BCL6-AS1

Summary

BCL6-AS1 (BCL6 antisense RNA 1, HGNC:51843) is a long non-coding RNA gene on chromosome 3q27.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51843
Approved symbol	BCL6-AS1
Name	BCL6 antisense RNA 1
Location	3q27.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-RP11-211G3.3.1-1
Entrez	122526776
RNAcentral	URS00022AE73E — lncRNA, 1159 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• we found that the boundaries of lnc-RP11-211G3.3.1-1 match the boundaries of the BCL6 translocation zone quite precisely (PMID:26276666)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr3q27

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

299 predictions. Top by Δscore:

Variant	Effect	Δscore
3:187745515:CCA:C	donor_gain	0.9800
3:187745519:TGC:T	donor_gain	0.9800
3:187745611:A:AC	donor_gain	0.9700
3:187745612:C:CC	donor_gain	0.9700
3:187745632:T:TA	donor_gain	0.9700
3:187745142:A:C	donor_gain	0.9400
3:187745592:AAAG:A	donor_gain	0.9400
3:187745615:G:A	donor_gain	0.8900
3:187744611:G:A	donor_gain	0.8800
3:187744623:T:TA	donor_gain	0.8800
3:187745512:TTACC:T	donor_gain	0.8800
3:187744553:T:TA	donor_gain	0.8700
3:187745583:AAAGC:A	donor_gain	0.8600
3:187745596:C:CT	donor_gain	0.8600
3:187745553:T:A	donor_gain	0.8500
3:187744619:T:A	donor_gain	0.8400
3:187745614:G:T	donor_gain	0.8300
3:187743983:T:TA	donor_gain	0.8100
3:187743911:C:CA	donor_gain	0.7900
3:187743980:T:A	donor_gain	0.7900
3:187745649:T:TA	donor_gain	0.7900
3:187744120:C:CT	acceptor_gain	0.7800
3:187744327:C:T	donor_gain	0.7700
3:187745515:C:CT	donor_gain	0.7700
3:187745510:CT:C	donor_gain	0.7600
3:187745511:TT:T	donor_gain	0.7600
3:187745512:TT:T	donor_gain	0.7600
3:187743901:A:AC	donor_gain	0.7500
3:187743902:C:CC	donor_gain	0.7500
3:187745516:CAC:C	donor_gain	0.7500

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000083045 (3:187745356 AGCG>A,AGCGGCGGCG), RS1000122039 (3:187742795 T>C), RS1000754741 (3:187743033 T>A), RS1000960235 (3:187743456 A>C), RS1001246732 (3:187742493 T>G), RS1001344931 (3:187742086 A>G), RS1001351535 (3:187742229 T>C), RS1002229740 (3:187746094 T>A), RS1003168406 (3:187745335 G>A), RS1003633321 (3:187745215 T>A,C,G), RS1003942395 (3:187745650 C>G), RS1004133407 (3:187745842 G>A,C,T), RS1004196402 (3:187746247 G>A), RS1004670925 (3:187742473 G>A), RS1005423448 (3:187742822 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.