BAALC-AS1

Summary

BAALC-AS1 (BAALC antisense RNA 1, HGNC:50461) is a long non-coding RNA gene on chromosome 8q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50461
Approved symbol	BAALC-AS1
Name	BAALC antisense RNA 1
Location	8q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncFZD6, FZD6-DT
Ensembl gene	ENSG00000247081
Ensembl biotype	lncRNA
Entrez	100499183
RNAcentral	URS000075B9A4 — lncRNA, 726 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000499522, ENST00000500902, ENST00000519801, ENST00000520025, ENST00000521102, ENST00000521383, ENST00000522856, ENST00000523614, ENST00000523673, ENST00000523915, ENST00000653502, ENST00000660425, ENST00000663003, ENST00000667164, ENST00000669482, ENST00000734531, ENST00000734532, ENST00000734533, ENST00000734534, ENST00000734535, ENST00000734536, ENST00000734537, ENST00000734538, ENST00000734539, ENST00000734540, ENST00000734541, ENST00000734542

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499522 — 6 exons

Exon	Start	End
ENSE00001674185	103234280	103234372
ENSE00001974416	103285838	103285907
ENSE00001976015	103268692	103268843
ENSE00001980859	103267242	103267520
ENSE00001983304	103246294	103246684
ENSE00001985321	103165929	103166296

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 79.51.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0664 / max 108.5483, expressed in 593 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94327	0.7980	519
94320	0.4685	60
94322	0.2944	72
94323	0.1422	58
94324	0.1304	56
94321	0.0989	38
94326	0.0805	49
94325	0.0535	42

Top tissues by expression

272 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.51	gold quality
caudate nucleus	UBERON:0001873	79.31	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.44	gold quality
anterior cingulate cortex	UBERON:0009835	77.16	gold quality
cingulate cortex	UBERON:0003027	77.04	gold quality
right frontal lobe	UBERON:0002810	76.99	gold quality
thoracic aorta	UBERON:0001515	76.91	gold quality
ascending aorta	UBERON:0001496	76.89	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.72	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.30	gold quality
descending thoracic aorta	UBERON:0002345	76.12	gold quality
putamen	UBERON:0001874	75.65	gold quality
nucleus accumbens	UBERON:0001882	75.42	gold quality
aorta	UBERON:0000947	75.13	gold quality
stromal cell of endometrium	CL:0002255	74.91	gold quality
right coronary artery	UBERON:0001625	74.80	gold quality
pituitary gland	UBERON:0000007	74.60	gold quality
adenohypophysis	UBERON:0002196	74.60	gold quality
calcaneal tendon	UBERON:0003701	74.57	gold quality
popliteal artery	UBERON:0002250	74.14	gold quality
tibial artery	UBERON:0007610	74.12	gold quality
islet of Langerhans	UBERON:0000006	74.04	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	73.95	gold quality
right adrenal gland cortex	UBERON:0035827	73.78	gold quality
amygdala	UBERON:0001876	73.67	gold quality
left adrenal gland	UBERON:0001234	73.64	gold quality
right testis	UBERON:0004534	73.57	gold quality
left adrenal gland cortex	UBERON:0035825	73.50	gold quality
left testis	UBERON:0004533	73.36	gold quality
spinal cord	UBERON:0002240	73.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncFZD6 is highly expressed in liver cancer cells and liver tumor-initiating cells.LncFZD6 is required for liver tumor-initiating cells self-renewal.LncFZD6 interacts and recruits BRG1 to FZD6 promoter to initiate transcription. (PMID:29535420)
• BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma. (PMID:33476486)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.