BABAM2-AS1

Summary

BABAM2-AS1 (BABAM2 antisense RNA 1, HGNC:44171) is a long non-coding RNA gene on chromosome 2p23.2.

At a glance

• GWAS associations: 1

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44171
Approved symbol	BABAM2-AS1
Name	BABAM2 antisense RNA 1
Location	2p23.2
Locus type	RNA, long non-coding
Status	Approved
Entrez	100302650
RNAcentral	URS000075DC60 — lncRNA, 1667 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Long non-coding RNA BRE-AS1 represses non-small cell lung cancer cell growth and survival via up-regulating NR4A3 (PMID:30227111)
• Overexpression of long non-coding RNA (LncRNA) BRE-AS1 (BRE-AS1) and miR-145-5p led to inhibited proliferation and promoted apoptosis of prostate carcinoma (PC). (PMID:30833361)
• Long non-coding RNA BRE-AS1 inhibits proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating miR-106b-5p. (PMID:37530129)
• Clinical value of BRE-AS1 in myocardial infarction and its role in myocardial infarction-induced cardiac muscle cell apoptosis. (PMID:38733316)
• LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells. (PMID:39468152)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000150176 (2:27891731 C>T), RS1003695720 (2:27892912 C>T), RS1003725406 (2:27892624 A>G), RS1004735826 (2:27892535 A>C), RS1005265562 (2:27892990 T>G), RS1006203640 (2:27890812 G>C), RS1006742598 (2:27891602 G>T), RS1008145662 (2:27890070 A>G), RS1009174557 (2:27890104 G>A,C), RS1009188924 (2:27890417 C>G,T), RS1010430467 (2:27891180 G>A), RS1010546443 (2:27890825 G>A,C), RS1011552308 (2:27892925 G>T), RS1011987797 (2:27891792 A>G), RS1012441713 (2:27892473 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST008103_38	Bipolar disorder	1.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
diethyl maleate	increases expression	1
diethyl malate	increases expression	1
jinfukang	increases expression	1
Smoke	decreases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.