BHLHA15

Summary

BHLHA15 (basic helix-loop-helix family member a15, HGNC:22265) is a protein-coding gene on chromosome 7q21.3, encoding Class A basic helix-loop-helix protein 15 (Q7RTS1). Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated.

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; endoplasmic reticulum unfolded protein response; and negative regulation of myotube differentiation. Predicted to act upstream of or within several processes, including cell-cell adhesion mediated by cadherin; epithelial cell maturation; and intracellular distribution of mitochondria. Predicted to be located in chromatin. Predicted to be active in nucleus.

Source: NCBI Gene 168620 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 42 total
• Transcription factor: yes — 21 downstream targets (CollecTRI)
• MANE Select transcript: NM_177455

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:22265
Approved symbol	BHLHA15
Name	basic helix-loop-helix family member a15
Location	7q21.3
Locus type	gene with protein product
Status	Approved
Aliases	MIST1
Ensembl gene	ENSG00000180535
Ensembl biotype	protein_coding
OMIM	608606
Entrez	168620

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000314018, ENST00000609256, ENST00000930537

RefSeq mRNA: 1 — MANE Select: NM_177455 NM_177455

CCDS: CCDS5655

Canonical transcript exons

ENST00000609256 — 2 exons

Exon	Start	End
ENSE00003706225	98211439	98211498
ENSE00003708212	98212256	98215457

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 99.55.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6812 / max 609.5341, expressed in 253 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
79812	1.6812	253

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	99.55	gold quality
body of pancreas	UBERON:0001150	99.20	gold quality
pancreas	UBERON:0001264	88.42	gold quality
bone marrow cell	CL:0002092	82.58	gold quality
body of stomach	UBERON:0001161	80.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.30	gold quality
saliva-secreting gland	UBERON:0001044	78.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.93	gold quality
stomach	UBERON:0000945	76.66	gold quality
ileal mucosa	UBERON:0000331	76.65	silver quality
trachea	UBERON:0003126	75.64	silver quality
prostate gland	UBERON:0002367	74.68	gold quality
minor salivary gland	UBERON:0001830	73.72	gold quality
cardia of stomach	UBERON:0001162	73.12	silver quality
tonsil	UBERON:0002372	73.07	gold quality
cortical plate	UBERON:0005343	71.84	gold quality
duodenum	UBERON:0002114	71.65	gold quality
buccal mucosa cell	CL:0002336	71.41	gold quality
nasal cavity mucosa	UBERON:0001826	71.30	gold quality
fundus of stomach	UBERON:0001160	71.14	gold quality
seminal vesicle	UBERON:0000998	70.93	silver quality
vermiform appendix	UBERON:0001154	70.69	gold quality
spleen	UBERON:0002106	70.65	gold quality
mouth mucosa	UBERON:0003729	70.57	gold quality
right lobe of liver	UBERON:0001114	70.11	gold quality
pancreatic ductal cell	CL:0002079	69.82	silver quality
islet of Langerhans	UBERON:0000006	68.80	gold quality
lower esophagus mucosa	UBERON:0035834	68.17	gold quality
lymph node	UBERON:0000029	67.32	gold quality
palpebral conjunctiva	UBERON:0001812	66.76	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.95

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

21 targets.

Target	Regulation
AGFG1
APOE
CDH1	Unknown
CDKN1A	Activation
EIF3K
EPO	Unknown
FGF21
FPR2
GATA4	Unknown
GJB1	Activation
GJB2
INS	Repression
KRT19
KRT20
MIB1
NKX2-5	Unknown
POSTN	Unknown
RAB26
RAB3D	Unknown
SCT	Unknown
TYR	Activation

JASPAR motifs

Motif	Name	Family
MA0607.2	BHLHA15	Tal-related
MA1472.1	BHLHA15	Tal-related

JASPAR matrix evidence (PMIDs): PMID:9482738, PMID:28174210

Upstream regulators (CollecTRI, top): GATA2, XBP1

Literature-anchored findings (GeneRIF, showing 14)

• Mist1 within the hierarchy of known helix-loop-helix/basic helix-loop-helix proteins that control mammary epithelial cell development (PMID:16645041)
• MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. (PMID:20038531)
• Our findings implicate MIST1 as a reliable marker of mature, healthy chief cells, and we provide the first evidence that metaplasia in humans arises at least in part from the chief cell lineage. (PMID:20709804)
• MIST1 is enriched upon plasma cell differentiation. (PMID:21098683)
• Chief cells emerge from the Mist. (PMID:21907708)
• Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. (PMID:22374815)
• noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells (PMID:22495370)
• restoring the expression of MIST1 reverses the EMT and reduces the tumorigenicity of pancreatic cancer cells partly via the Snail/E-cadherin pathway (PMID:29859299)
• Overexpression of MIST1-induced AMY1 expression while it had little effect on CK19 expression. (PMID:30759717)
• Mist1 is a sensitive marker for serous acinar cells of salivary glands and acinic cell carcinoma (AciCC), and background non-tumour acinar cells and plasma cells can serve as good internal positive controls. (PMID:31187185)
• High MIST1 expression is associated with lymph node metastasis in Gastric cancer. (PMID:31827644)
• Diffuse MIST1 expression and decreased alpha1,4-linked N-acetylglucosamine (alphaGlcNAc) glycosylation on MUC6 are distinct hallmarks for gastric neoplasms showing oxyntic gland differentiation. (PMID:32502322)
• Clinical Significance of Tumour CD44v and MIST1 Expression in Patients With Non-small-cell Lung Cancer. (PMID:33109579)
• DDX56 transcriptionally activates MIST1 to facilitate tumorigenesis of HCC through PTEN-AKT signaling. (PMID:36168636)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	bhlha15	ENSDARG00000045166
mus_musculus	Bhlha15	ENSMUSG00000052271
rattus_norvegicus	Bhlha15	ENSRNOG00000025164
drosophila_melanogaster	dimm	FBGN0023091

Paralogs (15): NEUROG3 (ENSG00000122859), NEUROD4 (ENSG00000123307), BHLHE23 (ENSG00000125533), NEUROD1 (ENSG00000162992), NEUROD6 (ENSG00000164600), ATOH8 (ENSG00000168874), NEUROD2 (ENSG00000171532), ATOH1 (ENSG00000172238), OLIG3 (ENSG00000177468), NEUROG2 (ENSG00000178403), ATOH7 (ENSG00000179774), BHLHE22 (ENSG00000180828), NEUROG1 (ENSG00000181965), OLIG1 (ENSG00000184221), OLIG2 (ENSG00000205927)

Protein

Protein identifiers

Class A basic helix-loop-helix protein 15 — Q7RTS1 (reviewed: Q7RTS1)

Alternative names: Class B basic helix-loop-helix protein 8, Muscle, intestine and stomach expression 1

All UniProt accessions (1): Q7RTS1

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5’-CANNTG-3'.

Subunit / interactions. Forms homodimers or heterodimers with TCF3 gene products E12 and E47. These dimers bind to the E-box site, however, heterodimer with MYOD1 does not bind target DNA.

Subcellular location. Nucleus.

Tissue specificity. Expressed in brain, liver, spleen and skeletal muscle.

Domain organisation. Lacks a classic transcription activation domain and instead possesses an N-terminal region capable of inhibiting heterologous activators.

RefSeq proteins (1): NP_803238* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011598	bHLH_dom	Domain
IPR036638	HLH_DNA-bd_sf	Homologous_superfamily
IPR050359	bHLH_transcription_factors	Family

Pfam: PF00010

UniProt features (7 total): region of interest 2, compositionally biased region 2, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7RTS1-F1	70.10	0.28

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 25

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-9925561	Developmental Lineage of Pancreatic Acinar Cells
R-HSA-1266738	Developmental Biology
R-HSA-9734767	Developmental Cell Lineages

MSigDB gene sets: 123 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_UP, GOBP_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION, GOBP_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_STRIATED_MUSCLE_CELL_DIFFERENTIATION, GOBP_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION, GOBP_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION, GOBP_NEUROGENESIS, GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_CELL_CELL_SIGNALING, GOBP_CELL_CELL_ADHESION, GOBP_ANATOMICAL_STRUCTURE_MATURATION, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_MUSCLE_STRUCTURE_DEVELOPMENT

GO Biological Process (20): glandular epithelial cell maturation (GO:0002071), mitochondrial calcium ion transmembrane transport (GO:0006851), Golgi organization (GO:0007030), G protein-coupled receptor signaling pathway (GO:0007186), cell-cell signaling (GO:0007267), sensory organ development (GO:0007423), negative regulation of myotube differentiation (GO:0010832), calcium-mediated signaling (GO:0019722), endoplasmic reticulum unfolded protein response (GO:0030968), cellular response to glucose starvation (GO:0042149), glucose homeostasis (GO:0042593), cell-cell adhesion mediated by cadherin (GO:0044331), cell-cell junction organization (GO:0045216), positive regulation of transcription by RNA polymerase II (GO:0045944), intracellular distribution of mitochondria (GO:0048312), establishment of localization in cell (GO:0051649), localization of cell (GO:0051674), axon development (GO:0061564), type B pancreatic cell maturation (GO:0072560), cell differentiation (GO:0030154)

GO Molecular Function (9): DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), identical protein binding (GO:0042802), protein dimerization activity (GO:0046983), E-box binding (GO:0070888), sequence-specific double-stranded DNA binding (GO:1990837), RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Developmental Cell Lineages of the Exocrine Pancreas	1
Developmental Biology	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
protein binding	2
glandular epithelial cell development	1
columnar/cuboidal epithelial cell maturation	1
calcium ion transmembrane transport	1
organelle organization	1
endomembrane system organization	1
G protein-coupled receptor activity	1
signal transduction	1
cell communication	1
signaling	1
animal organ development	1
regulation of myotube differentiation	1
myotube differentiation	1
negative regulation of striated muscle cell differentiation	1
intracellular signaling cassette	1
cellular response to unfolded protein	1
response to endoplasmic reticulum stress	1
intracellular signal transduction	1
cellular response to starvation	1
carbohydrate homeostasis	1
cell-cell adhesion	1
cell junction organization	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
mitochondrion distribution	1
establishment of localization	1
cellular localization	1
cellular process	1
localization	1
neuron projection development	1
epithelial cell maturation	1
type B pancreatic cell development	1
cellular developmental process	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1

Protein interactions and networks

STRING

808 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BHLHA15	XBP1	P17861	662
BHLHA15	ATF6B	Q99941	662
BHLHA15	EDEM1	Q92611	600
BHLHA15	TFF2	Q03403	593
BHLHA15	MYOD1	P15172	566
BHLHA15	CCK	P06307	545
BHLHA15	PIK3R2	O00459	544
BHLHA15	ERN1	O75460	515
BHLHA15	RBPJL	Q9UBG7	511
BHLHA15	CBLIF	P27352	505
BHLHA15	NR5A2	O00482	479
BHLHA15	ATF6	P18850	476
BHLHA15	AQP5	P55064	464
BHLHA15	SOX9	P48436	448
BHLHA15	MUC6	Q6W4X9	432

IntAct

24 interactions, top by confidence:

A	B	Type	Score
RPL7A	NOP56	psi-mi:“MI:0914”(association)	0.640
MYOG	BHLHA15	psi-mi:“MI:0915”(physical association)	0.560
BHLHA15	RPLP0	psi-mi:“MI:0914”(association)	0.530
PARP12	GCLM	psi-mi:“MI:0914”(association)	0.530
NHLH2	AP3B1	psi-mi:“MI:0914”(association)	0.530
BHLHA15	YBX3	psi-mi:“MI:0914”(association)	0.530
ZCCHC9	RPS3A	psi-mi:“MI:0914”(association)	0.530
RPS3A	CBX6	psi-mi:“MI:0914”(association)	0.530
RPL19	ZBTB24	psi-mi:“MI:0914”(association)	0.530
CXCL11	BHLHA15	psi-mi:“MI:0915”(physical association)	0.370
PF4V1	BHLHA15	psi-mi:“MI:0915”(physical association)	0.370
BHLHA15	CFTR	psi-mi:“MI:0915”(physical association)	0.370
TCF4	TRIM24	psi-mi:“MI:0914”(association)	0.350
NEUROG3	MYO9A	psi-mi:“MI:0914”(association)	0.350
MRPS18B	GAPDHS	psi-mi:“MI:0914”(association)	0.350
BHLHA15	RNASEH1	psi-mi:“MI:0914”(association)	0.350
MRPS9	SLC25A20	psi-mi:“MI:0914”(association)	0.350
BHLHA15	RAB26	psi-mi:“MI:0914”(association)	0.350
BHLHA15	RAB3D	psi-mi:“MI:0914”(association)	0.350
BHLHA15	MYOG	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (102): BHLHA15 (Affinity Capture-MS), HIST1H1C (Affinity Capture-MS), CHCHD2 (Affinity Capture-MS), BHLHA15 (Affinity Capture-MS), FAF1 (Affinity Capture-MS), RNF41 (Affinity Capture-MS), PHF10 (Affinity Capture-MS), C1QBP (Affinity Capture-MS), HIST1H1T (Affinity Capture-MS), RPS27A (Affinity Capture-MS), BAG1 (Affinity Capture-MS), RBM23 (Affinity Capture-MS), PRDM10 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), LSM14B (Affinity Capture-MS)

ESM2 similar proteins: O60682, O88940, O96004, P10085, P17542, P22091, P24899, P27792, P48985, P57100, P59101, P70447, P70562, P70595, P70660, P70661, P79782, P97832, Q02346, Q02575, Q02577, Q0VCE2, Q12870, Q15672, Q28555, Q5E9S3, Q60539, Q60756, Q64124, Q64279, Q64305, Q66HH3, Q7JGP2, Q7RTS1, Q7RTU0, Q7RTU7, Q8BGW3, Q8MI06, Q8MIB9, Q8MID5

Diamond homologs: A3KNX5, O13125, O13126, O57598, P48985, P48987, P70661, Q10574, Q4ZHW1, Q5RJB0, Q7RTS1, Q7RTU4, Q7ZSX3, Q8AW52, Q8N100, Q923Z4, Q96RJ6, Q9QX98, Q9VGJ5, A8E5T6, B6VQA1, O09029, O09105, O16867, O35437, O42202, O42606, O43680, O45489, O88940, O96004, O96642, P10627, P13903, P46581, P48986, P57100, P57101, P57102, P59101

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 28 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Major pathway of rRNA processing in the nucleolus and cytosol	5	13.4×	7e-04

GO biological processes:

GO term	Partners	Fold	FDR
translation	5	19.0×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

42 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

272 predictions. Top by Δscore:

Variant	Effect	Δscore
7:98211497:AG:A	donor_loss	0.9900
7:98211498:GG:G	donor_loss	0.9900
7:98211499:GT:G	donor_loss	0.9900
7:98211500:T:G	donor_loss	0.9900
7:98212254:A:AG	acceptor_gain	0.9900
7:98212255:G:GG	acceptor_gain	0.9900
7:98212246:T:TA	acceptor_gain	0.9800
7:98212255:GCTCC:G	acceptor_gain	0.9700
7:98212247:G:A	acceptor_gain	0.9600
7:98212251:TTCA:T	acceptor_loss	0.9600
7:98212252:TCA:T	acceptor_loss	0.9600
7:98212253:CAG:C	acceptor_loss	0.9600
7:98212254:AGCT:A	acceptor_loss	0.9600
7:98212255:G:C	acceptor_loss	0.9600
7:98211499:G:GG	donor_gain	0.9500
7:98211857:G:GG	donor_gain	0.9500
7:98211891:C:G	donor_gain	0.9500
7:98212255:GCTC:G	acceptor_gain	0.9400
7:98212255:GCT:G	acceptor_gain	0.9200
7:98211507:G:GT	donor_gain	0.9100
7:98212252:TCAG:T	acceptor_gain	0.9000
7:98212253:CAGC:C	acceptor_gain	0.9000
7:98212256:CTCCA:C	acceptor_gain	0.8900
7:98211854:G:GT	donor_gain	0.8800
7:98212246:T:A	acceptor_loss	0.8800
7:98212255:GC:G	acceptor_gain	0.8700
7:98212254:AG:A	acceptor_gain	0.8200
7:98211499:GTA:G	donor_gain	0.8000
7:98211894:G:A	donor_gain	0.7900
7:98212241:T:TA	acceptor_loss	0.7900

AlphaMissense

1204 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:98212646:A:G	K113E	1.000
7:98212648:G:C	K113N	1.000
7:98212648:G:T	K113N	1.000
7:98212659:T:A	L117H	1.000
7:98212659:T:C	L117P	1.000
7:98212559:G:A	E84K	0.999
7:98212560:A:T	E84V	0.999
7:98212561:G:C	E84D	0.999
7:98212561:G:T	E84D	0.999
7:98212563:G:C	R85P	0.999
7:98212581:T:C	L91P	0.999
7:98212592:T:C	F95L	0.999
7:98212594:C:A	F95L	0.999
7:98212594:C:G	F95L	0.999
7:98212602:T:C	L98P	0.999
7:98212644:C:T	S112F	0.999
7:98212646:A:C	K113Q	0.999
7:98212665:T:C	L119P	0.999
7:98212667:G:C	A120P	0.999
7:98212668:C:A	A120D	0.999
7:98212689:T:C	L127P	0.999
7:98212558:G:C	R83S	0.998
7:98212558:G:T	R83S	0.998
7:98212560:A:C	E84A	0.998
7:98212569:G:C	R87P	0.998
7:98212573:G:A	M88I	0.998
7:98212573:G:C	M88I	0.998
7:98212573:G:T	M88I	0.998
7:98212584:A:T	N92I	0.998
7:98212585:T:A	N92K	0.998

dbSNP variants (sampled 300 via entrez): RS1000017888 (7:98211632 C>A,G), RS1000028315 (7:98209439 C>T), RS1000360363 (7:98215339 T>G), RS1000623505 (7:98209905 T>C), RS1002046459 (7:98213080 A>G), RS1002413487 (7:98211581 T>G), RS1002692179 (7:98215674 C>G,T), RS1002767325 (7:98215536 A>G), RS1003878610 (7:98211896 G>A), RS1004469037 (7:98210190 G>T), RS1005170162 (7:98214747 G>A), RS1005553861 (7:98215132 C>T), RS1005876262 (7:98215553 A>G), RS1006090269 (7:98211457 C>A,T), RS1006171397 (7:98213360 A>C)

Disease associations

OMIM: gene MIM:608606 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Particulate Matter	increases abundance, increases expression, decreases expression	3
(+)-JQ1 compound	decreases expression	2
Air Pollutants	increases abundance, increases expression, decreases expression	2
aristolochic acid I	increases expression	1
dicrotophos	increases expression	1
beta-lapachone	increases expression	1
CGP 52608	affects binding, increases reaction	1
jinfukang	affects cotreatment, increases expression	1
Glyphosate	decreases expression	1
Aldrin	affects cotreatment, decreases expression	1
Hexachlorocyclohexane	affects cotreatment, decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	affects cotreatment, increases expression, decreases expression	1
Dichlorodiphenyldichloroethane	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	affects cotreatment, decreases expression	1
DDT	affects cotreatment, decreases expression	1
Dieldrin	affects cotreatment, decreases expression	1
Endrin	affects cotreatment, decreases expression	1
Estradiol	increases expression	1
Glucose	affects expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	decreases expression	1
Valproic Acid	increases methylation	1
2,4-Dichlorophenoxyacetic Acid	decreases expression	1
Cadmium Chloride	increases expression	1
Okadaic Acid	increases expression	1
Lactic Acid	decreases expression	1
Simvastatin	affects cotreatment, decreases expression	1
Genistein	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.