B3GNT7

Summary

B3GNT7 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7, HGNC:18811) is a protein-coding gene on chromosome 2q37.1, encoding UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (Q8NFL0). N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans.

Enables acetylglucosaminyltransferase activity. Involved in keratan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane.

Source: NCBI Gene 93010 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 58 total
• MANE Select transcript: NM_145236

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18811
Approved symbol	B3GNT7
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Location	2q37.1
Locus type	gene with protein product
Status	Approved
Aliases	beta3GnT7
Ensembl gene	ENSG00000156966
Ensembl biotype	protein_coding
OMIM	615313
Entrez	93010

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 2 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000287590, ENST00000479618, ENST00000714191, ENST00000714192

RefSeq mRNA: 1 — MANE Select: NM_145236 NM_145236

CCDS: CCDS46540

Canonical transcript exons

ENST00000287590 — 2 exons

Exon	Start	End
ENSE00001029366	231397731	231401164
ENSE00001750133	231395710	231395814

Expression profiles

Bgee: expression breadth ubiquitous, 228 present calls, max score 97.64.

FANTOM5 (CAGE): breadth broad, TPM avg 5.6043 / max 251.5725, expressed in 665 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25893	3.5330	595
25895	1.5219	431
25892	0.2890	123
25894	0.1465	74
25891	0.1139	70

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nasal cavity epithelium	UBERON:0005384	97.64	gold quality
mucosa of sigmoid colon	UBERON:0004993	95.85	gold quality
rectum	UBERON:0001052	95.00	gold quality
colonic mucosa	UBERON:0000317	92.86	gold quality
tendon of biceps brachii	UBERON:0008188	90.79	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	90.15	gold quality
cartilage tissue	UBERON:0002418	90.02	gold quality
bronchial epithelial cell	CL:0002328	88.90	gold quality
nasal cavity mucosa	UBERON:0001826	88.45	gold quality
bronchus	UBERON:0002185	88.23	gold quality
duodenum	UBERON:0002114	87.72	gold quality
epithelium of nasopharynx	UBERON:0001951	87.45	gold quality
mucosa of transverse colon	UBERON:0004991	87.14	gold quality
transverse colon	UBERON:0001157	84.98	gold quality
gall bladder	UBERON:0002110	84.73	gold quality
palpebral conjunctiva	UBERON:0001812	83.70	gold quality
parotid gland	UBERON:0001831	83.07	gold quality
decidua	UBERON:0002450	82.90	gold quality
myocardium	UBERON:0002349	82.81	gold quality
small intestine	UBERON:0002108	82.61	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.58	gold quality
upper lobe of left lung	UBERON:0008952	82.56	gold quality
right adrenal gland cortex	UBERON:0035827	82.27	gold quality
upper lobe of lung	UBERON:0008948	82.26	gold quality
left adrenal gland cortex	UBERON:0035825	82.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.73	gold quality
body of stomach	UBERON:0001161	81.70	gold quality
left ovary	UBERON:0002119	81.68	gold quality
jejunal mucosa	UBERON:0000399	81.64	gold quality
left adrenal gland	UBERON:0001234	81.64	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-MTAB-6678	yes	1961.74
E-MTAB-6701	yes	93.79
E-GEOD-84465	yes	22.81
E-MTAB-5061	yes	19.11
E-GEOD-125970	yes	17.45
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

109 targeting B3GNT7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-629-3P	99.85	67.99	1875

Literature-anchored findings (GeneRIF, showing 4)

• sulfated keratan sulfate is produced by beta3GNT7, beta4GalT4, CGn6ST, and KSG6ST (PMID:17690104)
• The nude mice xenograft model demonstrated that ectopic expression of the B3GNT7 gene in colon cancer cells diminished the migration capability and the liver-metastasis potential, respectively, of colon cancer cells. (PMID:24418929)
• Interleukin-22 regulates B3GNT7 expression to induce fucosylation of glycoproteins in intestinal epithelial cells. (PMID:34864058)
• Identification of glycogene-based prognostic signature and validation of B3GNT7 as a potential biomarker and therapeutic target in breast cancer. (PMID:37740763)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	b3gnt7	ENSDARG00000038489
mus_musculus	B3gnt7	ENSMUSG00000079445
rattus_norvegicus	B3gnt7	ENSRNOG00000018267
drosophila_melanogaster	brn	FBGN0000221
caenorhabditis_elegans		WBGENE00000270
caenorhabditis_elegans		WBGENE00007096
caenorhabditis_elegans		WBGENE00017653

Paralogs (15): B3GALT2 (ENSG00000162630), B3GALNT2 (ENSG00000162885), B3GALNT1 (ENSG00000169255), B3GNT2 (ENSG00000170340), B3GALT1 (ENSG00000172318), B3GALT6 (ENSG00000176022), B3GNT4 (ENSG00000176383), B3GNT5 (ENSG00000176597), B3GNT8 (ENSG00000177191), B3GNT3 (ENSG00000179913), B3GALT5 (ENSG00000183778), B3GNT6 (ENSG00000198488), B3GALT9 (ENSG00000214654), B3GALT4 (ENSG00000235863), B3GNT9 (ENSG00000237172)

Protein

Protein identifiers

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 — Q8NFL0 (reviewed: Q8NFL0)

All UniProt accessions (2): Q8NFL0, A0AAQ5BHP6

UniProt curated annotations — full annotation on UniProt →

Function. N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency. May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion.

Subcellular location. Golgi apparatus membrane.

Tissue specificity. Expressed in corneal epithelial cells.

Pathway. Protein modification; protein glycosylation.

Similarity. Belongs to the glycosyltransferase 31 family.

RefSeq proteins (1): NP_660279* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002659	Glyco_trans_31	Family

Pfam: PF01762

Enzyme classification (BRENDA):

• EC 2.4.1.149 — N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (BRENDA: 6 organisms, 107 substrates, 59 inhibitors, 27 Km, 1 kcat entries)

Substrate kinetics (BRENDA)

10 substrates with measured Km, best-characterized 10. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
UDP-N-ACETYL-D-GLUCOSAMINE	0.129–15.97	11
N-ACETYLLACTOSAMINE	2.2–19.6	4
LACTOSE	5.2–29.8	3
GALBETA(1-4)GLCNACBETA(1-4)GLCNAC-2-AMINOPYRIDIN	0.44–0.9	2
ASIALO-ALPHA1-ACID GLYCOPROTEIN	0.6	1
GALBETA(1->4)GLCNACBETA(1->3)GALBETA(1->4)GLCNAC	1	1
GALBETA1,4(SO3-,6)-GLCNACBETA1,3-GALBETA1,4(SO3-	0.36	1
LACTONEOTETRAOSYLCERAMIDE	0.19	1
LACTONORHEXAOSYLCERAMIDE	0.19	1
NEOLACTOTETRAOSYLCERAMIDE	0.09	1

UniProt features (11 total): glycosylation site 4, topological domain 2, chain 1, sequence variant 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NFL0-F1	86.79	0.75

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (4): 88, 94, 214, 391

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-2022854	Keratan sulfate biosynthesis
R-HSA-913709	O-linked glycosylation of mucins
R-HSA-1430728	Metabolism
R-HSA-1630316	Glycosaminoglycan metabolism
R-HSA-1638074	Keratan sulfate/keratin metabolism
R-HSA-392499	Metabolism of proteins
R-HSA-5173105	O-linked glycosylation
R-HSA-597592	Post-translational protein modification
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives

MSigDB gene sets: 122 (showing top): RNGTGGGC_UNKNOWN, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS, ARGGGTTAA_UNKNOWN, RYTTCCTG_ETS2_B, GOBP_GLYCOPROTEIN_METABOLIC_PROCESS, REACTOME_METABOLISM_OF_CARBOHYDRATES_AND_CARBOHYDRATE_DERIVATIVES, GOMF_HEXOSYLTRANSFERASE_ACTIVITY, GOMF_GLYCOSYLTRANSFERASE_ACTIVITY, YNTTTNNNANGCARM_UNKNOWN, GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY, GOMF_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY, DODD_NASOPHARYNGEAL_CARCINOMA_DN, HMGIY_Q6

GO Biological Process (5): protein O-linked glycosylation (GO:0006493), keratan sulfate proteoglycan biosynthetic process (GO:0018146), poly-N-acetyllactosamine biosynthetic process (GO:0030311), obsolete protein glycosylation (GO:0006486), protein O-linked glycosylation via N-acetylgalactosamine (GO:0016266)

GO Molecular Function (12): UDP-glycosyltransferase activity (GO:0008194), acetylglucosaminyltransferase activity (GO:0008375), N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity (GO:0008532), nuclease activity (GO:0004518), endonuclease activity (GO:0004519), protein binding (GO:0005515), N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity (GO:0008499), transferase activity (GO:0016740), glycosyltransferase activity (GO:0016757), hexosyltransferase activity (GO:0016758), nucleotidyltransferase activity (GO:0016779), hydrolase activity (GO:0016787)

GO Cellular Component (3): Golgi membrane (GO:0000139), Golgi apparatus (GO:0005794), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-7 pathways:

Category	Pathways
Keratan sulfate/keratin metabolism	1
O-linked glycosylation	1
Metabolism of carbohydrates and carbohydrate derivatives	1
Glycosaminoglycan metabolism	1
Post-translational protein modification	1
Metabolism of proteins	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
glycosyltransferase activity	2
catalytic activity	2
glycoprotein biosynthetic process	1
proteoglycan biosynthetic process	1
keratan sulfate proteoglycan metabolic process	1
aminoglycan biosynthetic process	1
poly-N-acetyllactosamine metabolic process	1
protein O-linked glycosylation	1
UDP-glycosyltransferase activity	1
hexosyltransferase activity	1
acetylglucosaminyltransferase activity	1
catalytic activity, acting on a nucleic acid	1
nuclease activity	1
binding	1
UDP-galactosyltransferase activity	1
beta-1,3-galactosyltransferase activity	1
transferase activity	1
transferase activity, transferring phosphorus-containing groups	1
Golgi apparatus	1
bounding membrane of organelle	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

606 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
B3GNT7	CHST6	Q9GZX3	678
B3GNT7	B4GALT4	O60513	628
B3GNT7	KERA	O60938	590
B3GNT7	KRTAP20-3	Q3LI60	541
B3GNT7	CHST5	Q9GZS9	510
B3GNT7	CHST1	O43916	499
B3GNT7	B4GALT1	P15291	441
B3GNT7	GCNT3	O95395	431
B3GNT7	B4GALNT2	Q8NHY0	407
B3GNT7	ST3GAL1	Q11201	403
B3GNT7	MYBL2	P10244	385
B3GNT7	CAND2	O75155	384
B3GNT7	C2orf72	A6NCS6	377
B3GNT7	LHFPL3	Q86UP9	375
B3GNT7	CHPF	Q8IZ52	371

IntAct

9 interactions, top by confidence:

A	B	Type	Score
	B3GNT7	psi-mi:“MI:0915”(physical association)	0.560
B3GNT7	GPR152	psi-mi:“MI:0915”(physical association)	0.560
B3GNT7	TUFM	psi-mi:“MI:0915”(physical association)	0.400
B3GNT7	B4GALT5	psi-mi:“MI:0914”(association)	0.350
B3GNT7		psi-mi:“MI:0915”(physical association)	0.000
B3GNT7	GPR152	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (24): CASC4 (Two-hybrid), GPR152 (Two-hybrid), B3GNT7 (Proximity Label-MS), GHITM (Affinity Capture-MS), ATP12A (Affinity Capture-MS), BNIP1 (Affinity Capture-MS), NRN1 (Affinity Capture-MS), CANX (Affinity Capture-MS), PHB2 (Affinity Capture-MS), SLC39A11 (Affinity Capture-MS), SOGA3 (Affinity Capture-MS), ENTPD7 (Affinity Capture-MS), ERGIC2 (Affinity Capture-MS), PHB (Affinity Capture-MS), STX10 (Affinity Capture-MS)

ESM2 similar proteins: A0A2C9JXL4, O43825, O54904, O54905, O75752, O93403, P79948, P79949, Q08BL3, Q0VC84, Q24342, Q5F3G7, Q5HZL5, Q5R5Y3, Q5RAL7, Q5XJP0, Q5YB40, Q66H69, Q6AY39, Q6DE15, Q6GNL1, Q6P3P5, Q6QMG1, Q76EC5, Q793U7, Q7JK24, Q7JK25, Q7JK26, Q7K237, Q7SYI5, Q7T3S5, Q864U6, Q864U8, Q8BGY6, Q8K0J2, Q8NFL0, Q920V1, Q99NB2, Q9BYG0, Q9JI67

Diamond homologs: O43825, O54904, O54905, O75752, O88178, Q1RLK6, Q3USF0, Q5HZL5, Q5R5Y3, Q5RAL7, Q5XJP0, Q66H69, Q6AY39, Q6DE15, Q6P3P5, Q6ZMB0, Q793U7, Q7JK24, Q7JK25, Q7JK26, Q7T3S5, Q7Z7M8, Q864U6, Q864U8, Q8BGY6, Q8K0J2, Q8NFL0, Q8R3I9, Q920V1, Q99NB2, Q9BYG0, Q9C0J1, Q9JI67, Q9MYM7, Q9N293, Q9N294, Q9N295, Q9NY97, Q9Y2C3, Q9Y5Z6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

280 predictions. Top by Δscore:

Variant	Effect	Δscore
2:231395811:TGTGG:T	donor_loss	0.9900
2:231395812:GTG:G	donor_gain	0.9900
2:231395814:GGT:G	donor_loss	0.9900
2:231395815:GT:G	donor_loss	0.9900
2:231395816:T:A	donor_loss	0.9900
2:231397716:C:CA	acceptor_gain	0.9900
2:231397729:A:AC	acceptor_loss	0.9900
2:231397729:A:AG	acceptor_gain	0.9900
2:231397729:AG:A	acceptor_gain	0.9900
2:231397730:G:GC	acceptor_gain	0.9900
2:231397730:GG:G	acceptor_gain	0.9900
2:231397730:GGA:G	acceptor_gain	0.9900
2:231397730:GGAA:G	acceptor_gain	0.9900
2:231395683:A:T	donor_gain	0.9800
2:231395810:CTGTG:C	donor_gain	0.9800
2:231395813:TG:T	donor_gain	0.9800
2:231395814:GG:G	donor_gain	0.9800
2:231395815:G:GG	donor_gain	0.9800
2:231397179:T:G	acceptor_gain	0.9800
2:231397710:ACT:A	acceptor_gain	0.9800
2:231397710:A:AG	acceptor_gain	0.9700
2:231397711:C:G	acceptor_gain	0.9700
2:231397727:ACAG:A	acceptor_gain	0.9700
2:231397712:T:A	acceptor_gain	0.9600
2:231395811:TGTG:T	donor_gain	0.9500
2:231395812:GTGG:G	donor_gain	0.9500
2:231395813:TGGT:T	donor_gain	0.9500
2:231395814:GGTG:G	donor_gain	0.9500
2:231397727:A:AG	acceptor_gain	0.9300
2:231397728:C:G	acceptor_gain	0.9300

AlphaMissense

2617 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:231398167:C:A	R150S	0.999
2:231398373:G:C	K218N	0.999
2:231398373:G:T	K218N	0.999
2:231398444:A:T	D242V	0.999
2:231398563:T:C	Y282H	0.999
2:231398564:A:G	Y282C	0.999
2:231398699:A:C	D327A	0.999
2:231398699:A:G	D327G	0.999
2:231398699:A:T	D327V	0.999
2:231398700:C:A	D327E	0.999
2:231398700:C:G	D327E	0.999
2:231398839:C:G	H374D	0.999
2:231398188:T:A	W157R	0.998
2:231398188:T:C	W157R	0.998
2:231398190:G:C	W157C	0.998
2:231398190:G:T	W157C	0.998
2:231398438:A:T	D240V	0.998
2:231398444:A:G	D242G	0.998
2:231398696:A:T	D326V	0.998
2:231398698:G:C	D327H	0.998
2:231398698:G:T	D327Y	0.998
2:231398142:G:C	K141N	0.997
2:231398142:G:T	K141N	0.997
2:231398179:C:A	R154S	0.997
2:231398243:T:C	F175S	0.997
2:231398306:A:T	E196V	0.997
2:231398341:T:C	F208L	0.997
2:231398343:T:A	F208L	0.997
2:231398343:T:G	F208L	0.997
2:231398363:T:C	L215P	0.997

dbSNP variants (sampled 300 via entrez): RS1000538956 (2:231400627 G>A), RS1000687449 (2:231394262 G>C), RS1000763936 (2:231400915 G>A,T), RS1000831213 (2:231399628 G>A), RS1000865922 (2:231395626 G>A), RS1000976954 (2:231395876 C>T), RS1001330429 (2:231399762 T>G), RS1001598614 (2:231399902 C>T), RS1001601522 (2:231399846 C>T), RS1001782194 (2:231400170 C>G,T), RS1001933903 (2:231401124 G>A), RS1002103711 (2:231395455 C>G), RS1002168182 (2:231393925 C>T), RS1002285885 (2:231395049 C>T), RS1002311856 (2:231395926 G>A,T)

Disease associations

OMIM: gene MIM:615313 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST001969_18	Heart rate	1.000000e-10
GCST002710_1	Anti-saccade response	6.000000e-08
GCST003818_20	Resting heart rate	1.000000e-17
GCST005789_7	Resting heart rate	5.000000e-07
GCST010002_411	Refractive error	1.000000e-123
GCST010796_4295	Electrocardiogram morphology (amplitude at temporal datapoints)	5.000000e-08
GCST010796_4296	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0006874	antisaccade response measurement
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	6
sodium arsenite	increases expression	2
entinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Copper	affects cotreatment, increases expression, affects binding, decreases expression	2
Smoke	decreases expression	2
Tobacco Smoke Pollution	increases expression, affects expression	2
aristolochic acid I	increases expression	1
TL8-506	affects cotreatment, increases expression	1
bisphenol A	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
nutlin 3	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
NSC 689534	affects binding, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Camptothecin	increases expression	1
Cisplatin	decreases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Formaldehyde	increases expression	1
Naled	affects expression	1
Niclosamide	increases expression	1
Poly I-C	affects cotreatment, increases expression	1
Tretinoin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.