B4GALT1-AS1

Summary

B4GALT1-AS1 (B4GALT1 antisense RNA 1, HGNC:49910) is a long non-coding RNA gene on chromosome 9p21.1.

Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting.

Source: NCBI Gene 101929639 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49910
Approved symbol	B4GALT1-AS1
Name	B4GALT1 antisense RNA 1
Location	9p21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233554
Ensembl biotype	lncRNA
Entrez	101929639
RNAcentral	URS000075AF86 — lncRNA, 1185 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000426270, ENST00000442432, ENST00000654325, ENST00000729825, ENST00000729826, ENST00000729827, ENST00000729828

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426270 — 3 exons

Exon	Start	End
ENSE00001618321	33177420	33177469
ENSE00004057785	33166789	33167046
ENSE00004057787	33179325	33179988

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 84.88.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2300 / max 23.1037, expressed in 99 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
96436	0.2103	96
205455	0.0116	3
96437	0.0081	3

Top tissues by expression

135 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	84.88	gold quality
left testis	UBERON:0004533	84.65	gold quality
testis	UBERON:0000473	84.28	gold quality
mucosa of transverse colon	UBERON:0004991	77.59	gold quality
descending thoracic aorta	UBERON:0002345	77.10	gold quality
popliteal artery	UBERON:0002250	76.73	gold quality
tibial artery	UBERON:0007610	76.70	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.35	gold quality
thoracic aorta	UBERON:0001515	76.29	gold quality
ascending aorta	UBERON:0001496	76.15	gold quality
right lobe of liver	UBERON:0001114	75.37	gold quality
liver	UBERON:0002107	74.93	gold quality
right coronary artery	UBERON:0001625	74.81	gold quality
subcutaneous adipose tissue	UBERON:0002190	74.73	gold quality
left coronary artery	UBERON:0001626	74.45	gold quality
hindlimb stylopod muscle	UBERON:0004252	74.17	gold quality
adipose tissue	UBERON:0001013	73.69	gold quality
rectum	UBERON:0001052	72.86	gold quality
leukocyte	CL:0000738	72.58	gold quality
monocyte	CL:0000576	72.49	gold quality
omental fat pad	UBERON:0010414	72.25	gold quality
thoracic mammary gland	UBERON:0005200	70.96	gold quality
calcaneal tendon	UBERON:0003701	70.54	gold quality
bone marrow cell	CL:0002092	70.35	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	70.21	gold quality
muscle of leg	UBERON:0001383	69.96	gold quality
stromal cell of endometrium	CL:0002255	69.86	gold quality
gastrocnemius	UBERON:0001388	69.72	gold quality
lower esophagus mucosa	UBERON:0035834	69.58	gold quality
left adrenal gland cortex	UBERON:0035825	69.38	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-30	yes	251.57
E-ANND-3	no	1.51

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• B4GALT1-AS1 recruited HuR to enhance YAP mRNA stability and thus its transcriptional activity (PMID:30182452)
• These results identify the direct binding of long noncoding RNA B4GALT1-AS1 to YAP, which is responsible for colon cancer cell stemness. (PMID:30912138)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.