BIN3-IT1

Summary

BIN3-IT1 (BIN3 intronic transcript 1, HGNC:25868) is a long non-coding RNA gene on chromosome 8p21.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25868
Approved symbol	BIN3-IT1
Name	BIN3 intronic transcript 1
Location	8p21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ14107
Entrez	80094
RNAcentral	URS000075E0E5 — lncRNA, 1839 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000581370 (8:22641566 C>T), RS1001839117 (8:22642423 G>C), RS1002808045 (8:22643267 C>T), RS1002842209 (8:22643480 A>C,G), RS1005057687 (8:22643426 G>A), RS1005110972 (8:22643569 A>G), RS1005171936 (8:22639967 T>A), RS1005202891 (8:22640115 G>A,C), RS1006194240 (8:22641253 G>A,C), RS1006691181 (8:22640142 C>G,T), RS1006889175 (8:22640418 G>A), RS1007838626 (8:22639971 C>T), RS1008045216 (8:22641331 G>A,T), RS1008365584 (8:22641287 C>A,T), RS1008898445 (8:22642539 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
Acetaminophen	increases expression	1
Methotrexate	decreases expression	1
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.