BACE1-AS

Summary

BACE1-AS (BACE1 antisense RNA, HGNC:37125) is a long non-coding RNA gene on chromosome 11q23.3.

This gene encodes an unspliced long non-coding RNA transcribed from the opposite strand to BACE1. The encoded transcript is thought to form an RNA duplex with BACE1 mRNA thereby regulating its expression and is also thought to promote post-transcriptional feed-forward regulation of BACE1. This may lead to increased levels of beta amyloid and increased senile plaque deposition, and therefore may play a role in the pathophysiology of Alzheimer’s disease.

Source: NCBI Gene 100379571 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37125
Approved symbol	BACE1-AS
Name	BACE1 antisense RNA
Location	11q23.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FJ573250, NCRNA00177, BACE1-AS1
Ensembl gene	ENSG00000278768
Ensembl biotype	lncRNA
OMIM	614263
Entrez	100379571
RNAcentral	URS0000D590B2 — lncRNA, 825 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000614401, ENST00000618857, ENST00000649580, ENST00000717907

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614401 — 4 exons

Exon	Start	End
ENSE00003730287	117293075	117293346
ENSE00003744815	117292211	117292333
ENSE00003749662	117290874	117290929
ENSE00004033681	117291703	117291771

Expression profiles

Bgee: expression breadth ubiquitous, 201 present calls, max score 90.92.

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.92	gold quality
tibialis anterior	UBERON:0001385	90.40	silver quality
pancreatic ductal cell	CL:0002079	89.76	silver quality
body of pancreas	UBERON:0001150	88.08	gold quality
oviduct epithelium	UBERON:0004804	87.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.74	gold quality
right uterine tube	UBERON:0001302	86.71	gold quality
cerebellar hemisphere	UBERON:0002245	86.25	gold quality
cerebellar cortex	UBERON:0002129	86.20	gold quality
deltoid	UBERON:0001476	85.60	silver quality
cerebellum	UBERON:0002037	84.98	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	84.52	gold quality
medial globus pallidus	UBERON:0002477	84.34	gold quality
gastrocnemius	UBERON:0001388	84.07	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.07	gold quality
right ovary	UBERON:0002118	83.80	gold quality
left ovary	UBERON:0002119	83.28	gold quality
muscle of leg	UBERON:0001383	83.23	gold quality
ileal mucosa	UBERON:0000331	82.81	silver quality
adenohypophysis	UBERON:0002196	82.68	gold quality
cortical plate	UBERON:0005343	82.67	gold quality
ganglionic eminence	UBERON:0004023	82.64	gold quality
body of uterus	UBERON:0009853	82.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.58	gold quality
right lobe of thyroid gland	UBERON:0001119	82.41	gold quality
ovary	UBERON:0000992	82.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	82.13	gold quality
left lobe of thyroid gland	UBERON:0001120	82.12	gold quality
lower esophagus	UBERON:0013473	82.12	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	82.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.33

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): POU5F1, PPARG

Literature-anchored findings (GeneRIF, showing 10)

• Report BACE1/BACE1-AS induction and beta-amyloid accumulation in failing hearts. (PMID:28158647)
• Low BACE1-AS expression is associated with Gastric Cancer. (PMID:30805871)
• ROC curve analysis revealed that lncRNA BACE1-AS may discriminate pre-AD and healthy control (75% sensitivity and 100% specificity), full-AD and healthy control (68% sensitivity and 100% specificity), and pre-AD and full-AD subgroups (78% sensitivity and 100% specificity), highlighting its potential as a biomarker for AD development. (PMID:31264051)
• Elevated plasma levels of exosomal BACE1AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer’s disease. (PMID:32377715)
• LncRNA BACE1-AS enhances the invasive and metastatic capacity of hepatocellular carcinoma cells through mediating miR-377-3p/CELF1 axis. (PMID:33667514)
• Long non-coding RNA BACE1-AS plays an oncogenic role in hepatocellular carcinoma cells through miR-214-3p/APLN axis. (PMID:34636395)
• Identification and Validation of the lncRNA BACE1-AS as Immune-Related Influencing Factor in Tumorigenesis following Pan-Carcinoma Analysis. (PMID:34926701)
• LncRNA BACE1-AS promotes the progression of osteosarcoma through miR-762/SOX7 axis. (PMID:35332412)
• Long noncoding RNA BACE1-antisense transcript plays a critical role in Parkinson’s disease via microRNA-214-3p/Cell death-inducing p53-target protein 1 axis. (PMID:35481549)
• Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease. (PMID:35915966)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.