BIRC8

Summary

BIRC8 (baculoviral IAP repeat containing 8, HGNC:14878) is a protein-coding gene on chromosome 19q13.42, encoding Baculoviral IAP repeat-containing protein 8 (Q96P09). Protects against apoptosis mediated by BAX.

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; and positive regulation of protein ubiquitination. Predicted to be active in cytoplasm and nucleus.

Source: NCBI Gene 112401 — RefSeq curated summary.

At a glance

• Gene type: non-coding (transcribed_processed_pseudogene) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14878
Approved symbol	BIRC8
Name	baculoviral IAP repeat containing 8
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Aliases	ILP-2, hILP2, RNF136
Ensembl gene	ENSG00000163098
Ensembl biotype	transcribed_processed_pseudogene
OMIM	621072
Entrez	112401

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 transcribed_processed_pseudogene

ENST00000652230

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000652230 — 1 exons

Exon	Start	End
ENSE00003844300	53289664	53291131

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 73.37.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0230 / max 25.2608, expressed in 3 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182560	0.0192	3
182559	0.0038	3

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
testis	UBERON:0000473	73.37	gold quality
left testis	UBERON:0004533	73.18	gold quality
right testis	UBERON:0004534	71.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	53.47	gold quality
bone marrow cell	CL:0002092	38.39	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	29.22	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
monocyte	CL:0000576	28.96	gold quality
leukocyte	CL:0000738	28.83	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
right coronary artery	UBERON:0001625	27.03	gold quality
blood	UBERON:0000178	26.78	gold quality
urinary bladder	UBERON:0001255	26.72	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.47

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

Literature-anchored findings (GeneRIF, showing 6)

• role in preventing shear-stress induced endothelial cell apoptosis via negative regulation of caspase-3 (PMID:12372615)
• ILP2 is an unstable protein, and cannot inhibit caspase 9 in a physiological way on its own; possibly ILP2 requires assistance from unidentified cellular factors to be an effective inhibitor of apoptosis in vivo (PMID:15485395)
• results indicate that ILP-2 is a novel breast cancer biomarker in the peripheral blood. (PMID:23222679)
• increased expression with progression of chronic myeloid leukaemia (PMID:24266799)
• Fumonisin B1 caused dose-dependent increase in BIRC-8/ILP-2 mRNA and protein expression in HepG2 cells to inhibit apoptosis. (PMID:25800559)
• High ILP-2 expression is associated with breast cancer. (PMID:30106449)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.