BET1L

Summary

BET1L (Bet1 golgi vesicular membrane trafficking protein like, HGNC:19348) is a protein-coding gene on chromosome 11p15.5, encoding BET1-like protein (Q9NYM9). Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex.

Enables SNAP receptor activity. Involved in regulation of retrograde vesicle-mediated transport, Golgi to ER and retrograde transport, endosome to Golgi. Located in Golgi apparatus and endosome. Implicated in uterine fibroid. Biomarker of endometrial adenocarcinoma.

Source: NCBI Gene 51272 — RefSeq curated summary.

At a glance

• GWAS associations: 25
• Clinical variants (ClinVar): 36 total
• MANE Select transcript: NM_001098787

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19348
Approved symbol	BET1L
Name	Bet1 golgi vesicular membrane trafficking protein like
Location	11p15.5
Locus type	gene with protein product
Status	Approved
Aliases	GS15, GOLIM3
Ensembl gene	ENSG00000177951
Ensembl biotype	protein_coding
OMIM	615417
Entrez	51272

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000325147, ENST00000332865, ENST00000382762, ENST00000410108, ENST00000479463, ENST00000486280, ENST00000529614, ENST00000851020

RefSeq mRNA: 2 — MANE Select: NM_001098787 NM_001098787, NM_016526

CCDS: CCDS41582, CCDS7689

Canonical transcript exons

ENST00000382762 — 4 exons

Exon	Start	End
ENSE00001747069	205611	205667
ENSE00001784479	202924	205469
ENSE00003531019	205952	206043
ENSE00004283420	207303	207399

Expression profiles

Bgee: expression breadth ubiquitous, 241 present calls, max score 95.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.3718 / max 150.6083, expressed in 1819 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117719	24.0779	1817
117716	0.4122	189
117715	0.4005	172
117717	0.3213	139
117718	0.1600	68

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	95.82	gold quality
adenohypophysis	UBERON:0002196	94.97	gold quality
pituitary gland	UBERON:0000007	93.90	gold quality
left ovary	UBERON:0002119	93.70	gold quality
right coronary artery	UBERON:0001625	93.60	gold quality
descending thoracic aorta	UBERON:0002345	93.56	gold quality
body of stomach	UBERON:0001161	93.34	gold quality
mucosa of stomach	UBERON:0001199	93.34	gold quality
endocervix	UBERON:0000458	93.25	gold quality
thoracic aorta	UBERON:0001515	93.20	gold quality
ascending aorta	UBERON:0001496	93.15	gold quality
stromal cell of endometrium	CL:0002255	93.13	gold quality
popliteal artery	UBERON:0002250	93.13	gold quality
tibial artery	UBERON:0007610	93.12	gold quality
aorta	UBERON:0000947	93.08	gold quality
right ovary	UBERON:0002118	92.83	gold quality
right lung	UBERON:0002167	92.65	gold quality
left uterine tube	UBERON:0001303	92.63	gold quality
left coronary artery	UBERON:0001626	92.57	gold quality
granulocyte	CL:0000094	92.47	gold quality
pancreas	UBERON:0001264	92.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	92.27	gold quality
minor salivary gland	UBERON:0001830	92.25	gold quality
body of uterus	UBERON:0009853	92.13	gold quality
coronary artery	UBERON:0001621	92.10	gold quality
left lobe of thyroid gland	UBERON:0001120	92.08	gold quality
transverse colon	UBERON:0001157	92.01	gold quality
right lobe of liver	UBERON:0001114	91.99	gold quality
left adrenal gland cortex	UBERON:0035825	91.96	gold quality
right lobe of thyroid gland	UBERON:0001119	91.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	14.16

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

96 targeting BET1L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-1197	99.70	67.75	1027
HSA-MIR-518A-5P	99.70	69.01	2209

Literature-anchored findings (GeneRIF, showing 9)

• Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport. (PMID:12388752)
• single nucleotide polymorphisms in the BET1L gene is associated with uterine fibroid. (PMID:23604678)
• Meta-analysis showed a strong association at blocked early in transport 1 homolog (BET1L) rs2280543 for intramural uterine fibroid type in european americans. (PMID:23892540)
• COG sub-complexes are spatially separated on the Golgi with lobe A preferential localization on Golgi stacks and the presence of lobe B on vesicle-like structures, where it physically interacts with v-SNARE GS15. (PMID:27385402)
• both BET1L and TNRC6B contributed to the risk of UL in Chinese women (PMID:29743541)
• BET1L rs2280543 polymorphisms are associated with an increased risk of intracranial aneurysm. (PMID:31275455)
• Transcriptome analysis using patient iPSC-derived skeletal myocytes: Bet1L as a new molecule possibly linked to neuromuscular junction degeneration in ALS. (PMID:34310943)
• Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet. (PMID:35477381)
• Genetic Modulation of BET1L Confers Colorectal Cancer Susceptibility by Reducing miRNA Binding and m6A Modification. (PMID:37115853)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Bet1l	ENSMUSG00000025484
rattus_norvegicus	Bet1l	ENSRNOG00000013165

Protein

Protein identifiers

BET1-like protein — Q9NYM9 (reviewed: Q9NYM9)

Alternative names: Golgi SNARE with a size of 15 kDa, Vesicle transport protein GOS15

All UniProt accessions (6): A0A0C4DH16, B8ZZS0, E9PHY4, E9PQJ6, Q9NYM9, H7BXT7

UniProt curated annotations — full annotation on UniProt →

Function. Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex.

Subunit / interactions. Component of a SNARE complex consisting of STX5, YKT6, GOSR1 and BET1L. Interacts with STX5.

Subcellular location. Golgi apparatus membrane. Golgi apparatus. trans-Golgi network membrane.

RefSeq proteins (2): NP_001092257, NP_057610 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000727	T_SNARE_dom	Domain
IPR039899	BET1_SNARE	Domain

UniProt features (7 total): topological domain 2, modified residue 2, chain 1, transmembrane region 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NYM9-F1	89.02	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 9, 37

Function

Pathways and Gene Ontology

Reactome pathways

10 pathways

ID	Pathway
R-HSA-6807878	COPI-mediated anterograde transport
R-HSA-6811438	Intra-Golgi traffic
R-HSA-199977	ER to Golgi Anterograde Transport
R-HSA-199991	Membrane Trafficking
R-HSA-392499	Metabolism of proteins
R-HSA-446203	Asparagine N-linked glycosylation
R-HSA-5653656	Vesicle-mediated transport
R-HSA-597592	Post-translational protein modification
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-948021	Transport to the Golgi and subsequent modification

MSigDB gene sets: 142 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_UP, MODULE_97, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_MEMBRANE_FUSION, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, LANG_MYB_FAMILY_TARGETS, MODULE_182, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, AGCGCTT_MIR518F_MIR518E_MIR518A, MODULE_480, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, GOBP_MEMBRANE_ORGANIZATION

GO Biological Process (4): protein transport (GO:0015031), retrograde transport, endosome to Golgi (GO:0042147), regulation of retrograde vesicle-mediated transport, Golgi to ER (GO:2000156), membrane fusion (GO:0061025)

GO Molecular Function (2): SNAP receptor activity (GO:0005484), protein binding (GO:0005515)

GO Cellular Component (8): Golgi membrane (GO:0000139), endosome (GO:0005768), Golgi apparatus (GO:0005794), Golgi stack (GO:0005795), cytosol (GO:0005829), membrane (GO:0016020), SNARE complex (GO:0031201), endomembrane system (GO:0012505)

Reactome top-level categories

Rollup of top-8 pathways:

Category	Pathways
Membrane Trafficking	2
ER to Golgi Anterograde Transport	1
Intra-Golgi and retrograde Golgi-to-ER traffic	1
Transport to the Golgi and subsequent modification	1
Vesicle-mediated transport	1
Post-translational protein modification	1
Metabolism of proteins	1
Asparagine N-linked glycosylation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
cellular anatomical structure	3
endomembrane system	2
transport	1
intracellular protein localization	1
establishment of protein localization	1
intercellular transport	1
endosomal transport	1
cytosolic transport	1
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	1
regulation of vesicle-mediated transport	1
membrane organization	1
protein-macromolecule adaptor activity	1
membrane fusion	1
fusogenic activity	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
cytoplasmic vesicle	1
intracellular membrane-bounded organelle	1
Golgi apparatus subcompartment	1
membrane protein complex	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

1102 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BET1L	VCPIP1	Q96JH7	769
BET1L	GOSR1	O95249	755
BET1L	GOSR2	O14653	747
BET1L	STX5	Q13190	739
BET1L	GOLGA2	Q08379	701
BET1L	YKT6	O15498	695
BET1L	SEC22A	Q96IW7	691
BET1L	TNRC6B	Q9UPQ9	663
BET1L	VCP	P55072	605
BET1L	FAM228B	P0C875	591
BET1L	NPLOC4	Q8TAT6	589
BET1L	PTPN3	P26045	545
BET1L	STX16	O14662	508
BET1L	RIC8A	Q9NPQ8	506
BET1L	UFD1	Q92890	497

IntAct

28 interactions, top by confidence:

A	B	Type	Score
GOSR2	BET1	psi-mi:“MI:0914”(association)	0.810
STX18	NBAS	psi-mi:“MI:0914”(association)	0.810
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
STX5	GOSR2	psi-mi:“MI:0914”(association)	0.670
NAPA	NBAS	psi-mi:“MI:0914”(association)	0.530
VAMP5	NBAS	psi-mi:“MI:0914”(association)	0.530
BET1L	TRAPPC12	psi-mi:“MI:0915”(physical association)	0.400
GORAB	BET1L	psi-mi:“MI:0915”(physical association)	0.370
VAMP5	ESYT2	psi-mi:“MI:0914”(association)	0.350
STX18	NBAS	psi-mi:“MI:0914”(association)	0.350
BET1L	GOSR1	psi-mi:“MI:0914”(association)	0.350
RAB18	GDI2	psi-mi:“MI:0914”(association)	0.350
SCFD1	NBAS	psi-mi:“MI:0914”(association)	0.350
NRSN1	FAM171A2	psi-mi:“MI:0914”(association)	0.350
SEC22B	NBAS	psi-mi:“MI:0914”(association)	0.350
SLC35F3	TMEM223	psi-mi:“MI:0914”(association)	0.350
TMEM17	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
TMEM216	GPR89A	psi-mi:“MI:2364”(proximity)	0.270
TMEM216	SNAP23	psi-mi:“MI:2364”(proximity)	0.270
BET1	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
TGOLN2	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
FHIP2A	MED19	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (71): BET1L (Proximity Label-MS), BET1L (Proximity Label-MS), BET1L (Affinity Capture-MS), BET1L (Proximity Label-MS), BET1L (Proximity Label-MS), BET1L (Affinity Capture-MS), BET1L (Affinity Capture-MS), BET1L (Proximity Label-MS), BET1L (Proximity Label-MS), BET1L (Affinity Capture-Western), GOSR1 (Affinity Capture-Western), STX5 (Affinity Capture-Western), YKT6 (Affinity Capture-Western), BET1L (Affinity Capture-Western), BET1L (Proximity Label-MS)

ESM2 similar proteins: A8XLW0, A8XP14, O13644, O14653, O35152, O35165, O35166, O65359, O89116, O94531, O94651, P25385, P32854, P38736, P41941, P59277, P78768, P93654, Q03322, Q04338, Q09835, Q12981, Q39233, Q54CK6, Q54IX6, Q6BVM4, Q6BZQ6, Q6CRX0, Q6FKA1, Q6QD59, Q75CY3, Q8L9S0, Q8VHI8, Q95ZW1, Q96AJ9, Q9FFK1, Q9FK28, Q9HGN3, Q9JI51, Q9LMP7

Diamond homologs: O13932, O15155, O35152, O35153, O35623, Q3MHP8, Q5RBX2, Q62896, Q68EL3, Q9M2J9, Q9NYM9, Q553P5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 28 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPII-mediated vesicle transport	6	48.9×	4e-08
ER to Golgi Anterograde Transport	5	33.2×	5e-06
Intra-Golgi and retrograde Golgi-to-ER traffic	6	31.4×	4e-07
COPI-mediated anterograde transport	5	27.4×	9e-06
Transport to the Golgi and subsequent modification	5	25.7×	1e-05
Membrane Trafficking	9	16.7×	4e-08
Vesicle-mediated transport	9	15.7×	4e-08
Asparagine N-linked glycosylation	5	15.0×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	5	70.2×	7e-07
endoplasmic reticulum to Golgi vesicle-mediated transport	6	34.0×	8e-07
intracellular protein transport	5	13.5×	4e-04
protein transport	7	12.8×	2e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	25
Likely benign	1
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

2258 predictions. Top by Δscore:

Variant	Effect	Δscore
11:193152:GCC:G	donor_gain	1.0000
11:193155:G:GG	donor_gain	1.0000
11:197412:AGGT:A	donor_loss	1.0000
11:197413:GGTA:G	donor_loss	1.0000
11:197414:G:GA	donor_loss	1.0000
11:197414:G:GG	donor_gain	1.0000
11:199516:G:GT	donor_gain	1.0000
11:199517:A:T	donor_gain	1.0000
11:199527:C:G	donor_gain	1.0000
11:199531:GAGGG:G	donor_gain	1.0000
11:199533:GGG:G	donor_gain	1.0000
11:199534:GGG:G	donor_gain	1.0000
11:205664:CGAG:C	acceptor_gain	1.0000
11:205668:C:CC	acceptor_gain	1.0000
11:205674:A:T	acceptor_gain	1.0000
11:205948:TGACC:T	donor_loss	1.0000
11:205949:GAC:G	donor_loss	1.0000
11:205950:A:AC	donor_gain	1.0000
11:205950:A:AG	donor_loss	1.0000
11:205951:C:CA	donor_loss	1.0000
11:205951:C:CC	donor_gain	1.0000
11:206044:C:CC	acceptor_gain	1.0000
11:197410:ACAG:A	donor_gain	0.9900
11:197555:CCACA:C	acceptor_loss	0.9900
11:197556:CACA:C	acceptor_loss	0.9900
11:197559:A:AG	acceptor_gain	0.9900
11:197559:AG:A	acceptor_gain	0.9900
11:197559:AGG:A	acceptor_loss	0.9900
11:197560:G:GG	acceptor_gain	0.9900
11:197560:G:GT	acceptor_loss	0.9900

AlphaMissense

730 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:205956:T:A	K36I	0.912
11:205428:G:C	S70R	0.909
11:205428:G:T	S70R	0.909
11:205430:T:G	S70R	0.909
11:205971:T:A	K31I	0.895
11:205955:T:A	K36N	0.881
11:205955:T:G	K36N	0.881
11:205959:A:G	L35P	0.880
11:205959:A:T	L35H	0.878
11:206000:G:C	N21K	0.878
11:206000:G:T	N21K	0.878
11:206001:T:A	N21I	0.871
11:205663:G:T	A39D	0.867
11:205664:C:G	A39P	0.867
11:205358:C:G	G94R	0.841
11:205416:A:C	F74L	0.841
11:205416:A:T	F74L	0.841
11:205418:A:G	F74L	0.841
11:206002:T:C	N21D	0.819
11:206001:T:G	N21T	0.817
11:205666:A:G	L38P	0.816
11:205990:C:G	A25P	0.808
11:205357:C:T	G94D	0.803
11:206002:T:A	N21Y	0.798
11:205968:A:T	V32D	0.797
11:206002:T:G	N21H	0.793
11:205643:C:G	A46P	0.782
11:205954:A:G	S37P	0.781
11:205980:A:G	L28P	0.770
11:205654:A:T	I42N	0.768

dbSNP variants (sampled 300 via entrez): RS1000026443 (11:209151 G>A), RS1000211245 (11:203704 G>C,T), RS1000463030 (11:208998 G>A,C,T), RS1000464743 (11:205470 C>G,T), RS1000586469 (11:206898 A>G), RS1000587197 (11:203921 T>C), RS1000980696 (11:207795 A>C), RS1001013272 (11:206637 T>G), RS1001192096 (11:202725 G>T), RS1001870999 (11:205754 AACAACTCTGCCAG>A), RS1002019134 (11:206392 G>A,T), RS1002359501 (11:206045 T>C,G), RS1002553365 (11:203933 G>C), RS1003025084 (11:205144 C>T), RS1003224912 (11:204087 G>A,T)

Disease associations

OMIM: gene MIM:615417 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

25 associations (top):

Study	Trait	p-value
GCST000497_6	Mean platelet volume	1.000000e-14
GCST001027_3	Uterine fibroids	4.000000e-12
GCST001388_3	Intracranial aneurysm	3.000000e-06
GCST001482_25	Lumbar spine bone mineral density	2.000000e-06
GCST002186_8	Platelet count	5.000000e-12
GCST004607_122	Plateletcrit	3.000000e-24
GCST004621_19	Red cell distribution width	4.000000e-24
GCST005992_32	Mean corpuscular hemoglobin concentration	3.000000e-12
GCST005996_50	Red blood cell count	4.000000e-14
GCST006011_28	Mean corpuscular volume	3.000000e-13
GCST006462_50	Uterine fibroids	5.000000e-12
GCST007954_6	Glycated hemoglobin levels	2.000000e-10
GCST008423_8	Uterine fibroids	1.000000e-20
GCST009158_1	Uterine fibroids	2.000000e-14
GCST009822_3	Gynecologic disease	4.000000e-17
GCST009823_2	Gynecologic disease (multivariate analysis)	8.000000e-16
GCST009824_5	Gynecologic disease	3.000000e-16
GCST009833_2	Uterine fibroids (MTAG)	4.000000e-17
GCST009834_36	Uterine fibroids	1.000000e-21
GCST010867_73	Coronary artery disease	2.000000e-10
GCST90002395_43	Mean platelet volume	1.000000e-17
GCST90002400_625	Plateletcrit	9.000000e-52
GCST90002401_174	Platelet distribution width	1.000000e-37
GCST90002404_501	Red cell distribution width	1.000000e-21
GCST90014268_24	Cataracts	4.000000e-11

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004309	platelet count
EFO:0007985	platelet crit
EFO:0009188	Red cell distribution width
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0004305	erythrocyte count
EFO:0004541	HbA1c measurement
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	increases expression	2
Valproic Acid	affects expression, increases methylation	2
Cyclosporine	decreases methylation, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	increases phosphorylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
coumarin	increases phosphorylation	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
Air Pollutants	increases abundance, affects expression	1
Caffeine	decreases phosphorylation	1
Diazinon	increases methylation	1
Bucladesine	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, increases expression	1
Ivermectin	increases expression	1
Niclosamide	increases expression	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Tunicamycin	increases expression	1
Medroxyprogesterone Acetate	affects cotreatment, increases expression	1
Thapsigargin	increases expression	1
Palmitic Acid	decreases phosphorylation	1
Copper Sulfate	decreases expression	1
Acrylamide	decreases expression	1
Vitamin K 3	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.