BGLT3

Summary

BGLT3 (beta globin locus transcript 3, HGNC:49033) is a long non-coding RNA gene on chromosome 11p15.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49033
Approved symbol	BGLT3
Name	beta globin locus transcript 3
Location	11p15.4
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC01083, BGL3, lncRNA-BGL3
Ensembl gene	ENSG00000260629
Ensembl biotype	lncRNA
OMIM	616308
Entrez	103344929
RNAcentral	URS000075A80B — lncRNA, 1019 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000564523

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000564523 — 1 exons

Exon	Start	End
ENSE00002591403	5244554	5245546

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 87.55.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0425 / max 15.8044, expressed in 21 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118367	0.0425	21

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	87.55	gold quality
myocardium	UBERON:0002349	82.96	gold quality
cardiac muscle of right atrium	UBERON:0003379	82.08	gold quality
kidney epithelium	UBERON:0004819	81.92	gold quality
left ventricle myocardium	UBERON:0006566	81.90	gold quality
buccal mucosa cell	CL:0002336	81.52	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	80.67	gold quality
epithelial cell of pancreas	CL:0000083	78.21	gold quality
vena cava	UBERON:0004087	78.03	gold quality
sperm	CL:0000019	77.99	silver quality
body of tongue	UBERON:0011876	77.62	gold quality
caecum	UBERON:0001153	76.25	gold quality
tongue	UBERON:0001723	75.95	gold quality
cerebellar hemisphere	UBERON:0002245	75.93	silver quality
saliva-secreting gland	UBERON:0001044	75.91	gold quality
nucleus accumbens	UBERON:0001882	75.73	gold quality
lateral nuclear group of thalamus	UBERON:0002736	75.23	gold quality
corpus callosum	UBERON:0002336	75.08	gold quality
cortex of kidney	UBERON:0001225	75.00	gold quality
parotid gland	UBERON:0001831	74.91	gold quality
superior surface of tongue	UBERON:0007371	74.90	gold quality
pylorus	UBERON:0001166	74.82	gold quality
pericardium	UBERON:0002407	74.75	gold quality
cerebellar vermis	UBERON:0004720	74.70	gold quality
nipple	UBERON:0002030	74.69	gold quality
lateral globus pallidus	UBERON:0002476	74.60	gold quality
pons	UBERON:0000988	74.57	silver quality
pharyngeal mucosa	UBERON:0000355	74.55	gold quality
vastus lateralis	UBERON:0001379	74.44	gold quality
trachea	UBERON:0003126	74.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• BGL3 inhibits papillary thyroid carcinoma progression via regulating PTEN stability. (PMID:33543443)
• LRF Promotes Indirectly Advantageous Chromatin Conformation via BGLT3-lncRNA Expression and Switch from Fetal to Adult Hemoglobin. (PMID:35806029)
• A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. (PMID:36635268)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.