BACE2-IT1

Summary

BACE2-IT1 (BACE2 intronic transcript 1, HGNC:16024) is a long non-coding RNA gene on chromosome 21q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16024
Approved symbol	BACE2-IT1
Name	BACE2 intronic transcript 1
Location	21q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRED43
Ensembl gene	ENSG00000224388
Ensembl biotype	lncRNA
Entrez	282569
RNAcentral	URS000030AA97 — lncRNA, 382 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000433378

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433378 — 2 exons

Exon	Start	End
ENSE00001752650	41180433	41180626
ENSE00001788165	41180097	41180284

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 86.32.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	86.32	gold quality
placenta	UBERON:0001987	86.25	gold quality
sural nerve	UBERON:0015488	78.02	gold quality
tonsil	UBERON:0002372	71.70	gold quality
bone marrow cell	CL:0002092	66.37	silver quality
skeletal muscle tissue	UBERON:0001134	66.25	gold quality
bone marrow	UBERON:0002371	65.25	gold quality
liver	UBERON:0002107	65.07	gold quality
calcaneal tendon	UBERON:0003701	64.15	gold quality
muscle tissue	UBERON:0002385	63.31	gold quality
lymph node	UBERON:0000029	61.24	gold quality
monocyte	CL:0000576	59.28	gold quality
right lobe of liver	UBERON:0001114	58.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.69	gold quality
prefrontal cortex	UBERON:0000451	57.55	gold quality
gall bladder	UBERON:0002110	57.10	gold quality
apex of heart	UBERON:0002098	56.08	gold quality
vagina	UBERON:0000996	55.88	gold quality
blood	UBERON:0000178	55.22	gold quality
islet of Langerhans	UBERON:0000006	55.19	gold quality
kidney	UBERON:0002113	54.80	gold quality
muscle of leg	UBERON:0001383	52.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	52.33	gold quality
gastrocnemius	UBERON:0001388	51.78	gold quality
adult mammalian kidney	UBERON:0000082	51.56	gold quality
thoracic mammary gland	UBERON:0005200	51.42	gold quality
myometrium	UBERON:0001296	51.19	gold quality
cortex of kidney	UBERON:0001225	50.33	gold quality
adrenal tissue	UBERON:0018303	50.28	silver quality
adenohypophysis	UBERON:0002196	49.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.