BARX1

Summary

BARX1 (BARX homeobox 1, HGNC:955) is a protein-coding gene on chromosome 9q22.32, encoding Homeobox protein BarH-like 1 (Q9HBU1). Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis.

This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia.

Source: NCBI Gene 56033 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 38 total — 1 likely-pathogenic
• Phenotypes (HPO): 2
• MANE Select transcript: NM_021570

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:955
Approved symbol	BARX1
Name	BARX homeobox 1
Location	9q22.32
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000131668
Ensembl biotype	protein_coding
OMIM	603260
Entrez	56033

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000253968, ENST00000401724

RefSeq mRNA: 1 — MANE Select: NM_021570 NM_021570

CCDS: CCDS35070

Canonical transcript exons

ENST00000253968 — 4 exons

Exon	Start	End
ENSE00000712408	93952896	93953187
ENSE00000869833	93952729	93952813
ENSE00001185580	93954924	93955355
ENSE00001560385	93951627	93952328

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 98.95.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.4502 / max 270.2555, expressed in 181 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101503	1.2839	169
101505	0.1286	68
101504	0.0378	21

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of stomach	UBERON:0001199	98.95	gold quality
body of stomach	UBERON:0001161	92.06	gold quality
stomach	UBERON:0000945	89.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	84.03	gold quality
fundus of stomach	UBERON:0001160	83.24	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.05	gold quality
cartilage tissue	UBERON:0002418	77.22	gold quality
omental fat pad	UBERON:0010414	74.92	gold quality
peritoneum	UBERON:0002358	74.83	gold quality
adipose tissue of abdominal region	UBERON:0007808	73.05	gold quality
periodontal ligament	UBERON:0008266	71.86	silver quality
pylorus	UBERON:0001166	66.17	silver quality
cardia of stomach	UBERON:0001162	63.71	gold quality
mucosa of paranasal sinus	UBERON:0005030	63.64	gold quality
left testis	UBERON:0004533	61.01	gold quality
right testis	UBERON:0004534	60.89	gold quality
triceps brachii	UBERON:0001509	60.86	gold quality
gluteal muscle	UBERON:0002000	60.70	gold quality
upper leg skin	UBERON:0004262	60.45	silver quality
testis	UBERON:0000473	58.74	gold quality
tibia	UBERON:0000979	57.16	gold quality
superficial temporal artery	UBERON:0001614	56.43	gold quality
tendon of biceps brachii	UBERON:0008188	55.88	gold quality
nasal cavity epithelium	UBERON:0005384	55.58	gold quality
right coronary artery	UBERON:0001625	54.24	gold quality
endothelial cell	CL:0000115	54.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.11	gold quality
quadriceps femoris	UBERON:0001377	53.41	gold quality
pancreatic ductal cell	CL:0002079	52.96	silver quality
vastus lateralis	UBERON:0001379	52.70	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-8060	no	47.20
E-ANND-3	no	0.47

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

9 targets.

Target	Regulation
ADAM2
BMP2
BMP4
EMX2
FBN1
MCL1
NCAM1	Unknown
SOX9	Unknown
TPM2	Unknown

JASPAR motifs

Motif	Name	Family
MA0875.1	BARX1	NK
MA0875.2	BARX1	NK

JASPAR matrix evidence (PMIDs): PMID:18585359

Upstream regulators (CollecTRI, top): HOXA2, HOXD13, ISL1

miRNA regulators (miRDB)

10 targeting BARX1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-520E-5P	99.27	68.90	1513
HSA-MIR-4726-3P	98.49	63.89	1385
HSA-MIR-1271-3P	97.56	64.85	865
HSA-MIR-550A-3-5P	97.56	65.35	823
HSA-MIR-550A-5P	97.56	65.35	823
HSA-MIR-5694	97.06	67.70	682
HSA-MIR-874-5P	96.93	63.92	1014

Literature-anchored findings (GeneRIF, showing 10)

• PITX2, BARX1, and FOXC1 mutations were absent in De Hauwere syndrome and suggest that De Hauwere syndrome is caused by a different gene. (PMID:17486624)
• Regional expression of barx1 was observed in epithelium before mixed dentition, while during mixed dentition gene appeared in hyaline cartilage. Expression of barx1 appears in cleft lip palate affected structures mainly in mixed dentition. (PMID:18708738)
• we provide supportive evidence that genetic variants at FOXP1, BARX1, and FOXF1 confer risk for the development of EAC. (PMID:26383589)
• results suggest that genetic variants at 9q22 are associated with the risk of both esophageal adenocarcinoma/Barrett esophagus and esophageal squamous cell carcinoma, possibly by regulating the function of BARX1 (PMID:29454095)
• associated with Infantile hypertrophic pyloric stenosis risk (PMID:30281099)
• Congenital hiatal hernia segregating with a duplication in 9q22.31q22.32 in two families. (PMID:33026187)
• HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. (PMID:33451979)
• BARX1 promotes osteosarcoma cell proliferation and invasion by regulating HSPA6 expression. (PMID:36927457)
• ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC. (PMID:37587140)
• BARX1 repressed FOXF1 expression and activated Wnt/beta-catenin signaling pathway to drive lung adenocarcinoma. (PMID:38290639)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	barx1	ENSDARG00000007407
mus_musculus	Barx1	ENSMUSG00000021381
rattus_norvegicus	Barx1	ENSRNOG00000016915
drosophila_melanogaster	B-H2	FBGN0004854
drosophila_melanogaster	B-H1	FBGN0011758
caenorhabditis_elegans		WBGENE00000451
caenorhabditis_elegans		WBGENE00000452

Paralogs (3): BARX2 (ENSG00000043039), BARHL1 (ENSG00000125492), BARHL2 (ENSG00000143032)

Protein

Protein identifiers

Homeobox protein BarH-like 1 — Q9HBU1 (reviewed: Q9HBU1)

All UniProt accessions (1): Q9HBU1

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter.

Subcellular location. Nucleus.

Tissue specificity. Widely expressed. Expressed at higher levels in testis and heart. Detected in craniofacial tissue and adult iris, but not in lymphocytes, fibroblasts, choroid retina, retinal pigment epithelium, kidney, or fetal liver.

Polymorphism. The polymorphism is not associated with Axenfeld-Reiger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS) or related ocular malformations.

Similarity. Belongs to the BAR homeobox family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9HBU1-1	1	yes
Q9HBU1-2	2

RefSeq proteins (1): NP_067545* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000047	HTH_motif	Conserved_site
IPR001356	HD	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR020479	HD_metazoa	Domain
IPR050848	Homeobox_TF	Family

Pfam: PF00046

UniProt features (14 total): sequence conflict 4, helix 3, region of interest 2, chain 1, DNA-binding region 1, compositionally biased region 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2DMT	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HBU1-F1	65.51	0.24

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 94 (showing top): GOBP_EPITHELIUM_DEVELOPMENT, BENPORATH_ES_WITH_H3K27ME3, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, AP2_Q3, GOBP_CELL_CELL_SIGNALING, GOBP_DIGESTIVE_SYSTEM_DEVELOPMENT, GOBP_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION, GOBP_HEMATOPOIETIC_OR_LYMPHOID_ORGAN_DEVELOPMENT, KIM_GASTRIC_CANCER_CHEMOSENSITIVITY, chr9q22, DOUGLAS_BMI1_TARGETS_UP, HAMAI_APOPTOSIS_VIA_TRAIL_DN, GOBP_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_4, AP2GAMMA_01

GO Biological Process (11): regulation of transcription by RNA polymerase II (GO:0006357), cell-cell signaling (GO:0007267), anterior/posterior pattern specification (GO:0009952), Wnt signaling pathway (GO:0016055), negative regulation of Wnt signaling pathway (GO:0030178), endothelial cell differentiation (GO:0045446), spleen development (GO:0048536), digestive system development (GO:0055123), regulation of DNA-templated transcription (GO:0006355), tissue development (GO:0009888), animal organ development (GO:0048513)

GO Molecular Function (4): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription factor activity (GO:0003700), DNA binding (GO:0003677)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
anatomical structure development	2
transcription cis-regulatory region binding	2
transcription by RNA polymerase II	1
cell communication	1
signaling	1
regionalization	1
cell surface receptor signaling pathway	1
negative regulation of signal transduction	1
Wnt signaling pathway	1
regulation of Wnt signaling pathway	1
endothelium development	1
epithelial cell differentiation	1
hematopoietic or lymphoid organ development	1
system development	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transcription regulator activity	1
nucleic acid binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1048 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BARX1	BMP4	P12644	740
BARX1	FGF8	P55075	707
BARX1	SFRP2	Q96HF1	664
BARX1	SHH	Q15465	655
BARX1	PAX9	P55771	652
BARX1	NOG	Q13253	617
BARX1	MSX1	P28360	616
BARX1	NKX3-2	P78367	609
BARX1	LHX8	Q68G74	609
BARX1	SFRP1	Q8N474	608
BARX1	TBX22	Q9Y458	606
BARX1	FOXF1	Q12946	602
BARX1	OSR2	Q8N2R0	583
BARX1	HAND2	P61296	552
BARX1	LHX6	Q9UPM6	552

IntAct

7 interactions, top by confidence:

A	B	Type	Score
CYP17A1	BARX1	psi-mi:“MI:0915”(physical association)	0.370
BARX1	HOXD9	psi-mi:“MI:0915”(physical association)	0.370
BARX1	MAPK6	psi-mi:“MI:0915”(physical association)	0.370
BARX1	RPS6KA3	psi-mi:“MI:0915”(physical association)	0.370
FOXA3	DDX39A	psi-mi:“MI:0914”(association)	0.350
FOXS1	DDX39A	psi-mi:“MI:0914”(association)	0.350

BioGRID (13): BARX1 (Affinity Capture-MS), BARX1 (Affinity Capture-MS), BARX1 (Affinity Capture-MS), RPL14 (Cross-Linking-MS (XL-MS)), BARX1 (Proximity Label-MS), BARX1 (Proximity Label-MS), BARX1 (Proximity Label-MS), BARX1 (Proximity Label-MS), BARX1 (Two-hybrid), BARX1 (Two-hybrid), BARX1 (Reconstituted Complex), CYP17A1 (Two-hybrid), HOXD9 (Two-hybrid)

ESM2 similar proteins: A1YEV8, A1YF08, A1YG25, A1YG85, A2RU54, A2T711, A2T756, A8MTQ0, O14813, O15522, O35160, O35602, O43763, O70218, P28360, P42580, P43687, P50223, P52945, P52946, P52947, P70118, P70354, P81062, Q06348, Q2VL79, Q2VL84, Q2VL85, Q2VL87, Q2VL88, Q61663, Q62066, Q62782, Q6XYB7, Q7YRX0, Q96IS3, Q99811, Q9DED6, Q9ER42, Q9GK08

Diamond homologs: A0JPN1, A1YG85, A5PKG8, A6NJ46, A6NMT0, A7MB54, A9L937, B0VXK3, D2KQB0, E7FDX5, M0R6D8, O08686, O13023, O35762, O42365, O43364, O43711, O55144, O88181, O93366, O93367, O93590, P0C1T1, P10035, P14652, P14837, P20009, P28468, P31245, P31246, P31261, P31314, P42583, P42584, P43120, P43345, P43688, P50219, P52945, P52950

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	35
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
873324	Single allele	Likely pathogenic

SpliceAI

614 predictions. Top by Δscore:

Variant	Effect	Δscore
9:93952727:A:AC	donor_gain	1.0000
9:93952728:C:CC	donor_gain	1.0000
9:93952728:CT:C	donor_gain	1.0000
9:93952728:CTA:C	donor_gain	1.0000
9:93952809:CTATT:C	acceptor_gain	1.0000
9:93952812:TT:T	acceptor_gain	1.0000
9:93952814:C:CC	acceptor_gain	1.0000
9:93952892:CTACC:C	donor_loss	1.0000
9:93952894:A:AC	donor_gain	1.0000
9:93952894:AC:A	donor_loss	1.0000
9:93952895:C:CC	donor_gain	1.0000
9:93952895:C:CT	donor_loss	1.0000
9:93952895:CCTGT:C	donor_gain	1.0000
9:93952918:T:TA	donor_gain	1.0000
9:93952328:CCT:C	acceptor_loss	0.9900
9:93952329:CTGC:C	acceptor_loss	0.9900
9:93952722:CACT:C	donor_loss	0.9900
9:93952723:ACTC:A	donor_loss	0.9900
9:93952725:T:TA	donor_loss	0.9900
9:93952726:C:CC	donor_loss	0.9900
9:93952727:ACTA:A	donor_loss	0.9900
9:93952728:C:T	donor_loss	0.9900
9:93952728:CTAT:C	donor_gain	0.9900
9:93952737:T:TA	donor_gain	0.9900
9:93952810:TATT:T	acceptor_gain	0.9900
9:93952811:ATTC:A	acceptor_loss	0.9900
9:93952812:TTCTG:T	acceptor_loss	0.9900
9:93952813:TC:T	acceptor_loss	0.9900
9:93952814:CT:C	acceptor_loss	0.9900
9:93952815:T:G	acceptor_loss	0.9900

AlphaMissense

1621 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:93952733:T:A	K199I	1.000
9:93952735:C:A	K198N	1.000
9:93952735:C:G	K198N	1.000
9:93952736:T:A	K198M	1.000
9:93952736:T:G	K198T	1.000
9:93952737:T:C	K198E	1.000
9:93952738:C:A	W197C	1.000
9:93952738:C:G	W197C	1.000
9:93952739:C:G	W197S	1.000
9:93952740:A:G	W197R	1.000
9:93952740:A:T	W197R	1.000
9:93952741:C:A	K196N	1.000
9:93952741:C:G	K196N	1.000
9:93952743:T:C	K196E	1.000
9:93952744:C:A	M195I	1.000
9:93952744:C:G	M195I	1.000
9:93952744:C:T	M195I	1.000
9:93952745:A:C	M195R	1.000
9:93952745:A:G	M195T	1.000
9:93952745:A:T	M195K	1.000
9:93952747:C:A	R194S	1.000
9:93952747:C:G	R194S	1.000
9:93952748:C:A	R194M	1.000
9:93952748:C:G	R194T	1.000
9:93952749:T:C	R194G	1.000
9:93952751:C:A	R193L	1.000
9:93952751:C:G	R193P	1.000
9:93952752:G:A	R193W	1.000
9:93952752:G:C	R193G	1.000
9:93952753:A:C	N192K	1.000

dbSNP variants (sampled 300 via entrez): RS1000994459 (9:93956936 G>C), RS1001448225 (9:93952687 G>C), RS1001778056 (9:93956073 C>T), RS1002024232 (9:93954461 C>A,T), RS1002053091 (9:93954167 G>A,T), RS1002230320 (9:93955893 G>A), RS1002327458 (9:93951934 G>A,C), RS1002625329 (9:93956624 G>A,C), RS1003556739 (9:93951465 T>C), RS1003756282 (9:93951674 G>A,C), RS1005869802 (9:93953425 C>G,T), RS1006663608 (9:93952494 G>A,C), RS1006840477 (9:93952436 A>G), RS1007808291 (9:93953383 G>A), RS1008811561 (9:93955388 G>A,C)

Disease associations

OMIM: gene MIM:603260 | disease phenotypes: MIM:142400

GenCC curated gene-disease

Mondo (2): microcephaly (MONDO:0001149), hiatus hernia (MONDO:0007721)

Orphanet (0):

HPO phenotypes

2 total (2 of 2 shown, HPO-id order):

HPO	Term
HP:0000252	Microcephaly
HP:0002036	Hiatus hernia

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST002230_4	Barrett’s esophagus	5.000000e-06
GCST002231_5	Digestive system disease (Barrett’s esophagus and esophageal adenocarcinoma combined)	1.000000e-09
GCST002232_5	Esophageal adenocarcinoma	2.000000e-07
GCST003059_16	Parkinson’s disease	1.000000e-06
GCST006137_16	Serum folate levels	5.000000e-06
GCST006288_482	Heel bone mineral density	9.000000e-06
GCST006288_618	Heel bone mineral density	2.000000e-12
GCST006288_741	Heel bone mineral density	1.000000e-07
GCST012227_462	Hip circumference adjusted for BMI	1.000000e-08
GCST012229_70	Hip index	5.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009270	heel bone mineral density
EFO:0008039	BMI-adjusted hip circumference

MeSH disease descriptors (2)

Descriptor	Name	Tree numbers
D006551	Hernia, Hiatal	C23.300.707.960.500.467
D008831	Microcephaly	C05.660.207.620; C10.500.507.400.500; C16.131.621.207.620; C16.131.666.507.400.500

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
propionaldehyde	increases expression	1
arsenite	increases methylation	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
pentanal	increases expression	1
abrine	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Aldehydes	increases expression	1
Benzo(a)pyrene	increases methylation	1
Calcitriol	increases expression	1
Aflatoxin B1	increases methylation	1
Asbestos, Serpentine	decreases methylation	1
Asbestos, Crocidolite	decreases methylation	1
Asbestos, Amosite	decreases methylation	1
Particulate Matter	increases expression, increases abundance	1

Clinical trials (associated diseases)

67 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT00872755	PHASE4	COMPLETED	Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD)
NCT02242526	PHASE4	UNKNOWN	Biologic Versus Synthetic Mesh for Treatment of Paraesophageal Hernia
NCT04936711	PHASE4	UNKNOWN	Pain Relief After Hiatal Hernia Repair Surgery
NCT05518188	PHASE1/PHASE2	RECRUITING	Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)
NCT00001639	Not specified	COMPLETED	Evaluation of Patients With Unresolved Chromosome Abnormalities
NCT01151462	Not specified	WITHDRAWN	Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes.
NCT01565005	Not specified	COMPLETED	Microcephaly Genetic Deficiency in Neural Progenitors
NCT02510170	Not specified	COMPLETED	Fetal and Maternal Head Circumference During Pregnancy in Israeli Population
NCT02741882	Not specified	COMPLETED	Zika and Microcephaly: Case-control Study
NCT02943304	Not specified	COMPLETED	Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
NCT03255369	Not specified	UNKNOWN	Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF)
NCT03325946	Not specified	RECRUITING	The FBRI VTC Neuromotor Research Clinic
NCT03330600	Not specified	COMPLETED	Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome
NCT03548779	Not specified	COMPLETED	North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
NCT03651687	Not specified	COMPLETED	Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM)
NCT03922594	Not specified	TERMINATED	Surveillance of Zika-related Microcephaly in Sub-Saharan Africa and Asia
NCT04816175	Not specified	COMPLETED	Intensive Therapy for Children With Microcephaly, Hyperkinetic Movements, or Global Developmental Delay
NCT05322980	Not specified	COMPLETED	Summary of Infants Weighing 500 Grams or Less
NCT06019182	Not specified	RECRUITING	MEHMO Natural History and Biomarkers
NCT06566066	Not specified	RECRUITING	Register for Patients With Thyroid Hormone Resistance.
NCT02328248	PHASE2/PHASE3	UNKNOWN	Usage of Biological Patch Versus Plastic in the Laparoscopic Repair of Hiatal Hernias
NCT00155805	Not specified	UNKNOWN	Immunologic Factors in Reflux Esophagitis and Barrett’s Esophagus
NCT00260585	Not specified	RECRUITING	Esophageal Cancer Risk Registry
NCT00287612	Not specified	COMPLETED	Necessity of Esophageal Dissection During Laparoscopic Fundoplication
NCT00507377	Not specified	COMPLETED	Foreshortened Esophagus and Its Surgical Therapy
NCT00786084	Not specified	UNKNOWN	Study of Paraesophageal Hernia Repair With Small Intestine Submucosa
NCT01099033	Not specified	COMPLETED	The Biologic Basis of Hernia Formation
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