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AURKAIP1

gene
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Also known as Cox24AKIPAIPFLJ20608mS38

Summary

AURKAIP1 (aurora kinase A interacting protein 1, HGNC:24114) is a protein-coding gene on chromosome 1p36.33, encoding Small ribosomal subunit protein bS22, mitochondrial (Q9NWT8). May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation. It is a selective cancer dependency (DepMap: 35.3% of cell lines).

Acts upstream of or within positive regulation of proteolysis. Located in mitochondrial matrix and nucleoplasm.

Source: NCBI Gene 54998 — RefSeq curated summary.

At a glance

  • GWAS associations: 5
  • Clinical variants (ClinVar): 35 total — 1 pathogenic
  • Druggable target: yes — 1 molecules with ChEMBL bioactivity
  • Cancer dependency (DepMap): dependent in 35.3% of screened cell lines
  • MANE Select transcript: NM_017900

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:24114
Approved symbolAURKAIP1
Nameaurora kinase A interacting protein 1
Location1p36.33
Locus typegene with protein product
StatusApproved
AliasesCox24, AKIP, AIP, FLJ20608, mS38
Ensembl geneENSG00000175756
Ensembl biotypeprotein_coding
OMIM609183
Entrez54998

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 15 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000321751, ENST00000338338, ENST00000338370, ENST00000378853, ENST00000489799, ENST00000496905, ENST00000883185, ENST00000883186, ENST00000883187, ENST00000883188, ENST00000883189, ENST00000883190, ENST00000883191, ENST00000883192, ENST00000929719, ENST00000929720, ENST00000929721

RefSeq mRNA: 3 — MANE Select: NM_017900 NM_001127229, NM_001127230, NM_017900

CCDS: CCDS25

Canonical transcript exons

ENST00000338338 — 4 exons

ExonStartEnd
ENSE0000162977513740001374445
ENSE0000169786613751541375207
ENSE0000178969313747051374790
ENSE0000392682013737361373902

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 99.27.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 88.6017 / max 349.1398, expressed in 1821 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter IDTPM avgSamples expressed
977284.34371821
97761.4668541
97740.8802606
97750.6736429
97730.6557406
2013130.5817301

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
right testisUBERON:000453499.27gold quality
left testisUBERON:000453399.25gold quality
apex of heartUBERON:000209898.94gold quality
mucosa of transverse colonUBERON:000499198.40gold quality
heart left ventricleUBERON:000208498.32gold quality
cardiac ventricleUBERON:000208298.30gold quality
hindlimb stylopod muscleUBERON:000425298.27gold quality
testisUBERON:000047398.25gold quality
gastrocnemiusUBERON:000138898.18gold quality
right atrium auricular regionUBERON:000663198.08gold quality
heart right ventricleUBERON:000208097.87gold quality
cardiac atriumUBERON:000208197.86gold quality
muscle of legUBERON:000138397.81gold quality
right lobe of liverUBERON:000111497.74gold quality
lower esophagus mucosaUBERON:003583497.69gold quality
cingulate cortexUBERON:000302797.66gold quality
anterior cingulate cortexUBERON:000983597.66gold quality
muscle organUBERON:000163097.65gold quality
right adrenal glandUBERON:000123397.59gold quality
amygdalaUBERON:000187697.57gold quality
type B pancreatic cellCL:000016997.55gold quality
prefrontal cortexUBERON:000045197.51gold quality
vastus lateralisUBERON:000137997.50gold quality
nucleus accumbensUBERON:000188297.49gold quality
adult organismUBERON:000702397.49gold quality
body of tongueUBERON:001187697.47gold quality
putamenUBERON:000187497.46gold quality
caudate nucleusUBERON:000187397.45gold quality
body of stomachUBERON:000116197.43gold quality
heartUBERON:000094897.41gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

ExperimentMarker?Max mean expression
E-MTAB-7037yes472.87
E-ANND-3yes16.86
E-CURD-88yes3.90
E-MTAB-8060no587.08

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): EHMT2, GATA3, MTA3

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 35.3% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 10)

  • Results describe the identification of a novel negative regulator of Aurora-A, named AIP (Aurora-A kinase Interacting Protein). (PMID:12244051)
  • Phe31Ile polymorphism in Aurora A may be a genetic modifier for developing breast carcinoma. (PMID:15271856)
  • We propose that AURKAIP1 might function upstream of the Az1 by enhancing the binding affinity of Az1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation. (PMID:17452972)
  • AKURA phosphorylation of AIP and stabilization of the enzyme-substrate complex are reported. (PMID:17957726)
  • GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP. (PMID:18391981)
  • Plk1 controls Aurora A localization and function by regulating cellular levels of hBora. (PMID:18521620)
  • Aurora A is necessary for the maintenance of the mitotic delay induced in response to microtubule-perturbing agents. (PMID:19221504)
  • Aurora-A protein increased in stomach cancer cells in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin. (PMID:21932983)
  • Encodes a mitochondrial protein (PMID:22356826)
  • AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer. (PMID:38040691)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
danio_rerioaurkaip1ENSDARG00000074985
mus_musculusAurkaip1ENSMUSG00000065990

Protein

Protein identifiers

Small ribosomal subunit protein bS22, mitochondrial — Q9NWT8 (reviewed: Q9NWT8)

Alternative names: 28S ribosomal protein S38, mitochondrial, Aurora kinase A-interacting protein, Small ribosomal subunit protein mS38

All UniProt accessions (1): Q9NWT8

UniProt curated annotations — full annotation on UniProt →

Function. May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

Subunit / interactions. Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. Interacts with Aurora-A.

Subcellular location. Mitochondrion matrix. Nucleus.

Tissue specificity. Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.

Miscellaneous. Initially thought to be mitochondrial specific, comparison with ribosomes from Actinomycetota shows this protein is also found in some bacteria. Thus it has been renamed.

Similarity. Belongs to the bacterial ribosomal protein bS22 family.

RefSeq proteins (3): NP_001120701, NP_001120702, NP_060370* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR013177Ribosomal_bS22_CDomain

Pfam: PF08213

UniProt features (6 total): helix 2, transit peptide 1, chain 1, sequence variant 1, strand 1

Structure

Experimental structures (PDB)

73 structures, top 30 by resolution.

PDBMethodResolution (Å)
7QI4ELECTRON MICROSCOPY2.21
8CSSELECTRON MICROSCOPY2.36
7P2EELECTRON MICROSCOPY2.4
8RRIELECTRON MICROSCOPY2.4
9OLFELECTRON MICROSCOPY2.46
9OJMELECTRON MICROSCOPY2.5
8CSQELECTRON MICROSCOPY2.54
8CSRELECTRON MICROSCOPY2.54
6ZM6ELECTRON MICROSCOPY2.59
7QI5ELECTRON MICROSCOPY2.63
7PNXELECTRON MICROSCOPY2.76
8ANYELECTRON MICROSCOPY2.85
8CSTELECTRON MICROSCOPY2.85
6ZM5ELECTRON MICROSCOPY2.89
7PO0ELECTRON MICROSCOPY2.9
8K2AELECTRON MICROSCOPY2.9
9PGLELECTRON MICROSCOPY2.9
7PO1ELECTRON MICROSCOPY2.92
7PO3ELECTRON MICROSCOPY2.92
9PGFELECTRON MICROSCOPY2.93
6VMIELECTRON MICROSCOPY2.96
6RW4ELECTRON MICROSCOPY2.97
6VLZELECTRON MICROSCOPY2.97
7QI6ELECTRON MICROSCOPY2.98
8QRNELECTRON MICROSCOPY2.98
9PSMELECTRON MICROSCOPY2.98
8OISELECTRON MICROSCOPY3
9G5CELECTRON MICROSCOPY3
9G5DELECTRON MICROSCOPY3
9HFMELECTRON MICROSCOPY3

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9NWT8-F170.140.38

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

IDPathway
R-HSA-5368286Mitochondrial translation initiation
R-HSA-5389840Mitochondrial translation elongation
R-HSA-5419276Mitochondrial translation termination
R-HSA-9937383Mitochondrial ribosome-associated quality control
R-HSA-392499Metabolism of proteins
R-HSA-5368287Mitochondrial translation
R-HSA-72766Translation

MSigDB gene sets: 650 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, REACTOME_BIOLOGICAL_OXIDATIONS, MODY_HIPPOCAMPUS_POSTNATAL, TGCGCANK_UNKNOWN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, MODULE_255, PAL_PRMT5_TARGETS_UP, GOBP_PROTEIN_TARGETING, GOBP_MITOCHONDRIAL_TRANSLATION, MODULE_317, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, chr11q13, GOBP_TRANSLATION, GOBP_PROTEIN_MATURATION, YY1_02

GO Biological Process (2): mitochondrial translation (GO:0032543), positive regulation of proteolysis (GO:0045862)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (8): nucleus (GO:0005634), nucleoplasm (GO:0005654), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial matrix (GO:0005759), mitochondrial small ribosomal subunit (GO:0005763), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

CategoryPathways
Mitochondrial translation4
Translation1
Metabolism of proteins1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
mitochondrion2
intracellular membrane-bounded organelle2
translation1
mitochondrial gene expression1
proteolysis1
regulation of proteolysis1
positive regulation of protein metabolic process1
binding1
nuclear lumen1
cellular anatomical structure1
cytoplasm1
organelle inner membrane1
mitochondrial membrane1
intracellular organelle lumen1
organellar small ribosomal subunit1
mitochondrial ribosome1
mitochondrial protein-containing complex1
intracellular membraneless organelle1
protein-containing complex1

Protein interactions and networks

STRING

1636 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
AURKAIP1AURKAO14965731
AURKAIP1AKIP1Q9NQ31642
AURKAIP1MRM1Q6IN84554
AURKAIP1MRPS31Q92665524
AURKAIP1CHCHD1Q96BP2489
AURKAIP1PET117Q6UWS5483
AURKAIP1RALGPS2Q86X27467
AURKAIP1NBEAQ8NFP9463
AURKAIP1CCDC77Q9BR77448
AURKAIP1MRPS28Q9Y2Q9446
AURKAIP1HYAL2Q12891437
AURKAIP1PRKACAP17612434
AURKAIP1CCDC124Q96CT7432
AURKAIP1NFKB1P19838427
AURKAIP1NBR1Q14596418

IntAct

51 interactions, top by confidence:

ABTypeScore
AURKAIP1FAM9Bpsi-mi:“MI:0915”(physical association)0.560
FAM9BAURKAIP1psi-mi:“MI:0915”(physical association)0.560
DEFB127AURKAIP1psi-mi:“MI:0915”(physical association)0.560
ABHD4AURKAIP1psi-mi:“MI:0915”(physical association)0.560
MRPS34MRPS12psi-mi:“MI:0914”(association)0.530
AURKAIP1AURKApsi-mi:“MI:0915”(physical association)0.520
COQ4COQ9psi-mi:“MI:0914”(association)0.500
AURKAIP1NRDCpsi-mi:“MI:0914”(association)0.480
DDX21MED19psi-mi:“MI:2364”(proximity)0.480
AURKAIP1SEPTIN7psi-mi:“MI:0915”(physical association)0.400
GSK3AAURKAIP1psi-mi:“MI:0915”(physical association)0.370
CNOT1IBTKpsi-mi:“MI:0914”(association)0.350
Rad21ZNF768psi-mi:“MI:0914”(association)0.350
Cxxc1HCFC1psi-mi:“MI:0914”(association)0.350
GEMIN7CSNK1Dpsi-mi:“MI:0914”(association)0.350
Cul3psi-mi:“MI:0914”(association)0.350
CUL3PXDNLpsi-mi:“MI:0914”(association)0.350
AURKAIP1HNRNPRpsi-mi:“MI:0914”(association)0.350
CHCHD2POLRMTpsi-mi:“MI:0914”(association)0.350
CHCHD1ALDH1L1psi-mi:“MI:0914”(association)0.350
PRSS35NDUFAB1psi-mi:“MI:0914”(association)0.350
COQ2NME6psi-mi:“MI:0914”(association)0.350
PRKRAGTPBP10psi-mi:“MI:0914”(association)0.350
MRPS25POLRMTpsi-mi:“MI:0914”(association)0.350

BioGRID (352): FAM9B (Two-hybrid), AURKAIP1 (Proximity Label-MS), AURKAIP1 (Affinity Capture-MS), AURKAIP1 (Affinity Capture-MS), AURKAIP1 (Affinity Capture-MS), AURKAIP1 (Affinity Capture-MS), AURKAIP1 (Affinity Capture-MS), AURKAIP1 (Affinity Capture-MS), MMADHC (Affinity Capture-MS), NRD1 (Affinity Capture-MS), NOA1 (Affinity Capture-MS), WDR83 (Affinity Capture-MS), STRBP (Affinity Capture-MS), NSUN4 (Affinity Capture-MS), MRPS18C (Affinity Capture-MS)

ESM2 similar proteins: A2A8U2, A6H773, A6QPI4, D4A6L0, E1BBQ2, O60232, P54098, Q05B67, Q08BI9, Q148E1, Q2KI76, Q2KJ58, Q2NL34, Q32Q90, Q4R4I0, Q5C9Z4, Q5RE99, Q5SNT2, Q5T6X4, Q5T848, Q5VUE5, Q5XIJ4, Q5ZLJ4, Q6DVA0, Q6P3B9, Q7T076, Q80YR4, Q86UK7, Q8C419, Q8CEG5, Q8IYL2, Q8N0V3, Q8NC56, Q8TBN0, Q8VDV3, Q8VE22, Q8VHV8, Q921N7, Q96IL0, Q96ND0

Diamond homologs: Q9DCJ7, Q9NWT8

SIGNOR signaling

2 interactions.

AEffectBMechanism
AURKAIP1“form complex”“28S mitochondrial small ribosomal subunit”binding
AURKA“up-regulates quantity by stabilization”AURKAIP1phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 56 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Mitochondrial ribosome-associated quality control619.4×9e-05
Mitochondrial translation initiation516.7×4e-04
Mitochondrial translation elongation516.7×4e-04
Mitochondrial translation termination514.4×7e-04
mRNA Splicing - Major Pathway68.6×2e-03

GO biological processes:

GO termPartnersFoldFDR
mitochondrial translation518.5×2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

35 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic1
Likely pathogenic0
Uncertain significance29
Likely benign1
Benign0

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
393899GRCh37/hg19 1p36.33-36.32(chr1:19225-4401691)x3Pathogenic

SpliceAI

1552 predictions. Top by Δscore:

VariantEffectΔscore
11:67483216:G:GTdonor_gain1.0000
11:67487001:CACA:Cacceptor_loss1.0000
11:67487003:CA:Cacceptor_loss1.0000
11:67487004:A:AGacceptor_gain1.0000
11:67487004:AG:Aacceptor_gain1.0000
11:67487004:AGG:Aacceptor_loss1.0000
11:67487005:G:GGacceptor_gain1.0000
11:67487005:GG:Gacceptor_gain1.0000
11:67487005:GGC:Gacceptor_gain1.0000
11:67487005:GGCC:Gacceptor_gain1.0000
11:67487005:GGCCA:Gacceptor_gain1.0000
11:67487104:G:GTdonor_gain1.0000
11:67487108:TTC:Tdonor_gain1.0000
11:67487155:G:Tdonor_gain1.0000
11:67487182:CAAG:Cdonor_loss1.0000
11:67487183:AAG:Adonor_loss1.0000
11:67487184:AGG:Adonor_loss1.0000
11:67487186:G:GGdonor_loss1.0000
11:67489261:CCGCA:Cacceptor_loss1.0000
11:67489263:GCAG:Gacceptor_loss1.0000
11:67489264:CA:Cacceptor_loss1.0000
11:67489265:A:ACacceptor_loss1.0000
11:67489265:A:AGacceptor_gain1.0000
11:67489265:AGCAT:Aacceptor_gain1.0000
11:67489266:G:GGacceptor_gain1.0000
11:67489266:GC:Gacceptor_gain1.0000
11:67489266:GCAT:Gacceptor_gain1.0000
11:67489266:GCATG:Gacceptor_gain1.0000
11:67489454:AGGT:Adonor_loss1.0000
11:67489455:GGTGA:Gdonor_loss1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000297776 (1:1376957 G>A), RS1000639625 (1:1375720 G>C), RS1001558956 (1:1375854 G>A,C), RS1001885257 (1:1376068 C>T), RS1002260828 (1:1375124 G>A,C), RS1002291060 (1:1374851 G>A,C), RS1002719732 (1:1374956 TCCCAAG>T), RS1003151813 (1:1375057 G>C), RS1003793207 (1:1375082 G>A,C), RS1003845351 (1:1375300 C>T), RS1004203967 (1:1375163 G>A), RS1005849645 (1:1373298 T>C,G), RS1006150260 (1:1373346 C>T), RS1007108912 (1:1376905 G>A), RS1007372368 (1:1375517 G>A)

Disease associations

OMIM: gene MIM:609183 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

StudyTraitp-value
GCST004131_103Inflammatory bowel disease2.000000e-07
GCST004133_40Ulcerative colitis3.000000e-06
GCST005580_249Intraocular pressure1.000000e-10
GCST005580_72Intraocular pressure1.000000e-11
GCST006979_847Heel bone mineral density1.000000e-09

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0004695intraocular pressure measurement
EFO:0009270heel bone mineral density

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5910 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 2,998 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

MoleculeNamePhasePatents
CHEMBL572878TOZASERTIB22,998

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
9.22Ki0.6nMTOZASERTIB
5.10IC507943nMCHEMBL520308

PubChem BioAssay actives

2 with measured affinity, of 3 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide383102: Inhibition of Aurora Aki0.0006uM
N-(2-hydroxyethyl)-N-methyl-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide354259: Inhibition of Aurora A kinaseic507.9433uM

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arseniteaffects cotreatment, increases abundance, increases expression3
Valproic Acidaffects cotreatment, increases expression, increases methylation3
triphenyl phosphateaffects expression1
bisphenol Aaffects cotreatment, decreases methylation1
arseniteincreases reaction, affects binding1
manganese chlorideincreases abundance, increases expression, affects cotreatment1
chloropicrinincreases expression1
(+)-JQ1 compounddecreases expression1
Fulvestrantaffects cotreatment, decreases methylation1
Air Pollutantsaffects expression, increases abundance1
Arsenicincreases expression, affects cotreatment, increases abundance1
Atrazinedecreases expression1
Benzo(a)pyreneincreases methylation1
Dimethyl Sulfoxideaffects expression1
Doxorubicinincreases expression1
Hydralazineaffects cotreatment, increases expression1
Manganeseincreases abundance, increases expression, affects cotreatment1
Ozoneaffects expression, increases abundance1
Smokedecreases expression1
Tretinoindecreases expression1
Cadmium Chlorideincreases expression1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL974017BindingInhibition of Aurora AIdentification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. — Proc Natl Acad Sci U S A

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 79

This page pulls from 79 datasets indexed by BioBTree:

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