BOD1L1

Summary

BOD1L1 (biorientation of chromosomes in cell division 1 like 1, HGNC:31792) is a protein-coding gene on chromosome 4p15.33, encoding Biorientation of chromosomes in cell division protein 1-like 1 (Q8NFC6). Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection.

Involved in DNA damage response and replication fork processing. Located in nucleoplasm. Part of Set1C/COMPASS complex.

Source: NCBI Gene 259282 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 491 total — 1 likely-pathogenic
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• MANE Select transcript: NM_148894

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31792
Approved symbol	BOD1L1
Name	biorientation of chromosomes in cell division 1 like 1
Location	4p15.33
Locus type	gene with protein product
Status	Approved
Aliases	FLJ33215, KIAA1327
Ensembl gene	ENSG00000038219
Ensembl biotype	protein_coding
OMIM	616746
Entrez	259282

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 protein_coding, 3 retained_intron, 1 nonsense_mediated_decay

ENST00000040738, ENST00000482713, ENST00000505343, ENST00000507943, ENST00000509897, ENST00000511119, ENST00000927661, ENST00000927662

RefSeq mRNA: 1 — MANE Select: NM_148894 NM_148894

CCDS: CCDS3411

Canonical transcript exons

ENST00000040738 — 26 exons

Exon	Start	End
ENSE00000432286	13595860	13595944
ENSE00000704789	13577582	13577631
ENSE00000704845	13579928	13579973
ENSE00000704905	13581020	13581054
ENSE00000705080	13591923	13591966
ENSE00000705082	13597104	13597168
ENSE00000816722	13581132	13581207
ENSE00001035646	13582237	13582310
ENSE00001193549	13568738	13570128
ENSE00001655701	13607117	13607189
ENSE00001696141	13608530	13608668
ENSE00001728858	13613512	13613661
ENSE00001749326	13609295	13609406
ENSE00001769699	13610934	13611100
ENSE00001796707	13598946	13605084
ENSE00001909770	13627345	13627725
ENSE00003479560	13619943	13620067
ENSE00003499569	13588722	13588792
ENSE00003586222	13615312	13615502
ENSE00003588106	13582652	13582736
ENSE00003595760	13614196	13614810
ENSE00003599609	13577403	13577487
ENSE00003620347	13586396	13586475
ENSE00003626077	13590386	13590446
ENSE00003684276	13576838	13576991
ENSE00003687440	13587699	13587771

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 96.70.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.7076 / max 1031.2089, expressed in 1816 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
51424	26.5663	1815
51423	2.1413	790

Top tissues by expression

263 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.70	gold quality
tendon of biceps brachii	UBERON:0008188	96.48	gold quality
tendon	UBERON:0000043	95.23	gold quality
calcaneal tendon	UBERON:0003701	95.14	gold quality
cardiac muscle of right atrium	UBERON:0003379	94.27	gold quality
cerebellar vermis	UBERON:0004720	93.61	gold quality
ileal mucosa	UBERON:0000331	93.59	gold quality
bone marrow cell	CL:0002092	93.31	gold quality
left ovary	UBERON:0002119	92.53	gold quality
nerve	UBERON:0001021	92.38	gold quality
tibial nerve	UBERON:0001323	92.38	gold quality
medial globus pallidus	UBERON:0002477	92.22	gold quality
corpus callosum	UBERON:0002336	92.14	gold quality
blood	UBERON:0000178	92.00	gold quality
right ovary	UBERON:0002118	91.93	gold quality
mucosa of stomach	UBERON:0001199	91.70	gold quality
cerebellar cortex	UBERON:0002129	91.66	gold quality
cerebellar hemisphere	UBERON:0002245	91.64	gold quality
monocyte	CL:0000576	91.59	gold quality
cerebellum	UBERON:0002037	91.41	gold quality
bone marrow	UBERON:0002371	91.40	gold quality
tibialis anterior	UBERON:0001385	91.36	gold quality
leukocyte	CL:0000738	91.33	gold quality
body of uterus	UBERON:0009853	91.33	gold quality
spleen	UBERON:0002106	91.28	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.26	gold quality
globus pallidus	UBERON:0001875	91.02	gold quality
ovary	UBERON:0000992	90.97	gold quality
colonic epithelium	UBERON:0000397	90.96	gold quality
left ventricle myocardium	UBERON:0006566	90.88	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.17
E-MTAB-7606	no	539.73
E-MTAB-6075	no	511.74

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

166 targeting BOD1L1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-590-3P	99.96	74.34	6478

Literature-anchored findings (GeneRIF, showing 3)

• Results show that BOD1L protects against severe genome instability caused by replication stress; it maintains fork stability by stabilizing RAD51 nucleofilaments. (PMID:26166705)
• Protection or resection: BOD1L as a novel replication fork protection factor. (PMID:26889944)
• BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A. (PMID:38989615)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	bod1l1	ENSDARG00000089505
mus_musculus	Bod1l	ENSMUSG00000061755
rattus_norvegicus	Bod1l1	ENSRNOG00000050437

Paralogs (2): BOD1 (ENSG00000145919), BOD1L2 (ENSG00000228075)

Protein

Protein identifiers

Biorientation of chromosomes in cell division protein 1-like 1 — Q8NFC6 (reviewed: Q8NFC6)

All UniProt accessions (3): F8WDD0, H0Y9Y2, Q8NFC6

UniProt curated annotations — full annotation on UniProt →

Function. Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation.

Subunit / interactions. Interacts (via COMPASS-Shg1 domain) with SETD1A at stalled replication forks; this interaction mediates FANCD2-dependent nucleosome remodeling at reversed forks protecting them from nucleolytic degradation.

Subcellular location. Chromosome.

Similarity. Belongs to the BOD1 family.

RefSeq proteins (1): NP_683692* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR043244	BOD1L1	Family
IPR055264	BOD1/SHG1_dom	Domain

Pfam: PF05205

UniProt features (100 total): compositionally biased region 35, modified residue 31, region of interest 15, sequence variant 10, sequence conflict 5, cross-link 2, chain 1, DNA-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

No AlphaFold model available for Q8NFC6 — AlphaFold DB does not currently provide models for proteins above ~3000 aa.

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (33): 266, 473, 482, 484, 635, 659, 660, 733, 1077, 1145, 1318, 1354, 1531, 1701, 1710, 2013, 2025, 2128, 2203, 2475 …

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes
R-HSA-212165	Epigenetic regulation of gene expression
R-HSA-74160	Gene expression (Transcription)
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes

MSigDB gene sets: 155 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP, GOBP_DNA_TEMPLATED_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN, GCM_GSPT1, GCM_BCL2L1, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, MODULE_480, GOBP_DNA_DAMAGE_RESPONSE, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GCM_NF2, BURTON_ADIPOGENESIS_12, CHANDRAN_METASTASIS_UP, GOBP_DNA_REPLICATION, MODULE_427

GO Biological Process (3): DNA repair (GO:0006281), DNA damage response (GO:0006974), replication fork processing (GO:0031297)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): nucleoplasm (GO:0005654), chromosome (GO:0005694), Set1C/COMPASS complex (GO:0048188)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Epigenetic regulation by WDR5-containing histone modifying complexes	1
Gene expression (Transcription)	1
Epigenetic regulation of gene expression	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA metabolic process	1
DNA damage response	1
cellular response to stress	1
DNA-templated DNA replication maintenance of fidelity	1
binding	1
nuclear lumen	1
cellular anatomical structure	1
intracellular membraneless organelle	1
histone methyltransferase complex	1

Protein interactions and networks

STRING

1316 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BOD1L1	ABRAXAS2	Q15018	668
BOD1L1	BRCA2	P51587	658
BOD1L1	DNA2	P51530	650
BOD1L1	RADX	Q6NSI4	623
BOD1L1	PAXIP1	Q6ZW49	603
BOD1L1	FBH1	Q8NFZ0	603
BOD1L1	ZRANB3	Q5FWF4	602
BOD1L1	WRNIP1	Q96S55	598
BOD1L1	SETD1A	O15047	594
BOD1L1	SMARCAL1	Q9NZC9	592
BOD1L1	EXO1	Q9UQ84	511
BOD1L1	HLTF	Q14527	507
BOD1L1	C1orf159	Q96HA4	498
BOD1L1	FANCD2	Q9BXW9	481
BOD1L1	SSH2	Q76I76	471

IntAct

76 interactions, top by confidence:

A	B	Type	Score
WDR5	KMT2D	psi-mi:“MI:0914”(association)	0.910
ASH2L	KMT2D	psi-mi:“MI:0914”(association)	0.890
RBBP5	KMT2D	psi-mi:“MI:0914”(association)	0.840
NUP50	KPNA4	psi-mi:“MI:0914”(association)	0.830
NUP50	KPNA3	psi-mi:“MI:0914”(association)	0.780
BOD1L1	WDR5	psi-mi:“MI:0915”(physical association)	0.770
CXXC1	SETD1A	psi-mi:“MI:0914”(association)	0.760
WDR5	MEN1	psi-mi:“MI:0914”(association)	0.710
YWHAG	BLTP3B	psi-mi:“MI:0914”(association)	0.640
KPNA1	TCERG1	psi-mi:“MI:0914”(association)	0.640
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
MDK	SETD1A	psi-mi:“MI:0914”(association)	0.530
HCFC2	SETD1A	psi-mi:“MI:0914”(association)	0.530
EPB41L3	AP3B1	psi-mi:“MI:0914”(association)	0.530
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
EPB41L5	SETD1A	psi-mi:“MI:0914”(association)	0.530
Nf2	BOD1L1	psi-mi:“MI:0915”(physical association)	0.400
BOD1L1	CNPY3	psi-mi:“MI:0915”(physical association)	0.400
DLEC1	BOD1L1	psi-mi:“MI:0915”(physical association)	0.400
H1-2	BOD1L1	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (202): BOD1L1 (Affinity Capture-MS), BOD1L1 (Affinity Capture-MS), BOD1L1 (Affinity Capture-MS), MYL6 (Affinity Capture-MS), NCBP1 (Affinity Capture-MS), RBBP5 (Affinity Capture-MS), TAF6 (Affinity Capture-MS), SEMA3B (Affinity Capture-MS), MKNK1 (Affinity Capture-MS), AKR7A2 (Affinity Capture-MS), SETD1A (Affinity Capture-MS), KEAP1 (Affinity Capture-MS), TACC3 (Affinity Capture-MS), SKIV2L2 (Affinity Capture-MS), TRIM29 (Affinity Capture-MS)

ESM2 similar proteins: A2A6A1, A8MW92, B5DE93, D2H526, E1BB50, E9Q309, E9Q4F7, E9Q6J5, F1QBY1, O14513, O60284, P30414, P30415, P31629, Q01538, Q14AX6, Q17QQ9, Q3KPW4, Q3MJK5, Q498L0, Q499E5, Q4V9H5, Q5R6I3, Q5SW79, Q5VT06, Q6A065, Q6P9P0, Q6PCB5, Q6UB98, Q6UB99, Q80TY4, Q80YR5, Q86V48, Q8BLG0, Q8BYK8, Q8C5W0, Q8CCJ9, Q8CFC2, Q8IX21, Q8NFC6

Diamond homologs: E9Q6J5, Q5SQY2, Q68FB1, Q6AYJ2, Q6DFL2, Q8IYS8, Q8NFC6, Q96IK1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 83 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of WDR5-containing histone-modifying complexes	11	48.7×	7e-14
NS1 Mediated Effects on Host Pathways	5	23.8×	2e-04
Deactivation of the beta-catenin transactivating complex	6	23.3×	3e-05
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	5	16.4×	9e-04
Influenza Infection	5	14.6×	1e-03
SARS-CoV-1-host interactions	5	14.6×	1e-03
PKMTs methylate histone lysines	5	13.4×	2e-03
Epigenetic regulation by WDR5-containing histone modifying complexes	5	12.9×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
protein import into nucleus	7	13.8×	4e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

491 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	413
Likely benign	40
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
814529	GRCh37/hg19 4p16.2-15.32(chr4:5914109-17264668)x1	Likely pathogenic

SpliceAI

3956 predictions. Top by Δscore:

Variant	Effect	Δscore
4:13576987:GGATT:G	acceptor_gain	1.0000
4:13576988:GATT:G	acceptor_gain	1.0000
4:13576989:ATT:A	acceptor_gain	1.0000
4:13576990:TT:T	acceptor_gain	1.0000
4:13576991:TC:T	acceptor_loss	1.0000
4:13576992:C:CA	acceptor_loss	1.0000
4:13576992:C:CC	acceptor_gain	1.0000
4:13577398:CATA:C	donor_loss	1.0000
4:13577399:ATAC:A	donor_loss	1.0000
4:13577400:TACCA:T	donor_loss	1.0000
4:13577401:A:AC	donor_gain	1.0000
4:13577401:A:AT	donor_loss	1.0000
4:13577401:ACCAG:A	donor_gain	1.0000
4:13577402:C:CA	donor_gain	1.0000
4:13577402:CCAG:C	donor_gain	1.0000
4:13577402:CCAGC:C	donor_gain	1.0000
4:13577443:T:TA	donor_gain	1.0000
4:13577483:TCATC:T	acceptor_gain	1.0000
4:13577484:CATC:C	acceptor_gain	1.0000
4:13577484:CATCC:C	acceptor_gain	1.0000
4:13577485:ATC:A	acceptor_gain	1.0000
4:13577486:TC:T	acceptor_gain	1.0000
4:13577486:TCCTA:T	acceptor_loss	1.0000
4:13577487:CC:C	acceptor_gain	1.0000
4:13577488:C:CC	acceptor_gain	1.0000
4:13577495:C:CT	acceptor_gain	1.0000
4:13577496:A:T	acceptor_gain	1.0000
4:13577497:A:AC	acceptor_gain	1.0000
4:13577497:A:C	acceptor_gain	1.0000
4:13577580:A:AC	donor_gain	1.0000

AlphaMissense

20252 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:13613609:G:C	S409R	1.000
4:13613609:G:T	S409R	1.000
4:13613611:T:G	S409R	1.000
4:13614747:A:T	I208K	1.000
4:13614759:A:T	I204K	1.000
4:13615397:A:C	F158L	1.000
4:13615397:A:T	F158L	1.000
4:13615398:A:G	F158S	1.000
4:13615399:A:G	F158L	1.000
4:13615411:C:G	A154P	1.000
4:13615419:A:T	V151E	1.000
4:13615430:G:C	F147L	1.000
4:13615430:G:T	F147L	1.000
4:13615431:A:C	F147C	1.000
4:13615431:A:G	F147S	1.000
4:13615432:A:G	F147L	1.000
4:13615445:C:A	K142N	1.000
4:13615445:C:G	K142N	1.000
4:13615458:A:T	V138D	1.000
4:13615461:T:G	Q137P	1.000
4:13615467:A:T	I135N	1.000
4:13615470:A:C	I134S	1.000
4:13615470:A:G	I134T	1.000
4:13615470:A:T	I134N	1.000
4:13615471:T:A	I134F	1.000
4:13615473:C:G	R133P	1.000
4:13615482:C:T	G130D	1.000
4:13615483:C:G	G130R	1.000
4:13615491:A:G	L127S	1.000
4:13619949:A:T	V121D	1.000

dbSNP variants (sampled 300 via entrez): RS1000016956 (4:13628886 A>T), RS1000097589 (4:13581994 C>T), RS1000126836 (4:13623291 T>C), RS1000153971 (4:13604422 TTTG>T), RS10001811 (4:13568528 T>A,C), RS1000254429 (4:13608752 A>G), RS1000378969 (4:13597748 T>C), RS1000404587 (4:13601581 G>A), RS1000436363 (4:13623064 C>T), RS1000503121 (4:13584268 T>A), RS10005265 (4:13575941 A>C,T), RS10005546 (4:13579052 C>A,T), RS1000602163 (4:13595628 G>A,T), RS1000606060 (4:13577132 C>G,T), RS1000659367 (4:13621830 C>T)

Disease associations

OMIM: gene MIM:616746 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002312_4	Periodontal disease-related phenotype (Socransky)	1.000000e-06
GCST002312_7	Periodontal disease-related phenotype (Socransky)	4.000000e-06
GCST003441_1	Response to paclitaxel in ovarian cancer (MTT IC50)	2.000000e-07
GCST004793_2	Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006952	cytotoxicity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5724770 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL1232461	MOLIBRESIB	2	1,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.19	Kd	65	nM	MOLIBRESIB
7.16	IC50	70	nM	MOLIBRESIB

PubChem BioAssay actives

2 with measured affinity, of 7 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide	2179246: Binding affinity against FAM44A (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	kd	0.0650	uM

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression, affects cotreatment	2
Tobacco Smoke Pollution	increases expression	2
FR900359	affects phosphorylation	1
geldanamycin	increases expression	1
arsenite	affects binding, decreases reaction	1
methylparaben	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
coumarin	affects phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
bisphenol S	decreases expression, affects cotreatment	1
Irinotecan	decreases expression	1
Arsenic Trioxide	increases expression	1
Vorinostat	decreases expression	1
Arsenic	decreases expression, increases abundance, affects cotreatment	1
Caffeine	affects phosphorylation	1
Cisplatin	decreases expression	1
Clorgyline	increases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases phosphorylation, affects phosphorylation, affects response to substance	1
Indomethacin	affects cotreatment, decreases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Ribonucleotides	affects binding	1
Thimerosal	decreases expression	1
Thiram	increases expression	1
Toluene	increases expression	1
Valproic Acid	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1

ChEMBL screening assays

7 unique, capped per target: 7 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5697788	Binding	Inhibition of FAM44A (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.