BAGE4

Summary

BAGE4 (BAGE family member 4, HGNC:15730) is a protein-coding gene on chromosome 21p11.1 not on reference assembly, encoding B melanoma antigen 4 (Q86Y28). Unknown.

Predicted to be located in extracellular region.

Source: NCBI Gene 85317 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15730
Approved symbol	BAGE4
Name	BAGE family member 4
Location	21p11.1 not on reference assembly
Locus type	gene with protein product
Status	Approved
Aliases	CT2.4
Entrez	85317

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

B melanoma antigen 4 — Q86Y28 (reviewed: Q86Y28)

Alternative names: Cancer/testis antigen 2.4

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Unknown. Candidate gene encoding tumor antigens.

Subcellular location. Secreted.

Tissue specificity. Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas.

Miscellaneous. The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

Similarity. Belongs to the BAGE family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012530	BAGE-like	Family

Pfam: PF08180

UniProt features (2 total): signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86Y28-F1	72.89	0.16

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

2 interactions, top by confidence:

A	B	Type	Score
ECE1	BAGE4	psi-mi:“MI:0915”(physical association)	0.370

ESM2 similar proteins: A0A0U1RRA0, A0T0A9, A2C0D1, A2CCQ0, A2CCQ1, A5GQF4, A5GWI2, B0C6T2, B2JA13, B8HTR1, D5AP83, E9Q9R3, O10337, P04123, P0C420, P0C421, P0C422, P0CZ12, P0DJZ4, P13293, P35089, P35090, P35091, P35098, P35099, P35101, P35104, P35105, P51769, P52587, P80107, P80587, P80654, Q00644, Q0IDJ7, Q10XU6, Q20F20, Q2JS34, Q2KS19, Q32RU4

Diamond homologs: Q13072, Q86Y27, Q86Y28, Q86Y29, Q86Y30

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.