B3GALT5-AS1

Summary

B3GALT5-AS1 (B3GALT5 antisense RNA 1, HGNC:16424) is a long non-coding RNA gene on chromosome 21q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16424
Approved symbol	B3GALT5-AS1
Name	B3GALT5 antisense RNA 1
Location	21q22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000184809
Ensembl biotype	lncRNA
Entrez	114041
RNAcentral	URS000075B4E2 — lncRNA, 1469 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000329618, ENST00000380604, ENST00000380612, ENST00000489821, ENST00000661806, ENST00000670049, ENST00000670883, ENST00000839278

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000329618 — 3 exons

Exon	Start	End
ENSE00001295606	39609583	39609665
ENSE00001719814	39604134	39606576
ENSE00003852386	39612297	39612876

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 88.25.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4297 / max 39.8145, expressed in 192 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190504	0.2577	137
190503	0.1570	81
190505	0.0150	6

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	88.25	gold quality
palpebral conjunctiva	UBERON:0001812	76.99	gold quality
nucleus accumbens	UBERON:0001882	76.93	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.32	gold quality
putamen	UBERON:0001874	76.18	gold quality
mucosa of transverse colon	UBERON:0004991	75.94	gold quality
caudate nucleus	UBERON:0001873	75.86	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.81	silver quality
islet of Langerhans	UBERON:0000006	72.78	gold quality
body of pancreas	UBERON:0001150	70.96	gold quality
adenohypophysis	UBERON:0002196	70.94	gold quality
pancreas	UBERON:0001264	70.80	gold quality
pituitary gland	UBERON:0000007	69.86	gold quality
mucosa of sigmoid colon	UBERON:0004993	69.82	silver quality
minor salivary gland	UBERON:0001830	68.28	gold quality
colonic mucosa	UBERON:0000317	68.05	gold quality
hypothalamus	UBERON:0001898	67.78	gold quality
sural nerve	UBERON:0015488	66.08	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	64.86	gold quality
saliva-secreting gland	UBERON:0001044	64.78	gold quality
anterior cingulate cortex	UBERON:0009835	64.73	gold quality
cortical plate	UBERON:0005343	64.72	gold quality
mouth mucosa	UBERON:0003729	64.66	gold quality
amygdala	UBERON:0001876	63.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	63.25	gold quality
prefrontal cortex	UBERON:0000451	63.01	gold quality
forebrain	UBERON:0001890	62.87	gold quality
ventricular zone	UBERON:0003053	62.79	gold quality
spinal cord	UBERON:0002240	62.62	gold quality
lower esophagus mucosa	UBERON:0035834	62.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The C21orf88 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. (PMID:20494980)
• Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing expression of microRNA-203. (PMID:30530918)
• Abnormally expressed long noncoding RNA B3GALT5-AS1 may serve as a biomarker for the diagnostic and prognostic of gastric cancer. (PMID:31338903)
• Highly expressed B3GALT5-AS1 contributes to gastric cancer progression by recruiting WDR5 to mediate B3GALT5 and regulating beta-catenin/ZEB1 axis. (PMID:39224045)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.