BANCR

Summary

BANCR (BRAF-activated non-protein coding RNA, HGNC:43877) is a long non-coding RNA gene on chromosome 9q21.11-q21.12.

This gene produces a long non-coding RNA that plays a role in tumor progression and epithelial to mesenchymal transition. This transcript acts through the MAP kinase signaling pathway.

Source: NCBI Gene 100885775 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43877
Approved symbol	BANCR
Name	BRAF-activated non-protein coding RNA
Location	9q21.11-q21.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00586
Ensembl gene	ENSG00000278910
Ensembl biotype	lncRNA
OMIM	619589
Entrez	100885775
RNAcentral	URS0000759AA6 — lncRNA, 688 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000624238, ENST00000625062, ENST00000690153, ENST00000691130, ENST00000693755, ENST00000787798, ENST00000787799, ENST00000787800, ENST00000787801, ENST00000787802, ENST00000787803

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000624238 — 4 exons

Exon	Start	End
ENSE00003755980	69304936	69305077
ENSE00003758077	69306148	69306290
ENSE00004165703	69306854	69307181
ENSE00004165707	69296671	69296867

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 84.96.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1820 / max 76.6168, expressed in 40 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100803	0.1585	35
100804	0.0235	5

Top tissues by expression

222 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.96	gold quality
buccal mucosa cell	CL:0002336	81.50	silver quality
left ventricle myocardium	UBERON:0006566	77.71	gold quality
heart left ventricle	UBERON:0002084	75.02	gold quality
cardiac ventricle	UBERON:0002082	74.92	gold quality
smooth muscle tissue	UBERON:0001135	71.93	gold quality
heart right ventricle	UBERON:0002080	69.51	gold quality
myocardium	UBERON:0002349	69.25	silver quality
heart	UBERON:0000948	68.83	gold quality
kidney epithelium	UBERON:0004819	67.56	gold quality
pigmented layer of retina	UBERON:0001782	65.41	gold quality
sperm	CL:0000019	65.18	silver quality
epithelial cell of pancreas	CL:0000083	63.20	gold quality
apex of heart	UBERON:0002098	62.78	gold quality
islet of Langerhans	UBERON:0000006	61.01	gold quality
right atrium auricular region	UBERON:0006631	59.45	gold quality
right lung	UBERON:0002167	59.20	gold quality
cardiac atrium	UBERON:0002081	58.85	gold quality
secondary oocyte	CL:0000655	58.62	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	56.38	gold quality
skeletal muscle tissue	UBERON:0001134	56.19	silver quality
pancreatic ductal cell	CL:0002079	55.86	silver quality
left lobe of thyroid gland	UBERON:0001120	55.80	gold quality
deltoid	UBERON:0001476	55.60	gold quality
quadriceps femoris	UBERON:0001377	55.54	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.49	gold quality
biceps brachii	UBERON:0001507	55.04	gold quality
thyroid gland	UBERON:0002046	55.01	gold quality
tibialis anterior	UBERON:0001385	54.60	silver quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 30)

• The lncRNA BRAF-activated non-protein coding RNA (BANCR) was upregulated in EoE and induced in interleukin-13 (IL-13)-treated primary esophageal epithelial cells. (PMID:24920534)
• BANCR levels were downregulated in lung carcinoma cells. (PMID:25661343)
• In conclusion, lncRNA BANCR plays a significant role in retinoblastoma aggressiveness and prognosis and may act as a promising target for therapeutic strategy and prognostic prediction. (PMID:25894373)
• findings suggest that down-regulation of BANCR contributes to the proliferation of colorectal cancer cells, at least in part, through the regulation of p21 protein. (PMID:25928067)
• high expression of BANCR was an independent unfavorable prognostic factor in gastric cancer patients. (PMID:26054683)
• BANCR was highly expressed both in gastric tumor tissues and in cancer cells. NF-kappaB1 and miR-9 were involved in BANCR-mediated gastric cancer cell growth and apoptosis. (PMID:26248136)
• Fentanyl showed anti-tumor like effects on CRC cells, including less cell clone formation and inhibited cell migration and invasion. (PMID:26296467)
• BANCR inhibits tumorigenesis in papillary thyroid carcinoma and that BANCR levels may be used as a novel prognostic marker. (PMID:27462868)
• BANCR may be a novel tumor biomarker for early detection, a prospective prognostic indicator and a potential therapeutic target for Esophageal squamous cell cancer. (PMID:27470379)
• Study shows that lncRNA BANCR is decreased in bladder cancer tissues and correlates with advanced TNM stage and suggest that BANCR is a tumor suppressor player in bladder cancer which contributes to tumor proliferation, apoptosis and migration. (PMID:27514530)
• BANCR is highly expressed in type 1 endometrial cancer (EC) tissue and promotes EC-cell proliferation, migration, and invasion by activating ERK/MAPK signaling pathway that regulates MMP2/MMP1 expression. (PMID:27898420)
• Review/Meta-analysis: BANCR as a promising prognostic biomarker in Chinese patients with gastrointestinal cancer. (PMID:28009984)
• Upregulation of lncRNA BANCR may be associated with the lymph node metastasis and poor survival of colorectal. LncRNA BANCR could be served as a novel and useful biomarker for colorectal lymph node metastasis and prognosis. (PMID:28969673)
• BANCR expression induced by IFN-gamma was suppressed when STAT1 phosphorylation was blocked by JAK inhibitor 1. (PMID:29054724)
• BANCR may promote melanoma cell growth through inhibition of miR204, leading to the activation of Notch2 pathway. Authors further demonstrated that BANCR knockdown inhibited tumor growth in vivo. Results suggest the BANCR/miR204/Notch2 axis mediates melanoma cell proliferation and tumor progression. (PMID:29075789)
• BANCR plays a role in PTC development. (PMID:29917164)
• These results suggest a possible role of lncRNA-BANCR in proliferation of esophageal tissues and may be considered as a potential prognostic value for Esophageal squamous cell carcinoma metastasis. (PMID:30552615)
• Transfection with the BANCR expression vector significantly inhibited proliferation and promoted apoptosis of KGN cells, and significantly promoted the expression levels of proapoptotic Bax and p53. Therefore, it may be concluded that lncRNA BANCR participates in PCOS by promoting cell apoptosis through the upregulation of Bax and p53. (PMID:30592281)
• lncRNA BANCR is overexpressed in patients with diabetic retinopathy and can promote apoptosis of retinal pigment epithelial cells. (PMID:30996220)
• We found IFN-gamma gene (rs2069705 and rs2430561), and 2 variants in lncRNA BANCR (rs6559446 and rs79823312) could increase coronary artery disease (CAD) susceptibility in allelic and dominant model, while IFN-gamma rs2069705 and rs2430561, BANCR rs79823312 were also associated with CAD risk in additive model. IFN-gamma rs2069705 and rs2430561 were associated with higher level of serum IFN-gamma in CAD patients (PMID:31141710)
• Dysregulation of miR-204-3p Driven by the Viability and Motility of Retinoblastoma via Wnt/beta-catenin Pathway In Vitro and In Vivo. (PMID:31482398)
• High BANCR expression is associated with metastasis in cancer (meta analysis). (PMID:31983132)
• BRAF(V600E) mutation, BRAF-activated long non-coding RNA and miR-9 expression in papillary thyroid carcinoma, and their association with clinicopathological features. (PMID:32593310)
• Elevated BANCR expression levels have different effects on papillary thyroid carcinoma progression depending on the presence of the BRAFV600E mutation. (PMID:32651027)
• High BANCR expression is associated with worse prognosis in human malignant carcinomas: an updated systematic review and meta-analysis. (PMID:32907530)
• Long noncoding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR3383p. (PMID:32945416)
• Comparison of therapeutic effects of ticagrelor and clopidogrel on patients with acute myocardial infarction and influence of lncRNA BANCR. (PMID:33336751)
• Long noncoding RNA BANCR promotes proliferation, invasion and migration in esophageal squamous cell carcinoma cells via the Raf/MEK/ERK signaling pathway. (PMID:33880577)
• lncRNA BANCR promotes the colorectal cancer metastasis through accelerating exosomes-mediated M2 macrophage polarization via regulating RhoA/ROCK signaling. (PMID:36988779)
• LncRNA BANCR promotes oral squamous cell carcinoma progression via regulating Rab1A signaling. (PMID:37433101)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.