BMPR1B-DT

Summary

BMPR1B-DT (BMPR1B divergent transcript, HGNC:50864) is a long non-coding RNA gene on chromosome 4q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50864
Approved symbol	BMPR1B-DT
Name	BMPR1B divergent transcript
Location	4q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00007797
Ensembl gene	ENSG00000249599
Ensembl biotype	lncRNA
Entrez	100507012
RNAcentral	URS0000759CD9 — lncRNA, 643 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000510795, ENST00000730467, ENST00000730468, ENST00000730469

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000510795 — 3 exons

Exon	Start	End
ENSE00002043200	94754830	94754905
ENSE00004059023	94743664	94744094
ENSE00004059029	94757394	94757762

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 85.54.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0434 / max 8.1195, expressed in 18 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
53189	0.0434	18

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.54	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.92	gold quality
right uterine tube	UBERON:0001302	80.86	gold quality
testis	UBERON:0000473	77.99	gold quality
left testis	UBERON:0004533	77.98	gold quality
right testis	UBERON:0004534	76.23	gold quality
fallopian tube	UBERON:0003889	70.95	gold quality
quadriceps femoris	UBERON:0001377	70.41	gold quality
prostate gland	UBERON:0002367	70.12	gold quality
endometrium	UBERON:0001295	69.80	gold quality
bone marrow cell	CL:0002092	69.09	silver quality
thymus	UBERON:0002370	68.59	silver quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
skeletal muscle tissue	UBERON:0001134	67.19	silver quality
calcaneal tendon	UBERON:0003701	67.16	gold quality
putamen	UBERON:0001874	66.30	gold quality
caudate nucleus	UBERON:0001873	64.36	gold quality
ganglionic eminence	UBERON:0004023	63.64	gold quality
ventricular zone	UBERON:0003053	62.75	gold quality
nucleus accumbens	UBERON:0001882	61.25	gold quality
adult mammalian kidney	UBERON:0000082	56.95	gold quality
kidney	UBERON:0002113	56.78	gold quality
prefrontal cortex	UBERON:0000451	56.14	gold quality
endocervix	UBERON:0000458	56.00	gold quality
liver	UBERON:0002107	55.16	gold quality
multicellular organism	UBERON:0000468	54.53	gold quality
brain	UBERON:0000955	54.51	gold quality
uterine cervix	UBERON:0000002	54.30	gold quality
amygdala	UBERON:0001876	53.84	gold quality
superior frontal gyrus	UBERON:0002661	53.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-kappaB pathway. (PMID:35404759)
• Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway. (PMID:38703029)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.