BCL2L14

Summary

BCL2L14 (BCL2 like 14, HGNC:16657) is a protein-coding gene on chromosome 12p13.2, encoding Apoptosis facilitator Bcl-2-like protein 14 (Q9BZR8). Plays a role in apoptosis.

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene.

Source: NCBI Gene 79370 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_138723

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16657
Approved symbol	BCL2L14
Name	BCL2 like 14
Location	12p13.2
Locus type	gene with protein product
Status	Approved
Aliases	BCLG, BCL-G
Ensembl gene	ENSG00000121380
Ensembl biotype	protein_coding
OMIM	606126
Entrez	79370

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 17 protein_coding, 5 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000266434, ENST00000298566, ENST00000308721, ENST00000396367, ENST00000461264, ENST00000464885, ENST00000466531, ENST00000479717, ENST00000484949, ENST00000545463, ENST00000586576, ENST00000588270, ENST00000589718, ENST00000591235, ENST00000864816, ENST00000864818, ENST00000864819, ENST00000864821, ENST00000864823, ENST00000864825, ENST00000864827, ENST00000955330, ENST00000955331

RefSeq mRNA: 5 — MANE Select: NM_138723 NM_001370268, NM_001370269, NM_030766, NM_138722, NM_138723

CCDS: CCDS8645, CCDS8646

Canonical transcript exons

ENST00000308721 — 6 exons

Exon	Start	End
ENSE00000822019	12087213	12087386
ENSE00000822020	12090779	12090849
ENSE00001346602	12094664	12094930
ENSE00001812597	12070939	12071137
ENSE00003475500	12098950	12099695
ENSE00003557359	12079299	12079738

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 93.67.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5318 / max 60.5576, expressed in 145 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124290	0.2604	81
124292	0.1261	65
124289	0.0573	21
124287	0.0416	3
124291	0.0317	13
124286	0.0065	3
124288	0.0045	3
206627	0.0036	2

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	93.67	gold quality
duodenum	UBERON:0002114	91.45	gold quality
left testis	UBERON:0004533	89.18	gold quality
right testis	UBERON:0004534	89.13	gold quality
testis	UBERON:0000473	88.69	gold quality
mucosa of transverse colon	UBERON:0004991	87.70	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.74	gold quality
colonic epithelium	UBERON:0000397	81.61	gold quality
transverse colon	UBERON:0001157	79.20	gold quality
small intestine	UBERON:0002108	78.54	gold quality
body of pancreas	UBERON:0001150	78.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.46	gold quality
vermiform appendix	UBERON:0001154	77.26	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.84	gold quality
stomach	UBERON:0000945	74.57	gold quality
body of stomach	UBERON:0001161	74.44	gold quality
pancreas	UBERON:0001264	74.40	gold quality
gall bladder	UBERON:0002110	73.73	gold quality
intestine	UBERON:0000160	71.40	gold quality
lymph node	UBERON:0000029	68.58	gold quality
colon	UBERON:0001155	67.91	gold quality
islet of Langerhans	UBERON:0000006	67.13	gold quality
tonsil	UBERON:0002372	65.92	gold quality
fundus of stomach	UBERON:0001160	65.78	gold quality
sural nerve	UBERON:0015488	63.12	silver quality
urinary bladder	UBERON:0001255	62.88	gold quality
prostate gland	UBERON:0002367	61.19	gold quality
liver	UBERON:0002107	60.83	gold quality
saliva-secreting gland	UBERON:0001044	60.69	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7381	yes	247.91
E-ANND-3	no	2.63

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTCF, STAT1, TP53

miRNA regulators (miRDB)

62 targeting BCL2L14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-498-3P	99.91	71.27	1114
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-221-3P	99.86	71.56	1329
HSA-MIR-222-3P	99.86	71.35	1337
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-4679	99.76	69.19	1229
HSA-MIR-4645-3P	99.76	69.33	993
HSA-MIR-3177-5P	99.65	70.38	1174
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-7159-3P	99.51	70.17	1920
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-125A-5P	99.36	70.59	1640
HSA-MIR-125B-5P	99.36	70.36	1662
HSA-MIR-4312	99.34	67.30	511

Literature-anchored findings (GeneRIF, showing 14)

• There was no somatic mutation of BH3 domains of Bad, Bmf and Bcl-G genes in transitional cell carcinoma samples. The data presented here indicate that BH3 domain mutation of these genes is rare in TCCs and may not contribute to the pathogenesis of TCCs. (PMID:16484005)
• the kinase activity of MELK is likely to affect mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL (PMID:17280616)
• data presented here indicate that BH3 domain mutation of the proapoptotic genes Bad, Bmf and Bcl-G is rare in laryngeal squamous cell carcinoma and may not contribute to the apoptosis-resistance mechanisms of laryngeal squamous cell carcinoma (PMID:17557568)
• JAB1 is involved in the regulation of mitochondrial apoptotic pathway through specific interaction with BclGs. (PMID:18006276)
• Increased BclG(L) expression may contribute to the aberrant CD4+ T cell apoptosis which causes an inappropriate immune response and impaired homeostasis in systemic lupus erythematosus. (PMID:19524489)
• siRNA downregulation of Bcl-G inhibited breast cancer cell apoptosis. Adding an siRNA against Fau revealed control of Bcl-G by Fau. The most important factors controlling Bcl-G are post-translational modification by Fau & MELK, not transcription rate. (PMID:19671159)
• prior knockdown of Bcl-G expression ablates the stimulation of basal apoptosis by FAU, consistent with an essential downstream role for Bcl-G, itself a candidate tumour suppressor, in mediating the apoptosis regulatory role of FAU. (PMID:21550398)
• Single nucleotide polymorphism in BCL2L14 is associated with lung cancer. (PMID:22573796)
• Data indicate that LRP6, BCL2L14, DUSP16, CREBL2, and CDKN1B were involed in centromeric (12p11.21-12p13.2) deletion in ETV6-RUNX1 B-cell precursor acute lymphoblastic leukemia (BCP-ALL). (PMID:23077088)
• The results show that BCLG is overexpressed more frequently in medullary breast carcinoma than other histological types of basal like carcinomas. (PMID:30075151)
• BCL2L14 knockdown exhibited similar effects similar to those of miR-496 overexpression, and the restored BCL2L14expression reversed the protective effects of miR-496 on SH-SY5Y cells (PMID:30597231)
• Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. (PMID:31296963)
• Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-gamma and TNF-alpha in intestinal epithelial cells. (PMID:31988296)
• these data reveal adjacent gene rearrangements as a class of underexplored genetic aberrations that could be pathological in breast cancer, and identify BCL2L14-ETV6 as a recurrent gene fusion in more aggressive form of Triple-negative breast cancer tumor (PMID:32321829)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000090401
mus_musculus	Bcl2l14	ENSMUSG00000030200
rattus_norvegicus	Bcl2l14	ENSRNOG00000028632

Paralogs (1): BCL2L12 (ENSG00000126453)

Protein

Protein identifiers

Apoptosis facilitator Bcl-2-like protein 14 — Q9BZR8 (reviewed: Q9BZR8)

Alternative names: Apoptosis regulator Bcl-G

All UniProt accessions (6): A0A140VJF2, C9J3S1, C9K0Q9, Q9BZR8, K7EKK7, K7EMX4

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in apoptosis.

Subcellular location. Cytoplasm Cytoplasm. Cytosol Endomembrane system.

Tissue specificity. Isoform 1 is widely expressed. Isoform 2 is testis-specific.

Post-translational modifications. Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the Bcl-2 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9BZR8-1	1, Bcl-Gl, Long	yes
Q9BZR8-2	2, Bcl-Gs, Short
Q9BZR8-3	3, Median

RefSeq proteins (5): NP_001357197, NP_001357198, NP_110393, NP_620048, NP_620049* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002475	Bcl2-like	Family
IPR036834	Bcl-2-like_sf	Homologous_superfamily

UniProt features (8 total): splice variant 4, short sequence motif 2, chain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BZR8-F1	62.91	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 44

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-212436	Generic Transcription Pathway
R-HSA-3700989	Transcriptional Regulation by TP53
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)

MSigDB gene sets: 158 (showing top): GSE45365_NK_CELL_VS_BCELL_DN, MODULE_255, MODULE_317, GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, WANG_RESPONSE_TO_BEXAROTENE_UP, GOBP_APOPTOTIC_SIGNALING_PATHWAY, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2, GOBP_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, PID_P53_DOWNSTREAM_PATHWAY, GOBP_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY, TGGAAA_NFAT_Q4_01, GOBP_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY, MODULE_69, COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP

GO Biological Process (3): apoptotic process (GO:0006915), regulation of apoptotic process (GO:0042981), positive regulation of extrinsic apoptotic signaling pathway (GO:2001238)

GO Molecular Function (2): protein kinase binding (GO:0019901), protein binding (GO:0005515)

GO Cellular Component (5): cytosol (GO:0005829), endomembrane system (GO:0012505), intracellular organelle (GO:0043229), cytoplasm (GO:0005737), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
TP53 Regulates Transcription of Cell Death Genes	1
RNA Polymerase II Transcription	1
Generic Transcription Pathway	1
Transcriptional Regulation by TP53	1
Gene expression (Transcription)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
intracellular anatomical structure	2
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
apoptotic process	1
regulation of programmed cell death	1
extrinsic apoptotic signaling pathway	1
positive regulation of apoptotic signaling pathway	1
regulation of extrinsic apoptotic signaling pathway	1
kinase binding	1
binding	1
cytoplasm	1
vacuole	1
plasma membrane	1
organelle	1

Protein interactions and networks

STRING

938 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BCL2L14	FAU	P35544	880
BCL2L14	BCL2L1	Q07817	695
BCL2L14	BCL2	P10415	641
BCL2L14	BCL2L15	Q5TBC7	625
BCL2L14	BCL2L13	Q9BXK5	595
BCL2L14	BOK	Q9UMX3	587
BCL2L14	BCL2A1	Q16548	579
BCL2L14	MANSC1	Q9H8J5	535
BCL2L14	BCL2L10	Q9HD36	527
BCL2L14	LRP6	O75581	498
BCL2L14	HRK	O00198	480
BCL2L14	BCL2L2-PABPN1	Q92843	476
BCL2L14	AGBL4	Q5VU57	447
BCL2L14	CASP2	P42575	437
BCL2L14	CHADL	Q6NUI6	427

IntAct

21 interactions, top by confidence:

A	B	Type	Score
MELK	BCL2L14	psi-mi:“MI:0915”(physical association)	0.650
BCL2L14	MELK	psi-mi:“MI:0915”(physical association)	0.650
MELK	BCL2L14	psi-mi:“MI:0407”(direct interaction)	0.650
BCL2L14	MELK	psi-mi:“MI:0217”(phosphorylation reaction)	0.650
BCL2L14	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
DDIT4L	BCL2L14	psi-mi:“MI:0915”(physical association)	0.560
TEPSIN	BCL2L14	psi-mi:“MI:0915”(physical association)	0.560
BCL2L14	PICK1	psi-mi:“MI:0915”(physical association)	0.560
BCL2L14	CHEK1	psi-mi:“MI:0914”(association)	0.530
LGALS3BP	BCL2L14	psi-mi:“MI:0915”(physical association)	0.500
	BCL2L14	psi-mi:“MI:0915”(physical association)	0.370
BCL2L14		psi-mi:“MI:0914”(association)	0.350
BCL2L14	POTEF	psi-mi:“MI:0914”(association)	0.350
BCL2L14	PICK1	psi-mi:“MI:0915”(physical association)	0.000
BCL2L14	DDIT4L	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (164): TRAPPC10 (Affinity Capture-MS), TRAPPC4 (Affinity Capture-MS), MTA2 (Affinity Capture-MS), C7orf43 (Affinity Capture-MS), PPP2R2D (Affinity Capture-MS), TRAPPC9 (Affinity Capture-MS), TRAPPC6B (Affinity Capture-MS), TRAPPC1 (Affinity Capture-MS), TRAPPC3 (Affinity Capture-MS), TRAPPC5 (Affinity Capture-MS), TRAPPC2L (Affinity Capture-MS), TRAPPC2 (Affinity Capture-MS), CHEK1 (Affinity Capture-MS), VHL (Affinity Capture-MS), C7orf43 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8GUX5, A0A571BF63, A0A8M9QN10, A1L1K1, A2ARM1, A2AVJ5, A7YDW0, O08576, O60268, P0C6P5, P97433, Q08E29, Q0V9V7, Q0VDN7, Q17QK1, Q2NKQ1, Q2NL11, Q3B7K9, Q3SYZ9, Q4R7B9, Q561Q8, Q59EK9, Q5E9L4, Q5E9R0, Q5EB20, Q5NVC2, Q5PQS0, Q5R565, Q5U3W3, Q5XHG1, Q61194, Q6AYK4, Q6MZQ0, Q6NXJ0, Q6P7D5, Q6PDC0, Q6ZUJ8, Q80ZQ3, Q8BPQ7, Q8N1W1

Diamond homologs: Q5E9L4, Q6AYK4, Q9BZR8, Q9CPT0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

5131 predictions. Top by Δscore:

Variant	Effect	Δscore
12:12124658:AAAAT:A	acceptor_gain	1.0000
12:12124659:AAAT:A	acceptor_gain	1.0000
12:12124660:AAT:A	acceptor_gain	1.0000
12:12124660:AATC:A	acceptor_loss	1.0000
12:12124661:AT:A	acceptor_gain	1.0000
12:12124661:ATCT:A	acceptor_loss	1.0000
12:12124662:TCTAA:T	acceptor_loss	1.0000
12:12124663:C:CA	acceptor_loss	1.0000
12:12124663:C:CC	acceptor_gain	1.0000
12:12125291:CTTA:C	donor_gain	1.0000
12:12125292:TTA:T	donor_loss	1.0000
12:12125294:A:AC	donor_gain	1.0000
12:12125294:ACTG:A	donor_gain	1.0000
12:12125295:C:CG	donor_gain	1.0000
12:12125295:CT:C	donor_gain	1.0000
12:12125295:CTG:C	donor_gain	1.0000
12:12125295:CTGC:C	donor_gain	1.0000
12:12125295:CTGCA:C	donor_gain	1.0000
12:12125428:CATTC:C	acceptor_gain	1.0000
12:12125429:ATTC:A	acceptor_gain	1.0000
12:12125430:TTC:T	acceptor_gain	1.0000
12:12125430:TTCC:T	acceptor_gain	1.0000
12:12125431:TC:T	acceptor_gain	1.0000
12:12125431:TCCT:T	acceptor_gain	1.0000
12:12125432:CC:C	acceptor_gain	1.0000
12:12125433:C:CC	acceptor_gain	1.0000
12:12125438:A:AC	acceptor_gain	1.0000
12:12130777:A:AC	donor_gain	1.0000
12:12130778:C:CC	donor_gain	1.0000
12:12130778:CTT:C	donor_loss	1.0000

AlphaMissense

2147 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:12094928:T:A	W315R	0.990
12:12094928:T:C	W315R	0.990
12:12087246:G:C	R156P	0.989
12:12094883:T:G	Y300D	0.988
12:12094803:C:A	A273D	0.986
12:12094887:T:C	L301P	0.985
12:12094930:G:C	W315C	0.985
12:12094930:G:T	W315C	0.985
12:12087240:C:A	A154D	0.983
12:12094875:G:A	G297D	0.983
12:12094830:T:C	L282P	0.981
12:12094871:T:C	F296L	0.981
12:12094873:T:A	F296L	0.981
12:12094873:T:G	F296L	0.981
12:12087261:T:A	V161D	0.976
12:12079375:T:C	F24L	0.975
12:12079377:C:A	F24L	0.975
12:12079377:C:G	F24L	0.975
12:12094721:T:C	F246L	0.975
12:12094723:C:A	F246L	0.975
12:12094723:C:G	F246L	0.975
12:12094898:T:C	F305L	0.975
12:12094900:C:A	F305L	0.975
12:12094900:C:G	F305L	0.975
12:12079393:T:G	Y30D	0.974
12:12094883:T:C	Y300H	0.973
12:12094884:A:C	Y300S	0.973
12:12094802:G:C	A273P	0.972
12:12094806:T:C	L274P	0.972
12:12094812:T:A	I276K	0.972

dbSNP variants (sampled 300 via entrez): RS1000004613 (12:12073953 G>A,C), RS1000030616 (12:12082674 T>G), RS1000042838 (12:12088702 C>T), RS1000054810 (12:12050240 C>A,T), RS1000121685 (12:12085194 G>C), RS1000131958 (12:12048298 T>C), RS1000230812 (12:12085507 G>A), RS1000397858 (12:12074294 C>T), RS1000431634 (12:12088464 G>A), RS1000453340 (12:12066803 C>T), RS1000504196 (12:12048602 A>G), RS1000567405 (12:12065366 T>C), RS1000635071 (12:12081102 G>A,C), RS1000730265 (12:12075626 T>C), RS1000749285 (12:12078912 G>A)

Disease associations

OMIM: gene MIM:606126 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST005981_4	Phosphorus levels	2.000000e-08
GCST007002_5	Cerebrospinal fluid t-tau levels in normal cognition	6.000000e-07
GCST008058_237	Estimated glomerular filtration rate	5.000000e-14
GCST008059_36	Estimated glomerular filtration rate	2.000000e-14
GCST008062_94	Blood urea nitrogen levels	3.000000e-07
GCST008491_11	Voxel-wise structural brain imaging measurements in Alzheimer’s disease	2.000000e-06
GCST012490_260	Femur bone mineral density x serum urate levels interaction	1.000000e-08
GCST012490_322	Femur bone mineral density x serum urate levels interaction	2.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004861	phosphorus measurement
EFO:0004760	t-tau measurement
EFO:0004346	neuroimaging measurement
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic Trioxide	affects cotreatment, increases expression, decreases response to substance	3
Tetrachlorodibenzodioxin	affects expression, affects cotreatment, increases expression	2
aristolochic acid I	increases expression	1
sotorasib	affects cotreatment, increases expression	1
sanguinarine	affects cotreatment, increases expression	1
bisphenol A	decreases methylation	1
testosterone undecanoate	increases expression, affects cotreatment	1
mono-(2-ethylhexyl)phthalate	decreases methylation, increases abundance	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
entinostat	decreases expression	1
gardiquimod	increases expression, decreases reaction	1
trametinib	affects cotreatment, increases expression	1
NVP-BKM120	affects cotreatment, increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Ascorbic Acid	decreases expression, affects cotreatment	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Clozapine	decreases expression	1
Cycloheximide	affects cotreatment, increases expression	1
Diethylhexyl Phthalate	increases abundance, decreases methylation	1
Hydrogen Peroxide	affects expression	1
Manganese	decreases expression, increases abundance, affects cotreatment	1
Menthol	increases expression	1
Methapyrilene	increases methylation	1
Nickel	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.