BLTP3A

Summary

BLTP3A (bridge-like lipid transfer protein family member 3A, HGNC:21216) is a protein-coding gene on chromosome 6p21.31, encoding Bridge-like lipid transfer protein family member 3A (Q6BDS2). Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites.

Enables histone deacetylase binding activity and identical protein binding activity. Located in late endosome.

Source: NCBI Gene 54887 — RefSeq curated summary.

At a glance

• GWAS associations: 72
• Clinical variants (ClinVar): 245 total
• MANE Select transcript: NM_017754

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21216
Approved symbol	BLTP3A
Name	bridge-like lipid transfer protein family member 3A
Location	6p21.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20302, dJ349A12.1
Ensembl gene	ENSG00000065060
Ensembl biotype	protein_coding
OMIM	619570
Entrez	54887

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000192788

RefSeq mRNA: 1 — MANE Select: NM_017754 NM_017754

CCDS: CCDS43455

Canonical transcript exons

ENST00000192788 — 21 exons

Exon	Start	End
ENSE00000849555	34821653	34821815
ENSE00000849557	34823257	34823348
ENSE00000849558	34834217	34834406
ENSE00000849559	34834721	34834861
ENSE00000849560	34835294	34835464
ENSE00001032558	34821917	34821955
ENSE00001536064	34792083	34792294
ENSE00001913117	34872313	34877514
ENSE00002204269	34855617	34855703
ENSE00002240288	34857724	34857917
ENSE00002241779	34836156	34836348
ENSE00002244306	34856239	34856409
ENSE00002251966	34857329	34857470
ENSE00002261815	34864002	34864198
ENSE00002267363	34867466	34867616
ENSE00002286867	34856790	34856929
ENSE00002287164	34871584	34871692
ENSE00002302200	34858124	34859571
ENSE00002303238	34871819	34871925
ENSE00002316639	34870854	34871116
ENSE00002323076	34867225	34867379

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 94.87.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.3174 / max 182.7254, expressed in 1783 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67380	9.1121	1719
203970	3.9194	1509
67379	0.2859	132

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ventricle myocardium	UBERON:0006566	94.87	gold quality
tibialis anterior	UBERON:0001385	93.95	gold quality
sperm	CL:0000019	93.69	gold quality
deltoid	UBERON:0001476	93.36	gold quality
epithelial cell of pancreas	CL:0000083	91.89	gold quality
vastus lateralis	UBERON:0001379	91.35	gold quality
quadriceps femoris	UBERON:0001377	91.23	gold quality
biceps brachii	UBERON:0001507	90.27	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.11	gold quality
parotid gland	UBERON:0001831	89.98	gold quality
parietal pleura	UBERON:0002400	89.81	gold quality
myocardium	UBERON:0002349	89.55	gold quality
visceral pleura	UBERON:0002401	89.14	gold quality
heart right ventricle	UBERON:0002080	89.09	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	88.75	gold quality
pancreatic ductal cell	CL:0002079	88.39	silver quality
skeletal muscle tissue	UBERON:0001134	88.15	gold quality
muscle tissue	UBERON:0002385	86.89	gold quality
trabecular bone tissue	UBERON:0002483	86.58	gold quality
oviduct epithelium	UBERON:0004804	86.42	gold quality
ileal mucosa	UBERON:0000331	86.11	gold quality
germinal epithelium of ovary	UBERON:0001304	86.03	gold quality
upper leg skin	UBERON:0004262	86.01	gold quality
palpebral conjunctiva	UBERON:0001812	85.85	gold quality
eye	UBERON:0000970	85.31	gold quality
secondary oocyte	CL:0000655	84.85	gold quality
Brodmann (1909) area 23	UBERON:0013554	84.80	gold quality
skeletal muscle organ	UBERON:0014892	84.77	gold quality
pigmented layer of retina	UBERON:0001782	83.70	gold quality
adult organism	UBERON:0007023	83.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.86

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

miRNA regulators (miRDB)

251 targeting BLTP3A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-3692-3P	99.98	70.27	2139

Literature-anchored findings (GeneRIF, showing 5)

• identified five new systemic lupus erythematosus susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). (PMID:19838195)
• Cross-population confirmation establishes the involvement of UHRF1BP1 locus in SLE and indicates that distinct alleles are contributing to disease susceptibility. (PMID:21326321)
• Study shows that SESN1 mRNA, UHRF1BP11 mRNA and miRNA-377-3p levels are prognostically relevant in human papillomavirus-negative head and neck squamous cell carcinoma patients. (PMID:28886272)
• The association of the UHRF1BP1 gene with systemic lupus erythematosus was replicated in a Han Chinese population from mainland China. (PMID:31691269)
• PP7080 expedites the proliferation and migration of lung adenocarcinoma cells via sponging miR-670-3p and regulating UHRF1BP1. (PMID:33844396)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	bltp3a	ENSDARG00000077011
mus_musculus	Bltp3a	ENSMUSG00000039512
rattus_norvegicus	Bltp3a	ENSRNOG00000000495
drosophila_melanogaster	CG34126	FBGN0083962
caenorhabditis_elegans		WBGENE00008094

Paralogs (1): BLTP3B (ENSG00000111647)

Protein

Protein identifiers

Bridge-like lipid transfer protein family member 3A — Q6BDS2 (reviewed: Q6BDS2)

Alternative names: ICBP90-binding protein 1, UHRF1-binding protein 1, Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1

All UniProt accessions (1): Q6BDS2

UniProt curated annotations — full annotation on UniProt →

Function. Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites. May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex.

Subunit / interactions. Homodimer (Potential). Interacts with UHRF1.

Subcellular location. Late endosome.

RefSeq proteins (1): NP_060224* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026728	BLTP3A/B	Family

Pfam: PF24917

UniProt features (26 total): modified residue 7, compositionally biased region 5, region of interest 5, sequence variant 5, coiled-coil region 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6BDS2-F1	67.37	0.31

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 444, 446, 755, 758, 988, 1103, 1106

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 141 (showing top): GSE45365_NK_CELL_VS_BCELL_DN, TGACCTY_ERR1_Q2, MCBRYAN_PUBERTAL_BREAST_4_5WK_DN, MCBRYAN_PUBERTAL_BREAST_3_4WK_UP, MCBRYAN_PUBERTAL_BREAST_5_6WK_UP, PPAR_DR1_Q2, AACTTT_UNKNOWN, MAF_Q6, HOXA4_Q2, SENESE_HDAC3_TARGETS_DN, GOMF_HISTONE_DEACETYLASE_BINDING, GEORGES_TARGETS_OF_MIR192_AND_MIR215, COUP_DR1_Q6, MCBRYAN_PUBERTAL_BREAST_6_7WK_DN, CCTNTMAGA_UNKNOWN

GO Biological Process (0):

GO Molecular Function (3): identical protein binding (GO:0042802), histone deacetylase binding (GO:0042826), protein binding (GO:0005515)

GO Cellular Component (2): late endosome (GO:0005770), endosome (GO:0005768)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein binding	1
enzyme binding	1
binding	1
endosome	1
endomembrane system	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

686 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BLTP3A	PHRF1	Q9P1Y6	657
BLTP3A	ILRUN	Q9H6K1	588
BLTP3A	SCUBE3	Q8IX30	511
BLTP3A	PXK	Q7Z7A4	502
BLTP3A	TNIP1	Q15025	499
BLTP3A	ANKS1A	Q92625	491
BLTP3A	JAZF1	Q86VZ6	490
BLTP3A	UHRF1	Q96T88	481
BLTP3A	COBLL1	Q53SF7	476
BLTP3A	LYPLAL1	Q5VWZ2	448
BLTP3A	GRB14	Q14449	445
BLTP3A	UBAP2	Q5T6F2	439
BLTP3A	TCP11	Q8WWU5	435
BLTP3A	BANK1	Q8NDB2	431
BLTP3A	RGL2	O15211	426

IntAct

91 interactions, top by confidence:

A	B	Type	Score
BCL2L2	BCL2L11	psi-mi:“MI:0914”(association)	0.930
HMG20A	KDM1A	psi-mi:“MI:0914”(association)	0.730
FOXK2	DVL2	psi-mi:“MI:0914”(association)	0.640
DNAJC7	PLD2	psi-mi:“MI:0914”(association)	0.640
KLHL22	TMEM223	psi-mi:“MI:0914”(association)	0.640
RUVBL1	POLR3A	psi-mi:“MI:0914”(association)	0.640
RAB9A	CHM	psi-mi:“MI:0914”(association)	0.610
PCNA	POM121C	psi-mi:“MI:0914”(association)	0.550
CREB3L1	AP3B1	psi-mi:“MI:0914”(association)	0.530
FAM131B	AURKA	psi-mi:“MI:0914”(association)	0.530
RAB30	UBB	psi-mi:“MI:0914”(association)	0.530
STK16	FLG	psi-mi:“MI:0914”(association)	0.530
EPB41L5	SETD1A	psi-mi:“MI:0914”(association)	0.530
STK16	UNC119B	psi-mi:“MI:0914”(association)	0.530
CREB3	MYO9A	psi-mi:“MI:0914”(association)	0.530
MAGEA4	MAGEA8	psi-mi:“MI:0914”(association)	0.530
CBY1	CFAP410	psi-mi:“MI:0914”(association)	0.510
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
BLTP3A	H1-2	psi-mi:“MI:0915”(physical association)	0.400
BLTP3A	H2BC9	psi-mi:“MI:0915”(physical association)	0.400
BLTP3A	HMGA1	psi-mi:“MI:0915”(physical association)	0.400
BLTP3A	POLE	psi-mi:“MI:0915”(physical association)	0.400
Tube1		psi-mi:“MI:0914”(association)	0.350
RAPGEF2	BDP1	psi-mi:“MI:0914”(association)	0.350
ZNF644	ATP9A	psi-mi:“MI:0914”(association)	0.350

BioGRID (112): UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS), UHRF1BP1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IES7, A0JN62, A0JNW5, A2AAE1, A2AGL3, A2RSJ4, A2RT67, A2RUS2, A2RV80, B0LPN4, B1H2P5, E7F240, E9Q401, O00507, O94967, P30957, P48553, P51593, Q14161, Q2LD37, Q3TLI0, Q3UHE1, Q3UVG3, Q3UX43, Q5F361, Q5M7Q1, Q5RAQ5, Q5ZJK1, Q658Y4, Q68CL5, Q6BDS2, Q6P6Y1, Q6TEP1, Q6VNB8, Q7TMY8, Q7TSG1, Q7Z6Z7, Q8BHY8, Q8CB44, Q8CGF6

Diamond homologs: A0JNW5, A2RSJ4, Q54KX3, Q6BDS2, Q6NRZ1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 131 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
mitophagy	9	24.1×	5e-08
autophagosome maturation	8	23.6×	5e-07
autophagosome assembly	6	11.3×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

245 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	199
Likely benign	7
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

3032 predictions. Top by Δscore:

Variant	Effect	Δscore
6:34821648:TTCA:T	acceptor_loss	1.0000
6:34821649:TCAG:T	acceptor_loss	1.0000
6:34821650:CA:C	acceptor_loss	1.0000
6:34821651:A:AC	acceptor_loss	1.0000
6:34821651:A:AG	acceptor_gain	1.0000
6:34821652:G:A	acceptor_loss	1.0000
6:34821652:G:GG	acceptor_gain	1.0000
6:34821652:GGTTC:G	acceptor_gain	1.0000
6:34823253:TCA:T	acceptor_loss	1.0000
6:34823254:CAGTG:C	acceptor_loss	1.0000
6:34823255:A:AG	acceptor_gain	1.0000
6:34823255:A:AT	acceptor_loss	1.0000
6:34823256:G:GA	acceptor_gain	1.0000
6:34823256:GT:G	acceptor_gain	1.0000
6:34823256:GTGT:G	acceptor_gain	1.0000
6:34823344:CAGAG:C	donor_loss	1.0000
6:34823345:AGAG:A	donor_loss	1.0000
6:34823346:GAG:G	donor_gain	1.0000
6:34823346:GAGGT:G	donor_loss	1.0000
6:34823349:GTT:G	donor_loss	1.0000
6:34834403:A:T	donor_gain	1.0000
6:34834716:TCCA:T	acceptor_loss	1.0000
6:34834719:A:C	acceptor_loss	1.0000
6:34834720:G:A	acceptor_loss	1.0000
6:34834857:GAAGA:G	donor_gain	1.0000
6:34834860:GA:G	donor_gain	1.0000
6:34834862:G:GG	donor_gain	1.0000
6:34835282:T:TA	acceptor_gain	1.0000
6:34835289:CTCAG:C	acceptor_loss	1.0000
6:34835290:TCAG:T	acceptor_loss	1.0000

AlphaMissense

9469 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:34821771:T:A	W55R	1.000
6:34821771:T:C	W55R	1.000
6:34821795:T:C	C63R	1.000
6:34821797:C:G	C63W	1.000
6:34821923:T:A	W72R	1.000
6:34821923:T:C	W72R	1.000
6:34821925:G:C	W72C	1.000
6:34821925:G:T	W72C	1.000
6:34834745:T:A	W185R	1.000
6:34834745:T:C	W185R	1.000
6:34834818:T:C	L209P	1.000
6:34835351:T:A	W243R	1.000
6:34835351:T:C	W243R	1.000
6:34792264:T:A	I5N	0.999
6:34792279:T:C	L10P	0.999
6:34792288:T:C	L13P	0.999
6:34821654:T:C	F16L	0.999
6:34821655:T:C	F16S	0.999
6:34821656:C:A	F16L	0.999
6:34821656:C:G	F16L	0.999
6:34821702:G:A	G32R	0.999
6:34821702:G:C	G32R	0.999
6:34821703:G:A	G32E	0.999
6:34821715:T:C	L36P	0.999
6:34821724:T:C	L39P	0.999
6:34821730:T:A	L41Q	0.999
6:34821730:T:C	L41P	0.999
6:34821745:T:C	L46P	0.999
6:34821796:G:A	C63Y	0.999
6:34821805:C:A	A66D	0.999

dbSNP variants (sampled 300 via entrez): RS1000009669 (6:34824451 G>A), RS1000035238 (6:34800822 G>T), RS1000051575 (6:34852911 A>G), RS1000066968 (6:34877564 A>G), RS1000158913 (6:34813047 T>C), RS1000216690 (6:34866979 A>G), RS1000248197 (6:34833279 C>T), RS1000269459 (6:34806574 C>T), RS1000270128 (6:34852652 A>G), RS1000282579 (6:34845619 T>C,G), RS1000299837 (6:34866379 C>T), RS1000305418 (6:34874689 A>G), RS1000335998 (6:34827800 T>G), RS1000369050 (6:34820120 T>C), RS1000402193 (6:34797853 T>G)

Disease associations

OMIM: gene MIM:619570 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

72 associations (top):

Study	Trait	p-value
GCST001526_12	Fasting blood insulin (BMI interaction)	4.000000e-08
GCST001795_32	Systemic lupus erythematosus	1.000000e-12
GCST002069_12	Systemic lupus erythematosus and Systemic sclerosis	3.000000e-07
GCST003155_52	Systemic lupus erythematosus	8.000000e-09
GCST003156_31	Systemic lupus erythematosus	1.000000e-08
GCST003622_56	Systemic lupus erythematosus	1.000000e-10
GCST004065_54	Waist circumference	6.000000e-06
GCST004065_58	Waist circumference	3.000000e-08
GCST004066_34	Hip circumference	8.000000e-08
GCST004066_5	Hip circumference	2.000000e-08
GCST004066_86	Hip circumference	1.000000e-13
GCST004067_168	Hip circumference adjusted for BMI	9.000000e-10
GCST004067_181	Hip circumference adjusted for BMI	3.000000e-06
GCST004067_61	Hip circumference adjusted for BMI	3.000000e-13
GCST004557_193	Body mass index	2.000000e-10
GCST004557_222	Body mass index	8.000000e-08
GCST004557_54	Body mass index	2.000000e-07
GCST004557_92	Body mass index	2.000000e-10
GCST004558_215	Body mass index (joint analysis main effects and physical activity interaction)	2.000000e-09
GCST004558_238	Body mass index (joint analysis main effects and physical activity interaction)	2.000000e-06
GCST004558_65	Body mass index (joint analysis main effects and physical activity interaction)	5.000000e-10
GCST004558_92	Body mass index (joint analysis main effects and physical activity interaction)	3.000000e-07
GCST004559_124	Body mass index in physically active individuals	2.000000e-07
GCST004559_46	Body mass index in physically active individuals	2.000000e-07
GCST004559_85	Body mass index in physically active individuals	4.000000e-06
GCST004603_22	Platelet count	3.000000e-17
GCST004607_140	Plateletcrit	2.000000e-17
GCST004867_10	Systemic lupus erythematosus	2.000000e-08
GCST005185_10	Fasting blood insulin	7.000000e-06
GCST005194_132	Coronary artery disease	1.000000e-10

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0008039	BMI-adjusted hip circumference
EFO:0008002	physical activity measurement
EFO:0004309	platelet count
EFO:0007985	platelet crit
EFO:0006941	grip strength measurement
EFO:0004341	body fat distribution
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0009933	Thyroid preparation use measurement
EFO:0007789	BMI-adjusted waist circumference
EFO:0010100	multisite chronic pain
EFO:0005090	basophil count
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	3
Cyclosporine	increases expression	3
Acetaminophen	decreases expression, increases expression	2
Benzo(a)pyrene	affects methylation	2
Estradiol	affects cotreatment, decreases expression, increases expression	2
Tobacco Smoke Pollution	decreases expression, increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
bisphenol A	affects cotreatment, increases methylation	1
salinomycin	decreases expression	1
arsenite	affects binding, decreases reaction	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
S-(1,2-dichlorovinyl)cysteine	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
perfluoro-n-nonanoic acid	increases expression	1
ICG 001	increases expression	1
NSC668394	increases expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Caffeine	decreases phosphorylation	1
Calcitriol	increases expression	1
Doxorubicin	decreases expression	1
Methapyrilene	increases methylation	1
1-Methyl-4-phenylpyridinium	increases expression	1
Gold Compounds	decreases expression	1
Antirheumatic Agents	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E9W1	A549 BLTP3A KO clone C2	Cancer cell line	Male
CVCL_E9W2	A549 BLTP3A KO clone D9	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.