BISPR

Summary

BISPR (BST2 interferon stimulated positive regulator, HGNC:51290) is a long non-coding RNA gene on chromosome 19p13.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51290
Approved symbol	BISPR
Name	BST2 interferon stimulated positive regulator
Location	19p13.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncBST2
Ensembl gene	ENSG00000282851
Ensembl biotype	lncRNA
Entrez	105221694
RNAcentral	URS0000812110 — lncRNA, 1969 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000634291, ENST00000634568, ENST00000634577, ENST00000634675, ENST00000634731, ENST00000634813, ENST00000634942, ENST00000635060, ENST00000635176, ENST00000635339, ENST00000635435, ENST00000635536, ENST00000635572, ENST00000645062, ENST00000645298, ENST00000645376, ENST00000646744, ENST00000647283

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000634291 — 3 exons

Exon	Start	End
ENSE00003790271	17406077	17406296
ENSE00003815712	17413097	17413397
ENSE00003821391	17405710	17405771

Expression profiles

Bgee: expression breadth ubiquitous, 176 present calls, max score 89.94.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.4863 / max 1633.1079, expressed in 985 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174509	4.1194	663
174507	1.0178	502
174508	0.9785	429
174510	0.7297	261
174511	0.5243	218
174506	0.0952	40
174512	0.0802	20

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	89.94	gold quality
leukocyte	CL:0000738	89.71	gold quality
granulocyte	CL:0000094	88.68	gold quality
left ovary	UBERON:0002119	87.37	gold quality
bone marrow cell	CL:0002092	87.19	gold quality
right ovary	UBERON:0002118	86.56	gold quality
spleen	UBERON:0002106	84.09	gold quality
ovary	UBERON:0000992	83.98	gold quality
blood	UBERON:0000178	83.85	gold quality
lymph node	UBERON:0000029	82.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.86	gold quality
vermiform appendix	UBERON:0001154	81.33	gold quality
right lobe of liver	UBERON:0001114	80.71	gold quality
right lobe of thyroid gland	UBERON:0001119	80.61	gold quality
left lobe of thyroid gland	UBERON:0001120	80.17	gold quality
left adrenal gland	UBERON:0001234	79.64	gold quality
left adrenal gland cortex	UBERON:0035825	79.63	gold quality
right adrenal gland	UBERON:0001233	79.21	gold quality
thyroid gland	UBERON:0002046	78.91	gold quality
right adrenal gland cortex	UBERON:0035827	78.75	gold quality
adrenal gland	UBERON:0002369	78.21	gold quality
gall bladder	UBERON:0002110	77.92	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.85	gold quality
adrenal cortex	UBERON:0001235	77.08	gold quality
small intestine	UBERON:0002108	76.58	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.45	gold quality
rectum	UBERON:0001052	76.25	gold quality
bone marrow	UBERON:0002371	76.09	gold quality
descending thoracic aorta	UBERON:0002345	75.79	gold quality
liver	UBERON:0002107	75.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• BISPR promoted the development of TPC cells by inhibiting miR-21-5p expression. (PMID:29856242)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.