BATF3

Summary

BATF3 (basic leucine zipper ATF-like transcription factor 3, HGNC:28915) is a protein-coding gene on chromosome 1q32.3, encoding Basic leucine zipper transcriptional factor ATF-like 3 (Q9NR55). AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system.

This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.

Source: NCBI Gene 55509 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 14 total
• MANE Select transcript: NM_018664

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28915
Approved symbol	BATF3
Name	basic leucine zipper ATF-like transcription factor 3
Location	1q32.3
Locus type	gene with protein product
Status	Approved
Aliases	JUNDM1, SNFT, JDP1
Ensembl gene	ENSG00000123685
Ensembl biotype	protein_coding
OMIM	612470
Entrez	55509

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding_CDS_not_defined, 1 protein_coding

ENST00000243440, ENST00000471382, ENST00000478275

RefSeq mRNA: 1 — MANE Select: NM_018664 NM_018664

CCDS: CCDS1508

Canonical transcript exons

ENST00000243440 — 3 exons

Exon	Start	End
ENSE00000792272	212696961	212697065
ENSE00001162929	212699673	212699840
ENSE00003532676	212686417	212686979

Expression profiles

Bgee: expression breadth ubiquitous, 191 present calls, max score 90.13.

FANTOM5 (CAGE): breadth broad, TPM avg 5.3161 / max 490.8869, expressed in 697 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17419	1.7121	212
17422	1.1055	387
17420	1.0384	123
17418	0.7703	146
17421	0.4343	133
17423	0.2371	98
17403	0.0136	6
17404	0.0046	2

Top tissues by expression

270 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.13	gold quality
spleen	UBERON:0002106	84.49	gold quality
nucleus accumbens	UBERON:0001882	83.66	gold quality
monocyte	CL:0000576	82.62	gold quality
granulocyte	CL:0000094	82.46	gold quality
putamen	UBERON:0001874	82.19	gold quality
mononuclear cell	CL:0000842	82.16	gold quality
caudate nucleus	UBERON:0001873	82.13	gold quality
leukocyte	CL:0000738	82.01	gold quality
omental fat pad	UBERON:0010414	80.82	gold quality
peritoneum	UBERON:0002358	80.77	gold quality
upper lobe of left lung	UBERON:0008952	80.21	gold quality
adipose tissue of abdominal region	UBERON:0007808	80.00	gold quality
cingulate cortex	UBERON:0003027	79.90	gold quality
anterior cingulate cortex	UBERON:0009835	79.89	gold quality
prefrontal cortex	UBERON:0000451	78.90	gold quality
right coronary artery	UBERON:0001625	78.90	gold quality
right frontal lobe	UBERON:0002810	78.83	gold quality
lymph node	UBERON:0000029	78.09	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.82	gold quality
upper lobe of lung	UBERON:0008948	77.69	gold quality
cervix squamous epithelium	UBERON:0006922	77.52	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.44	gold quality
left coronary artery	UBERON:0001626	77.34	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.31	gold quality
coronary artery	UBERON:0001621	76.94	gold quality
choroid plexus epithelium	UBERON:0003911	76.88	gold quality
telencephalon	UBERON:0001893	76.74	gold quality
type B pancreatic cell	CL:0000169	76.59	gold quality
frontal cortex	UBERON:0001870	76.52	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-HCAD-32	yes	242.81
E-HCAD-1	yes	20.73
E-MTAB-6701	yes	20.58
E-CURD-88	yes	8.63
E-MTAB-10042	yes	7.97
E-MTAB-6678	yes	7.13
E-ANND-3	yes	4.57

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

4 targets.

Target	Regulation
CD8A
IL2	Repression
MMP1	Repression
TPM1

JASPAR motifs

Motif	Name	Family
MA0835.2	BATF3	B-ATF-related factors
MA0835.3	BATF3	B-ATF-related factors

JASPAR matrix evidence (PMIDs): PMID:29588546

Upstream regulators (CollecTRI, top): FOS, JUN

miRNA regulators (miRDB)

39 targeting BATF3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-4677-3P	99.49	67.91	1246
HSA-MIR-7849-3P	99.47	68.17	1224
HSA-MIR-4777-5P	99.33	67.53	1148
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-3125	99.14	68.49	2269
HSA-MIR-6749-3P	99.00	65.73	1443
HSA-MIR-6859-5P	98.99	68.07	2049
HSA-MIR-3916	98.99	68.04	2155
HSA-MIR-3154	98.94	66.55	1455
HSA-MIR-3194-3P	98.83	66.22	1167
HSA-MIR-760	98.81	66.65	1392
HSA-MIR-4297	98.77	66.95	2013

Literature-anchored findings (GeneRIF, showing 13)

• correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions (PMID:12087103)
• overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80% (PMID:15467742)
• Batf3-dependent dendritic cells elicit the rejection of cells and grafts expressing mismatched minor histocompatibility antigens. (PMID:26034174)
• The authors identified highly significant associations with better melanoma overall survival for rs6673928, impacting IL19 expression (HR, 0.56; 95% CI, 0.41-0.77; P = 0.0002) and rs6695772, controlling the expression of BATF3 (HR, 1.64; 95% CI, 1.19-2.24; P = 0.0019). (PMID:26733611)
• Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3), an AP-1 family transcription factor, is a glucocorticoid receptor coregulator whose interaction with glucocorticoid receptor is modulated by the lever arm. (PMID:28708849)
• Circular RNA circ_0034642/miR-1205/BATF3 pathway may play an important role in glioma. (PMID:30551880)
• Upregulation of circular RNA circ_0034642 indicates unfavorable prognosis in glioma and facilitates cell proliferation and invasion via the miR-1205/BATF3 axis. (PMID:30938850)
• These findings identify the importance of tumor cell oncogene activity in modulating the Batf3-dependent dendritic cell lineage. (PMID:31000683)
• BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis. (PMID:33057139)
• Long noncoding RNA LINC01638 contributes to laryngeal squamous cell cancer progression by modulating miR-523-5p/BATF3 axis. (PMID:33714208)
• Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma. (PMID:34552066)
• The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling. (PMID:36409527)
• siRNA-mediated downregulation of BATF3 diminished proliferation and induced apoptosis through downregulating c-Myc expression in chronic myelogenous leukemia cells. (PMID:38217769)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	batf3	ENSDARG00000042577
mus_musculus	Batf3	ENSMUSG00000026630
rattus_norvegicus	Batf3	ENSRNOG00000003716
drosophila_melanogaster	Atf3	FBGN0028550

Paralogs (8): FOSL2 (ENSG00000075426), FOSB (ENSG00000125740), JDP2 (ENSG00000140044), BATF (ENSG00000156127), ATF3 (ENSG00000162772), BATF2 (ENSG00000168062), FOS (ENSG00000170345), FOSL1 (ENSG00000175592)

Protein

Protein identifiers

Basic leucine zipper transcriptional factor ATF-like 3 — Q9NR55 (reviewed: Q9NR55)

Alternative names: 21 kDa small nuclear factor isolated from T-cells, Jun dimerization protein p21SNFT

All UniProt accessions (1): Q9NR55

UniProt curated annotations — full annotation on UniProt →

Function. AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5’-TGA[CG]TCA-3’ and regulates expression of target genes.

Subunit / interactions. Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.

Subcellular location. Nucleus.

Similarity. Belongs to the bZIP family.

RefSeq proteins (1): NP_061134* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000837	AP-1	Family
IPR004827	bZIP	Domain
IPR046347	bZIP_sf	Homologous_superfamily

Pfam: PF00170

UniProt features (9 total): region of interest 3, modified residue 2, chain 1, domain 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NR55-F1	83.05	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 31

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 232 (showing top): GOBP_MYELOID_CELL_DIFFERENTIATION, GOBP_DENDRITIC_CELL_DIFFERENTIATION, BENPORATH_ES_WITH_H3K27ME3, DARWICHE_SKIN_TUMOR_PROMOTER_UP, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_UP, RACCACAR_AML_Q6, DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN, GOBP_MYELOID_LEUKOCYTE_DIFFERENTIATION, USF_C, GOLDRATH_ANTIGEN_RESPONSE, ZHAN_MULTIPLE_MYELOMA_CD1_UP, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, GOBP_MYELOID_LEUKOCYTE_ACTIVATION, AML_Q6

GO Biological Process (7): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), response to virus (GO:0009615), myeloid dendritic cell differentiation (GO:0043011), dendritic cell differentiation (GO:0097028), integrated stress response signaling (GO:0140467), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DNA-binding transcription factor activity (GO:0003700), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (6): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), RNA polymerase II transcription regulator complex (GO:0090575)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
cellular anatomical structure	3
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
regulation of DNA-templated transcription	2
nuclear lumen	2
negative regulation of DNA-templated transcription	1
response to other organism	1
myeloid dendritic cell activation	1
myeloid leukocyte differentiation	1
dendritic cell differentiation	1
mononuclear cell differentiation	1
cellular response to stress	1
intracellular signaling cassette	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
chromosome	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
cytoplasm	1
transcription regulator complex	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

1740 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BATF3	MPPE1	Q53F39	865
BATF3	JUN	P05412	854
BATF3	ITGAX	P20702	802
BATF3	IRF8	Q02556	796
BATF3	ITGAE	P38570	794
BATF3	XCR1	P46094	775
BATF3	IRF4	Q15306	744
BATF3	CLEC9A	Q6UXN8	733
BATF3	ZBTB46	Q86UZ6	712
BATF3	CD8A	P01732	693
BATF3	TLR3	O15455	689
BATF3	ITGAM	P11215	641
BATF3	ID2	Q02363	632
BATF3	THBD	P07204	612
BATF3	FLT3LG	P49771	610

IntAct

94 interactions, top by confidence:

A	B	Type	Score
JUN	ATF2	psi-mi:“MI:0914”(association)	0.950
JUNB	BATF3	psi-mi:“MI:0407”(direct interaction)	0.880
BATF3	JUNB	psi-mi:“MI:0407”(direct interaction)	0.880
JUNB	BATF3	psi-mi:“MI:0915”(physical association)	0.880
JUN	BATF3	psi-mi:“MI:0407”(direct interaction)	0.870
BATF3	JUN	psi-mi:“MI:0407”(direct interaction)	0.870
BATF3	DDIT3	psi-mi:“MI:0407”(direct interaction)	0.820
DDIT3	BATF3	psi-mi:“MI:0915”(physical association)	0.820
DDIT3	BATF3	psi-mi:“MI:0407”(direct interaction)	0.820
BACH2	BATF3	psi-mi:“MI:0915”(physical association)	0.810
BATF3	BACH2	psi-mi:“MI:0407”(direct interaction)	0.810
ATF2	BATF3	psi-mi:“MI:0407”(direct interaction)	0.780
IFIT2	IFIT3	psi-mi:“MI:0914”(association)	0.780
BATF3	ATF2	psi-mi:“MI:0407”(direct interaction)	0.780
BATF3	ATF3	psi-mi:“MI:0407”(direct interaction)	0.710
ATF3	BATF3	psi-mi:“MI:0407”(direct interaction)	0.710
ATF3	BATF3	psi-mi:“MI:0915”(physical association)	0.710
JUND	BATF3	psi-mi:“MI:0407”(direct interaction)	0.690
BATF3	JUND	psi-mi:“MI:0407”(direct interaction)	0.690

BioGRID (104): BATF3 (Two-hybrid), BATF3 (Two-hybrid), BATF3 (Two-hybrid), BATF3 (Two-hybrid), BATF3 (Affinity Capture-MS), JUNB (Affinity Capture-MS), BACH2 (Affinity Capture-MS), ATF7 (Affinity Capture-MS), LDOC1L (Affinity Capture-MS), ZNF451 (Affinity Capture-MS), JUND (Affinity Capture-MS), ATF2 (Affinity Capture-MS), BACH1 (Affinity Capture-MS), ZBTB10 (Affinity Capture-MS), JUN (Affinity Capture-MS)

ESM2 similar proteins: A1L2X1, D4A7E1, E1BD44, F1QW76, F7EMX9, G5ECU7, G5EF76, O09015, O35284, O57598, O96642, P13096, P13097, P13098, P13903, P46505, P50539, P50540, P50541, P97831, P97876, Q00P32, Q01068, Q01069, Q01070, Q01071, Q04788, Q05195, Q07291, Q09771, Q09926, Q0VFI9, Q0VH34, Q10574, Q16520, Q18711, Q21361, Q23579, Q62282, Q8AW52

Diamond homologs: A1L2X1, B4PPK2, D4A7E1, E1BD44, F1QW76, F7EMX9, O02761, O35284, O77628, O88479, O97930, P01100, P01101, P01102, P11939, P12841, P18847, P23050, P29176, P53450, P79702, P97876, Q16520, Q2KII1, Q56TN0, Q56TT7, Q8HZP6, Q8N1L9, Q91496, Q9D275, Q9NR55, Q9Z2Q8, P29596, Q60765, Q6DGM8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 37 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Response of EIF2AK1 (HRI) to heme deficiency	5	132.2×	5e-08
ATF4 activates genes in response to endoplasmic reticulum stress	5	75.5×	5e-07
Cellular response to starvation	5	30.6×	2e-05
Response of EIF2AK4 (GCN2) to amino acid deficiency	6	24.6×	6e-06
Regulation of PD-L1(CD274) transcription	5	20.1×	7e-05
Signaling by Interleukins	6	14.3×	6e-05
Cellular responses to stress	8	10.9×	2e-05
Cellular responses to stimuli	8	9.3×	3e-05

GO biological processes:

GO term	Partners	Fold	FDR
integrated stress response signaling	12	263.3×	3e-25
liver development	5	34.6×	2e-05
response to endoplasmic reticulum stress	5	26.1×	6e-05
regulation of cell population proliferation	6	21.6×	2e-05
regulation of cell cycle	6	14.0×	1e-04
positive regulation of gene expression	8	9.7×	6e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

14 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	10
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

654 predictions. Top by Δscore:

Variant	Effect	Δscore
1:212686975:TATTC:T	acceptor_gain	1.0000
1:212686976:ATTC:A	acceptor_gain	1.0000
1:212686977:TTC:T	acceptor_gain	1.0000
1:212686978:TC:T	acceptor_gain	1.0000
1:212686978:TCCTG:T	acceptor_loss	1.0000
1:212686979:CC:C	acceptor_gain	1.0000
1:212686980:C:CC	acceptor_gain	1.0000
1:212686980:CTGG:C	acceptor_loss	1.0000
1:212686981:T:A	acceptor_loss	1.0000
1:212696957:TCA:T	donor_loss	1.0000
1:212696958:CACC:C	donor_loss	1.0000
1:212696959:A:C	donor_loss	1.0000
1:212696960:CCTC:C	donor_loss	1.0000
1:212686980:C:T	acceptor_gain	0.9900
1:212697064:CT:C	acceptor_gain	0.9900
1:212697066:C:CC	acceptor_gain	0.9900
1:212699667:CTCTA:C	donor_loss	0.9900
1:212699668:TCTA:T	donor_loss	0.9900
1:212699669:CTAC:C	donor_loss	0.9900
1:212699670:TA:T	donor_loss	0.9900
1:212699671:ACCT:A	donor_loss	0.9900
1:212699672:C:CT	donor_loss	0.9900
1:212699672:CCTG:C	donor_gain	0.9900
1:212696960:CCT:C	donor_gain	0.9800
1:212697062:GGCT:G	acceptor_gain	0.9800
1:212697065:TCTGG:T	acceptor_loss	0.9800
1:212697066:CTGG:C	acceptor_loss	0.9800
1:212697067:T:A	acceptor_loss	0.9800
1:212699665:C:CA	donor_gain	0.9800
1:212699675:G:A	donor_gain	0.9800

AlphaMissense

824 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:212686924:A:G	L84P	1.000
1:212686966:A:G	L70P	1.000
1:212696966:G:C	H64D	1.000
1:212696968:A:G	L63P	1.000
1:212696978:C:G	A60P	1.000
1:212696998:C:A	R53L	1.000
1:212696998:C:G	R53P	1.000
1:212696998:C:T	R53Q	1.000
1:212696999:G:A	R53W	1.000
1:212696999:G:C	R53G	1.000
1:212697000:A:C	S52R	1.000
1:212697000:A:T	S52R	1.000
1:212697002:T:G	S52R	1.000
1:212697003:T:A	R51S	1.000
1:212697003:T:G	R51S	1.000
1:212697010:G:A	A49V	1.000
1:212697010:G:T	A49D	1.000
1:212697011:C:G	A49P	1.000
1:212697013:G:T	A48D	1.000
1:212697014:C:G	A48P	1.000
1:212697019:C:G	R46P	1.000
1:212697020:G:C	R46G	1.000
1:212697021:G:C	N45K	1.000
1:212697021:G:T	N45K	1.000
1:212697022:T:C	N45S	1.000
1:212697023:T:C	N45D	1.000
1:212697030:T:A	R42S	1.000
1:212697030:T:G	R42S	1.000
1:212697033:C:A	R41S	1.000
1:212697033:C:G	R41S	1.000

dbSNP variants (sampled 300 via entrez): RS1000156045 (1:212685979 G>A), RS1000207982 (1:212686263 G>A,C), RS1000236003 (1:212689987 TACAC>T), RS1000338125 (1:212692626 T>C), RS1000494757 (1:212687344 C>G), RS1000731123 (1:212694321 G>C,T), RS1000793978 (1:212692966 C>G), RS1000822850 (1:212696089 T>C), RS1000841495 (1:212700438 G>A,T), RS1000934455 (1:212700186 G>A,C,T), RS1001399555 (1:212691519 T>C), RS1001453736 (1:212686468 G>A), RS1001744725 (1:212691005 C>T), RS1001869903 (1:212691659 C>A,T), RS1002095561 (1:212697586 C>A,T)

Disease associations

OMIM: gene MIM:612470 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST002772_11	Leprosy	3.000000e-08
GCST006202_1	Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232)	1.000000e-06
GCST009597_275	Multiple sclerosis	9.000000e-14
GCST010042_107	Asthma	4.000000e-08
GCST010043_92	Asthma	3.000000e-08
GCST90014023_15	Type 1 diabetes	4.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	7
(+)-JQ1 compound	decreases expression	4
Benzo(a)pyrene	decreases expression, increases expression, increases methylation	4
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
Aflatoxin B1	increases expression	2
FR900359	increases phosphorylation	1
sotorasib	affects cotreatment, decreases expression	1
methyleugenol	increases expression	1
propionaldehyde	increases expression	1
bisphenol A	affects cotreatment, increases methylation	1
sulforaphane	increases expression	1
butyraldehyde	increases expression	1
perfluorooctanoic acid	increases expression	1
zinc chromate	increases abundance, decreases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
diallyl trisulfide	increases expression	1
pentanal	increases expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	increases expression	1
trametinib	affects cotreatment, decreases expression	1
NVP-BKM120	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Panobinostat	affects expression, affects cotreatment	1
Acetaminophen	increases expression	1
Aldehydes	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A0H2	SEES3-1V human BATF3, clone1	Embryonic stem cell	Male
CVCL_A0H3	SEES3-1V human BATF3, clone2	Embryonic stem cell	Male
CVCL_A0H4	SEES3-1V human BATF3, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.