BBOX1-AS1

Summary

BBOX1-AS1 (BBOX1 antisense RNA 1, HGNC:50700) is a long non-coding RNA gene on chromosome 11p14.2-p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50700
Approved symbol	BBOX1-AS1
Name	BBOX1 antisense RNA 1
Location	11p14.2-p14.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254560
Ensembl biotype	lncRNA
Entrez	103695435
RNAcentral	URS00007E3393 — lncRNA, 943 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000525302, ENST00000526061, ENST00000530430, ENST00000531363, ENST00000670273, ENST00000721017, ENST00000721018, ENST00000721019, ENST00000721020, ENST00000721021, ENST00000721022, ENST00000721023, ENST00000721024, ENST00000721025, ENST00000721026, ENST00000721027, ENST00000721028, ENST00000721029, ENST00000721030, ENST00000721031

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000525302 — 5 exons

Exon	Start	End
ENSE00002162382	27151050	27151152
ENSE00002172446	27066492	27066662
ENSE00002185403	27062983	27063060
ENSE00002196313	27220047	27220113
ENSE00002199917	27217317	27217480

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 90.67.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0692 / max 7.8975, expressed in 18 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119047	0.0692	18

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	90.67	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.85	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.62	gold quality
pancreatic ductal cell	CL:0002079	70.51	silver quality
oocyte	CL:0000023	70.04	gold quality
secondary oocyte	CL:0000655	70.02	silver quality
lower esophagus mucosa	UBERON:0035834	68.68	gold quality
cortical plate	UBERON:0005343	67.89	gold quality
spleen	UBERON:0002106	67.49	gold quality
ventricular zone	UBERON:0003053	66.79	gold quality
urinary bladder	UBERON:0001255	66.13	gold quality
adult mammalian kidney	UBERON:0000082	65.48	gold quality
right adrenal gland cortex	UBERON:0035827	64.72	gold quality
apex of heart	UBERON:0002098	64.34	gold quality
esophagus mucosa	UBERON:0002469	64.10	gold quality
right adrenal gland	UBERON:0001233	63.97	gold quality
tibialis anterior	UBERON:0001385	63.42	silver quality
nasal cavity mucosa	UBERON:0001826	63.23	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.79	gold quality
gall bladder	UBERON:0002110	62.27	gold quality
muscle of leg	UBERON:0001383	62.05	gold quality
placenta	UBERON:0001987	61.69	gold quality
gastrocnemius	UBERON:0001388	61.63	gold quality
left adrenal gland	UBERON:0001234	61.57	gold quality
epithelium of nasopharynx	UBERON:0001951	61.53	gold quality
monocyte	CL:0000576	61.50	gold quality
ileal mucosa	UBERON:0000331	61.47	silver quality
granulocyte	CL:0000094	61.15	gold quality
endothelial cell	CL:0000115	61.08	gold quality
lymph node	UBERON:0000029	61.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 15)

• BBOX1-AS1 contributes to colorectal cancer progression by sponging hsa-miR-361-3p and targeting SH2B1. (PMID:31984680)
• LncRNA BBOX1-AS1 Aggravates the Development of Ovarian Cancer by Sequestering miR-361-3p to Augment PODXL Expression. (PMID:33159291)
• Identification of a Prognostic Colorectal Cancer Model Including LncRNA FOXP4-AS1 and LncRNA BBOX1-AS1 Based on Bioinformatics Analysis. (PMID:33481661)
• Targeted regulation of BBOX1-AS1 on miR-361-3p and its effect on the biological function of non-small cell lung cancer cell. (PMID:34278772)
• Long non-coding RNA BBOX1 antisense RNA 1 increases the apoptosis of granulosa cells in premature ovarian failure by sponging miR-146b. (PMID:35188872)
• LncRNA BBOX1-AS1 promotes pituitary adenoma progression via sponging miR-361-3p/E2F1 axis. (PMID:35324526)
• Long non-coding RNA BBOX1-AS1 exacerbates esophageal squamous cell carcinoma development by regulating HOXB7/beta-catenin axis. (PMID:35351402)
• lncRNA BBOX1-AS1 silencing inhibits esophageal squamous cell cancer progression by promoting ferroptosis via miR-513a-3p/SLC7A11 axis. (PMID:36216119)
• LncRNA BBOX1-AS1 Contributes to the Progression of Esophageal Carcinoma by Targeting the miR-361-3p/COL5A1 Axis. (PMID:36586008)
• BBOX1-AS1 mediates trophoblast cells dysfunction via regulating hnRNPK/GADD45A axisdagger. (PMID:36617174)
• Long noncoding RNA BBOX1-AS1 promotes the progression of gastric cancer by regulating the miR-361-3p/Mucin 13 signaling axis. (PMID:36700475)
• BBOX1-AS1 Activates Hedgehog Signaling Pathway to Facilitate the Proliferation and Stemness of Esophageal Squamous Cell Carcinoma Cells via miR-506-5p/EIF5A/PTCH1 Axis. (PMID:36717994)
• LncRNA BBOX1-AS1 Contributes to the Development of Nasopharyngeal Carcinoma via miR-204-5p/MUC4 Axis. (PMID:37437933)
• Regulation of tumorigenesis and ferroptosis in non-small cell lung cancer by a novel BBOX1-AS1/miR-326/PROM2 axis. (PMID:37639200)
• The long non-coding RNA BBOX1 antisense RNA 1 is upregulated in polycystic ovary syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian granulose cells : Short title: BBOX1 antisense RNA 1 in cell proliferation. (PMID:37735639)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.