
E-MTAB-6678	yes	26.58
E-HCAD-25	yes	15.01
E-CURD-122	yes	12.59
E-ANND-3	yes	11.58
E-MTAB-9067	yes	11.43
E-CURD-112	yes	10.08
E-MTAB-9801	yes	8.09

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

102 targeting ATP8B4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-607	99.97	73.62	5593
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-202-3P	99.84	71.41	1290

Literature-anchored findings (GeneRIF, showing 3)

• ATP8B4 gene was associated with a significant increase in the risk of systemic sclerosis. ATP8B4 is overexpressed in systemic sclerosis patients. (PMID:26473621)
• Study did not find statistically significant differences in the frequency of the ATP8B4 rs55687265*C allele between the SSc patients and controls. (PMID:28141915)
• Study found that circATP8B4 in extracellular vesicles isolated from radioresistant U251 glioma cells acts as a U251 miR766 sponge, which may be involved in glioma radioresistance. (PMID:30664179)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	atp8b4	ENSDARG00000079453
mus_musculus	Atp8b4	ENSMUSG00000060131
rattus_norvegicus	Atp8b4	ENSRNOG00000031598
drosophila_melanogaster	CG31729	FBGN0051729
caenorhabditis_elegans	tat-5	WBGENE00009498
caenorhabditis_elegans		WBGENE00017174

Paralogs (13): ATP9A (ENSG00000054793), ATP11B (ENSG00000058063), ATP11A (ENSG00000068650), ATP8B1 (ENSG00000081923), ATP11C (ENSG00000101974), ATP10B (ENSG00000118322), ATP8A1 (ENSG00000124406), ATP8B3 (ENSG00000130270), ATP8A2 (ENSG00000132932), ATP8B2 (ENSG00000143515), ATP10D (ENSG00000145246), ATP9B (ENSG00000166377), ATP10A (ENSG00000206190)

Protein

Protein identifiers

Probable phospholipid-transporting ATPase IM — Q8TF62 (reviewed: Q8TF62)

Alternative names: ATPase class I type 8B member 4, P4-ATPase flippase complex alpha subunit ATP8B4

All UniProt accessions (8): A0A6I8PRR9, A0A6I8PS08, Q8TF62, H0YLC1, H0YLJ1, H0YM66, H0YMB5, H0YMP8

UniProt curated annotations — full annotation on UniProt →

Function. Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules.

Subunit / interactions. Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with beta subunits TMEM30A and TMEM30B.

Subcellular location. Cell membrane. Golgi apparatus.

Tissue specificity. Ubiquitously expressed at moderate levels.

Similarity. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.

RefSeq proteins (1): NP_079113* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001757	P_typ_ATPase	Family
IPR006539	P-type_ATPase_IV	Family
IPR008250	ATPase_P-typ_transduc_dom_A_sf	Homologous_superfamily
IPR018303	ATPase_P-typ_P_site	PTM
IPR023214	HAD_sf	Homologous_superfamily
IPR023298	ATPase_P-typ_TM_dom_sf	Homologous_superfamily
IPR023299	ATPase_P-typ_cyto_dom_N	Homologous_superfamily
IPR032630	P_typ_ATPase_c	Domain
IPR032631	P-type_ATPase_N	Domain
IPR036412	HAD-like_sf	Homologous_superfamily
IPR044492	P_typ_ATPase_HD_dom	Domain

Pfam: PF13246, PF16209, PF16212

UniProt features (49 total): binding site 18, topological domain 11, transmembrane region 10, sequence variant 4, region of interest 2, chain 1, compositionally biased region 1, active site 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TF62-F1	82.12	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 392 (4-aspartylphosphate intermediate)

Ligand- & substrate-binding residues (18): 392; 392; 393; 394; 394; 496; 537; 560; 594; 674; 675; 676 …

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-936837	Ion transport by P-type ATPases
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-382551	Transport of small molecules
R-HSA-983712	Ion channel transport

MSigDB gene sets: 244 (showing top): REACTOME_INNATE_IMMUNE_SYSTEM, GOCC_SECRETORY_GRANULE, GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, GOCC_TRANS_GOLGI_NETWORK, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, GOBP_PHOSPHOLIPID_TRANSPORT, GOBP_MEMBRANE_ORGANIZATION, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, GOBP_LIPID_LOCALIZATION, GOBP_GOLGI_ORGANIZATION, GOCC_SECRETORY_VESICLE, GAVIN_FOXP3_TARGETS_CLUSTER_P4, GOCC_SPECIFIC_GRANULE, GOCC_SECRETORY_GRANULE_MEMBRANE

GO Biological Process (5): Golgi organization (GO:0007030), phospholipid translocation (GO:0045332), lipid transport (GO:0006869), phospholipid transport (GO:0015914), lipid translocation (GO:0034204)

GO Molecular Function (8): magnesium ion binding (GO:0000287), ATP binding (GO:0005524), ATP hydrolysis activity (GO:0016887), ATPase-coupled intramembrane lipid carrier activity (GO:0140326), nucleotide binding (GO:0000166), transporter activity (GO:0005215), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (9): Golgi apparatus (GO:0005794), trans-Golgi network (GO:0005802), plasma membrane (GO:0005886), specific granule membrane (GO:0035579), tertiary granule membrane (GO:0070821), phospholipid-translocating ATPase complex (GO:1990531), cytoplasm (GO:0005737), endomembrane system (GO:0012505), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Innate Immune System	1
Ion channel transport	1
Immune System	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
lipid transport	2
ATP-dependent activity	2
secretory granule membrane	2
organelle organization	1
endomembrane system organization	1
phospholipid transport	1
lipid translocation	1
transport	1
lipid localization	1
organophosphate ester transport	1
regulation of membrane lipid distribution	1
metal ion binding	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
ribonucleoside triphosphate phosphatase activity	1
intramembrane lipid carrier activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
molecular_function	1
binding	1
cation binding	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
Golgi apparatus subcompartment	1
membrane	1
cell periphery	1
specific granule	1
tertiary granule	1
transporter complex	1
intracellular anatomical structure	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

1194 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ATP8B4	CDC50B	Q3MIR4	746
ATP8B4	CDC50A	Q9NV96	583
ATP8B4	SLC27A2	O14975	535
ATP8B4	DEPDC7	Q96QD5	466
ATP8B4	FLRT3	Q9NZU0	418
ATP8B4	RPN2	P04844	412
ATP8B4	GCFC2	P16383	393
ATP8B4	C10orf120	Q5SQS8	391
ATP8B4	ABTB2	Q8N961	379
ATP8B4	PAXBP1	Q9Y5B6	378
ATP8B4	MOSPD2	Q8NHP6	363
ATP8B4	TDRD9	Q8NDG6	342
ATP8B4	DEPDC4	Q8N2C3	330
ATP8B4	PARVG	Q9HBI0	326
ATP8B4	CEP128	Q6ZU80	325

IntAct

9 interactions, top by confidence:

A	B	Type	Score
ATP8B4	TMEM30A	psi-mi:“MI:0915”(physical association)	0.650
ATP8B4	TMEM30A	psi-mi:“MI:0403”(colocalization)	0.650
TMEM30A	ATP8B4	psi-mi:“MI:0915”(physical association)	0.650
TMEM30A	ATP8B4	psi-mi:“MI:0403”(colocalization)	0.650
ATP8B4	TMEM30B	psi-mi:“MI:0915”(physical association)	0.570
ATP8B4	TMEM30B	psi-mi:“MI:0403”(colocalization)	0.570
TMEM30B	ATP8B4	psi-mi:“MI:0403”(colocalization)	0.570
ATP8B4	ELAVL4	psi-mi:“MI:0914”(association)	0.350

BioGRID (6): ATP8B4 (Affinity Capture-MS), ATP8B4 (Affinity Capture-RNA), ELAVL4 (Affinity Capture-MS), ATP8B2 (Affinity Capture-MS), TMEM230 (Affinity Capture-MS), ATP8B4 (Affinity Capture-RNA)

ESM2 similar proteins: A3FIN4, D3K0R6, D4AA47, O14072, O23087, O43520, O60423, O75185, O94296, P22189, P23634, P39524, P54678, P57709, P90747, P98194, P98196, P98197, P98198, P98199, P98204, P98205, Q09891, Q10309, Q148W0, Q21286, Q27533, Q3TYU2, Q42883, Q4VNC0, Q4VNC1, Q5BL50, Q5XF90, Q5ZKB7, Q64542, Q6DFW5, Q6Q477, Q6UQ17, Q7XB51, Q8NB49

Diamond homologs: A1A4J6, A3FIN4, D4ABB8, F1Q4S1, G2X7W6, G5EBH1, O43861, O70228, O75110, O94296, P05025, P13607, P25489, P35317, P39524, P40527, P57792, P70704, P98195, P98196, P98197, P98198, P98199, P98205, Q10309, Q29449, Q6DFW5, Q6RWA9, Q8TF62, Q92123, Q9GKS6, Q9LK90, Q9N0Z4, Q9NTI2, Q9Y2G3, Q9Y2Q0, Q9YH26, S7VVK4, B1AWN4, C7EXK4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

193 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	162
Likely benign	9
Benign	2

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
1526451	GRCh37/hg19 15q21.1-21.2(chr15:47574384-50369056)	Pathogenic
815710	GRCh37/hg19 15q21.1-21.2(chr15:47192561-50819726)x1	Pathogenic

SpliceAI

6281 predictions. Top by Δscore:

Variant	Effect	Δscore
15:49860473:GATC:G	acceptor_loss	1.0000
15:49860474:ATCT:A	acceptor_loss	1.0000
15:49860475:TCTGG:T	acceptor_loss	1.0000
15:49860476:C:CC	acceptor_gain	1.0000
15:49860476:C:CG	acceptor_loss	1.0000
15:49879456:CAGT:C	acceptor_gain	1.0000
15:49897403:T:A	donor_gain	1.0000
15:49898066:A:AC	donor_gain	1.0000
15:49898067:C:CC	donor_gain	1.0000
15:49916929:CCTA:C	donor_loss	1.0000
15:49916930:CTA:C	donor_loss	1.0000
15:49916932:A:AT	donor_loss	1.0000
15:49916933:C:CG	donor_loss	1.0000
15:49917036:GTTT:G	acceptor_gain	1.0000
15:49917036:GTTTC:G	acceptor_loss	1.0000
15:49917037:TTT:T	acceptor_gain	1.0000
15:49917038:TT:T	acceptor_gain	1.0000
15:49917038:TTCTA:T	acceptor_loss	1.0000
15:49917039:TCT:T	acceptor_loss	1.0000
15:49917040:C:CC	acceptor_gain	1.0000
15:49917040:CTAA:C	acceptor_loss	1.0000
15:49917041:T:A	acceptor_loss	1.0000
15:49918956:T:C	acceptor_gain	1.0000
15:49918956:T:TC	acceptor_gain	1.0000
15:49920241:CATA:C	donor_loss	1.0000
15:49920242:ATAC:A	donor_gain	1.0000
15:49920243:TACC:T	donor_loss	1.0000
15:49920244:A:AC	donor_gain	1.0000
15:49920245:C:CC	donor_gain	1.0000
15:49920245:CCAT:C	donor_gain	1.0000

AlphaMissense

7930 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:49931150:G:C	F537L	0.999
15:49931150:G:T	F537L	0.999
15:49931152:A:G	F537L	0.999
15:49979635:G:C	P339R	0.999
15:50010882:C:T	G133E	0.999
15:49898085:T:G	D819A	0.998
15:49898157:T:A	K795I	0.998
15:49917033:G:T	A681D	0.998
15:49918856:A:G	L673P	0.998
15:49923457:T:A	K560N	0.998
15:49923457:T:G	K560N	0.998
15:49931223:C:G	R513P	0.998
15:49972650:T:G	D392A	0.998
15:49972790:A:C	S345R	0.998
15:49972790:A:T	S345R	0.998
15:49979618:T:G	S345R	0.998
15:49979635:G:T	P339H	0.998
15:50002200:A:C	S153R	0.998
15:50002200:A:T	S153R	0.998
15:50002202:T:G	S153R	0.998
15:50010882:C:A	G133V	0.998
15:50047372:A:C	F60L	0.998
15:50047372:A:T	F60L	0.998
15:50047374:A:G	F60L	0.998
15:49866428:G:C	S1028R	0.997
15:49866428:G:T	S1028R	0.997
15:49866430:T:G	S1028R	0.997
15:49897349:A:C	N880K	0.997
15:49897349:A:T	N880K	0.997
15:49897352:C:A	K879N	0.997

dbSNP variants (sampled 300 via entrez): RS1000002345 (15:49906434 C>A,T), RS1000003259 (15:49949169 A>G), RS1000022730 (15:50073209 A>G), RS1000026309 (15:49863985 T>C), RS1000028187 (15:50076202 A>C), RS1000031116 (15:50145098 A>C), RS1000037190 (15:50040719 T>C), RS1000059487 (15:50121846 T>G), RS1000092854 (15:50146380 A>G), RS1000094187 (15:50033348 A>G), RS1000098985 (15:49862017 A>G), RS1000100016 (15:50076356 G>A), RS1000110165 (15:50035678 C>T), RS1000134039 (15:50023929 T>C), RS1000140725 (15:50150545 G>A)

Disease associations

OMIM: gene MIM:609123 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST002701_22	Verbal declarative memory	6.000000e-06
GCST004219_5	Skin pigmentation	2.000000e-07
GCST004631_26	Basophil percentage of white cells	1.000000e-10
GCST004634_42	Basophil percentage of granulocytes	3.000000e-10
GCST004744_1	Lung adenocarcinoma	9.000000e-09
GCST004748_35	Lung cancer	3.000000e-06
GCST005976_10	White blood cell count (basophil)	6.000000e-13
GCST007269_150	Pulse pressure	9.000000e-09
GCST009856_23	Leukocyte telomere length	1.000000e-07
GCST90002380_30	Basophil percentage of white cells	1.000000e-12

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004874	memory performance
EFO:0006805	word list delayed recall measurement
EFO:0006806	paragraph delayed recall measurement
EFO:0007992	basophil percentage of leukocytes
EFO:0007995	basophil percentage of granulocytes
EFO:0005090	basophil count
EFO:0005763	pulse pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — P4 P-type ATPases: Phospholipid-transporting ATPases

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Vorinostat	affects cotreatment, decreases expression	2
Benzo(a)pyrene	affects methylation, decreases expression, decreases methylation, increases methylation	2
GSK-J4	decreases expression	1
aminomethylphosphonic acid (AMPA)	decreases expression	1
methyleugenol	decreases expression	1
bisphenol A	affects methylation	1
butyraldehyde	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
S-(1,2-dichlorovinyl)cysteine	decreases expression, affects cotreatment	1
chromium hexavalent ion	increases abundance, decreases expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Boron Compounds	decreases expression	1
Cadmium	decreases expression	1
Cytarabine	decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
N-Nitrosopyrrolidine	decreases expression	1
Silicon Dioxide	decreases expression	1
Testosterone	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Urethane	decreases expression	1
Valproic Acid	increases expression	1
2,4-Dichlorophenoxyacetic Acid	decreases expression	1
Aflatoxin B1	decreases expression	1
Tungsten Compounds	decreases expression	1
Particulate Matter	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.